Ian Sayers
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View article: Sex-specific genetic effects on susceptibility to idiopathic pulmonary fibrosis
Sex-specific genetic effects on susceptibility to idiopathic pulmonary fibrosis Open
Background Idiopathic pulmonary fibrosis (IPF) is a chronic lung condition that is more prevalent in males than females. The reasons for this are not fully understood; differing environmental exposures due to historically sex-biased occupa…
View article: Defining the Blood Cytokine Profile in Asthma to Understand Asthma Heterogeneity
Defining the Blood Cytokine Profile in Asthma to Understand Asthma Heterogeneity Open
Background Asthma is a heterogeneous disease characterized by overlapping clinical and inflammatory features. Objective This study aimed to provide insight into the systemic inflammatory profile in asthma, greater understanding of asthma e…
View article: Genome-wide association study of Idiopathic Pulmonary Fibrosis susceptibility using clinically-curated European-ancestry datasets
Genome-wide association study of Idiopathic Pulmonary Fibrosis susceptibility using clinically-curated European-ancestry datasets Open
Background Idiopathic pulmonary fibrosis (IPF) is a rare, incurable lung disease with a median survival of 3-5 years after diagnosis. Treatment options are limited. Genetic association studies can identify new genes involved in disease tha…
View article: Epithelial Interleukin‐1 Receptor‐Like‐1 Activation Is Contingent on Interleukin‐33 Isoforms and Asthma‐Related Receptor Variation
Epithelial Interleukin‐1 Receptor‐Like‐1 Activation Is Contingent on Interleukin‐33 Isoforms and Asthma‐Related Receptor Variation Open
Introduction The interleukin‐33/interleukin‐1 receptor‐like‐1 (IL‐33/IL1RL1) signalling pathway is implicated in asthma pathogenesis, with IL1RL1 nonsynonymous genetic polymorphisms associated with disease risk. We aimed to determine these…
View article: Interleukin‐1 receptor‐associated kinase 4 (IRAK4) is a critical regulator of inflammatory signalling through toll‐like receptors 4 and 7/8 in murine and human lungs
Interleukin‐1 receptor‐associated kinase 4 (IRAK4) is a critical regulator of inflammatory signalling through toll‐like receptors 4 and 7/8 in murine and human lungs Open
Background and Purpose Toll‐like receptors 4 (TLR4) and TLR7/TLR8 play an important role in mediating the inflammatory effects of bacterial and viral pathogens. Interleukin‐1 receptor‐associated kinase 4 (IRAK4) is an important regulator o…
View article: IRAK4 is a critical regulator of inflammatory signalling through Toll like receptors (TLR) 4 and 7/8 in murine and human lungs
IRAK4 is a critical regulator of inflammatory signalling through Toll like receptors (TLR) 4 and 7/8 in murine and human lungs Open
Background and purpose: Toll like receptors (TLR) 4 and 7/8 play an important role in mediating the inflammatory effects of bacterial and viral pathogens. IRAK4 is an important regulator of TLR signalling, and hence is a potential therapeu…
View article: IL-33 induced gene expression in activated Th2 effector cells is dependent on IL-1RL1 haplotype and asthma status
IL-33 induced gene expression in activated Th2 effector cells is dependent on IL-1RL1 haplotype and asthma status Open
IL-33 response in Th2 cells is specific to asthma and represents a high risk haplotype, highlighting its role in airway wall cells. Yet, its detection is challenging in bulk asthma transcriptomes due to the scarcity of effector Th2 cells. …
View article: Transcriptomics using lung resection material to advance our understanding of COPD and idiopathic pulmonary fibrosis pathogenesis
Transcriptomics using lung resection material to advance our understanding of COPD and idiopathic pulmonary fibrosis pathogenesis Open
Genes involved in cell death, inflammation and viral infection are common to both COPD and IPF. A link to rheumatic disease is unique to COPD, and IPF-specific analyses showed increases in gene expression of keratins, collagens, mucins and…
View article: Mepolizumab-induced Changes in Nasal Methylome and Transcriptome to Predict Response in Asthma
Mepolizumab-induced Changes in Nasal Methylome and Transcriptome to Predict Response in Asthma Open
"Mepolizumab Induced Changes in Nasal Methylome and Transcriptome to Predict Response in Asthma." American Journal of Respiratory and Critical Care Medicine, 0(ja), pp.
