Ian G. Davison
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View article: Robust speckle contrast imaging based on spatial covariance
Robust speckle contrast imaging based on spatial covariance Open
Speckle contrast is a simple metric for characterizing tissue dynamics such as blood flow. In conventional laser speckle contrast imaging (LSCI), speckle patterns are captured by a camera and their contrast, spatial or temporal, is calcula…
View article: Targeted micro-fiber arrays for measuring and manipulating localized multi-scale neural dynamics over large, deep brain volumes during behavior
Targeted micro-fiber arrays for measuring and manipulating localized multi-scale neural dynamics over large, deep brain volumes during behavior Open
Neural population dynamics relevant to behavior vary over multiple spatial and temporal scales across three-dimensional volumes. Current optical approaches lack the spatial coverage and resolution necessary to measure and manipulate natura…
View article: Robust single-shot 3D fluorescence imaging in scattering media with a simulator-trained neural network
Robust single-shot 3D fluorescence imaging in scattering media with a simulator-trained neural network Open
Imaging through scattering is a pervasive and difficult problem in many biological applications. The high background and the exponentially attenuated target signals due to scattering fundamentally limits the imaging depth of fluorescence m…
View article: Targeted micro-fiber arrays for measuring and manipulating localized multi-scale neural dynamics over large, deep brain volumes during behavior: resources and main figure data
Targeted micro-fiber arrays for measuring and manipulating localized multi-scale neural dynamics over large, deep brain volumes during behavior: resources and main figure data Open
Summary: Neural population dynamics relevant for behavior vary over multiple spatial and temporal scales across 3-dimensional volumes. Current optical approaches lack the spatial coverage and resolution necessary to measure and manipulate …
View article: Targeted micro-fiber arrays for measuring and manipulating localized multi-scale neural dynamics over large, deep brain volumes during behavior: resources and main figure data
Targeted micro-fiber arrays for measuring and manipulating localized multi-scale neural dynamics over large, deep brain volumes during behavior: resources and main figure data Open
Summary: Neural population dynamics relevant for behavior vary over multiple spatial and temporal scales across 3-dimensional volumes. Current optical approaches lack the spatial coverage and resolution necessary to measure and manipulate …
View article: Targeted micro-fiber arrays for measuring and manipulating localized multi-scale neural dynamics over large, deep brain volumes during behavior: resources and main figure data
Targeted micro-fiber arrays for measuring and manipulating localized multi-scale neural dynamics over large, deep brain volumes during behavior: resources and main figure data Open
Summary: Neural population dynamics relevant for behavior vary over multiple spatial and temporal scales across 3-dimensional volumes. Current optical approaches lack the spatial coverage and resolution necessary to measure and manipulate …
View article: Targeted micro-fiber arrays for measuring and manipulating localized multi-scale neural dynamics over large, deep brain volumes during behavior
Targeted micro-fiber arrays for measuring and manipulating localized multi-scale neural dynamics over large, deep brain volumes during behavior Open
Neural population dynamics relevant for behavior vary over multiple spatial and temporal scales across 3-dimensional volumes. Current optical approaches lack the spatial coverage and resolution necessary to measure and manipulate naturally…
View article: Pupil engineering for extended depth-of-field imaging in a fluorescence miniscope
Pupil engineering for extended depth-of-field imaging in a fluorescence miniscope Open
Built from off-the-shelf components and augmented by a customizable DOE, we expect that this low-cost EDoF-Miniscope may find utility in a wide range of neural recording applications.
View article: EDoF-Miniscope: pupil engineering for extended depth-of-field imaging in a fluorescence miniscope
EDoF-Miniscope: pupil engineering for extended depth-of-field imaging in a fluorescence miniscope Open
Extended depth of field (EDoF) microscopy has emerged as a powerful solution to greatly increase the access into neuronal populations in table-top imaging platforms. Here, we present EDoF-Miniscope, which integrates an optimized thin and l…
View article: High-Speed Low-Light <i>In Vivo</i> Two-Photon Voltage Imaging of Large Neuronal Populations
High-Speed Low-Light <i>In Vivo</i> Two-Photon Voltage Imaging of Large Neuronal Populations Open
SUMMARY Monitoring spiking activity across large neuronal populations at behaviorally relevant timescales is critical for understanding neural circuit function. Unlike calcium imaging, voltage imaging requires kilohertz sampling rates whic…
View article: Balancing memory fidelity and representational stability in the female mouse accessory olfactory bulb
Balancing memory fidelity and representational stability in the female mouse accessory olfactory bulb Open
Sensory systems must balance the value of efficient coding schemes against the need to update specific memorized representations without perturbing other memories. Here we describe a unique solution to this challenge that is implemented by…
View article: Scan multiplier unit for ultrafast laser scanning beyond the inertia limit
Scan multiplier unit for ultrafast laser scanning beyond the inertia limit Open
A passive add-on greatly multiplies the sweep rate of any mechanical scanner while also enhancing throughput, enabling a single linear scanner to produce ultrafast 1D or 2D laser scans for general applications.
