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View article: Severity of respiratory-syncytial-virus and other respiratory viruses versus seasonal influenza amongst hospitalized cancer patients
Severity of respiratory-syncytial-virus and other respiratory viruses versus seasonal influenza amongst hospitalized cancer patients Open
Background More data is required to contextualize disease burden attributable to respiratory-viral-infections (RVIs) in hematology/oncology patients; including vaccine-preventable RVIs (eg. influenza, respiratory-syncytial-virus[RSV]) and …
View article: Risk of dengue following prior SARS-CoV-2 infection: a population-based cohort study
Risk of dengue following prior SARS-CoV-2 infection: a population-based cohort study Open
View article: Acute and post-acute healthcare utilisation after Delta and Omicron BA.1/2, BA.4/5, XBB infection: a cohort study
Acute and post-acute healthcare utilisation after Delta and Omicron BA.1/2, BA.4/5, XBB infection: a cohort study Open
Background Elevated risk of healthcare utilisation in the post-acute phase following SARS-CoV-2 infection is well-documented. However, the burden of acute and post-acute healthcare utilisation following milder Omicron infection is unknown.…
View article: Cardiovascular complications in acute dengue infection: a population-based cohort study
Cardiovascular complications in acute dengue infection: a population-based cohort study Open
National-Medical-Research-Council, Singapore.
View article: Approaches for estimating COVID-19 vaccine effectiveness using observational data in administrative databases: a systematic review
Approaches for estimating COVID-19 vaccine effectiveness using observational data in administrative databases: a systematic review Open
Background COVID-19 vaccine policy relied on observational vaccine-effectiveness (VE) studies conducted amid rapid variant turnover, evolving schedules, and shifting surveillance, yielding substantial heterogeneity in methodological approa…
View article: Long-Run Public Health Impact of Doxycycline Post-Exposure Prophylaxis and Behavioural Factors on Syphilis Transmission: A Modelling Study in Singapore and England
Long-Run Public Health Impact of Doxycycline Post-Exposure Prophylaxis and Behavioural Factors on Syphilis Transmission: A Modelling Study in Singapore and England Open
Syphilis remains a significant global public health challenge, particularly among men who have sex with men (MSM). Although penicillin is highly effective for treatment, primary prevention strategies are limited. Recent trials indicate tha…
View article: Respiratory syncytial virus hospitalization costs, rates, and seasonality in Asia: a systematic review and meta-analysis
Respiratory syncytial virus hospitalization costs, rates, and seasonality in Asia: a systematic review and meta-analysis Open
Jue Tao Lim is supported by the Lee Kong Chian School of Medicine-Ministry of Education Start-Up Grant. YSL is funded by the National Centre for Infectious Diseases Department Research Fund.
View article: Acute and Postacute Health Care Utilization and Costs After Dengue Infection: A Population-Based Cohort Study
Acute and Postacute Health Care Utilization and Costs After Dengue Infection: A Population-Based Cohort Study Open
Background Emerging evidence suggests that postacute sequelae may arise following dengue infection. There has been no quantification of the risk and burden of acute and postacute health care utilization and cost due to dengue. Methods We u…
View article: Characterization of post-acute multi-organ sequelae following dengue infection
Characterization of post-acute multi-organ sequelae following dengue infection Open
View article: Long-term multisystemic sequelae post-hospitalisation for Omicron COVID-19 vs influenza: A retrospective cohort study
Long-term multisystemic sequelae post-hospitalisation for Omicron COVID-19 vs influenza: A retrospective cohort study Open
Risks of cognitive impairment/fatigue were increased while risk of cardiac sequelae was significantly lower post-COVID-19 vs influenza in unboosted/unvaccinated individuals. Vaccination for COVID-19/influenza remains important during endem…
View article: Real-World Effectiveness of Boosting Against Omicron Hospitalization in Older Adults, Stratified by Frailty
Real-World Effectiveness of Boosting Against Omicron Hospitalization in Older Adults, Stratified by Frailty Open
Background/Objectives: Older adults with frailty are at-risk of worse outcomes following respiratory-viral-infections such as COVID-19. Data on effectiveness of vaccination/boosting in frail older adults during Omicron is lacking. Methods:…
View article: Cardiac Events in Adults Hospitalized for Respiratory Syncytial Virus vs COVID-19 or Influenza
Cardiac Events in Adults Hospitalized for Respiratory Syncytial Virus vs COVID-19 or Influenza Open
Importance Respiratory viral infections (RVIs) are associated with elevated cardiovascular risk; however, less is known about cardiac complications after hospitalization for respiratory syncytial virus (RSV) vs other vaccine-preventable RV…
View article: Omicron SARS-CoV-2 outcomes in vaccinated individuals with heart failure and ischaemic heart disease
Omicron SARS-CoV-2 outcomes in vaccinated individuals with heart failure and ischaemic heart disease Open
Introduction: Outcomes after SARS-CoV 2 Omicron infection in patients with heart failure (HF) and ischaemic heart disease (IHD) remain poorly defined. Method: In a highly vaccinated cohort of adult Singapore citizens and permanent resident…
View article: Risk of New-Onset Type 2 Diabetes Among Vaccinated Adults After Omicron or Delta Variant SARS-CoV-2 Infection
Risk of New-Onset Type 2 Diabetes Among Vaccinated Adults After Omicron or Delta Variant SARS-CoV-2 Infection Open
This cohort study estimates the risk of new-onset type 2 diabetes after Delta or Omicron variant SARS-CoV-2 infection among vaccinated adults in Singapore.
