Ian Geh
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View article: Patient and multidisciplinary team perspectives on watch and wait in rectal cancer
Patient and multidisciplinary team perspectives on watch and wait in rectal cancer Open
This article adopts a multidisciplinary approach, including surgery, oncology, radiology and patient perspectives, to discuss the key points of debate surrounding a watch and wait approach. In an era of shared decision‐making, discussion o…
View article: Quality-of-life outcomes in older patients with early-stage rectal cancer receiving organ-preserving treatment with hypofractionated short-course radiotherapy followed by transanal endoscopic microsurgery (TREC): non-randomised registry of patients unsuitable for total mesorectal excision
Quality-of-life outcomes in older patients with early-stage rectal cancer receiving organ-preserving treatment with hypofractionated short-course radiotherapy followed by transanal endoscopic microsurgery (TREC): non-randomised registry of patients unsuitable for total mesorectal excision Open
Cancer Research UK.
View article: Can we Save the rectum by watchful waiting or TransAnal surgery following (chemo)Radiotherapy versus Total mesorectal excision for early REctal Cancer (STAR‐TREC)? Protocol for the international, multicentre, rolling phase II/III partially randomized patient preference trial evaluating long‐course concurrent chemoradiotherapy versus short‐course radiotherapy organ preservation approaches
Can we Save the rectum by watchful waiting or TransAnal surgery following (chemo)Radiotherapy versus Total mesorectal excision for early REctal Cancer (STAR‐TREC)? Protocol for the international, multicentre, rolling phase II/III partially randomized patient preference trial evaluating long‐course concurrent chemoradiotherapy versus short‐course radiotherapy organ preservation approaches Open
Aim Organ‐saving treatment for early‐stage rectal cancer can reduce patient‐reported side effects compared to standard total mesorectal excision (TME) and preserve quality of life. An optimal strategy for achieving organ preservation and l…
View article: Well-differentiated gastroenteropancreatic G3 NET: findings from a large single centre cohort
Well-differentiated gastroenteropancreatic G3 NET: findings from a large single centre cohort Open
View article: Complete response to neoadjuvant chemoradiotherapy in rectal cancer is associated with RAS/AKT mutations and high tumour mutational burden
Complete response to neoadjuvant chemoradiotherapy in rectal cancer is associated with RAS/AKT mutations and high tumour mutational burden Open
View article: P-49 Oesophageal neuroendocrine carcinoma: Retrospective evaluation of outcomes from a UK tertiary centre
P-49 Oesophageal neuroendocrine carcinoma: Retrospective evaluation of outcomes from a UK tertiary centre Open
View article: Additional file 1 of Complete response to neoadjuvant chemoradiotherapy in rectal cancer is associated with RAS/AKT mutations and high tumour mutational burden
Additional file 1 of Complete response to neoadjuvant chemoradiotherapy in rectal cancer is associated with RAS/AKT mutations and high tumour mutational burden Open
Additional file 1. Supplementary data from mutational analysis (MutSigCV, Intogen, Intogen Pathways and COSMIC mutational signatures).
