Ian N. Moore
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View article: Growing <i>Staphylococcus aureus</i> in Synthetic Cystic Fibrosis Medium Promotes Colonization in a Murine Pneumonia Model
Growing <i>Staphylococcus aureus</i> in Synthetic Cystic Fibrosis Medium Promotes Colonization in a Murine Pneumonia Model Open
Staphylococcus aureus is a leading cause of bacterial infections worldwide and can lead to diseases such as osteomyelitis, skin, and lung infections in humans. Murine mouse models have been essential to the study of S. aureus virulence but…
View article: Passive infusion of an S2-Stem broadly neutralizing antibody protects against SARS-CoV-2 infection and lower airway inflammation in rhesus macaques
Passive infusion of an S2-Stem broadly neutralizing antibody protects against SARS-CoV-2 infection and lower airway inflammation in rhesus macaques Open
The continued evolution of SARS-CoV-2 variants capable of subverting vaccine and infection-induced immunity suggests the advantage of a broadly protective vaccine against betacoronaviruses (β-CoVs). Recent studies have isolated monoclonal …
View article: SIV infection in sooty mangabeys does not impact survival but changes the relative frequency of the main cause of death
SIV infection in sooty mangabeys does not impact survival but changes the relative frequency of the main cause of death Open
Sooty mangabeys (SMs) are natural hosts of simian immunodeficiency virus (SIV) and do not progress to AIDS despite high viral replication. The main factors involved in the benign nature of this infection are (i) low level of immune activat…
View article: A nonhuman primate model for genital herpes simplex virus 2 infection that results in vaginal vesicular lesions, virus shedding, and seroconversion
A nonhuman primate model for genital herpes simplex virus 2 infection that results in vaginal vesicular lesions, virus shedding, and seroconversion Open
The most commonly used animal models for evaluating the efficacy of HSV-2 candidate vaccines are mice and guinea pigs. While numerous HSV-2 vaccine candidates have been tested in these animals and were effective in reducing disease and mor…
View article: Passive infusion of an S2-Stem broadly neutralizing antibody protects against SARS-CoV-2 infection and lower airway inflammation in rhesus macaques
Passive infusion of an S2-Stem broadly neutralizing antibody protects against SARS-CoV-2 infection and lower airway inflammation in rhesus macaques Open
The continued evolution of SARS-CoV-2 variants capable of subverting vaccine and infection-induced immunity suggests the advantage of a broadly protective vaccine against betacoronaviruses (beta-CoVs). Recent studies have isolated monoclon…
View article: Mucosal prime-boost immunization with live murine pneumonia virus-vectored SARS-CoV-2 vaccine is protective in macaques
Mucosal prime-boost immunization with live murine pneumonia virus-vectored SARS-CoV-2 vaccine is protective in macaques Open
View article: Broadly neutralizing antibody induction by non-stabilized SARS-CoV-2 Spike mRNA vaccination in nonhuman primates
Broadly neutralizing antibody induction by non-stabilized SARS-CoV-2 Spike mRNA vaccination in nonhuman primates Open
Immunization with mRNA or viral vectors encoding spike with diproline substitutions (S-2P) has provided protective immunity against severe COVID-19 disease. How immunization with Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)…
View article: Mucosal prime-boost immunization with live murine pneumonia virus-vectored SARS-CoV-2 vaccine is protective in macaques
Mucosal prime-boost immunization with live murine pneumonia virus-vectored SARS-CoV-2 vaccine is protective in macaques Open
View article: Pathogenesis and outcome of VA1 astrovirus infection in the human brain are defined by disruption of neural functions and imbalanced host immune responses
Pathogenesis and outcome of VA1 astrovirus infection in the human brain are defined by disruption of neural functions and imbalanced host immune responses Open
