Ian Sorrell
YOU?
Author Swipe
View article: Mechanistic Physiologically Based Pharmacokinetic Modeling of Dry Powder and Nebulized Formulations of Orally Inhaled <scp>TMEM16A</scp> Potentiator <scp>GDC</scp>‐6988
Mechanistic Physiologically Based Pharmacokinetic Modeling of Dry Powder and Nebulized Formulations of Orally Inhaled <span>TMEM16A</span> Potentiator <span>GDC</span>‐6988 Open
The orally inhaled route of administration for respiratory indications can maximize drug exposure to the site of action (lung) to increase efficacy while minimizing systemic exposure to achieve an improved safety profile. However, due to t…
View article: PBK modelling of topical application and characterisation of the uncertainty of Cmax estimate: A case study approach
PBK modelling of topical application and characterisation of the uncertainty of Cmax estimate: A case study approach Open
Combined with in vitro bioactivity data, physiologically based kinetic (PBK) models has increasing applications in next generation risk assessment for animal-free safety decision making. A tiered framework of building PBK models for such a…
View article: Predictive performance of next generation human physiologically based kinetic (PBK) model predictions based on in vitro and in silico input data
Predictive performance of next generation human physiologically based kinetic (PBK) model predictions based on in vitro and in silico input data Open
The goal of the present study was to assess the predictive performance of a generic human physiologically based kinetic (PBK) model based on in vitro and in silico input data and the effect of using different input approaches for chemical …
View article: Cosmetics Europe evaluation of 6 in silico skin penetration models
Cosmetics Europe evaluation of 6 in silico skin penetration models Open
The ADME TF aims to develop in silico skin penetration models using in vitro human skin penetration data for 25 chemicals solubilized in wataer. Since there are widely differing opinions on different in silico models, we evaluated 3 open s…
View article: Metabolism and plasma protein binding of 16 straight- and branched-chain parabens in in vitro liver and skin models
Metabolism and plasma protein binding of 16 straight- and branched-chain parabens in in vitro liver and skin models Open
Parabens are alkyl esters of 4-hydroxybenzoic acid (4-HBA), with short-chain parabens used as antimicrobials in cosmetics. We investigated the impact of chain structure on skin and liver metabolism. Incubations with primary human hepatocyt…
View article: Measurement of the penetration of 56 cosmetic relevant chemicals into and through human skin using a standardized protocol
Measurement of the penetration of 56 cosmetic relevant chemicals into and through human skin using a standardized protocol Open
OECD test guideline 428 compliant protocol using human skin was used to test the penetration of 56 cosmetic‐relevant chemicals. The penetration of finite doses (10 μL/cm 2 ) of chemicals was measured over 24 hours. The dermal delivery (DD)…
View article: Application of physiologically based kinetic (PBK) modelling in the next generation risk assessment of dermally applied consumer products
Application of physiologically based kinetic (PBK) modelling in the next generation risk assessment of dermally applied consumer products Open
Next Generation Risk Assessment (NGRA) is a procedure that integrates new approach methodologies (NAMs) to assure safety of a product without generating data from animal testing. One of the major challenges in the application of NGRA to co…
View article: Mathematical modelling of a liver hollow fibre bioreactor
Mathematical modelling of a liver hollow fibre bioreactor Open
View article: Development of a Two-Dimensional Model for Predicting Transdermal Permeation with the Follicular Pathway: Demonstration with a Caffeine Study
Development of a Two-Dimensional Model for Predicting Transdermal Permeation with the Follicular Pathway: Demonstration with a Caffeine Study Open
The follicular pathway contributes to not only short time fast penetration, but also the overall systemic bioavailability. With such in silico model, useful information can be obtained for caffeine disposition and localised delivery in lip…
View article: Hollow Fiber Bioreactors for <em>In Vivo</em>-like Mammalian Tissue Culture
Hollow Fiber Bioreactors for <em>In Vivo</em>-like Mammalian Tissue Culture Open
Tissue culture has been used for over 100 years to study cells and responses ex vivo. The convention of this technique is the growth of anchorage dependent cells on the 2-dimensional surface of tissue culture plastic. More recently, there …
View article: Hollow Fiber Bioreactors for <em>In Vivo</em>-like Mammalian Tissue Culture
Hollow Fiber Bioreactors for <em>In Vivo</em>-like Mammalian Tissue Culture Open
Tissue culture has been used for over 100 years to study cells and responses ex vivo. The convention of this technique is the growth of anchorage dependent cells on the 2-dimensional surface of tissue culture plastic. More recently, there …