View article: Genome-wide SNP-sex interaction analysis of susceptibility to idiopathic pulmonary fibrosis
Genome-wide SNP-sex interaction analysis of susceptibility to idiopathic pulmonary fibrosis Open
Background Idiopathic pulmonary fibrosis (IPF) is a chronic lung condition that is more prevalent in males than females. The reasons for this are not fully understood, with differing environmental exposures due to historically sex-biased o…
View article: Association study of human leukocyte antigen variants and idiopathic pulmonary fibrosis
Association study of human leukocyte antigen variants and idiopathic pulmonary fibrosis Open
Introduction Idiopathic pulmonary fibrosis (IPF) is a chronic interstitial pneumonia marked by progressive lung fibrosis and a poor prognosis. Recent studies have highlighted the potential role of infection in the pathogenesis of IPF, and …
View article: P189 Genetic differences between sexes in idiopathic pulmonary fibrosis: a genome-wide SNP-by-sex interaction analysis
P189 Genetic differences between sexes in idiopathic pulmonary fibrosis: a genome-wide SNP-by-sex interaction analysis Open
Introduction Idiopathic pulmonary fibrosis (IPF) is a chronic lung disease, whereby scarring of the lungs occurs. IPF is a complex disease and is more prevalent in males than females, however it is not understood why this is. Genome-wide a…
View article: P191 Exploring the association between human leukocyte antigen (HLA) genetics and idiopathic pulmonary fibrosis
P191 Exploring the association between human leukocyte antigen (HLA) genetics and idiopathic pulmonary fibrosis Open
Introduction and Objective Idiopathic pulmonary fibrosis (IPF) is a chronic interstitial lung disease characterised by progressive lung fibrosis. Recent studies support the role of infection in IPF development. The Human Leukocyte Antigen …
View article: Elevated PLAUR is observed in the airway epithelium of asthma patients and blocking improves barrier integrity
Elevated PLAUR is observed in the airway epithelium of asthma patients and blocking improves barrier integrity Open
Background Expression of the urokinase plasminogen activator receptor (uPAR) is elevated in the airway epithelium in asthma; however, the contribution of uPAR to asthma pathogenesis and scope for therapeutic targeting remains unknown. Obje…
View article: Association study of human leukocyte antigen (HLA) variants and idiopathic pulmonary fibrosis
Association study of human leukocyte antigen (HLA) variants and idiopathic pulmonary fibrosis Open
Introduction Idiopathic pulmonary fibrosis (IPF) is a chronic interstitial pneumonia marked by progressive lung fibrosis and a poor prognosis. Recent studies have highlighted the potential role of infection in the pathogenesis of IPF and a…
View article: Genome-wide association study of chronic sputum production implicates loci involved in mucus production and infection
Genome-wide association study of chronic sputum production implicates loci involved in mucus production and infection Open
Background Chronic sputum production impacts on quality of life and is a feature of many respiratory diseases. Identification of the genetic variants associated with chronic sputum production in a disease agnostic sample could improve unde…
View article: Mepolizumab induced changes in nasal methylome and transcriptome to predict response in asthma
Mepolizumab induced changes in nasal methylome and transcriptome to predict response in asthma Open
Rationale Mepolizumab is effective for a subset of severe asthma patients in reducing exacerbation frequency. Discovery of a predictive/early marker accurately identifying patients that will have a long-term beneficial clinical response wo…
View article: IL-33 induced gene expression in activated Th2 effector cells is dependent on IL-1RL1 haplotype and disease status
IL-33 induced gene expression in activated Th2 effector cells is dependent on IL-1RL1 haplotype and disease status Open
Background IL-33 can activate Th2 cells after binding to the IL-1RL1/IL-1RAcP receptor. However, it is unknown whether disease or genetic make-up regulate IL33 responsiveness of Th2 cells. Objective We investigated whether IL-1RL1 asthma r…
View article: Mendelian randomisation of eosinophils and other cell types in relation to lung function and disease
Mendelian randomisation of eosinophils and other cell types in relation to lung function and disease Open
Rationale Eosinophils are associated with airway inflammation in respiratory disease. Eosinophil production and survival is controlled partly by interleukin-5: anti-interleukin-5 agents reduce asthma and response correlates with baseline e…
View article: Genome-wide association study of chronic sputum production implicates loci involved in mucus production and infection
Genome-wide association study of chronic sputum production implicates loci involved in mucus production and infection Open
Background Chronic sputum production impacts on quality of life and is a feature of many respiratory diseases. Identification of the genetic variants associated with chronic sputum production in a disease agnostic sample could improve unde…
View article: Additional file 2 of Exome-wide analysis of copy number variation shows association of the human leukocyte antigen region with asthma in UK Biobank
Additional file 2 of Exome-wide analysis of copy number variation shows association of the human leukocyte antigen region with asthma in UK Biobank Open
Additional file 2. Tables S1–S6.
View article: Exome-wide analysis of copy number variation shows association of the human leukocyte antigen region with asthma in UK Biobank
Exome-wide analysis of copy number variation shows association of the human leukocyte antigen region with asthma in UK Biobank Open
Background The role of copy number variants (CNVs) in susceptibility to asthma is not well understood. This is, in part, due to the difficulty of accurately measuring CNVs in large enough sample sizes to detect associations. The recent ava…
View article: Human bronchial epithelial cells from patients with asthma have an altered gene expression profile
Human bronchial epithelial cells from patients with asthma have an altered gene expression profile Open
Gene changes observed in asthma bronchial epithelial cells are maintained following repeated culture, presenting with an exaggerated response to viral infection and immune responses as well as having differences in the rate of cell divisio…
View article: Functional genomics of GPR126 in airway smooth muscle and bronchial epithelial cells
Functional genomics of GPR126 in airway smooth muscle and bronchial epithelial cells Open
GPR126 is an adhesion G protein‐coupled receptor which lies on chromosome 6q24. Genetic variants in this region are reproducibly associated with lung function and COPD in genome wide association studies (GWAS). The aims of this study were …
View article: Purinergic Receptors in the Airways: Potential Therapeutic Targets for Asthma?
Purinergic Receptors in the Airways: Potential Therapeutic Targets for Asthma? Open
Extracellular ATP functions as a signaling messenger through its actions on purinergic receptors, and is known to be involved in numerous physiological and pathophysiological processes throughout the body, including in the lungs and airway…