Astroviruses (AstVs) can cause of severe infection of the central nervous system (CNS) in immunocompromised individuals. Here, we identified a human AstV of the VA1 genotype, HAstV-NIH, as the cause of fatal encephalitis in an immunocompro…
View article: Investigation of the impact of clonal hematopoiesis on severity and pathophysiology of COVID-19 in rhesus macaques
Investigation of the impact of clonal hematopoiesis on severity and pathophysiology of COVID-19 in rhesus macaques Open
Clinical manifestations of COVID-19 vary widely, ranging from asymptomatic to severe respiratory failure with profound inflammation. Although risk factors for severe illness have been identified, definitive determinants remain elusive. Clo…
View article: P26-023-23 Getting Good Data: Insights From an Agricultural Production Survey
P26-023-23 Getting Good Data: Insights From an Agricultural Production Survey Open
View article: Live-attenuated pediatric parainfluenza vaccine expressing 6P-stabilized SARS-CoV-2 spike protein is protective against SARS-CoV-2 variants in hamsters
Live-attenuated pediatric parainfluenza vaccine expressing 6P-stabilized SARS-CoV-2 spike protein is protective against SARS-CoV-2 variants in hamsters Open
The pediatric live-attenuated bovine/human parainfluenza virus type 3 (B/HPIV3)-vectored vaccine expressing the prefusion-stabilized SARS-CoV-2 spike (S) protein (B/HPIV3/S-2P) was previously evaluated in vitro and in hamsters. To improve …
View article: <i>Anopheles</i>salivary apyrase regulates blood meal hemostasis and drives malaria parasite transmission
<i>Anopheles</i>salivary apyrase regulates blood meal hemostasis and drives malaria parasite transmission Open
Mosquito salivary proteins play a crucial role in regulating hemostatic responses at the bite site during blood feeding. In this study, we investigate the function of Anopheles gambiae salivary apyrase (AgApyrase) in Plasmodium transmissio…
View article: Efficacy of mRNA-1273 and Novavax ancestral or BA.1 spike booster vaccines against SARS-CoV-2 BA.5 infection in nonhuman primates
Efficacy of mRNA-1273 and Novavax ancestral or BA.1 spike booster vaccines against SARS-CoV-2 BA.5 infection in nonhuman primates Open
Omicron SARS-CoV-2 variants escape vaccine-induced neutralizing antibodies and cause nearly all current COVID-19 cases. Here, we compared the efficacy of three booster vaccines against Omicron BA.5 challenge in rhesus macaques: mRNA-1273, …
View article: Figure S2 from Molecular Signature and Mechanisms of Hepatitis D Virus–Associated Hepatocellular Carcinoma
Figure S2 from Molecular Signature and Mechanisms of Hepatitis D Virus–Associated Hepatocellular Carcinoma Open
Genes associated with the twenty top-scored pathways of malignant hepatocytes of HDV-HCC.
View article: Data from Molecular Signature and Mechanisms of Hepatitis D Virus–Associated Hepatocellular Carcinoma
Data from Molecular Signature and Mechanisms of Hepatitis D Virus–Associated Hepatocellular Carcinoma Open
There is limited data on the molecular mechanisms whereby hepatitis D virus (HDV) promotes liver cancer. Therefore, serum and liver specimens obtained at the time of liver transplantation from well-characterized patients with HDV-HCC (n…
View article: Figure S3 from Molecular Signature and Mechanisms of Hepatitis D Virus–Associated Hepatocellular Carcinoma
Figure S3 from Molecular Signature and Mechanisms of Hepatitis D Virus–Associated Hepatocellular Carcinoma Open
Synopsis of the 20 top-scored pathways associated with genes identified in malignant hepatocytes derived from HDV-, HBV- and HCV-HCC.
View article: Figure S1 from Molecular Signature and Mechanisms of Hepatitis D Virus–Associated Hepatocellular Carcinoma
Figure S1 from Molecular Signature and Mechanisms of Hepatitis D Virus–Associated Hepatocellular Carcinoma Open
Experimental design.
View article: Figure S2 from Molecular Signature and Mechanisms of Hepatitis D Virus–Associated Hepatocellular Carcinoma
Figure S2 from Molecular Signature and Mechanisms of Hepatitis D Virus–Associated Hepatocellular Carcinoma Open
Genes associated with the twenty top-scored pathways of malignant hepatocytes of HDV-HCC.
