Ian Cheong
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View article: <i>BRCA1</i> is a molecular correlate of cell proliferation in human brain development and in Group 3 and 4 medulloblastoma
<i>BRCA1</i> is a molecular correlate of cell proliferation in human brain development and in Group 3 and 4 medulloblastoma Open
The role of the BRCA1-mediated DNA damage repair pathway in regulating human brain development remains unknown, although it has been studied in mouse development. We report evidence for breast cancer type 1 susceptibility protein (BRCA1) b…
View article: Meningeal Dissemination and Drop Metastasis From Glioma Presenting With Non-Epileptic Myoclonus and Minipolymyoclonus
Meningeal Dissemination and Drop Metastasis From Glioma Presenting With Non-Epileptic Myoclonus and Minipolymyoclonus Open
We describe the case of a 36-year-old woman with a past medical history of low grade right frontal lobe glioma and focal epilepsy presenting with subacute, progressive, multifocal myoclonus and neck and back pain. Unlike her typical seizur…
View article: Clinical relevance of urinary 8‑hydroxydeoxyguanosine levels in patients undergoing prostate biopsy
Clinical relevance of urinary 8‑hydroxydeoxyguanosine levels in patients undergoing prostate biopsy Open
Urinary 8-hydroxydeoxyguanosine (8-OHdG) level is an oxidative stress marker in patients with cancer; however, little is currently known about the clinical relevance of urinary 8-OHdG levels in patients with prostate cancer at diagnosis. V…
View article: Clinical performance of a prefabricated immunofluorescence assay for nasopharyngeal cancer screening
Clinical performance of a prefabricated immunofluorescence assay for nasopharyngeal cancer screening Open
Background Epstein–Barr virus (EBV) IgA serology for viral capsid antigen (VCA) and early antigen (EA) aids early detection of nasopharyngeal cancer (NPC), resulting in improved survival. We evaluated the diagnostic performance of a prefab…
View article: Detection of several respiratory viruses with Surface-Enhanced Raman Spectroscopy coupled with Artificial Intelligence
Detection of several respiratory viruses with Surface-Enhanced Raman Spectroscopy coupled with Artificial Intelligence Open
Diagnoses of viral infections are a challenge when facing a crisis like COVID-19, where their speed and reliability are critical to minimize diseases spread. The gold standard of diagnostics, quantitative Polymerase Chain Reaction, is time…
View article: Rigorous software pipeline for clinical somatic mutation analyses of solid tumors
Rigorous software pipeline for clinical somatic mutation analyses of solid tumors Open
Mutational analyses of tumor DNA guide the use of targeted therapies and checkpoint inhibitors in management of solid tumors. Reducing false positive mutation calls without compromising sensitivity as gene panels increase in size, and whol…
View article: A design of experiments screen reveals that Clostridium novyi-NT spore germinant sensing is stereoflexible for valine and its analogs
A design of experiments screen reveals that Clostridium novyi-NT spore germinant sensing is stereoflexible for valine and its analogs Open
Although Clostridium novyi- NT is an anti-cancer bacterial therapeutic which germinates within hypoxic tumors to kill cancer cells, the actual germination triggers for C. novyi -NT are still unknown. In this study, we screen candidate germ…
View article: Secondary causes of elevated hemoglobin in patients undergoing molecular testing for suspected polycythemia vera in southwestern Ontario: a chart review
Secondary causes of elevated hemoglobin in patients undergoing molecular testing for suspected polycythemia vera in southwestern Ontario: a chart review Open
Use of SGLT2 inhibitors may be a common and underrecognized secondary cause of elevated hemoglobin levels in patients investigated for erythrocytosis. Our findings underscore the importance of a detailed medical history to support judiciou…
View article: Mutational Landscape of Patients Referred for Elevated Hemoglobin Level
Mutational Landscape of Patients Referred for Elevated Hemoglobin Level Open
Background: Since the identification of JAK2 V617F and exon 12 mutations as driver mutations in polycythemia vera (PV) in 2005, molecular testing of these mutations for patients with erythrocytosis has become a routine clinical practice. H…
View article: P1019: A PREDICTION RULE TO GUIDE JAK2 MUTATION TESTING IN PATIENTS WITH SUSPECTED POLYCYTHEMIA VERA: RESULTS FROM THE JAK2 PREDICTION COHORT (JAKPOT) STUDY
P1019: A PREDICTION RULE TO GUIDE JAK2 MUTATION TESTING IN PATIENTS WITH SUSPECTED POLYCYTHEMIA VERA: RESULTS FROM THE JAK2 PREDICTION COHORT (JAKPOT) STUDY Open
Background: The widespread availability of molecular testing for JAK2 mutations in patients referred for elevated hemoglobin has facilitated the diagnosis of polycythemia vera (PV) but also raises concerns of test overuse. A prediction rul…
View article: A colorimetric chemical tongue detects and distinguishes between multiple analytes
A colorimetric chemical tongue detects and distinguishes between multiple analytes Open
The very photoinitiators used to polymerize hydrogels can react with analytes to produce distinctive colorimetric profiles.
View article: Primary Human Derived Blood Outgrowth Endothelial Cells: An Appropriate In Vitro Model to Study Shiga Toxin Mediated Damage of Endothelial Cells
Primary Human Derived Blood Outgrowth Endothelial Cells: An Appropriate In Vitro Model to Study Shiga Toxin Mediated Damage of Endothelial Cells Open
Hemolytic uremic syndrome (HUS) is a rare disease primarily characterized by hemolytic anemia, thrombocytopenia, and acute renal failure. Endothelial damage is the hallmark of the pathogenesis of HUS with an infection with the Shiga toxin …
View article: The degradation-promoting roles of deubiquitinases Ubp6 and Ubp3 in cytosolic and ER protein quality control
The degradation-promoting roles of deubiquitinases Ubp6 and Ubp3 in cytosolic and ER protein quality control Open
The quality control of intracellular proteins is achieved by degrading misfolded proteins which cannot be refolded by molecular chaperones. In eukaryotes, such degradation is handled primarily by the ubiquitin-proteasome system. However, i…
View article: Exploiting loss of heterozygosity for allele-selective colorectal cancer chemotherapy
Exploiting loss of heterozygosity for allele-selective colorectal cancer chemotherapy Open
Cancer chemotherapy targeting frequent loss of heterozygosity events is an attractive concept, since tumor cells may lack enzymatic activities present in normal constitutional cells. To find exploitable targets, we map prevalent genetic po…
View article: The Degradation-promoting Roles of Deubiquitinases Ubp6 and Ubp3 in Cytosolic and ER Protein Quality Control
The Degradation-promoting Roles of Deubiquitinases Ubp6 and Ubp3 in Cytosolic and ER Protein Quality Control Open
The quality control of intracellular proteins is achieved by degrading misfolded proteins which cannot be refolded by molecular chaperones. In eukaryotes, such degradation is handled primarily by the ubiquitin-proteasome system. However, i…