Ian A. Simpson
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View article: Triterpenoid wax esters confirm Ficus religiosa in archaeological sequences within the Mayadevi temple shrine, Lumbini – the birthplace of Buddha
Triterpenoid wax esters confirm Ficus religiosa in archaeological sequences within the Mayadevi temple shrine, Lumbini – the birthplace of Buddha Open
Leaf wax biomarkers permit chemotaxonomic identification of past vegetation in archaeological contexts. At the birthplace of Buddha, Lumbini in Nepal, archaeological evidence of a multi-phase tree shrine from the earliest beginnings of Bud…
View article: Drug-Induced Liver Injury Associated with Turmeric and Piperine: A Case and Review
Drug-Induced Liver Injury Associated with Turmeric and Piperine: A Case and Review Open
Introduction: Turmeric is a common spice used in traditional Chinese and Ayurvedic medicine for a variety of purported health benefits. Recent concerns have arisen regarding turmeric-induced liver injury linked to formulations with enhance…
View article: Extracellular vesicles from immortalised human amniotic epithelial cells reduce hepatic fibrosis in mice with Steatohepatitis and Hepatocellular Carcinoma
Extracellular vesicles from immortalised human amniotic epithelial cells reduce hepatic fibrosis in mice with Steatohepatitis and Hepatocellular Carcinoma Open
Background Metabolic dysfunction-associated steatotic liver disease (MASLD), metabolic dysfunction-associated steatohepatitis (MASH) and cirrhosis and hepatocellular carcinoma (HCC) describe progressive stages of liver disease that occurs …
View article: Gastric intestinal metaplasia: Prevalence in a large Australian center and nationwide survey of endoscopic practice
Gastric intestinal metaplasia: Prevalence in a large Australian center and nationwide survey of endoscopic practice Open
Background and Aim Atrophic gastritis (AG) and gastric intestinal metaplasia (GIM) are early changes in the stepwise progression to gastric adenocarcinoma. There is heterogeneity in international guidelines regarding the endoscopic diagnos…
View article: Brain iron acquisition depends on age and sex in iron‐deficient mice
Brain iron acquisition depends on age and sex in iron‐deficient mice Open
Adequate and timely delivery of iron is essential for brain development. The uptake of transferrin‐bound (Tf) iron into the brain peaks at the time of myelination, whereas the recently discovered H‐ferritin (FTH1) transport of iron into th…
View article: Amyloid‐β exposed astrocytes induce iron transport from endothelial cells at the blood–brain barrier by altering the ratio of apo‐ and holo‐transferrin
Amyloid‐β exposed astrocytes induce iron transport from endothelial cells at the blood–brain barrier by altering the ratio of apo‐ and holo‐transferrin Open
A bstract Excessive brain iron accumulation is observed early in the onset of Alzheimer's disease, notably prior to widespread proteinopathy. These findings suggest that increases in brain iron levels are due to a dysregulation of the iron…
View article: Apo- and holo-transferrin differentially interact with hephaestin and ferroportin in a novel mechanism of cellular iron release regulation
Apo- and holo-transferrin differentially interact with hephaestin and ferroportin in a novel mechanism of cellular iron release regulation Open
Background Apo- (iron free) and holo- (iron bound) transferrin (Tf) participate in precise regulation of brain iron uptake at endothelial cells of the blood–brain barrier. Apo-Tf indicates an iron-deficient environment and stimulates iron …
View article: Amyloid-β exposed astrocytes induce iron transport from endothelial cells at the blood-brain barrier by altering the ratio of apo- and holo-transferrin
Amyloid-β exposed astrocytes induce iron transport from endothelial cells at the blood-brain barrier by altering the ratio of apo- and holo-transferrin Open
Excessive brain iron accumulation is observed in early in the onset of Alzheimer’s disease, notably prior to widespread proteinopathy. These findings suggest that increases in brain iron levels are due to a dysregulation of the iron transp…
View article: Brain iron acquisition: An overview of homeostatic regulation and disease dysregulation
Brain iron acquisition: An overview of homeostatic regulation and disease dysregulation Open
Brain iron homeostasis is crucial for neurological health, with pathological fluctuations in brain iron levels associated with a variety of neurological disorders. Low levels are connected to cognitive impairment and restless legs syndrome…
