Jian Wang
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View article: Antibacterial activity of catechin-mediated green-synthesized selenium nanoparticles and their application in strawberry preservation
Antibacterial activity of catechin-mediated green-synthesized selenium nanoparticles and their application in strawberry preservation Open
Strawberries are highly perishable due to their soft texture, susceptibility to water loss, and vulnerability to microbial contamination, posing significant post-harvest challenges. The development of green, efficient, and health-promoting…
View article: Lumbar spine infection caused by candida albicans: A case report
Lumbar spine infection caused by candida albicans: A case report Open
Introduction: Lumbar spine infection caused by Candida albicans is a rare condition in clinical practice that often presents as chronic lower back pain. The combination of imaging and laboratory tests can aid in the accurate diagnosis of t…
View article: <scp>RasGRP4</scp> Exacerbates Diabetic Kidney Fibrosis via Aloxe3‐Mediated Oxidative Stress and Scar‐Associated Macrophage Activation
<span>RasGRP4</span> Exacerbates Diabetic Kidney Fibrosis via Aloxe3‐Mediated Oxidative Stress and Scar‐Associated Macrophage Activation Open
Renal fibrosis is an irreversible pathological feature of diabetic kidney disease (DKD), and targeting macrophage phenotype is a promising strategy to prolong it. Ras guanine nucleotide‐releasing protein 4 (RasGRP4) is a signaling protein …
View article: Stable H-bond networks are crucial for selective CLK1 inhibition: a computational perspective
Stable H-bond networks are crucial for selective CLK1 inhibition: a computational perspective Open
Studying the selectivity mechanism of inhibitors towards highly similar isoforms is an important task in the development of new drugs, which are designed to avoid the undesired side effects in vivo . CDC-like kinase isoforms (CLKs) are ser…
View article: Characteristics and sex differences in bronchopulmonary dysplasia-related pulmonary hypertension
Characteristics and sex differences in bronchopulmonary dysplasia-related pulmonary hypertension Open
This study confirmed sex differences in BPD-PH and emphasized the role of sex in the development and prognosis of the disease. Two web servers predicted personalized PH risk and survival outcomes in BPD.
View article: Hsa_circRNA_092488 Exacerbates the Progression of Deep Vein Thrombosis Through the NLRP3/NFkB Signaling Pathway
Hsa_circRNA_092488 Exacerbates the Progression of Deep Vein Thrombosis Through the NLRP3/NFkB Signaling Pathway Open
hsa_circRNA_092488/NLRP3/NF-κB signaling could be a novel therapeutic candidate for the treatment of DVT.
View article: Pantoea–Bacillus as a Composite Microbial Community: Inhibition and Potential Mechanism Against Potato Anthracnose Disease
Pantoea–Bacillus as a Composite Microbial Community: Inhibition and Potential Mechanism Against Potato Anthracnose Disease Open
The potato (Solanum tuberosum), an important component of global food security, often faces threats from various diseases during its growth process, especially potato anthracnose (Colletotrichum coccodes), which severely affects crop yield…
View article: Single-Cell Genomics Elucidates Molecular Variations and Regulatory Mechanisms in Circulating Immune Cells
Single-Cell Genomics Elucidates Molecular Variations and Regulatory Mechanisms in Circulating Immune Cells Open
The human peripheral blood displays diverse molecular characteristics across populations, understanding the drivers and underlying mechanisms of which remains challenging. Here, we introduce the Chinese Immune Multi-Omics Atlas (CIMA), elu…
View article: Utilizing network pharmacology, pharmacodynamics, molecular biology studies, and molecular docking techniques to uncover the mechanism of the Ligusticum wallichii-borneol medication combination for the treatment of ischemic stroke in rat models
Utilizing network pharmacology, pharmacodynamics, molecular biology studies, and molecular docking techniques to uncover the mechanism of the Ligusticum wallichii-borneol medication combination for the treatment of ischemic stroke in rat models Open
Objective.To use pharmacodynamics, molecular biology studies, network pharmacology, and molecular docking to study the mechanism of action of the Ligusticum wallichii (known as Chuanxiong in China, CX) and borneol (known as Bingpian in Chi…
View article: Correction: Zhang et al. GL-1196 Suppresses the Proliferation and Invasion of Gastric Cancer Cells via Targeting PAK4 and Inhibiting PAK4-Mediated Signaling Pathways. Int. J. Mol. Sci. 2016, 17, 470
Correction: Zhang et al. GL-1196 Suppresses the Proliferation and Invasion of Gastric Cancer Cells via Targeting PAK4 and Inhibiting PAK4-Mediated Signaling Pathways. Int. J. Mol. Sci. 2016, 17, 470 Open
In the original publication [...]
