Ian Pitha
YOU?
Author Swipe
View article: Clinical Outcomes of Hydrus Microstent Implantation for Open-Angle Glaucoma: Results from a Large Academic Center
Clinical Outcomes of Hydrus Microstent Implantation for Open-Angle Glaucoma: Results from a Large Academic Center Open
Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.
View article: Analysis of 2-dimensional regional differences in the peripapillary scleral fibroblast cytoskeleton of normotensive and hypertensive mouse eyes
Analysis of 2-dimensional regional differences in the peripapillary scleral fibroblast cytoskeleton of normotensive and hypertensive mouse eyes Open
These studies aimed to study the mechanisms of glaucomatous peripapillary scleral (PPS) remodeling by investigating IOP-induced changes in fibroblast actin-collagen alignment and nuclear morphology in mouse PPS. Cryosections from the optic…
View article: Regional differences in peripapillary scleral fibroblast cytoskeleton and nuclear morphology after intraocular pressure elevation in mouse eyes
Regional differences in peripapillary scleral fibroblast cytoskeleton and nuclear morphology after intraocular pressure elevation in mouse eyes Open
These studies aimed to study the mechanisms of glaucomatous peripapillary scleral (PPS) remodeling by investigating IOP-induced changes in fibroblast actin-collagen alignment and nuclear morphology in mouse PPS. Cryosections from the optic…
View article: The Mechanisms of Neuroprotection by Topical Rho Kinase Inhibition in Experimental Mouse Glaucoma and Optic Neuropathy
The Mechanisms of Neuroprotection by Topical Rho Kinase Inhibition in Experimental Mouse Glaucoma and Optic Neuropathy Open
Topical Rip reduced RGC loss in GL and ON crush, with suppression of ROCK signaling in the retina and ON. The neuroprotection mechanisms appear to involve effects on both RGC and astrocyte responses to IOP elevation.
View article: The relationship between intraocular pressure and glaucoma: An evolving concept
The relationship between intraocular pressure and glaucoma: An evolving concept Open
Intraocular pressure (IOP) is the most important modifiable risk factor for glaucoma and fluctuates considerably within patients over short and long time periods. Our field's understanding of IOP has evolved considerably in recent years, d…
View article: IOP and glaucoma damage: The essential role of optic nerve head and retinal mechanosensors
IOP and glaucoma damage: The essential role of optic nerve head and retinal mechanosensors Open
View article: Engineered peptide-drug conjugate provides sustained protection of retinal ganglion cells with topical administration in rats
Engineered peptide-drug conjugate provides sustained protection of retinal ganglion cells with topical administration in rats Open
View article: Machine learning-driven multifunctional peptide engineering for sustained ocular drug delivery
Machine learning-driven multifunctional peptide engineering for sustained ocular drug delivery Open
Sustained drug delivery strategies have many potential benefits for treating a range of diseases, particularly chronic diseases that require treatment for years. For many chronic ocular diseases, patient adherence to eye drop dosing regime…
View article: Targeted Microglial Attenuation through Dendrimer–Drug Conjugates Improves Glaucoma Neuroprotection
Targeted Microglial Attenuation through Dendrimer–Drug Conjugates Improves Glaucoma Neuroprotection Open
Retinal microglial/macrophage activation and optic nerve (ON) microglial/macrophage activation are glaucoma biomarkers and potential therapeutic targets for this blinding disease. We report targeting of activated microglia by PAMAM dendrim…
View article: Nanofiber‐based glaucoma drainage implant improves surgical outcomes by modulating fibroblast behavior
Nanofiber‐based glaucoma drainage implant improves surgical outcomes by modulating fibroblast behavior Open
Biomaterials are implanted in millions of individuals worldwide each year. Both naturally derived and synthetic biomaterials induce a foreign body reaction that often culminates in fibrotic encapsulation and reduced functional lifespan. In…
View article: TGFβ treatment alters the scleral fibroblast migratory response to cyclic strain in an ERK-dependent manner
TGFβ treatment alters the scleral fibroblast migratory response to cyclic strain in an ERK-dependent manner Open
Purpose Myofibroblasts are associated with scleral remodeling in myopia and glaucoma. We showed reduced myofibroblast alignment with topographic cues in sclera can be modeled by cyclic strain exposure of aligned myofibroblasts in vitro . H…
View article: Dendrimer-based nanoparticles for early detection and therapeutic targeting of microglia in a rat glaucoma model
Dendrimer-based nanoparticles for early detection and therapeutic targeting of microglia in a rat glaucoma model Open
View article: Ion-Complex Microcrystal Formulation Provides Sustained Delivery of a Multimodal Kinase Inhibitor from the Subconjunctival Space for Protection of Retinal Ganglion Cells
Ion-Complex Microcrystal Formulation Provides Sustained Delivery of a Multimodal Kinase Inhibitor from the Subconjunctival Space for Protection of Retinal Ganglion Cells Open
Glaucoma is the leading cause of irreversible blindness worldwide. Elevated intraocular pressure (IOP) is one of the major risk factors for glaucoma onset and progression, and available pharmaceutical interventions are exclusively targeted…
View article: A hypotonic gel-forming eye drop provides enhanced intraocular delivery of a kinase inhibitor with melanin-binding properties for sustained protection of retinal ganglion cells
A hypotonic gel-forming eye drop provides enhanced intraocular delivery of a kinase inhibitor with melanin-binding properties for sustained protection of retinal ganglion cells Open
View article: Engineering biomaterials to prevent post-operative infection and fibrosis
Engineering biomaterials to prevent post-operative infection and fibrosis Open
View article: Regional Differences and Physiologic Behaviors in Peripapillary Scleral Fibroblasts
Regional Differences and Physiologic Behaviors in Peripapillary Scleral Fibroblasts Open
Regions of the posterior sclera differ in cellular density and nuclear morphology. Topography alters the cellular response to mechanical strain.