View article: Long-term Sequelae Following Dengue Infection vs SARS-CoV-2 Infection in a Pediatric Population: A Retrospective Cohort Study
Long-term Sequelae Following Dengue Infection vs SARS-CoV-2 Infection in a Pediatric Population: A Retrospective Cohort Study Open
Background Long-term postacute sequelae following SARS-CoV-2 infection in children have been extensively documented. However, while persistence of chronic symptoms following pediatric dengue infection has been documented in small prospecti…
View article: Severity of respiratory syncytial virus versus SARS-CoV-2 Omicron and influenza infection amongst hospitalized Singaporean adults: a national cohort study
Severity of respiratory syncytial virus versus SARS-CoV-2 Omicron and influenza infection amongst hospitalized Singaporean adults: a national cohort study Open
National Medical Research Council, Singapore.
View article: P-420. Epidemiology of Patients with Laboratory-confirmed <i>Aspergillus</i> species in a Singaporean Hospital
P-420. Epidemiology of Patients with Laboratory-confirmed <i>Aspergillus</i> species in a Singaporean Hospital Open
Background Aspergillus species is an opportunistic mould associated with serious complications, healthcare costs and mortality, especially in immunocompromised patients. WHO has declared Aspergillus fumigatus as a “critical pathogen”. This…
View article: P-1995. A Nationwide Cohort Study of Delta and Omicron SARS-CoV-2 Outcomes and Vaccine Effectiveness amongst Individuals with Chronic Heart Failure or Ischemic Heart Disease
P-1995. A Nationwide Cohort Study of Delta and Omicron SARS-CoV-2 Outcomes and Vaccine Effectiveness amongst Individuals with Chronic Heart Failure or Ischemic Heart Disease Open
Background Individuals with heart failure (HF) / ischemic heart disease (IHD) have poorer outcomes following respiratory viral infections; however, data is lacking on outcomes and Vaccine Effectiveness (VEs) following SARS-CoV-2 infection …
View article: Piecing together the narrative of #longcovid: an unsupervised deep learning of 1,354,889 X (formerly Twitter) posts from 2020 to 2023
Piecing together the narrative of #longcovid: an unsupervised deep learning of 1,354,889 X (formerly Twitter) posts from 2020 to 2023 Open
Objective To characterize the public conversations around long COVID, as expressed through X (formerly Twitter) posts from May 2020 to April 2023. Methods Using X as the data source, we extracted tweets containing #long-covid, #long_covid,…
View article: Autoimmune Sequelae After Delta or Omicron Variant SARS-CoV-2 Infection in a Highly Vaccinated Cohort
Autoimmune Sequelae After Delta or Omicron Variant SARS-CoV-2 Infection in a Highly Vaccinated Cohort Open
Importance Studies have reported increased risk of autoimmune sequelae after SARS-CoV-2 infection. However, risk may potentially be attenuated by milder Omicron (B.1.1.529) variant infection and availability of booster vaccination. Objecti…
View article: Effects of Recent Prior Dengue Infection on Risk and Severity of Subsequent SARS-CoV-2 Infection: A Retrospective Cohort Study
Effects of Recent Prior Dengue Infection on Risk and Severity of Subsequent SARS-CoV-2 Infection: A Retrospective Cohort Study Open
Background and Aims Elucidating whether prior dengue potentially confers cross-protection against COVID-19 is of public health importance in tropical countries at risk of overlapping dengue and COVID-19 epidemics. However, studies to date …
View article: Risks of SARS-CoV-2 JN.1 Infection and COVID-19–Associated Emergency Department Visits/Hospitalizations Following Updated Boosters and Prior Infection: A Population-Based Cohort Study
Risks of SARS-CoV-2 JN.1 Infection and COVID-19–Associated Emergency Department Visits/Hospitalizations Following Updated Boosters and Prior Infection: A Population-Based Cohort Study Open
