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View article: Glycan microarray analysis of <i>Candida</i> -related antibodies in human and mice sera guides biomarker discovery and vaccine development
Glycan microarray analysis of <i>Candida</i> -related antibodies in human and mice sera guides biomarker discovery and vaccine development Open
Invasive, high-mortality yeast infections caused by pathogenic Candida species are the most common fungal nosocomial bloodstream infections. The World Health Organization (WHO) has called for improved prevention and diagnostic strategies f…
View article: Effects of Short-Chain Fatty Acid Combinations Relevant to the Healthy and Dysbiotic Gut upon Candida albicans
Effects of Short-Chain Fatty Acid Combinations Relevant to the Healthy and Dysbiotic Gut upon Candida albicans Open
The major fungal pathogen, Candida albicans , exists as a commensal in the gastrointestinal tract of healthy humans. Fungal colonisation levels increase during gut dysbiosis, when the local microbiota and short-chain fatty acid (SCFA) conc…
View article: Protein kinase A signaling regulates immune evasion by shaving and concealing fungal β-1,3-glucan
Protein kinase A signaling regulates immune evasion by shaving and concealing fungal β-1,3-glucan Open
Fungal pathogens infect billions and kill millions of people each year. Many of these pathogens have evolved strategies to evade our antifungal immune defenses. Candida albicans, for example, masks the proinflammatory pathogen-associated m…
View article: Multi‐Omics Analysis of Experimentally Evolved <i>Candida auris</i> Isolates Reveals Modulation of Sterols, Sphingolipids, and Oxidative Stress in Acquired Amphotericin B Resistance
Multi‐Omics Analysis of Experimentally Evolved <i>Candida auris</i> Isolates Reveals Modulation of Sterols, Sphingolipids, and Oxidative Stress in Acquired Amphotericin B Resistance Open
Clinical isolates of Candida auris show a high prevalence of resistance to Amphotericin B (AmB)—an uncommon trait in most Candida species. Alterations in ergosterol biosynthesis can contribute to acquired AmB resistance in C. auris laborat…
View article: Lactic acid in the vaginal milieu modulates the <i>Candida</i> -host interaction
Lactic acid in the vaginal milieu modulates the <i>Candida</i> -host interaction Open
Vulvovaginal candidiasis (VVC) is one of the most common infections caused by Candida albicans. VVC is characterized by an inadequate hyperinflammatory response and clinical symptoms associated with Candida colonization of the vaginal muco…
View article: Impact of secreted glucanases upon the cell surface and fitness of Candida albicans during colonisation and infection
Impact of secreted glucanases upon the cell surface and fitness of Candida albicans during colonisation and infection Open
Host recognition of the pathogen-associated molecular pattern (PAMP), β-1,3-glucan, plays a major role in antifungal immunity. β-1,3-glucan is an essential component of the inner cell wall of the opportunistic pathogen Candida albicans. Mo…
View article: A CO <sub>2</sub> sensing module modulates β-1,3-glucan exposure in <i>Candida albicans</i>
A CO <sub>2</sub> sensing module modulates β-1,3-glucan exposure in <i>Candida albicans</i> Open
Our innate immune defenses have evolved to protect us against microbial infection in part via receptor-mediated detection of “pathogen-associated molecular patterns” (PAMPs) expressed by invading microbes, which then triggers their immune …
View article: CRISPR-based tools for targeted genetic manipulation in pathogenic <i>Sporothrix</i> species
CRISPR-based tools for targeted genetic manipulation in pathogenic <i>Sporothrix</i> species Open
Sporothrix brasiliensis is an emerging fungal pathogen frequently associated with zoonotic transmission of sporotrichosis by contaminated cats. Within 25 years, the disease has spread not only throughout Brazil but now to neighboring count…
View article: Glucose-enhanced oxidative stress resistance—A protective anticipatory response that enhances the fitness of Candida albicans during systemic infection
Glucose-enhanced oxidative stress resistance—A protective anticipatory response that enhances the fitness of Candida albicans during systemic infection Open
Most microbes have developed responses that protect them against stresses relevant to their niches. Some that inhabit reasonably predictable environments have evolved anticipatory responses that protect against impending stresses that are …
View article: CRISPR-based tools for genetic manipulation in pathogenic<i>Sporothrix</i>species
CRISPR-based tools for genetic manipulation in pathogenic<i>Sporothrix</i>species Open
Summary Sporothrix brasiliensis is an emerging fungal pathogen frequently associated with zoonotic transmission of sporotrichosis. Although certain virulence factors have been proposed as potential sporotrichosis determinants, the scarcity…
View article: Nature of β-1,3-Glucan-Exposing Features on Candida albicans Cell Wall and Their Modulation
Nature of β-1,3-Glucan-Exposing Features on Candida albicans Cell Wall and Their Modulation Open
Microbes that coexist with humans have evolved ways of avoiding or evading our immunological defenses. These include the masking by these microbes of their “pathogen-associated molecular patterns” (PAMPs), which are recognized as “foreign”…
View article: S9.4c Diverse environmental inputs mediate changes in β-glucan exposure at the <i>Candida albicans</i> cell surface thereby influencing tissue colonisation during systemic infection
S9.4c Diverse environmental inputs mediate changes in β-glucan exposure at the <i>Candida albicans</i> cell surface thereby influencing tissue colonisation during systemic infection Open
S9.4 Free oral presentations (late breaking), September 23, 2022, 4:45 PM - 6:15 PM Candida albicans adaptation to host niches affects the exposure of key pathogen-associated molecular patterns (PAMPs) on its cell surface and, consequently…
View article: ARP2/3 complex associates with peroxisomes to participate in pexophagy in plants
ARP2/3 complex associates with peroxisomes to participate in pexophagy in plants Open
ARP2/3 is a heteroheptameric protein complex evolutionary conserved in all eukaryotic organisms. Its conserved role is based on the induction of actin polymerization at the interface between membranes and the cytoplasm. Plant ARP2/3 has be…
View article: ARP2/3 complex associates with peroxisomes to participate in pexophagy in plants
ARP2/3 complex associates with peroxisomes to participate in pexophagy in plants Open
ARP2/3 is a heteroheptameric protein complex evolutionary conserved in all eukaryotic organisms. Its conserved role is based on the induction of actin polymerization at the interface between membranes and the cytoplasm. Plant ARP2/3 has be…
View article: Anticipatory Stress Responses and Immune Evasion in Fungal Pathogens
Anticipatory Stress Responses and Immune Evasion in Fungal Pathogens Open
In certain niches, microbes encounter environmental challenges that are temporally linked. In such cases, microbial fitness is enhanced by the evolution of anticipatory responses where the initial challenge simultaneously activates pre-emp…