Ian A.J. Lorimer
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Transglutaminase 2 function in glioblastoma tumor efferocytosis Open
Glioblastoma is an aggressive and incurable type of brain cancer. Regions of tissue necrosis are a distinctive pathological feature of this cancer. These arise through thrombosis of tumor vasculature, driven by tumor-derived pro-coagulatio…
Modeling glioblastoma Open
Establishing a zebrafish model of a deadly type of brain tumor highlights the role of the immune system in the early stages of the disease.
Potential roles for efferocytosis in glioblastoma immune evasion Open
Glioblastoma is an aggressive and incurable brain cancer. This cancer establishes both local and systemic immunosuppression that creates a major obstacle to effective immunotherapies. Many studies point to tumor-resident myeloid cells (pri…
Engineered cells as glioblastoma therapeutics Open
In spite of significant recent advances in our understanding of the genetics and cell biology of glioblastoma, to date, this has not led to improved treatments for this cancer. In addition to small molecule, antibody, and engineered virus …
Rac guanine nucleotide exchange factors promoting Lgl1 phosphorylation in glioblastoma Open
The protein Lgl1 has key roles in the regulation of cell polarity. We have shown that Lgl1 is inactivated by hyperphosphorylation in glioblastoma as a consequence of PTEN loss and aberrant activation of the PI 3-kinase pathway; this contri…
CSIG-12. PREX1 LINKS ABERRANT PI 3-KINASE PATHWAY SIGNALING TO MAINTENANCE OF THE NEURAL STEM CELL-LIKE PHENOTYPE OF GLIOBLASTOMA CELLS Open
Virtually all primary glioblastomas have aberrant activation of the PI 3-kinase pathway through mutational inactivation of tumour suppressors such as PTEN and/or mutational activation of oncogenes. Most glioblastomas also overexpress the R…
Aberrant Rac pathway signalling in glioblastoma Open
Glioblastoma is an aggressive and incurable form of brain cancer. Both mutation analysis in human glioblastoma and mouse modelling studies have shown that aberrant activation of the PI 3-kinase pathway is a central driver of glioblastoma m…
CSIG-06. THE MOLECULAR SUBTYPE OF PRIMARY GLIOBLASTOMA CELLS CORRELATES WITH RESPONSE TO THERAPEUTIC AGENTS THAT INDUCE APOPTOSIS OR SENESCENCE Open
INTRODUCTION: Glioblastoma (GBM) is the most common adult primary brain tumour. Despite maximal therapy, median survival is 14 months. Resistance to therapy in GBM is due to extensive molecular heterogeneity. Gene expression profiling demo…
Engineering PTEN-L for Cell-Mediated Delivery Open
The tumor suppressor PTEN is frequently inactivated in glioblastoma. PTEN-L is a long form of PTEN produced by translation from an alternate upstream start codon. Unlike PTEN, PTEN-L has a signal sequence and a tract of six arginine residu…
PREX1 integrates G protein-coupled receptor and phosphoinositide 3-kinase signaling to promote glioblastoma invasion Open
A defining feature of the brain cancer glioblastoma is its highly invasive nature. When glioblastoma cells are isolated from patients using serum free conditions, they accurately recapitulate this invasive behaviour in animal models. The R…