Background Data on protection afforded by updated coronavirus disease 2019 (COVID-19) vaccines (bivalent/XBB 1.5 monovalent) against the emergent JN.1 variant remain limited. Methods We conducted a retrospective population-based cohort stu…
View article: Oral antiviral utilisation among older adults with COVID-19 in primary care: A population-wide study during successive Omicron waves in Singapore
Oral antiviral utilisation among older adults with COVID-19 in primary care: A population-wide study during successive Omicron waves in Singapore Open
Studies have repeatedly demonstrated the real-world effectiveness of oral antivirals (OAVs) in preventing hospitalisation and death in patients with mild-to-moderate COVID-19 at high risk for progression to severe COVID-19 when initiated w…
View article: Prediction model to identify infectious COVID-19 patients in the emergency department
Prediction model to identify infectious COVID-19 patients in the emergency department Open
Background: Real-time reverse-transcriptase polymerase chain reaction (RT-PCR) has been the gold standard for diagnosing coronavirus disease 2019 (COVID-19) but has a lag time for the results. An effective prediction algorithm for infectio…
View article: Burnout among COVID-19 hospital-based contact tracers in Singapore: results of a mixed-method, cross-sectional multicentre study
Burnout among COVID-19 hospital-based contact tracers in Singapore: results of a mixed-method, cross-sectional multicentre study Open
Introduction: During the coronavirus disease 2019 (COVID-19) pandemic, contact tracers were under immense pressure to deliver effective and timely contact tracing, raising concerns of higher susceptibility to burnout. Our study aimed to de…
View article: Effectiveness of Monovalent mRNA Vaccines Against Omicron XBB Infection in Singaporean Children Younger Than 5 Years
Effectiveness of Monovalent mRNA Vaccines Against Omicron XBB Infection in Singaporean Children Younger Than 5 Years Open
Importance Literature on vaccine effectiveness of SARS-CoV-2 messenger RNA (mRNA) vaccines for children younger than 5 years is limited. Objective To report the effectiveness of monovalent mRNA vaccines against SARS-CoV-2 infection among S…
View article: Factors associated with delayed diagnosis of symptomatic adult COVID-19 cases presenting to primary care: a population-wide study during transition from Delta to Omicron BA.1 in Singapore
Factors associated with delayed diagnosis of symptomatic adult COVID-19 cases presenting to primary care: a population-wide study during transition from Delta to Omicron BA.1 in Singapore Open
This study was not grant-funded.
View article: Long-term Cardiovascular, Cerebrovascular, and Other Thrombotic Complications in COVID-19 Survivors: A Retrospective Cohort Study
Long-term Cardiovascular, Cerebrovascular, and Other Thrombotic Complications in COVID-19 Survivors: A Retrospective Cohort Study Open
Background Growing evidence suggests that some coronavirus disease 2019 (COVID-19) survivors experience a wide range of long-term postacute sequelae. We examined the postacute risk and burden of new-incident cardiovascular, cerebrovascular…
View article: Real-world effectiveness of nirmatrelvir/ritonavir against COVID-19 hospitalizations and severe COVID-19 in community-dwelling elderly Singaporeans during Omicron BA.2, BA.4/5, and XBB transmission
Real-world effectiveness of nirmatrelvir/ritonavir against COVID-19 hospitalizations and severe COVID-19 in community-dwelling elderly Singaporeans during Omicron BA.2, BA.4/5, and XBB transmission Open
View article: Relapsing COVID-19 infection as a manifestation of Good syndrome: a case report and literature review
Relapsing COVID-19 infection as a manifestation of Good syndrome: a case report and literature review Open
Good syndrome (GS) is a rare acquired immunodeficiency disease characterized by the presence of thymoma with combined B and T cell immunodeficiency in adults. Recurrent bacterial infections, particularly sinopulmonary infections caused by …