View article: Radical surgery versus organ preservation via short-course radiotherapy followed by transanal endoscopic microsurgery for early-stage rectal cancer (TREC): a randomised, open-label feasibility study
Radical surgery versus organ preservation via short-course radiotherapy followed by transanal endoscopic microsurgery for early-stage rectal cancer (TREC): a randomised, open-label feasibility study Open
View article: Well-differentiated Gastroenteropancreatic G3 NET: Findings from a large single centre cohort
Well-differentiated Gastroenteropancreatic G3 NET: Findings from a large single centre cohort Open
Neuroendocrine neoplasms are known to have heterogeneous biological behavior. G3 neuroendocrine tumours (NET G3) are characterized by well-differentiated morphology and Ki67 > 20%. The prognosis of this disease is understood to be intermed…
View article: Response to neoadjuvant chemoradiotherapy in rectal cancer is associated with RAS/AKT pathway dysregulation and high tumour mutational burden
Response to neoadjuvant chemoradiotherapy in rectal cancer is associated with RAS/AKT pathway dysregulation and high tumour mutational burden Open
Purpose Pathological complete response (pathCR) in rectal cancer, seen in examination of the pathological specimen post-surgery is the phenomenon whereby a tumour completely regresses under treatment with chemoradiotherapy. This is benefic…
View article: Patterns and Predictors of Relapse Following Radical Chemoradiation Therapy Delivered Using Intensity Modulated Radiation Therapy With a Simultaneous Integrated Boost in Anal Squamous Cell Carcinoma
Patterns and Predictors of Relapse Following Radical Chemoradiation Therapy Delivered Using Intensity Modulated Radiation Therapy With a Simultaneous Integrated Boost in Anal Squamous Cell Carcinoma Open
View article: Association of Coloproctology of Great Britain & Ireland (<scp>ACPGBI</scp>): Guidelines for the Management of Cancer of the Colon, Rectum and Anus (2017) ‐ Introduction
Association of Coloproctology of Great Britain & Ireland (<span>ACPGBI</span>): Guidelines for the Management of Cancer of the Colon, Rectum and Anus (2017) ‐ Introduction Open
The ACPGBI has been at the forefront in developing guidelines, position statements and national training programs related to both common, and complex, colorectal pathology. These initiatives often serve as a global reference in this challe…
View article: Association of Coloproctology of Great Britain & Ireland (<scp>ACPGBI</scp>): Guidelines for the Management of Cancer of the Colon, Rectum and Anus (2017) – Diagnosis, Investigations and Screening
Association of Coloproctology of Great Britain & Ireland (<span>ACPGBI</span>): Guidelines for the Management of Cancer of the Colon, Rectum and Anus (2017) – Diagnosis, Investigations and Screening Open
Investigation of colorectal cancer may be considered in three distinct groups: Concern over a diagnosis of colorectal cancer should prompt urgent referral, in most cases within general practice through a 'two week wait rule'. Criteria for …
View article: Association of Coloproctology of Great Britain & Ireland (<scp>ACPGBI</scp>): Guidelines for the Management of Cancer of the Colon, Rectum and Anus (2017) – Multidisciplinary Management
Association of Coloproctology of Great Britain & Ireland (<span>ACPGBI</span>): Guidelines for the Management of Cancer of the Colon, Rectum and Anus (2017) – Multidisciplinary Management Open
A definition of rectal cancer is important for optimal planning of neoadjuvant therapy and surgical strategy. Anatomically the rectum is distal to the sigmoid colon and its upper limit is the termination of the sigmoid mesocolon. A commonl…
View article: Association of Coloproctology of Great Britain & Ireland (ACPGBI): Guidelines for the Management of Cancer of the Colon, Rectum and Anus (2017) – Surgical Management
Association of Coloproctology of Great Britain & Ireland (ACPGBI): Guidelines for the Management of Cancer of the Colon, Rectum and Anus (2017) – Surgical Management Open
The Department of Health published national referral guidelines in 2000 for suspected cancers, based on high-risk symptoms and signs, the so called ‘2 week rule’. The recommendation was that units should see in excess of 95% of referrals w…
View article: Association of Coloproctology of Great Britain & Ireland (<scp>ACPGBI</scp>): Guidelines for the Management of Cancer of the Colon, Rectum and Anus (2017) – Anal Cancer
Association of Coloproctology of Great Britain & Ireland (<span>ACPGBI</span>): Guidelines for the Management of Cancer of the Colon, Rectum and Anus (2017) – Anal Cancer Open
In these guidelines, anal cancer refers specifically to squamous cell carcinoma (SCC) of the anus. The key recommendations from the ACPGBI position statement for the management of anal cancer (Lindsey, 2011) are referenced here. Although a…
View article: Wide Variation in the Use of Radiotherapy in the Management of Surgically Treated Rectal Cancer Across the English National Health Service
Wide Variation in the Use of Radiotherapy in the Management of Surgically Treated Rectal Cancer Across the English National Health Service Open