Ian P. Whitehead
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View article: Current practice and surgical outcomes of neoadjuvant chemotherapy for early breast cancer: UK NeST study
Current practice and surgical outcomes of neoadjuvant chemotherapy for early breast cancer: UK NeST study Open
Neoadjuvant chemotherapy (NACT) is increasingly being used to treat early breast cancer, and offers several advantages, including reducing the extent of breast and axillary surgery, and providing an in vivo assessment of tumour sensitivity…
View article: Expression Cloning of lsc , a Novel Oncogene with Structural Similarities to the Dbl Family of Guanine Nucleotide Exchange Factors
Expression Cloning of lsc , a Novel Oncogene with Structural Similarities to the Dbl Family of Guanine Nucleotide Exchange Factors Open
In a screen for genes with oncogenic potential expressed by the murine B6SUtA1 myeloid progenitor cell line, we isolated a 2. 5-kilobase pair cDNA whose expression causes strong morphological transformation and deregulated proliferation of…
View article: Multifunctional Roles for the PH Domain of Dbs in Regulating Rho GTPase Activation
Multifunctional Roles for the PH Domain of Dbs in Regulating Rho GTPase Activation Open
Dbl family members are guanine nucleotide exchange factors specific for Rho guanosine triphosphatases (GTPases) and invariably possess tandem Dbl (DH) and pleckstrin homology (PH) domains. Dbs, a Dbl family member specific for Cdc42 and Rh…
View article: Transforming Potential of Dbl Family Proteins Correlates with Transcription from the Cyclin D1 Promoter but Not with Activation of Jun NH 2 -terminal Kinase, p38/Mpk2, Serum Response Factor, or c-Jun
Transforming Potential of Dbl Family Proteins Correlates with Transcription from the Cyclin D1 Promoter but Not with Activation of Jun NH 2 -terminal Kinase, p38/Mpk2, Serum Response Factor, or c-Jun Open
The dbl family of oncogenes encodes a large, structurally related, family of growth-regulatory molecules that possess guanine nucleotide exchange factor activity for specific members of the Rho family of Ras-related GTPases. We have evalua…
View article: Lfc and Lsc Oncoproteins Represent Two New Guanine Nucleotide Exchange Factors for the Rho GTP-binding Protein
Lfc and Lsc Oncoproteins Represent Two New Guanine Nucleotide Exchange Factors for the Rho GTP-binding Protein Open
Lfc and Lsc are two recently identified oncoproteins that contain a Dbl homology domain in tandem with a pleckstrin homology domain and thus share sequence similarity with a number of other growth regulatory proteins including Dbl, Tiam-1,…
View article: Functional Analysis of Cdc42 Residues Required for Guanine Nucleotide Exchange
Functional Analysis of Cdc42 Residues Required for Guanine Nucleotide Exchange Open
Guanine nucleotide exchange factors (GEFs) directly engage small GTPases to facilitate the exchange of bound GDP for GTP, leading to GTPase activation. Several recent crystal structures of GEFs in complex with Rho family GTPases highlight …
View article: RhoGEF Specificity Mutants Implicate RhoA as a Target for Dbs Transforming Activity
RhoGEF Specificity Mutants Implicate RhoA as a Target for Dbs Transforming Activity Open
Dbs is a Rho-specific guanine nucleotide exchange factor (RhoGEF) that exhibits transforming activity when overexpressed in NIH 3T3 mouse fibroblasts. Like many RhoGEFs, the in vitro catalytic activity of Dbs is not limited to a single sub…
View article: CDC42 and FGD1 Cause Distinct Signaling and Transforming Activities
CDC42 and FGD1 Cause Distinct Signaling and Transforming Activities Open
Activated forms of different Rho family members (CDC42, Rac1, RhoA, RhoB, and RhoG) have been shown to transform NIH 3T3 cells as well as contribute to Ras transformation. Rho family guanine nucleotide exchange factors (GEFs) (also known a…
View article: Regulation of RasGRP via a Phorbol Ester-Responsive C1 Domain
Regulation of RasGRP via a Phorbol Ester-Responsive C1 Domain Open
As part of a cDNA library screen for clones that induce transformation of NIH 3T3 fibroblasts, we have isolated a cDNA encoding the murine homolog of the guanine nucleotide exchange factor RasGRP. A point mutation predicted to prevent inte…
View article: Type III interferon is a critical regulator of innate antifungal immunity
Type III interferon is a critical regulator of innate antifungal immunity Open
Type III interferons activate neutrophils to promote antifungal immune responses to Aspergillus fumigatus .
View article: Fasudil, a Clinically Used ROCK Inhibitor, Stabilizes Rod Photoreceptor Synapses after Retinal Detachment
Fasudil, a Clinically Used ROCK Inhibitor, Stabilizes Rod Photoreceptor Synapses after Retinal Detachment Open
These results support the possibility, previously tested with Y27632, that ROCK inhibition may attenuate synaptic damage in iatrogenic detachments.
View article: RhoA Signaling and Synaptic Damage Occur Within Hours in a Live Pig Model of CNS Injury, Retinal Detachment
RhoA Signaling and Synaptic Damage Occur Within Hours in a Live Pig Model of CNS Injury, Retinal Detachment Open
Activation of the RhoA pathway occurs quickly after injury and promotes synaptic damage that can be controlled by RhoA kinase inhibition. We suggest that retinal detachment joins the list of central nervous system injuries, such as stroke …