Ian Streeter
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View article: Multiple genomic solutions for local adaptation in two closely related species (sheep and goats) facing the same climatic constraints
Multiple genomic solutions for local adaptation in two closely related species (sheep and goats) facing the same climatic constraints Open
The question of how local adaptation takes place remains a fundamental question in evolutionary biology. The variation of allele frequencies in genes under selection over environmental gradients remains mainly theoretical and its empirical…
View article: Multiple adaptive solutions to face climatic constraints: novel insights in the debate over the role of convergence in local adaptation
Multiple adaptive solutions to face climatic constraints: novel insights in the debate over the role of convergence in local adaptation Open
The extent to which genomic convergence shapes locally adapted phenotypes in different species remains a fundamental question in evolutionary biology. To bring new insights to this debate we set up a framework which aimed to compare the ad…
View article: Population-scale proteome variation in human induced pluripotent stem cells
Population-scale proteome variation in human induced pluripotent stem cells Open
Human disease phenotypes are driven primarily by alterations in protein expression and/or function. To date, relatively little is known about the variability of the human proteome in populations and how this relates to variability in mRNA …
View article: Author response: Population-scale proteome variation in human induced pluripotent stem cells
Author response: Population-scale proteome variation in human induced pluripotent stem cells Open
Article Figures and data Abstract Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract Human disease phenotypes are driven primar…
View article: Publisher Correction: Single-cell RNA-sequencing of differentiating iPS cells reveals dynamic genetic effects on gene expression
Publisher Correction: Single-cell RNA-sequencing of differentiating iPS cells reveals dynamic genetic effects on gene expression Open
View article: Single-cell RNA-sequencing of differentiating iPS cells reveals dynamic genetic effects on gene expression
Single-cell RNA-sequencing of differentiating iPS cells reveals dynamic genetic effects on gene expression Open
View article: An evaluation of sequencing coverage and genotyping strategies to assess neutral and adaptive diversity
An evaluation of sequencing coverage and genotyping strategies to assess neutral and adaptive diversity Open
Whole genome sequences (WGS) greatly increase our ability to precisely infer population genetic parameters, demographic processes, and selection signatures. However, WGS may still be not affordable for a representative number of individual…
View article: Chromosome assembly of large and complex genomes using multiple references
Chromosome assembly of large and complex genomes using multiple references Open
Despite the rapid development of sequencing technologies, the assembly of mammalian-scale genomes into complete chromosomes remains one of the most challenging problems in bioinformatics. To help address this difficulty, we developed Ragou…
View article: Repeat associated mechanisms of genome evolution and function revealed by the <i>Mus caroli</i> and <i>Mus pahari</i> genomes
Repeat associated mechanisms of genome evolution and function revealed by the <i>Mus caroli</i> and <i>Mus pahari</i> genomes Open
Understanding the mechanisms driving lineage-specific evolution in both primates and rodents has been hindered by the lack of sister clades with a similar phylogenetic structure having high-quality genome assemblies. Here, we have created …
View article: Convergent genomic signatures of domestication in sheep and goats
Convergent genomic signatures of domestication in sheep and goats Open
View article: A Standard Nomenclature for Referencing and Authentication of Pluripotent Stem Cells
A Standard Nomenclature for Referencing and Authentication of Pluripotent Stem Cells Open
View article: Repeat associated mechanisms of genome evolution and function revealed by the<i>Mus caroli</i>and<i>Mus pahari</i>genomes
Repeat associated mechanisms of genome evolution and function revealed by the<i>Mus caroli</i>and<i>Mus pahari</i>genomes Open
Understanding the mechanisms driving lineage-specific evolution in both primates and rodents has been hindered by the lack of sister clades with a similar phylogenetic structure having high-quality genome assemblies. Here, we have created …
View article: Erratum: Corrigendum: Common genetic variation drives molecular heterogeneity in human iPSCs
