Ian-Ling Yu
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View article: Differential disease tolerance mediates sex-biased illness severity in sepsis
Differential disease tolerance mediates sex-biased illness severity in sepsis Open
Sepsis in humans, as well as mouse models of infection, demonstrates sex-biased outcomes in which males tend to have a higher incidence, higher severity, and higher mortality compared to females. Despite this important sex-bias in sepsis o…
View article: Impaired systemic antibody response against gut microbiota pathobionts in critical illness and susceptibility to nosocomial infections
Impaired systemic antibody response against gut microbiota pathobionts in critical illness and susceptibility to nosocomial infections Open
Critically ill patients in intensive care units (ICUs) experience high rates of nosocomial infections, commonly caused by translocation and dissemination of pathogenic microorganisms that colonize the intestinal tract (pathobionts). Multip…
View article: Assessing the effects of fluids and antibiotics in an acute murine model of sepsis: study protocol for the National Preclinical Sepsis Platform-01 (NPSP-01) Study
Assessing the effects of fluids and antibiotics in an acute murine model of sepsis: study protocol for the National Preclinical Sepsis Platform-01 (NPSP-01) Study Open
Background Sepsis remains a leading cause of mortality in critical care. Despite extensive preclinical research on sepsis pathophysiology, the development of effective therapies has been largely unsuccessful. Key obstacles include limited …
View article: The detection of three species complexes similar to Diacyclops galbinus, D. versutus and D. improcerus (Copepoda: Cyclopoida) from Lake Baikal
The detection of three species complexes similar to Diacyclops galbinus, D. versutus and D. improcerus (Copepoda: Cyclopoida) from Lake Baikal Open
Cyclopoids are an extremely diverse and abundant group of arthropods found in Lake Baikal. Diacyclops Kiefer, 1927 is the most species-rich and highly endemic genus among them. The morphological characteristics of the three Baikal species,…
View article: Heat shock protein 27 in the pathogenesis of COVID-19 and non-COVID acute respiratory distress syndrome
Heat shock protein 27 in the pathogenesis of COVID-19 and non-COVID acute respiratory distress syndrome Open
View article: Multidrug-resistant E. coli encoding high genetic diversity in carbohydrate metabolism genes displace commensal E. coli from the intestinal tract
Multidrug-resistant E. coli encoding high genetic diversity in carbohydrate metabolism genes displace commensal E. coli from the intestinal tract Open
Extra-intestinal pathogenic Escherichia coli (ExPEC) can cause a variety of infections outside of the intestine and are a major causative agent of urinary tract infections. Treatment of these infections is increasingly frustrated by antimi…
View article: Development and characterization of a fecal-induced peritonitis model of murine sepsis: results from a multi-laboratory study and iterative modification of experimental conditions
Development and characterization of a fecal-induced peritonitis model of murine sepsis: results from a multi-laboratory study and iterative modification of experimental conditions Open
Background Preclinical sepsis models have been criticized for their inability to recapitulate human sepsis and suffer from methodological shortcomings that limit external validity and reproducibility. The National Preclinical Sepsis Platfo…
View article: Vascular traffic control of neutrophil recruitment to the liver by microbiota-endothelium crosstalk
Vascular traffic control of neutrophil recruitment to the liver by microbiota-endothelium crosstalk Open
During bloodstream infections, neutrophils home to the liver as part of an intravascular immune response to eradicate blood-borne pathogens, but the mechanisms regulating this crucial response are unknown. Using in vivo imaging of neutroph…
View article: Development and characterization of a fecal-induced peritonitis model of murine sepsis: results from a multi-laboratory study and iterative modification of experimental conditions
Development and characterization of a fecal-induced peritonitis model of murine sepsis: results from a multi-laboratory study and iterative modification of experimental conditions Open
Background: Preclinical sepsis models have been criticized for their inability to recapitulate human sepsis and suffer from methodological shortcomings that limit external validity and reproducibility. The National Preclinical Sepsis Platf…
View article: Dysbiosis of a microbiota–immune metasystem in critical illness is associated with nosocomial infections
Dysbiosis of a microbiota–immune metasystem in critical illness is associated with nosocomial infections Open
View article: Generation, maintenance, and monitoring of gnotobiotic mice
Generation, maintenance, and monitoring of gnotobiotic mice Open
View article: Programing of an Intravascular Immune Firewall by the Gut Microbiota Protects against Pathogen Dissemination during Infection
Programing of an Intravascular Immune Firewall by the Gut Microbiota Protects against Pathogen Dissemination during Infection Open