Ian T. Mathews
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View article: Distinct roles of Lysophosphatidylcholine in modulating neutrophil viability, inflammation and function 4040
Distinct roles of Lysophosphatidylcholine in modulating neutrophil viability, inflammation and function 4040 Open
Description Immune Checkpoint Blockade therapy advances solid tumor treatment, but a major challenge is immune-related adverse events (ICB-irAEs), which can lead to treatment discontinuation. Neutrophils, as key cellular mediators of syste…
View article: Sex differences in adenosine deaminase activity associate with disparities in SARS-CoV-2 innate immunity
Sex differences in adenosine deaminase activity associate with disparities in SARS-CoV-2 innate immunity Open
View article: Linoleoyl-lysophosphatidylcholine suppresses immune-related adverse events due to immune checkpoint blockade
Linoleoyl-lysophosphatidylcholine suppresses immune-related adverse events due to immune checkpoint blockade Open
Immune related adverse events (irAEs) after immune checkpoint blockade (ICB) therapy occur in a significant proportion of cancer patients. To date, the circulating mediators of ICB-irAEs remain poorly understood. Using non-targeted mass sp…
View article: The adult life span
The adult life span Open
Distance learning materials for the B.Sc(Hons) Social work programme as part of the 'Working with Adults' module. A discussion, with critical thinking exercises, that presents a biographical approach to the study of the adult life course.
View article: The complexities of failing (Social Work) students - a workshop for practice educators of Social Work students held at the University of Lincoln on Thursday 27th November 2014
The complexities of failing (Social Work) students - a workshop for practice educators of Social Work students held at the University of Lincoln on Thursday 27th November 2014 Open
This workshop for practice educators teaching social work students whilst on placement explored issues relating to failing students. Reasons why students might experience difficulties whilst on placement, early identification of problems, …
View article: 1416 Common metabolic adaptations empower CD8 T cell tissue residency and antitumor immunity
1416 Common metabolic adaptations empower CD8 T cell tissue residency and antitumor immunity Open
Background Lodged in tissues throughout the body, tissue-resident memory CD8 T cells (TRM) are key constituents of the memory T cell arsenal offering robust, long-term protection from reinfections. Effective anti-tumor immunity requires su…
View article: Metabolic programs of T cell tissue residency empower tumour immunity
Metabolic programs of T cell tissue residency empower tumour immunity Open
View article: ReIGNITE Radiation Therapy Boost: A Prospective, International Study of Radiation Oncologists’ Accuracy in Contouring Prostate Tumors for Focal Radiation Therapy Boost on Conventional Magnetic Resonance Imaging Alone or With Assistance of Restriction Spectrum Imaging
ReIGNITE Radiation Therapy Boost: A Prospective, International Study of Radiation Oncologists’ Accuracy in Contouring Prostate Tumors for Focal Radiation Therapy Boost on Conventional Magnetic Resonance Imaging Alone or With Assistance of Restriction Spectrum Imaging Open
View article: Bio-active lipids protect against immune-related adverse events due to immune checkpoint blockade therapy
Bio-active lipids protect against immune-related adverse events due to immune checkpoint blockade therapy Open
Introduction Immune checkpoint blockade (ICB) therapy has been revolutionary in its ability to treat advanced malignancies. Yet many patients receiving ICB develop Immune related adverse events (IRAEs), a leading cause for patients to disc…
View article: Supplementary Figure 6 from Mcl-1 Mediates TWEAK/Fn14-Induced Non–Small Cell Lung Cancer Survival and Therapeutic Response
Supplementary Figure 6 from Mcl-1 Mediates TWEAK/Fn14-Induced Non–Small Cell Lung Cancer Survival and Therapeutic Response Open
PDF file - 101K, EU-5148 inhibits Mcl-1-Bim protein interaction.
View article: Supplementary Figure 5 from SGEF Is Regulated via TWEAK/Fn14/NF-κB Signaling and Promotes Survival by Modulation of the DNA Repair Response to Temozolomide
Supplementary Figure 5 from SGEF Is Regulated via TWEAK/Fn14/NF-κB Signaling and Promotes Survival by Modulation of the DNA Repair Response to Temozolomide Open
Supplementary Figure 5. SGEF is required for BRCA1 recruitment to H2A.X foci following TMZ treatment.
