I. Caroline Le Poole
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View article: Evaluating Multiomics Integration Architectures for Training With Structured Missingness
Evaluating Multiomics Integration Architectures for Training With Structured Missingness Open
Multimodal bioinformatics datasets are increasingly common in biomedical research, for tasks such as cancer subtyping and outcome prediction. It is feasible that data from a given patient, or even all data from a given institution, does no…
View article: Benign tumors broaden the field of application for immunotherapy
Benign tumors broaden the field of application for immunotherapy Open
Immunotherapy has shown significant potential for treating malignancies. Not yet widely considered is the opportunity to employ immunotherapy for the treatment of benign tumors. By focusing on targetable antigens expressed following specif…
View article: Decreased Peripheral Blood Natural Killer Cell Count in Untreated Juvenile Dermatomyositis Is Associated with Muscle Weakness
Decreased Peripheral Blood Natural Killer Cell Count in Untreated Juvenile Dermatomyositis Is Associated with Muscle Weakness Open
Juvenile Dermatomyositis (JDM) is the most common inflammatory myopathy in pediatrics. This study evaluates the role of Natural Killer (NK) cells in Juvenile Dermatomyositis (JDM) pathophysiology. The study included 133 untreated JDM child…
View article: Topical antibiotics limit depigmentation in a mouse model of vitiligo
Topical antibiotics limit depigmentation in a mouse model of vitiligo Open
Oral neomycin administration impacts the gut microbiome and delays vitiligo development in mice, and topical antibiotics may likewise allow the microbiome to preserve skin health and delay depigmentation. Here, we examined the effects of 6…
View article: Immune Assessment Today: Optimizing and Standardizing Efforts to Monitor Immune Responses in Cancer and Beyond
Immune Assessment Today: Optimizing and Standardizing Efforts to Monitor Immune Responses in Cancer and Beyond Open
As part of a symposium, current and former directors of Immune Monitoring cores and investigative oncologists presented insights into the past, present and future of immune assessment. Dr. Gnjatic presented a classification of immune monit…
View article: Increased Otoferlin Expression in B Cells Is Associated with Muscle Weakness in Untreated Juvenile Dermatomyositis: A Pilot Study
Increased Otoferlin Expression in B Cells Is Associated with Muscle Weakness in Untreated Juvenile Dermatomyositis: A Pilot Study Open
Otoferlin mRNA expression is increased in JDM patients’ PBMCs and muscle compared to healthy controls. This study aims to evaluate the role of otoferlin in JDM disease pathophysiology and its association with disease activity in untreated …
View article: Melanocyte-keratinocyte cross-talk in vitiligo
Melanocyte-keratinocyte cross-talk in vitiligo Open
Vitiligo is a common acquired pigmentary disorder that presents as progressive loss of melanocytes from the skin. Epidermal melanocytes and keratinocytes are in close proximity to each other, forming a functional and structural unit where …
View article: Supplementary Table 1 from Targeting ULK1 Decreases IFNγ-Mediated Resistance to Immune Checkpoint Inhibitors
Supplementary Table 1 from Targeting ULK1 Decreases IFNγ-Mediated Resistance to Immune Checkpoint Inhibitors Open
List of the putative ULK1 interactor proteins identified by mass spectrometry analysis in A375 cells
View article: Data from Targeting ULK1 Decreases IFNγ-Mediated Resistance to Immune Checkpoint Inhibitors
Data from Targeting ULK1 Decreases IFNγ-Mediated Resistance to Immune Checkpoint Inhibitors Open
Immune checkpoint inhibitors (ICI) have transformed the treatment of melanoma. However, the majority of patients have primary or acquired resistance to ICIs, limiting durable responses and patient survival. IFNγ signaling and the expressio…
View article: Supplementary Figures and Supplementary Materials and Methods with References from Targeting ULK1 Decreases IFNγ-Mediated Resistance to Immune Checkpoint Inhibitors
Supplementary Figures and Supplementary Materials and Methods with References from Targeting ULK1 Decreases IFNγ-Mediated Resistance to Immune Checkpoint Inhibitors Open
S1. Overexpression of ULK1 in melanoma cells has minor effects on transcription of IFNγ-induced immunostimulatory genes.S2. Effects of gene targeted inhibition of ULK1 in transcription of IFNγ-induced immunostimulatory genes in melanoma ce…
View article: Supplementary Figures and Supplementary Materials and Methods with References from Targeting ULK1 Decreases IFNγ-Mediated Resistance to Immune Checkpoint Inhibitors
Supplementary Figures and Supplementary Materials and Methods with References from Targeting ULK1 Decreases IFNγ-Mediated Resistance to Immune Checkpoint Inhibitors Open
S1. Overexpression of ULK1 in melanoma cells has minor effects on transcription of IFNγ-induced immunostimulatory genes.S2. Effects of gene targeted inhibition of ULK1 in transcription of IFNγ-induced immunostimulatory genes in melanoma ce…
View article: Data from Targeting ULK1 Decreases IFNγ-Mediated Resistance to Immune Checkpoint Inhibitors
Data from Targeting ULK1 Decreases IFNγ-Mediated Resistance to Immune Checkpoint Inhibitors Open