Erratum: Corrigendum: Common genetic variation drives molecular heterogeneity in human iPSCs Open
View article: Alignment of 1000 Genomes Project reads to reference assembly GRCh38
Alignment of 1000 Genomes Project reads to reference assembly GRCh38 Open
The 1000 Genomes Project produced more than 100 trillion basepairs of short read sequence from more than 2600 samples in 26 populations over a period of five years. In its final phase, the project released over 85 million genotyped and pha…
View article: Common genetic variation drives molecular heterogeneity in human iPSCs
Common genetic variation drives molecular heterogeneity in human iPSCs Open
View article: Rapid establishment of the European Bank for induced Pluripotent Stem Cells (EBiSC) - the Hot Start experience
Rapid establishment of the European Bank for induced Pluripotent Stem Cells (EBiSC) - the Hot Start experience Open
View article: Chromosome assembly of large and complex genomes using multiple references
Chromosome assembly of large and complex genomes using multiple references Open
Despite the rapid development of sequencing technologies, assembly of mammalian-scale genomes into complete chromosomes remains one of the most challenging problems in bioinformatics. To help address this difficulty, we developed Ragout, a…
View article: The human-induced pluripotent stem cell initiative—data resources for cellular genetics
The human-induced pluripotent stem cell initiative—data resources for cellular genetics Open
The Human Induced Pluripotent Stem Cell Initiative (HipSci) isf establishing a large catalogue of human iPSC lines, arguably the most well characterized collection to date. The HipSci portal enables researchers to choose the right cell lin…
View article: The international Genome sample resource (IGSR): A worldwide collection of genome variation incorporating the 1000 Genomes Project data
The international Genome sample resource (IGSR): A worldwide collection of genome variation incorporating the 1000 Genomes Project data Open
The International Genome Sample Resource (IGSR; http://www.internationalgenome.org) expands in data type and population diversity the resources from the 1000 Genomes Project. IGSR represents the largest open collection of human variation d…
View article: Common genetic variation drives molecular heterogeneity in human IPSCs
Common genetic variation drives molecular heterogeneity in human IPSCs Open
Induced pluripotent stem cell (iPSC) technology has enormous potential to provide improved cellular models of human disease. However, variable genetic and phenotypic characterisation of many existing iPSC lines limits their potential use f…
View article: A high-content platform to characterise human induced pluripotent stem cell lines
A high-content platform to characterise human induced pluripotent stem cell lines Open
View article: Prospects and challenges for the conservation of farm animal genomic resources, 2015-2025
Prospects and challenges for the conservation of farm animal genomic resources, 2015-2025 Open
Livestock conservation practice is changing rapidly in light of policy developments, climate change and diversifying market demands. The last decade has seen a step change in technology and analytical approaches available to define, manage…
View article: A global reference for human genetic variation
A global reference for human genetic variation Open
The 1000 Genomes Project set out to provide a comprehensive description of common human genetic variation by applying whole-genome sequencing to a diverse set of individuals from multiple populations. Here we report completion of the proje…
View article: A global reference for human genetic variation
A global reference for human genetic variation Open
View article: Characterizing neutral genomic diversity and selection signatures in indigenous populations of Moroccan goats (Capra hircus) using WGS data
Characterizing neutral genomic diversity and selection signatures in indigenous populations of Moroccan goats (Capra hircus) using WGS data Open
Since the time of their domestication, goats (Capra hircus) have evolved in a large variety of locally adapted populations in response to different human and environmental pressures. In the present era, many indigenous populations are thre…
View article: The effect of water on the binding of glycosaminoglycan saccharides to hydroxyapatite surfaces: a molecular dynamics study
The effect of water on the binding of glycosaminoglycan saccharides to hydroxyapatite surfaces: a molecular dynamics study Open
Molecular dynamics simulations are used to investigate the binding of chondroitin sulfate to hydroxyapatite surfaces in the presence of water to evaluate the effect of the solvent on the adsorption of glycosaminoglycan.