Ian Simms
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View article: Epidemiologic and Genomic Investigation of Sexually Transmitted <i>Shigella sonnei</i>, England
Epidemiologic and Genomic Investigation of Sexually Transmitted <i>Shigella sonnei</i>, England Open
Shigellosis is a bacterial infection that causes enteric illness and can be sexually transmitted, particularly among gay, bisexual, and other men who have sex with men. Multiple extensively drug-resistant Shigella strains have been detecte…
View article: Adapting the Flexible Farrington Algorithm for daily situational awareness and alert system to support public health decision-making during the SARS-CoV-2 epidemic in England
Adapting the Flexible Farrington Algorithm for daily situational awareness and alert system to support public health decision-making during the SARS-CoV-2 epidemic in England Open
The Flexible Farrington Algorithm (FFA) is widely used to detect infectious disease outbreaks at national/regional levels on a weekly basis. The rapid spread of SARS-CoV-2 alongside the speed at which diagnostic and public health intervent…
View article: Outbreak of sexually transmitted<i>S. sonnei bla</i><sub>CTX-M-15</sub>in England: an epidemiological and genomic investigation
Outbreak of sexually transmitted<i>S. sonnei bla</i><sub>CTX-M-15</sub>in England: an epidemiological and genomic investigation Open
The diarrhoeal disease, shigellosis, can be sustained as a sexually transmissible enteric illness among gay, bisexual, and other men who have sex with men (GBMSM). Multiple extensively drug-resistant strains of Shigella have been detected …
View article: Trends in shigellosis notifications in England, January 2016 to March 2023
Trends in shigellosis notifications in England, January 2016 to March 2023 Open
We reviewed all diagnoses of Shigella species notified to the UK Health Security Agency from January 2016 to March 2023. An overall increase in notifications of shigellosis was seen between 2016 ( n = 415/quarter) and 2023 ( n = 1 029/quar…
View article: Accessible health care is critical to the effective control of sexually transmitted infections
Accessible health care is critical to the effective control of sexually transmitted infections Open
Bacterial sexually transmitted infections (STIs) are rising relentlessly in virtually every country and among most risk groups. These infections have substantial individual and community consequences and costs. This review summarises the e…
View article: Meet the Editors
Meet the Editors Open
Who you are and what you do?I'm the head of Young People's Health Research at the
View article: Investigating the decline in Lymphogranuloma venereum diagnoses in men who have sex with men in the United Kingdom since 2016: an analysis of surveillance data
Investigating the decline in Lymphogranuloma venereum diagnoses in men who have sex with men in the United Kingdom since 2016: an analysis of surveillance data Open
Background Following an upward trajectory in Lymphogranuloma venereum (LGV) diagnoses in the UK from 2004 to 2016, with annual diagnoses increasing from 28 to 904, diagnoses fell to 641 in 2017; this was inconsistent with the upward trend …
View article: Prevalence of new variants of Chlamydia trachomatis escaping detection by the Aptima Combo 2 assay, England, June to August 2019
Prevalence of new variants of Chlamydia trachomatis escaping detection by the Aptima Combo 2 assay, England, June to August 2019 Open
We identified two new Chlamydia trachomatis (CT) variants escaping Aptima Combo 2 (AC2) assay detection, in clinical specimens of two patients. One had a C1514T mutation the other a G1523A mutation, both within the AC2 23S rRNA target regi…
View article: Use of gender distribution in routine surveillance data to detect potential transmission of gastrointestinal infections among men who have sex with men in England
Use of gender distribution in routine surveillance data to detect potential transmission of gastrointestinal infections among men who have sex with men in England Open
Detecting gastrointestinal (GI) infection transmission among men who have sex with men (MSM) in England is complicated by a lack of routine sexual behavioural data. We investigated whether gender distributions might generate signals for in…
View article: Spatial clusters of gonorrhoea in England with particular reference to the outcome of partner notification: 2012 and 2013
Spatial clusters of gonorrhoea in England with particular reference to the outcome of partner notification: 2012 and 2013 Open
The English gonorrhoea epidemic is characterised by spatial-temporal variation. PN success varied between endemic areas and clusters. Greater emphasis should be placed on the role of PN in the control of gonorrhoea to reduce the risk of on…
View article: Factors associated with four atypical cases of congenital syphilis in England, 2016 to 2017: an ecological analysis
Factors associated with four atypical cases of congenital syphilis in England, 2016 to 2017: an ecological analysis Open
Four isolated cases of congenital syphilis born to mothers who screened syphilis negative in the first trimester were identified between March 2016 and January 2017 compared with three cases between 2010 and 2015. The mothers were United K…
View article: P3.153 Spatial and temporal associations between congenital syphilis cases and epidemiological characteristics of infectious syphilis in england
P3.153 Spatial and temporal associations between congenital syphilis cases and epidemiological characteristics of infectious syphilis in england Open
Introduction There has been a rapid rise in infectious syphilis (IS) diagnoses in England since 2011 but congenital syphilis (CS) is rare. In 2016, 3 CS cases were diagnosed in geographically dispersed areas of England. Unusually, their mo…
View article: O35 Spatial and temporal associations between sexually transmitted and recent congenital syphilis cases in england
O35 Spatial and temporal associations between sexually transmitted and recent congenital syphilis cases in england Open