View article: Supplementary Figure 5 from Mcl-1 Mediates TWEAK/Fn14-Induced Non–Small Cell Lung Cancer Survival and Therapeutic Response
Supplementary Figure 5 from Mcl-1 Mediates TWEAK/Fn14-Induced Non–Small Cell Lung Cancer Survival and Therapeutic Response Open
PDF file - 98K, Bcl-xL depletion sensitizes lung cancer cells to therapeutic insult but does not fully rescue TWEAK-induced cell survival.
View article: Supplementary Figure 6 from SGEF Is Regulated via TWEAK/Fn14/NF-κB Signaling and Promotes Survival by Modulation of the DNA Repair Response to Temozolomide
Supplementary Figure 6 from SGEF Is Regulated via TWEAK/Fn14/NF-κB Signaling and Promotes Survival by Modulation of the DNA Repair Response to Temozolomide Open
Supplementary Figure 6. SGEF protein levels across a panel of primary parental versus TMZ-R xenografts.
View article: Supplementary Figure 4 from Mcl-1 Mediates TWEAK/Fn14-Induced Non–Small Cell Lung Cancer Survival and Therapeutic Response
Supplementary Figure 4 from Mcl-1 Mediates TWEAK/Fn14-Induced Non–Small Cell Lung Cancer Survival and Therapeutic Response Open
PDF file - 35K, TWEAK exposure enhances Mcl-1 and Bcl-xL mRNA expression.
View article: Supplementary Methods and Figure Legends from Mcl-1 Mediates TWEAK/Fn14-Induced Non–Small Cell Lung Cancer Survival and Therapeutic Response
Supplementary Methods and Figure Legends from Mcl-1 Mediates TWEAK/Fn14-Induced Non–Small Cell Lung Cancer Survival and Therapeutic Response Open
PDF file - 113K
View article: Supplementary Figure 3 from SGEF Is Regulated via TWEAK/Fn14/NF-κB Signaling and Promotes Survival by Modulation of the DNA Repair Response to Temozolomide
Supplementary Figure 3 from SGEF Is Regulated via TWEAK/Fn14/NF-κB Signaling and Promotes Survival by Modulation of the DNA Repair Response to Temozolomide Open
Supplementary Figure 3. SGEF depletion in glioma cells display impaired DNA double strain break repair kinetics.
View article: Supplementary Figure 1 from SGEF Is Regulated via TWEAK/Fn14/NF-κB Signaling and Promotes Survival by Modulation of the DNA Repair Response to Temozolomide
Supplementary Figure 1 from SGEF Is Regulated via TWEAK/Fn14/NF-κB Signaling and Promotes Survival by Modulation of the DNA Repair Response to Temozolomide Open
Supplementary Figure 1. Depletion of SGEF expression does not alter glioma cell proliferation or cell cycle.
View article: Supplementary Figure 3 from Mcl-1 Mediates TWEAK/Fn14-Induced Non–Small Cell Lung Cancer Survival and Therapeutic Response
Supplementary Figure 3 from Mcl-1 Mediates TWEAK/Fn14-Induced Non–Small Cell Lung Cancer Survival and Therapeutic Response Open
PDF file - 61K, Mcl-1 gene expression correlates with higher stage and worse prognosis in NSCLC.
View article: Data from Mcl-1 Mediates TWEAK/Fn14-Induced Non–Small Cell Lung Cancer Survival and Therapeutic Response
Data from Mcl-1 Mediates TWEAK/Fn14-Induced Non–Small Cell Lung Cancer Survival and Therapeutic Response Open
Insensitivity to standard clinical interventions, including chemotherapy, radiotherapy, and tyrosine kinase inhibitor (TKI) treatment, remains a substantial hindrance towards improving the prognosis of patients with non–small cell lung can…
View article: Supplementary Figure 1 from SGEF Is Regulated via TWEAK/Fn14/NF-κB Signaling and Promotes Survival by Modulation of the DNA Repair Response to Temozolomide
Supplementary Figure 1 from SGEF Is Regulated via TWEAK/Fn14/NF-κB Signaling and Promotes Survival by Modulation of the DNA Repair Response to Temozolomide Open
Supplementary Figure 1. Depletion of SGEF expression does not alter glioma cell proliferation or cell cycle.
