Ian R McCracken
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View article: Essential regulation of heparan sulfate proteoglycan signalling controls cell behaviour to support cardiac development
Essential regulation of heparan sulfate proteoglycan signalling controls cell behaviour to support cardiac development Open
Heparan sulfate proteoglycan (HSPG)-dependent signalling is essential for cardiac development, yet how HSPGs are regulated in the forming heart is unknown. Here, we show that the extracellular heparan sulfate modifier, SULF1, expressed by …
View article: Evaluating the transcriptional regulators of arterial gene expression via a catalogue of characterized arterial enhancers
Evaluating the transcriptional regulators of arterial gene expression via a catalogue of characterized arterial enhancers Open
The establishment and growth of the arterial endothelium require the coordinated expression of numerous genes. However, regulation of this process is not yet fully understood. Here, we combined in silico analysis with transgenic mice and z…
View article: Author response: Evaluating the transcriptional regulators of arterial gene expression via a catalogue of characterized arterial enhancers
Author response: Evaluating the transcriptional regulators of arterial gene expression via a catalogue of characterized arterial enhancers Open
View article: A catalogue of verified and characterized arterial enhancers for key arterial identity genes
A catalogue of verified and characterized arterial enhancers for key arterial identity genes Open
The establishment and growth of the arterial endothelium requires the coordinated expression of numerous genes. However, the transcriptional and signalling pathways regulating this process are still not fully established, and only a small …
View article: Extracellular vesicles from differentiated stem cells contain novel proangiogenic miRNAs and induce angiogenic responses at low doses
Extracellular vesicles from differentiated stem cells contain novel proangiogenic miRNAs and induce angiogenic responses at low doses Open
View article: Human and murine single-cell RNA-sequencing reveal fibroblast heterogeneity in healthy and diseased vasculature and differential regulation by ageing and serum cholesterol
Human and murine single-cell RNA-sequencing reveal fibroblast heterogeneity in healthy and diseased vasculature and differential regulation by ageing and serum cholesterol Open
View article: Transcriptional regulators of arterial and venous identity in the developing mammalian embryo
Transcriptional regulators of arterial and venous identity in the developing mammalian embryo Open
View article: Human and murine fibroblast single-cell transcriptomics reveals fibroblast clusters are differentially affected by ageing and serum cholesterol
Human and murine fibroblast single-cell transcriptomics reveals fibroblast clusters are differentially affected by ageing and serum cholesterol Open
Aims Specific fibroblast markers and in-depth heterogeneity analysis are currently lacking, hindering functional studies in cardiovascular diseases (CVDs). Here, we established cell-type markers and heterogeneity in murine and human arteri…
View article: Human embryonic stem cell-derived endothelial cell product injection attenuates cardiac remodeling in myocardial infarction
Human embryonic stem cell-derived endothelial cell product injection attenuates cardiac remodeling in myocardial infarction Open
Background Mechanisms contributing to tissue remodeling of the infarcted heart following cell-based therapy remain elusive. While cell-based interventions have the potential to influence the cardiac healing process, there is little direct …
View article: Multi-species meta-analysis identifies transcriptional signatures associated with cardiac endothelial responses in the ischaemic heart
Multi-species meta-analysis identifies transcriptional signatures associated with cardiac endothelial responses in the ischaemic heart Open
Aim Myocardial infarction remains the leading cause of heart failure. The adult human heart lacks the capacity to undergo endogenous regeneration. New blood vessel growth is integral to regenerative medicine necessitating a comprehensive u…
View article: B A multi-OMICS approach to generate novel mechanistic insights and new targets for cardiovascular regeneration in the ischaemic adult heart
B A multi-OMICS approach to generate novel mechanistic insights and new targets for cardiovascular regeneration in the ischaemic adult heart Open