View article: Clinical Characteristics and Current Treatment Modality of Preterm Infants with Ureaplasma spp. Infection
Clinical Characteristics and Current Treatment Modality of Preterm Infants with Ureaplasma spp. Infection Open
Background: The impact of and countermeasures for Ureaplasma spp. in neonates remain controversial. The aim of this study was to evaluate the associated perinatal factors that can predict the likelihood of respiratory tract Ureaplasma spp.…
View article: Quantitative periodic homogenization for symmetric non-local stable-like operators
Quantitative periodic homogenization for symmetric non-local stable-like operators Open
Homogenization for non-local operators in periodic environments has been studied intensively. So far, these works are mainly devoted to the qualitative results, that is, to determine explicitly the operators in the limit. To the best of au…
View article: Comparative Effectiveness of Interventional Therapy versus Exercise Rehabilitation in Stable Angina Patients with Severe Coronary Artery Stenosis
Comparative Effectiveness of Interventional Therapy versus Exercise Rehabilitation in Stable Angina Patients with Severe Coronary Artery Stenosis Open
Interventional therapy did not reduce cardiovascular events compared to exercise-based rehabilitation in stable angina patients with severe coronary artery stenosis, but the rehabilitation can improve cardiovascular fitness and quality of …
View article: Sinomenine Alleviates Rheumatoid Arthritis by Suppressing the PI3K-Akt Signaling Pathway, as Demonstrated Through Network Pharmacology, Molecular Docking, and Experimental Validation
Sinomenine Alleviates Rheumatoid Arthritis by Suppressing the PI3K-Akt Signaling Pathway, as Demonstrated Through Network Pharmacology, Molecular Docking, and Experimental Validation Open
By utilizing network pharmacology, molecular modeling, and in vitro/in vivo validation, this study demonstrates that SIN can alleviate RA by inhibiting the PI3K-Akt signaling pathway. These findings enhance the understanding of the therape…
View article: Stomatal evolution and plant adaptation to future climate
Stomatal evolution and plant adaptation to future climate Open
Global climate change is affecting plant photosynthesis and transpiration processes, as well as increasing weather extremes impacting socio‐political and environmental events and decisions for decades to come. One major research challenge …
View article: Bufei Huoxue capsule attenuates COPD-related inflammation and regulates intestinal microflora, metabolites
Bufei Huoxue capsule attenuates COPD-related inflammation and regulates intestinal microflora, metabolites Open
Background: Bufei Huoxue capsule (BFHX) is widely used for the clinical treatment of chronic obstructive pulmonary disease (COPD) in China. Objectives: The aim of this study is to explore the effects on COPD and the underlying mechanism of…
View article: The Roles of Histone Deacetylases in the Regulation of Ovarian Cancer Metastasis
The Roles of Histone Deacetylases in the Regulation of Ovarian Cancer Metastasis Open
Ovarian cancer is the most lethal gynecologic malignancy, and metastasis is the major cause of death in patients with ovarian cancer, which is regulated by the coordinated interplay of genetic and epigenetic mechanisms. Histone deacetylase…
View article: Active compounds of Caodoukou () inhibit the migration, invasion and metastasis of human pancreatic cancer cells by targeting phosphoinosmde-3-kinase/ protein kinase B/mammalian target of rapamycin pathway.
Active compounds of Caodoukou () inhibit the migration, invasion and metastasis of human pancreatic cancer cells by targeting phosphoinosmde-3-kinase/ protein kinase B/mammalian target of rapamycin pathway. Open
ACAK can partly inhibit the activity of EMT and matrix metallopeptidases by down-regulating the downstream proteins of PI3K/Akt/mTOR signal pathway, thus inhibiting the ability of migration and invasion of pancreatic cancer.
View article: Corrigendum: Advanced NSCLC patients with EGFR T790M harbouring TP53 R273C or KRAS G12V cannot benefit from osimertinib based on a clinical multicentre study by tissue and liquid biopsy
Corrigendum: Advanced NSCLC patients with EGFR T790M harbouring TP53 R273C or KRAS G12V cannot benefit from osimertinib based on a clinical multicentre study by tissue and liquid biopsy Open
[This corrects the article DOI: 10.3389/fonc.2021.621992.].
View article: The Influence of Piper sarmentosum Extract on Growth Performance, Intestinal Barrier Function, and Metabolism of Growing Chickens
The Influence of Piper sarmentosum Extract on Growth Performance, Intestinal Barrier Function, and Metabolism of Growing Chickens Open
In the poultry industry, there is an urgent need to evaluate and introduce natural, effective, and safe alternatives for synthetic antibiotics, which have been banned in most countries. The present study aimed to investigate the effects of…
View article: Toxicity of Nanoscale Zero-Valent Iron to Soil Microorganisms and Related Defense Mechanisms: A Review
Toxicity of Nanoscale Zero-Valent Iron to Soil Microorganisms and Related Defense Mechanisms: A Review Open
Soil pollution is a global environmental problem. Nanoscale zero-valent iron (nZVI) as a kind of emerging remedial material is used for contaminated soil, which can quickly and effectively degrade and remove pollutants such as organic hali…
View article: Figure S2 from Anti-OX40 Antibody Directly Enhances The Function of Tumor-Reactive CD8<sup>+</sup> T Cells and Synergizes with PI3Kβ Inhibition in PTEN Loss Melanoma
Figure S2 from Anti-OX40 Antibody Directly Enhances The Function of Tumor-Reactive CD8<sup>+</sup> T Cells and Synergizes with PI3Kβ Inhibition in PTEN Loss Melanoma Open
Positively interaction of OX40 agonist antibody and PI3K inhibition in mice bearing PTEN-loss tumors