View article: Figure S7 from Molecular Signature and Mechanisms of Hepatitis D Virus–Associated Hepatocellular Carcinoma
Figure S7 from Molecular Signature and Mechanisms of Hepatitis D Virus–Associated Hepatocellular Carcinoma Open
HBV DNA levels in tumorous and non-tumorous tissues of individual patients with HBV-associated HCC.
View article: Figure S6 from Molecular Signature and Mechanisms of Hepatitis D Virus–Associated Hepatocellular Carcinoma
Figure S6 from Molecular Signature and Mechanisms of Hepatitis D Virus–Associated Hepatocellular Carcinoma Open
Synopsis of the 20 top-scored pathways associated with WLT-unique genes identified in the three tumors.
View article: Figure S4 from Molecular Signature and Mechanisms of Hepatitis D Virus–Associated Hepatocellular Carcinoma
Figure S4 from Molecular Signature and Mechanisms of Hepatitis D Virus–Associated Hepatocellular Carcinoma Open
Clusters of the 37 genes involved in the cell cycle and differentially expressed in malignant hepatocytes derived from HDV-HCC.
View article: Figure S7 from Molecular Signature and Mechanisms of Hepatitis D Virus–Associated Hepatocellular Carcinoma
Figure S7 from Molecular Signature and Mechanisms of Hepatitis D Virus–Associated Hepatocellular Carcinoma Open
HBV DNA levels in tumorous and non-tumorous tissues of individual patients with HBV-associated HCC.
View article: Figure S4 from Molecular Signature and Mechanisms of Hepatitis D Virus–Associated Hepatocellular Carcinoma
Figure S4 from Molecular Signature and Mechanisms of Hepatitis D Virus–Associated Hepatocellular Carcinoma Open
Clusters of the 37 genes involved in the cell cycle and differentially expressed in malignant hepatocytes derived from HDV-HCC.
View article: Figure S5 from Molecular Signature and Mechanisms of Hepatitis D Virus–Associated Hepatocellular Carcinoma
Figure S5 from Molecular Signature and Mechanisms of Hepatitis D Virus–Associated Hepatocellular Carcinoma Open
Venn diagrams of differentially expressed genes obtained from laser capture microdissected hepatocytes and whole liver tissue of patients with HDV-, HBV-and HCV-associated HCC
View article: Figure S5 from Molecular Signature and Mechanisms of Hepatitis D Virus–Associated Hepatocellular Carcinoma
Figure S5 from Molecular Signature and Mechanisms of Hepatitis D Virus–Associated Hepatocellular Carcinoma Open
Venn diagrams of differentially expressed genes obtained from laser capture microdissected hepatocytes and whole liver tissue of patients with HDV-, HBV-and HCV-associated HCC
View article: Figure S6 from Molecular Signature and Mechanisms of Hepatitis D Virus–Associated Hepatocellular Carcinoma
Figure S6 from Molecular Signature and Mechanisms of Hepatitis D Virus–Associated Hepatocellular Carcinoma Open
Synopsis of the 20 top-scored pathways associated with WLT-unique genes identified in the three tumors.
View article: Figure S1 from Molecular Signature and Mechanisms of Hepatitis D Virus–Associated Hepatocellular Carcinoma
Figure S1 from Molecular Signature and Mechanisms of Hepatitis D Virus–Associated Hepatocellular Carcinoma Open
Experimental design.
View article: Figure S3 from Molecular Signature and Mechanisms of Hepatitis D Virus–Associated Hepatocellular Carcinoma
Figure S3 from Molecular Signature and Mechanisms of Hepatitis D Virus–Associated Hepatocellular Carcinoma Open
Synopsis of the 20 top-scored pathways associated with genes identified in malignant hepatocytes derived from HDV-, HBV- and HCV-HCC.
View article: Data from Molecular Signature and Mechanisms of Hepatitis D Virus–Associated Hepatocellular Carcinoma
Data from Molecular Signature and Mechanisms of Hepatitis D Virus–Associated Hepatocellular Carcinoma Open
There is limited data on the molecular mechanisms whereby hepatitis D virus (HDV) promotes liver cancer. Therefore, serum and liver specimens obtained at the time of liver transplantation from well-characterized patients with HDV-HCC (n…