View article: Apo- and holo- transferrin differentially interact with ferroportin and hephaestin to regulate iron release at the blood-brain barrier
Apo- and holo- transferrin differentially interact with ferroportin and hephaestin to regulate iron release at the blood-brain barrier Open
Background: Apo- (iron free) and holo- (iron bound) transferrin (Tf) participate in precise regulation of brain iron uptake at endothelial cells of the blood-brain barrier. Apo-Tf indicates an iron deficient environment and stimulates iron…
View article: Apo- and holo- transferrin differentially interact with ferroportin and hephaestin to regulate iron release at the blood-brain barrier
Apo- and holo- transferrin differentially interact with ferroportin and hephaestin to regulate iron release at the blood-brain barrier Open
A bstract Background Apo- (iron free) and holo- (iron bound) transferrin (Tf) participate in precise regulation of brain iron uptake at endothelial cells of the blood-brain barrier. Apo-Tf indicates an iron deficient environment and stimul…
View article: Exosomes are involved in iron transport from human blood–brain barrier endothelial cells and are modified by endothelial cell iron status
Exosomes are involved in iron transport from human blood–brain barrier endothelial cells and are modified by endothelial cell iron status Open
View article: Urban gardens in Antiquity
Urban gardens in Antiquity Open
Funding: the Carlsberg Foundation, the Danish National Research Foundation (grant 119), the Deutsche Forschungsgemeinschaft, the Deutscher Palästina-Verein, the Danish EliteForsk Award and H. P. Hjerl Hansens mindefondet for Dansk Palæstin…
View article: The effect of chronic exposure to metformin in a new type-2 diabetic NONcNZO10/LtJ mouse model of stroke
The effect of chronic exposure to metformin in a new type-2 diabetic NONcNZO10/LtJ mouse model of stroke Open
View article: Regulation of brain iron uptake by apo- and holo-transferrin is dependent on sex and delivery protein
Regulation of brain iron uptake by apo- and holo-transferrin is dependent on sex and delivery protein Open
View article: Regulation of brain iron uptake by apo- and holo-transferrin is dependent on sex and delivery protein
Regulation of brain iron uptake by apo- and holo-transferrin is dependent on sex and delivery protein Open
Background : The brain requires iron for a number of processes, including energy production. Inadequate or excessive amounts of iron can be detrimental and lead to a number of neurological disorders. As such, regulation of brain iron uptak…
View article: Success and Failure in the Norse North Atlantic: Origins, Pathway Divergence, Extinction and Survival
Success and Failure in the Norse North Atlantic: Origins, Pathway Divergence, Extinction and Survival Open
In this chapter, we examine the iconic disappearance of the Medieval Norse Greenlanders and use qualitative scenarios and counterfactual analysis to produce lessons for policymakers. We stress the role that archaeologists and historians ha…
View article: Urbanization and Riverine Hinterlands: A Proposal for an Integrative High-Definition and Multi-Scalar Approach to Understanding Ancient Cities and their Dynamic Natural Resources
Urbanization and Riverine Hinterlands: A Proposal for an Integrative High-Definition and Multi-Scalar Approach to Understanding Ancient Cities and their Dynamic Natural Resources Open
Rivers have always been a magnet for human settlement, providing resources, such as water, food, and energy, and communication and travel routes. Climate- and human-made changes to the environment can easily affect the fragile balance betw…
View article: A Roman provincial city and its contamination legacy from artisanal and daily-life activities
A Roman provincial city and its contamination legacy from artisanal and daily-life activities Open
Roman metal use and related extraction activities resulted in heavy metal pollution and contamination, in particular of Pb near ancient mines and harbors, as well as producing a global atmospheric impact. New evidence from ancient Gerasa (…
View article: Earliest known human burial in Africa
Earliest known human burial in Africa Open
View article: Scaling up and zooming in: global history and high-definition archaeology perspectives on the longue durée of urban–environmental relations in Gerasa (Jerash, Jordan)