Introduction Four infants with congenital syphilis (CS) born to UK-born mothers who screened syphilis negative at first trimester antenatal screen were identified in England between March2016–January2017. Simulation modelling using histori…
View article: O07 National response to an outbreak of hepatitis a associated with men who have sex with men in england, 2016/2017
O07 National response to an outbreak of hepatitis a associated with men who have sex with men in england, 2016/2017 Open
Introduction Hepatitis A virus (HAV) is a vaccine-preventable infection, mainly travel-associated in the UK. Since July 2016 Public Health England has detected an increase in hepatitis A laboratory notifications in men who have sex with me…
View article: Outbreak of hepatitis A associated with men who have sex with men (MSM), England, July 2016 to January 2017
Outbreak of hepatitis A associated with men who have sex with men (MSM), England, July 2016 to January 2017 Open
Between July 2016 and January 2017, 37 confirmed cases of hepatitis A with two unique IA genotype strains primarily among men who have sex with men, were reported across eight areas in England and Northern Ireland. Epidemiological and labo…
View article: Pelvic inflammatory disease and salpingitis: incidence of primary and repeat episodes in England
Pelvic inflammatory disease and salpingitis: incidence of primary and repeat episodes in England Open
SUMMARY Pelvic inflammatory disease (PID) and more specifically salpingitis (visually confirmed inflammation) is the primary cause of tubal factor infertility and is an important risk factor for ectopic pregnancy. The risk of these outcome…
View article: Proportion of Pelvic Inflammatory Disease Cases Caused by<i>Chlamydia trachomatis</i>: Consistent Picture From Different Methods
Proportion of Pelvic Inflammatory Disease Cases Caused by<i>Chlamydia trachomatis</i>: Consistent Picture From Different Methods Open
The PEFs of PID due to C. trachomatis decline steeply with age by a factor of around 5-fold between younger and older women. Further studies of the etiology of PID in different age groups are required.
View article: P219 Responding to the LGV epidemic: are the right patients being tested for LGV?: Abstract Table 1
P219 Responding to the LGV epidemic: are the right patients being tested for LGV?: Abstract Table 1 Open
Background UK national guidelines will recommend that samples from all Chlamydia trachomatis (CT)-positive men who have sex with men (MSM) with proctitis and all asymptomatic CT-positive MSM with HIV should be tested for Lymphogranuloma ve…
View article: P200 Early detection of sexually transmitted infections - were there missed opportunities? A qualitative study in the UK
P200 Early detection of sexually transmitted infections - were there missed opportunities? A qualitative study in the UK Open
Background/introduction The early recognition and investigation of outbreaks of sexually transmitted infections (STIs) is vital for preventing onward transmission. Aim(s)/objectives We sought to understand the facilitators and barriers to …
View article: P205 Management of STI outbreaks. What can we learn from each other? A qualitative study in the UK
P205 Management of STI outbreaks. What can we learn from each other? A qualitative study in the UK Open
Background/introduction When outbreaks of sexually transmitted infections (STIs) are identified, effective management in a timely manner is essential for bringing the outbreak under control. Challenges to achieving this may vary, needing d…
View article: The incidence of congenital syphilis in the United Kingdom: February 2010 to January 2015
The incidence of congenital syphilis in the United Kingdom: February 2010 to January 2015 Open
Objective To estimate the incidence of congenital syphilis in the UK . Design Prospective study. Setting and population United Kingdom. Methods Children born between February 2010 and January 2015 with a suspected diagnosis of congenital s…
View article: The natural history of Chlamydia trachomatis infection in women: a multi-parameter evidence synthesis
The natural history of Chlamydia trachomatis infection in women: a multi-parameter evidence synthesis Open
Background and objectives The evidence base supporting the National Chlamydia Screening Programme, initiated in 2003, has been questioned repeatedly, with little consensus on modelling assumptions, parameter values or evidence sources to b…
View article: Rapid increase in lymphogranuloma venereum in men who have sex with men, United Kingdom, 2003 to September 2015
Rapid increase in lymphogranuloma venereum in men who have sex with men, United Kingdom, 2003 to September 2015 Open
United Kingdom (UK) national data show a sharp increase in diagnoses of lymphogranuloma venereum (LGV) since 2012. Most cases are in men who have sex with men (MSM) living in London, with high rates of co-infection with HIV and other sexua…
View article: P08.24 Alternative evidence sources present a consistent picture of the population excess fraction (pef) of pelvic inflammatory disease caused by<i>chlamydia trachomatis</i>infection in england
P08.24 Alternative evidence sources present a consistent picture of the population excess fraction (pef) of pelvic inflammatory disease caused by<i>chlamydia trachomatis</i>infection in england Open
Introduction Pelvic Inflammatory Disease (PID) is a leading cause of both Tubal Factor Infertility (TFI) and Ectopic pregnancy. Chlamydia trachomatis (CT) is an important risk factor for the development of PID but it is also caused by othe…
View article: P11.17 Intensification of a shigellosis epidemic associated with sexual transmission between men: diagnoses of<i>shigella flexneri</i>and<i>s. sonnei</i>in england, 2004 to 2015
P11.17 Intensification of a shigellosis epidemic associated with sexual transmission between men: diagnoses of<i>shigella flexneri</i>and<i>s. sonnei</i>in england, 2004 to 2015 Open
Introduction Although Shigellosis is often associated with travel to high incidence regions, outbreaks of Shigella flexneri and S. sonnei associated with sexual transmission between men have been reported in the UK, Australia and elsewhere…