Immune checkpoint inhibitors (ICI) have transformed the treatment of melanoma. However, the majority of patients have primary or acquired resistance to ICIs, limiting durable responses and patient survival. IFNγ signaling and the expressio…
View article: Supplementary Table 1 from Targeting ULK1 Decreases IFNγ-Mediated Resistance to Immune Checkpoint Inhibitors
Supplementary Table 1 from Targeting ULK1 Decreases IFNγ-Mediated Resistance to Immune Checkpoint Inhibitors Open
List of the putative ULK1 interactor proteins identified by mass spectrometry analysis in A375 cells
View article: Skin Infiltrate Composition as a Telling Measure of Responses to Checkpoint Inhibitors
Skin Infiltrate Composition as a Telling Measure of Responses to Checkpoint Inhibitors Open
Checkpoint inhibitors treat a variety of tumor types with significant benefits. Unfortunately, these therapies come with diverse adverse events. Skin rash is observed early into treatment and might serve as an indicator of downstream respo…
View article: Targeting ULK1 Decreases IFNγ-Mediated Resistance to Immune Checkpoint Inhibitors
Targeting ULK1 Decreases IFNγ-Mediated Resistance to Immune Checkpoint Inhibitors Open
Immune checkpoint inhibitors (ICI) have transformed the treatment of melanoma. However, the majority of patients have primary or acquired resistance to ICIs, limiting durable responses and patient survival. IFNγ signaling and the expressio…
View article: SARA suppresses myofibroblast precursor transdifferentiation in fibrogenesis in a mouse model of scleroderma
SARA suppresses myofibroblast precursor transdifferentiation in fibrogenesis in a mouse model of scleroderma Open
We previously reported that Smad anchor for receptor activation (SARA) plays a critical role in maintaining epithelial cell phenotype. Here, we show that SARA suppressed myofibroblast precursor transdifferentiation in a mouse model of scle…
View article: Characterization and initial demonstration of <i>in vivo</i> efficacy of a novel heat-activated metalloenediyne anti-cancer agent
Characterization and initial demonstration of <i>in vivo</i> efficacy of a novel heat-activated metalloenediyne anti-cancer agent Open
By leveraging the unique thermal activation properties of metalloenediynes, we propose that localized moderate hyperthermia can be used to confine the cytotoxicity of these compounds to tumors, while sparing normal tissue.
View article: Benign tumors in TSC are amenable to treatment by GD3 CAR T cells in mice
Benign tumors in TSC are amenable to treatment by GD3 CAR T cells in mice Open
Mutations underlying disease in tuberous sclerosis complex (TSC) give rise to tumors with biallelic mutations in TSC1 or TSC2 and hyperactive mammalian target of rapamycin complex 1 (mTORC1). Benign tumors might exhibit de novo expression …
View article: Editorial: Immunology of Vitiligo
Editorial: Immunology of Vitiligo Open
International audience
View article: A Palette of Cytokines to Measure Anti-Tumor Efficacy of T Cell-Based Therapeutics
A Palette of Cytokines to Measure Anti-Tumor Efficacy of T Cell-Based Therapeutics Open
Cytokines are key molecules within the tumor microenvironment (TME) that can be used as biomarkers to predict the magnitude of anti-tumor immune responses. During immune monitoring, it has been customary to predict outcomes based on the ab…
View article: Myron Gordon Award paper: Microbes, T‐cell diversity and pigmentation
Myron Gordon Award paper: Microbes, T‐cell diversity and pigmentation Open
Melanocytes are static, minimally proliferative cells. This leaves them vulnerable in vitiligo. Yet upon malignant transformation, they form vicious tumors. This profound switch in physiology is accompanied by genetic change and is driven …
View article: Antigen Specificity Enhances Disease Control by Tregs in Vitiligo
Antigen Specificity Enhances Disease Control by Tregs in Vitiligo Open
Vitiligo is an autoimmune skin disease characterized by melanocyte destruction. Regulatory T cells (Tregs) are greatly reduced in vitiligo skin, and replenishing peripheral skin Tregs can provide protection against depigmentation. Ganglios…
View article: 701 Nanoparticulate monobenzone (MBEH) as a potential drug candidate for melanoma
701 Nanoparticulate monobenzone (MBEH) as a potential drug candidate for melanoma Open
Background Monobenzone (MBEH) is a skin depigmenting agent FDA-approved for topical applications.1 It specifically interacts with tyrosinase,2 a key enzyme in melanogenesis, to form reactive quinones that are toxic to pigmented cells, incl…
View article: A Rapid Method for Multispectral Fluorescence Imaging of Frozen Tissue Sections
A Rapid Method for Multispectral Fluorescence Imaging of Frozen Tissue Sections Open
Multispectral fluorescence imaging on formalin-fixed paraffin-embedded (FFPE) tissues enables the detection of multiple markers in a single tissue sample that can provide information about antigen coexpression and spatial distribution of t…
View article: Adoptive T-Cell Transfer to Treat Lymphangioleiomyomatosis
Adoptive T-Cell Transfer to Treat Lymphangioleiomyomatosis Open
Patients with lymphangioleiomyomatosis (LAM) develop pulmonary cysts associated with neoplastic, smooth muscle-like cells that feature neuroendocrine cell markers. The disease preferentially affects premenopausal women. Existing therapeuti…