Scaling up and zooming in: global history and high-definition archaeology perspectives on the longue durée of urban–environmental relations in Gerasa (Jerash, Jordan) Open
Combining global perspectives with localized case studies and integrating scientific and material evidence of environmental change in historical narratives are amongst the main challenges for the field of global history in addressing the d…
View article: Evidence for communication of peripheral iron status to cerebrospinal fluid: clinical implications for therapeutic strategy
Evidence for communication of peripheral iron status to cerebrospinal fluid: clinical implications for therapeutic strategy Open
View article: Identifying archaeological evidence of past earthquakes in a contemporary disaster scenario: case studies of damage, resilience and risk reduction from the 2015 Gorkha Earthquake and past seismic events within the Kathmandu Valley UNESCO World Heritage Property (Nepal)
Identifying archaeological evidence of past earthquakes in a contemporary disaster scenario: case studies of damage, resilience and risk reduction from the 2015 Gorkha Earthquake and past seismic events within the Kathmandu Valley UNESCO World Heritage Property (Nepal) Open
The 2015 Gorkha Earthquake was a humanitarian disaster but also a cultural catastrophe that damaged and destroyed historic monuments across Nepal, including those within the Kathmandu Valley UNESCO World Heritage Property. In the rush to r…
View article: Induce Stroke via Hypoxia-Ischemia v2
Induce Stroke via Hypoxia-Ischemia v2 Open
Summary: This document describes the procedure for inducing a stroke in diabetic RCS10 mice, their non-diabetic controls and NON/ShiLtJ control mice. Our initial objective was to use those RCS10 mice that did not become diabetic as the con…
View article: Microliths in the South Asian rainforest ~45-4 ka: New insights from Fa-Hien Lena Cave, Sri Lanka
Microliths in the South Asian rainforest ~45-4 ka: New insights from Fa-Hien Lena Cave, Sri Lanka Open
Microliths-small, retouched, often-backed stone tools-are often interpreted to be the product of composite tools, including projectile weapons, and efficient hunting strategies by modern humans. In Europe and Africa these lithic toolkits a…
View article: Abstracts from the 22nd International Symposium on Signal Transduction at the Blood–Brain Barriers
Abstracts from the 22nd International Symposium on Signal Transduction at the Blood–Brain Barriers Open
Discoveries leading to an improved understanding of immune surveillance of the central nervous system (CNS) have repeatedly provoked dismissal of the existence of immune privilege of the CNS.Recent rediscoveries of lymphatic vessels within…
View article: Archaeological assessment reveals Earth’s early transformation through land use
Archaeological assessment reveals Earth’s early transformation through land use Open
A synthetic history of human land use Humans began to leave lasting impacts on Earth's surface starting 10,000 to 8000 years ago. Through a synthetic collaboration with archaeologists around the globe, Stephens et al. compiled a comprehens…
View article: Transferrin and H‐ferritin involvement in brain iron acquisition during postnatal development: impact of sex and genotype
Transferrin and H‐ferritin involvement in brain iron acquisition during postnatal development: impact of sex and genotype Open
Iron delivery to the developing brain is essential for energy and metabolic support needed for processes such as myelination and neuronal development. Iron deficiency, especially in the developing brain, can result in a number of long‐term…
View article: Urban-Riverine Hinterland Synergies in Semi-Arid Environments: Millennial-Scale Change, Adaptations, and Environmental Responses at Gerasa/Jerash
Urban-Riverine Hinterland Synergies in Semi-Arid Environments: Millennial-Scale Change, Adaptations, and Environmental Responses at Gerasa/Jerash Open
This interdisciplinary study addresses issues of urban-riverine hinterland relationships in semi-arid environments over millennia at Gerasa/Jerash in Jordan, presenting research that stimulates new lines of enquiry with much broader implic…
View article: Induce Stroke via Hypoxia-Ischemia v1
Induce Stroke via Hypoxia-Ischemia v1 Open
Summary: This document describes the procedure for inducing a stroke in diabetic RCS10 mice, their non-diabetic controls and NON/ShiLtJ control mice. Our initial objective was to use those RCS10 mice that did not become diabetic as the con…