Ian J. Fucci
YOU?
Author Swipe
View article: Analysis of apo and citraconate-bound hACOD1 (hIRG1) by X-ray crystallography and NMR spectroscopy: Structural insights for developing chemotherapeutic agents
Analysis of apo and citraconate-bound hACOD1 (hIRG1) by X-ray crystallography and NMR spectroscopy: Structural insights for developing chemotherapeutic agents Open
In this work, we present the high-resolution structure of human aconitate decarboxylase 1 (hACOD1) in its true apo form (active site empty) as well in complex with the inhibitor citraconate. These two new structures show the architecture o…
View article: Abstract 1598 Targeting prolyl endopeptidase with cysteine-reactive covalent inhibitors
Abstract 1598 Targeting prolyl endopeptidase with cysteine-reactive covalent inhibitors Open
View article: Inhibition of prolyl endopeptidase through a noncatalytic active site residue
Inhibition of prolyl endopeptidase through a noncatalytic active site residue Open
Prolyl endopeptidase (PREP) is a serine protease that cleaves C-terminal to proline residues and represents an important drug target in several neurodegenerative diseases. PREP consists of a catalytic α/β-hydrolase domain and regulatory β-…
View article: Abstract 2330: The Role of Ubiquitin Activating Enzyme (E1) Uba1’s Ubiquitin Fold Domain on Ubiquitin Conjugating Enzyme (E2) Selection
Abstract 2330: The Role of Ubiquitin Activating Enzyme (E1) Uba1’s Ubiquitin Fold Domain on Ubiquitin Conjugating Enzyme (E2) Selection Open
View article: <i>nightshift</i>: A Python program for plotting simulated <scp>NMR</scp> spectra from assigned chemical shifts from the Biological Magnetic Resonance Data Bank
<i>nightshift</i>: A Python program for plotting simulated <span>NMR</span> spectra from assigned chemical shifts from the Biological Magnetic Resonance Data Bank Open
Nuclear magnetic resonance (NMR) provides site specific information on local environments through chemical shifts. NMR is widely used in the study of proteins, ranging from determination of three‐dimensional (3D) structures to characterizi…
View article: The Role of Conformational Dynamics in the Recognition and Regulation of Ubiquitination
The Role of Conformational Dynamics in the Recognition and Regulation of Ubiquitination Open
The ubiquitination pathway is central to many cell signaling and regulatory events. One of the intriguing aspects of the pathway is the combinatorial sophistication of substrate recognition and ubiquitin chain building determinations. The …
View article: Stabilization of Active Site Dynamics Leads to Increased Activity with 3′-Azido-3′-deoxythymidine Monophosphate for F105Y Mutant Human Thymidylate Kinase
Stabilization of Active Site Dynamics Leads to Increased Activity with 3′-Azido-3′-deoxythymidine Monophosphate for F105Y Mutant Human Thymidylate Kinase Open
Thymidylate kinases are essential enzymes with roles in DNA synthesis and repair and have been the target of drug development for antimalarials, antifungals, HIV treatment, and cancer therapeutics. Human thymidylate kinase (hTMPK) conversi…
View article: NMR Dynamics Studies of Rho130-Polymer Conjugates and Human Thymidylate Kinase
NMR Dynamics Studies of Rho130-Polymer Conjugates and Human Thymidylate Kinase Open
Nuclear magnetic resonance (NMR) studies on two systems: the RNA binding domain of the E. coli transcriptional termination factor Rho (Rho130), and human thymidylate kinase (hTMPK) will be discussed. Protein-polymerconjugates produced by a…