View article: Gelling hypotonic polymer solution for extended topical drug delivery to the eye
Gelling hypotonic polymer solution for extended topical drug delivery to the eye Open
View article: A novel bilayered expanded polytetrafluoroethylene glaucoma implant creates a permeable thin capsule independent of aqueous humor exposure
A novel bilayered expanded polytetrafluoroethylene glaucoma implant creates a permeable thin capsule independent of aqueous humor exposure Open
The purpose of these studies was to evaluate clinical, functional, and histopathological features of glaucoma drainage implants (GDIs) fabricated from novel, custom‐tailored expanded polytetrafluoroethylene (ePTFE). Implants of matching fo…
View article: Nano-structured glaucoma drainage implant safely and significantly reduces intraocular pressure in rabbits via post-operative outflow modulation
Nano-structured glaucoma drainage implant safely and significantly reduces intraocular pressure in rabbits via post-operative outflow modulation Open
View article: Author response for "A novel bilayered expanded polytetrafluoroethylene glaucoma implant creates a permeable thin capsule independent of aqueous humor exposure"
Author response for "A novel bilayered expanded polytetrafluoroethylene glaucoma implant creates a permeable thin capsule independent of aqueous humor exposure" Open
View article: Design, development and evaluation of electrospun, nano-structured microshunts for controlled intraocular pressure (IOP) reduction
Design, development and evaluation of electrospun, nano-structured microshunts for controlled intraocular pressure (IOP) reduction Open
View article: Amyloid precursor protein transport block evaluation as a biomarker for experimental mouse glaucoma
Amyloid precursor protein transport block evaluation as a biomarker for experimental mouse glaucoma Open
View article: A method to quantify regional axonal transport blockade at the optic nerve head after short term intraocular pressure elevation in mice
A method to quantify regional axonal transport blockade at the optic nerve head after short term intraocular pressure elevation in mice Open
Axonal transport blockade is an initial step in retinal ganglion cell (RGC) degeneration in glaucoma and targeting maintenance of normal axonal transport could confer neuroprotection. We present an objective, quantitative method for assess…
View article: Dasatinib inhibits peripapillary scleral myofibroblast differentiation
Dasatinib inhibits peripapillary scleral myofibroblast differentiation Open
View article: Twenty-Four-Hour Light-Induced Ocular Hypertension in Rats Provides a Non-invasive Chronic Model for Testing Intraocular Pressure Lowering Drugs
Twenty-Four-Hour Light-Induced Ocular Hypertension in Rats Provides a Non-invasive Chronic Model for Testing Intraocular Pressure Lowering Drugs Open
View article: Rho-Kinase Inhibition Reduces Myofibroblast Differentiation and Proliferation of Scleral Fibroblasts Induced by Transforming Growth Factor β and Experimental Glaucoma
Rho-Kinase Inhibition Reduces Myofibroblast Differentiation and Proliferation of Scleral Fibroblasts Induced by Transforming Growth Factor β and Experimental Glaucoma Open
These findings suggest altered fibroblast activity promoted by ROCK inhibitors could modify scleral biomechanics and be relevant to glaucoma treatment.
View article: RHO-kinase-mediated regulation of myofibroblast differentiation in scleral fibroblasts during experimental glaucoma
RHO-kinase-mediated regulation of myofibroblast differentiation in scleral fibroblasts during experimental glaucoma Open
View article: Sustained Dorzolamide Release Prevents Axonal and Retinal Ganglion Cell Loss in a Rat Model of IOPâGlaucoma
Sustained Dorzolamide Release Prevents Axonal and Retinal Ganglion Cell Loss in a Rat Model of IOPâGlaucoma Open
Purpose: To determine if one injection of a sustained release formulation of dorzolamide in biodegradable microparticles (DPP) reduces retinal ganglion cell (RGC) loss in a rat model of glaucoma. Methods: We injected either DPP or control …
Sustained Dorzolamide Release Prevents Axonal and Retinal Ganglion Cell Loss in a Rat Model of IOP–Glaucoma Open
View article: Glaucoma Screening in Nepal: Cup-to-Disc Estimate With Standard Mydriatic Fundus Camera Compared to Portable Nonmydriatic Camera
Glaucoma Screening in Nepal: Cup-to-Disc Estimate With Standard Mydriatic Fundus Camera Compared to Portable Nonmydriatic Camera Open