Ian Setliff
YOU?
Author Swipe
View article: Isolation and characterization of IgG3 glycan-targeting antibodies with exceptional cross-reactivity for diverse viral families
Isolation and characterization of IgG3 glycan-targeting antibodies with exceptional cross-reactivity for diverse viral families Open
Broadly reactive antibodies that target sequence-diverse antigens are of interest for vaccine design and monoclonal antibody therapeutic development because they can protect against multiple strains of a virus and provide a barrier to evol…
View article: Digital wearable insole-based identification of knee arthropathies and gait signatures using machine learning
Digital wearable insole-based identification of knee arthropathies and gait signatures using machine learning Open
Gait is impaired in musculoskeletal conditions, such as knee arthropathy. Gait analysis is used in clinical practice to inform diagnosis and monitor disease progression or intervention response. However, clinical gait analysis relies on su…
View article: Differential modulation of allergic rhinitis nasal transcriptome by dupilumab and allergy immunotherapy
Differential modulation of allergic rhinitis nasal transcriptome by dupilumab and allergy immunotherapy Open
Background Nasal epithelial cells are important regulators of barrier function and immune signaling; however, in allergic rhinitis (AR) these functions can be disrupted by inflammatory mediators. We aimed to better discern AR disease mecha…
View article: Machine learning analysis of a digital insole versus clinical standard gait assessments for digital endpoint development
Machine learning analysis of a digital insole versus clinical standard gait assessments for digital endpoint development Open
Biomechanical gait analysis informs clinical practice and research by linking characteristics of gait with neurological or musculoskeletal injury or disease. However, there are limitations to analyses conducted at gait labs as they require…
View article: High-Throughput B Cell Epitope Determination by Next-Generation Sequencing
High-Throughput B Cell Epitope Determination by Next-Generation Sequencing Open
Development of novel technologies for the discovery of human monoclonal antibodies has proven invaluable in the fight against infectious diseases. Among the diverse antibody repertoires elicited by infection or vaccination, often only rare…
View article: Viral population genomics reveals host and infectivity impact on SARS-CoV-2 adaptive landscape
Viral population genomics reveals host and infectivity impact on SARS-CoV-2 adaptive landscape Open
Public health surveillance, drug treatment development, and optimization of immunological interventions all depend on understanding pathogen adaptation, which differ for specific pathogens. SARS-CoV-2 is an exceptionally successful human p…
View article: Sequence and functional characterization of a public HIV-specific antibody clonotype
Sequence and functional characterization of a public HIV-specific antibody clonotype Open
Public antibody clonotypes shared among multiple individuals have been identified for several pathogens. However, little is known about the determinants of antibody "publicness". Here, we characterize the sequence and functional properties…
View article: Sequence and functional characterization of a public HIV-specific antibody clonotype
Sequence and functional characterization of a public HIV-specific antibody clonotype Open
Summary Public antibody clonotypes shared among multiple individuals have been identified for several pathogens. However, little is known about the limits of what constitutes a public clonotype. Here, we characterize the sequence and funct…
View article: Human antibodies neutralize enterovirus D68 and protect against infection and paralytic disease
Human antibodies neutralize enterovirus D68 and protect against infection and paralytic disease Open
A human monoclonal antibody shows potential to prevent or treat acute flaccid myelitis associated with enterovirus D68 infection.
View article: Spontaneous Glycan Reattachment Following N-Glycanase Treatment of Influenza and HIV Vaccine Antigens
Spontaneous Glycan Reattachment Following N-Glycanase Treatment of Influenza and HIV Vaccine Antigens Open
In cells asparagine/N-linked glycans are added to glycoproteins co-translationally, in an attachment process that supports proper folding of the nascent polypeptide. We find that following pruning of N-glycan by the amidase PNGase F, the p…
View article: Prediction of VRC01 neutralization sensitivity by HIV-1 gp160 sequence features
Prediction of VRC01 neutralization sensitivity by HIV-1 gp160 sequence features Open
The broadly neutralizing antibody (bnAb) VRC01 is being evaluated for its efficacy to prevent HIV-1 infection in the Antibody Mediated Prevention (AMP) trials. A secondary objective of AMP utilizes sieve analysis to investigate how VRC01 p…
View article: NFPws: a web server for delineating broadly neutralizing antibody specificities from serum HIV-1 neutralization data
NFPws: a web server for delineating broadly neutralizing antibody specificities from serum HIV-1 neutralization data Open
Motivation A better understanding of antibody responses to HIV-1 infection in humans can provide novel insights for the development of an effective HIV-1 vaccine. Neutralization fingerprinting (NFP) is an efficient and accurate algorithm f…
View article: Adipose Tissue is Enriched for Activated and Late-Differentiated CD8+ T Cells and Shows Distinct CD8+ Receptor Usage, Compared With Blood in HIV-Infected Persons
Adipose Tissue is Enriched for Activated and Late-Differentiated CD8+ T Cells and Shows Distinct CD8+ Receptor Usage, Compared With Blood in HIV-Infected Persons Open
Background: Adverse viral and medication effects on adipose tissue contribute to the development of metabolic disease in HIV-infected persons, but T cells also have a central role modulating local inflammation and adipocyte function. We so…