View article: Large-scale cellular-resolution imaging of neural activity in freely behaving mice
Large-scale cellular-resolution imaging of neural activity in freely behaving mice Open
Miniaturized microscopes for head-mounted fluorescence imaging are powerful tools for visualizing neural activity during naturalistic behaviors, but the restricted field of view of first-generation ‘miniscopes’ limits the size of neural po…
View article: Synchronous Infra-Slow Oscillations Organize Ensembles of Accessory Olfactory Bulb Projection Neurons into Distinct Microcircuits
Synchronous Infra-Slow Oscillations Organize Ensembles of Accessory Olfactory Bulb Projection Neurons into Distinct Microcircuits Open
The accessory olfactory system controls social and sexual behavior. In the mouse accessory olfactory bulb, the first central stage of information processing along the accessory olfactory pathway, projection neurons (mitral cells) display i…
View article: Rapid disruption of the cortical microcirculation after mild traumatic brain injury
Rapid disruption of the cortical microcirculation after mild traumatic brain injury Open
Traumatic brain injury (TBI) is a major source of cognitive deficits affecting millions annually. The bulk of human injuries are mild, causing little or no macroscopic damage to neural tissue, yet can still lead to long-term neuropathology…
View article: Rapid Changes in Synaptic Strength After Mild Traumatic Brain Injury
Rapid Changes in Synaptic Strength After Mild Traumatic Brain Injury Open
Traumatic brain injury (TBI) affects millions of Americans annually, but effective treatments remain inadequate due to our poor understanding of how injury impacts neural function. Data are particularly limited for mild, closed-skull TBI, …
View article: Variation in pigmentation gene expression is associated with distinct aposematic color morphs in the poison frog Dendrobates auratus
Variation in pigmentation gene expression is associated with distinct aposematic color morphs in the poison frog Dendrobates auratus Open
Background:
\nColor and pattern phenotypes have clear implications for survival and reproduction in many species. However, the mechanisms that produce this coloration are still poorly characterized, especially at the genomic level. Here we…
View article: Additional file 1: of Variation in pigmentation gene expression is associated with distinct aposematic color morphs in the poison frog Dendrobates auratus
Additional file 1: of Variation in pigmentation gene expression is associated with distinct aposematic color morphs in the poison frog Dendrobates auratus Open
Table S1. Differentially expressed genes. A list of genes that were differentially expressed and relevant test statistics. (CSV 482 kb)
View article: Additional file 2: of Variation in pigmentation gene expression is associated with distinct aposematic color morphs in the poison frog Dendrobates auratus
Additional file 2: of Variation in pigmentation gene expression is associated with distinct aposematic color morphs in the poison frog Dendrobates auratus Open
Table S2. Fixed genomic variants of color genes. Contig, SNP position, gene name, and whether these changes produce synonymous or non-synonymous changes across color morphs. (CSV 2 kb)
View article: Simultaneous multiplane imaging with reverberation multiphoton microscopy
Simultaneous multiplane imaging with reverberation multiphoton microscopy Open
Multiphoton microscopy (MPM) has gained enormous popularity over the years for its capacity to provide high resolution images from deep within scattering samples1. However, MPM is generally based on single-point laser-focus scanning, which…
View article: Variation in pigmentation gene expression is associated with distinct aposematic color morphs in the poison frog, <i>Dendrobates auratus</i>
Variation in pigmentation gene expression is associated with distinct aposematic color morphs in the poison frog, <i>Dendrobates auratus</i> Open
Color and pattern phenotypes have clear implications for survival and reproduction in many species. However, the mechanisms that produce this coloration are still poorly characterized, especially at the genomic level. Here we have taken a …
View article: Neural mechanisms of social learning in the female mouse
Neural mechanisms of social learning in the female mouse Open
Social interactions are often powerful drivers of learning. In female mice, mating creates a long-lasting sensory memory for the pheromones of the stud male that alters neuroendocrine responses to his chemosignals for many weeks. The cellu…
View article: Author response: Neural mechanisms of social learning in the female mouse
Author response: Neural mechanisms of social learning in the female mouse Open
Article Figures and data Abstract eLife digest Introduction Results Discussion Materials and methods References Decision letter Author response Article and author information Metrics Abstract Social interactions are often powerful drivers …
View article: Olfactory receptor accessory proteins play crucial roles in receptor function and gene choice
Olfactory receptor accessory proteins play crucial roles in receptor function and gene choice Open
Each of the olfactory sensory neurons (OSNs) chooses to express a single G protein-coupled olfactory receptor (OR) from a pool of hundreds. Here, we show the receptor transporting protein (RTP) family members play a dual role in both norma…