View article: Data from Mcl-1 Mediates TWEAK/Fn14-Induced Non–Small Cell Lung Cancer Survival and Therapeutic Response
Data from Mcl-1 Mediates TWEAK/Fn14-Induced Non–Small Cell Lung Cancer Survival and Therapeutic Response Open
Insensitivity to standard clinical interventions, including chemotherapy, radiotherapy, and tyrosine kinase inhibitor (TKI) treatment, remains a substantial hindrance towards improving the prognosis of patients with non–small cell lung can…
View article: Supplementary Figure Legend from SGEF Is Regulated via TWEAK/Fn14/NF-κB Signaling and Promotes Survival by Modulation of the DNA Repair Response to Temozolomide
Supplementary Figure Legend from SGEF Is Regulated via TWEAK/Fn14/NF-κB Signaling and Promotes Survival by Modulation of the DNA Repair Response to Temozolomide Open
Supplementary Figure Legend
View article: Data from SGEF Is Regulated via TWEAK/Fn14/NF-κB Signaling and Promotes Survival by Modulation of the DNA Repair Response to Temozolomide
Data from SGEF Is Regulated via TWEAK/Fn14/NF-κB Signaling and Promotes Survival by Modulation of the DNA Repair Response to Temozolomide Open
Glioblastoma (GB) is the highest grade and most common form of primary adult brain tumors. Despite surgical removal followed by concomitant radiation and chemotherapy with the alkylating agent temozolomide, GB tumors develop treatment resi…
View article: Supplementary Figure 3 from SGEF Is Regulated via TWEAK/Fn14/NF-κB Signaling and Promotes Survival by Modulation of the DNA Repair Response to Temozolomide
Supplementary Figure 3 from SGEF Is Regulated via TWEAK/Fn14/NF-κB Signaling and Promotes Survival by Modulation of the DNA Repair Response to Temozolomide Open
Supplementary Figure 3. SGEF depletion in glioma cells display impaired DNA double strain break repair kinetics.
View article: Supplementary Figure 2 from SGEF Is Regulated via TWEAK/Fn14/NF-κB Signaling and Promotes Survival by Modulation of the DNA Repair Response to Temozolomide
Supplementary Figure 2 from SGEF Is Regulated via TWEAK/Fn14/NF-κB Signaling and Promotes Survival by Modulation of the DNA Repair Response to Temozolomide Open
Supplementary Figure 2. SGEF knockdown enhances glioma cell susceptibility to TMZ-induced cell death.
View article: Supplementary Figure 2 from SGEF Is Regulated via TWEAK/Fn14/NF-κB Signaling and Promotes Survival by Modulation of the DNA Repair Response to Temozolomide
Supplementary Figure 2 from SGEF Is Regulated via TWEAK/Fn14/NF-κB Signaling and Promotes Survival by Modulation of the DNA Repair Response to Temozolomide Open
Supplementary Figure 2. SGEF knockdown enhances glioma cell susceptibility to TMZ-induced cell death.
View article: Supplementary Figure 5 from SGEF Is Regulated via TWEAK/Fn14/NF-κB Signaling and Promotes Survival by Modulation of the DNA Repair Response to Temozolomide
Supplementary Figure 5 from SGEF Is Regulated via TWEAK/Fn14/NF-κB Signaling and Promotes Survival by Modulation of the DNA Repair Response to Temozolomide Open
Supplementary Figure 5. SGEF is required for BRCA1 recruitment to H2A.X foci following TMZ treatment.
View article: Supplementary Methods and Figure Legends from Mcl-1 Mediates TWEAK/Fn14-Induced Non–Small Cell Lung Cancer Survival and Therapeutic Response
Supplementary Methods and Figure Legends from Mcl-1 Mediates TWEAK/Fn14-Induced Non–Small Cell Lung Cancer Survival and Therapeutic Response Open
PDF file - 113K
View article: Supplementary Figure Legend from SGEF Is Regulated via TWEAK/Fn14/NF-κB Signaling and Promotes Survival by Modulation of the DNA Repair Response to Temozolomide
Supplementary Figure Legend from SGEF Is Regulated via TWEAK/Fn14/NF-κB Signaling and Promotes Survival by Modulation of the DNA Repair Response to Temozolomide Open
Supplementary Figure Legend
View article: Supplementary Figure 4 from Mcl-1 Mediates TWEAK/Fn14-Induced Non–Small Cell Lung Cancer Survival and Therapeutic Response
Supplementary Figure 4 from Mcl-1 Mediates TWEAK/Fn14-Induced Non–Small Cell Lung Cancer Survival and Therapeutic Response Open
PDF file - 35K, TWEAK exposure enhances Mcl-1 and Bcl-xL mRNA expression.