Background Myocardial infarction (MI) is the leading cause of heart failure. The adult human heart, unlike mouse or early neonatal hearts, lacks the capability to undergo extensive regeneration. Rapid re-establishment of blood flow post MI…
View article: Protective role of chaperone-mediated autophagy against atherosclerosis
Protective role of chaperone-mediated autophagy against atherosclerosis Open
Significance Cardiovascular diseases remain the leading cause of death worldwide, with atherosclerosis being the most common source of clinical events. Metabolic changes with aging associate with concurrent increased risk of both type 2 di…
View article: Multi-species meta-analysis identifies transcriptional signatures associated with cardiac endothelial responses in the ischaemic heart
Multi-species meta-analysis identifies transcriptional signatures associated with cardiac endothelial responses in the ischaemic heart Open
View article: Mapping the developing human cardiac endothelium at single-cell resolution identifies MECOM as a regulator of arteriovenous gene expression
Mapping the developing human cardiac endothelium at single-cell resolution identifies MECOM as a regulator of arteriovenous gene expression Open
Aims Coronary vasculature formation is a critical event during cardiac development, essential for heart function throughout perinatal and adult life. However, current understanding of coronary vascular development has largely been derived …
View article: Dissecting the transcriptome in cardiovascular disease
Dissecting the transcriptome in cardiovascular disease Open
The human transcriptome comprises a complex network of coding and non-coding RNAs implicated in a myriad of biological functions. Non-coding RNAs exhibit highly organized spatial and temporal expression patterns and are emerging as critica…
View article: The Influence of the LINC00961/SPAAR Locus Loss on Murine Development, Myocardial Dynamics, and Cardiac Response to Myocardial Infarction
The Influence of the LINC00961/SPAAR Locus Loss on Murine Development, Myocardial Dynamics, and Cardiac Response to Myocardial Infarction Open
Long non-coding RNAs (lncRNAs) have structural and functional roles in development and disease. We have previously shown that the LINC00961/SPAAR (small regulatory polypeptide of amino acid response) locus regulates endothelial cell functi…
View article: Lack of Evidence of Angiotensin-Converting Enzyme 2 Expression and Replicative Infection by SARS-CoV-2 in Human Endothelial Cells
Lack of Evidence of Angiotensin-Converting Enzyme 2 Expression and Replicative Infection by SARS-CoV-2 in Human Endothelial Cells Open
View article: Lack of evidence of ACE2 expression and replicative infection by SARS-CoV-2 in human endothelial cells
Lack of evidence of ACE2 expression and replicative infection by SARS-CoV-2 in human endothelial cells Open
A striking feature of severe COVID-19 is thrombosis in large as well as small vessels of multiple organs. This has led to the assumption that SARS-CoV-2 virus directly infects and damages the vascular endothelium. However, endothelial expr…
View article: The Influence of the LINC00961/SPAAR Locus Loss on Murine Development, Myocardial Dynamics, and Cardiac Response to Myocardial Infarction
The Influence of the LINC00961/SPAAR Locus Loss on Murine Development, Myocardial Dynamics, and Cardiac Response to Myocardial Infarction Open
Long non-coding RNAs (lncRNAs) have structural and functional roles in development and disease. We have previously shown that the LINC00961/SPAAR locus regulates endothelial cell function, and that both the lncRNA and micropeptide counter-…
View article: Transcriptional dynamics of pluripotent stem cell-derived endothelial cell differentiation revealed by single-cell RNA sequencing
Transcriptional dynamics of pluripotent stem cell-derived endothelial cell differentiation revealed by single-cell RNA sequencing Open
Aims Pluripotent stem cell-derived endothelial cell products possess therapeutic potential in ischaemic vascular disease. However, the factors that drive endothelial differentiation from pluripotency and cellular specification are largely …
View article: Unravelling atherosclerotic heterogeneity by single cell RNA sequencing
Unravelling atherosclerotic heterogeneity by single cell RNA sequencing Open
McCracken, Ian R.a; Taylor, Richard S.b; Henderson, Neil C.b; Sluimer, Judith C.a,c; Baker, Andrew H.a,c Author Information