Imran Siddiqui
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Rationales for Non-standard GBCA Dosing—Low?—High?—When? and Why? Open
Background: The current standard dose of extracellular, multipurpose gadolinium-based contrast agents (GBCAs) of 0.1 mmol Gd/kg body weight (bw) was first suggested in 1984, 40 years ago. Although the safety and efficacy of both higher and…
The Transformative Effect of Training on Informed Consent: A Comparative Study Among Medical Postgraduate Researchers Open
A structured, comprehensive training significantly and immediately improves the quality of IC documentation and practices among medical postgraduates, moving performance from a "Satisfactory" to an "Excellent" standard. Integrating such ta…
View article: Endoscopic or surgical gastroenterostomy for malignant gastric outlet obstruction: a randomised trial
Endoscopic or surgical gastroenterostomy for malignant gastric outlet obstruction: a randomised trial Open
Background Although surgical gastrojejunostomy (SGJ) is the standard method for palliation of gastric outlet obstruction (GOO), an endoscopic method—endoscopic ultrasound-guided gastroenterostomy (EUS-GE)—has been proposed as a novel, less…
View article: Analgesic Efficacy and Perioperative Safety of the Erector Spinae Plane Block in Adult Cardiac Surgery
Analgesic Efficacy and Perioperative Safety of the Erector Spinae Plane Block in Adult Cardiac Surgery Open
Introduction Severe post-sternotomy pain and the constraints of neuraxial techniques under anticoagulation highlight the need for opioid-sparing, feasible analgesia in adult cardiac surgery. The erector spinae plane (ESP) block—providing p…
Exploring the Use of Metaverse in Future Medical Education: Navigating Adoption and Challenges (Preprint) Open
BACKGROUND The metaverse driven by immersive technologies such as virtual reality (VR), augmented reality (AR), mixed reality (MR), artificial intelligence (AI), and blockchain has begun to reshape medical education. By creating highly int…
View article: Exploring landscape of drug abuse trends in Pakistan: A decade and a half of clinical laboratory big data analysis
Exploring landscape of drug abuse trends in Pakistan: A decade and a half of clinical laboratory big data analysis Open
The utilization of urine testing for drugs of abuse has emerged as a valuable tool in discerning the evolving landscape of drug abuse patterns. The objective of this study was to determine the patterns of drug of abuse within the Pakistani…
A label-free sensing of creatinine using radio frequency-driven lab-on-chip (LoC) system Open
This paper presents a promising avenue of Radio Frequency (RF) biosensors for sensitive and real-time monitoring of creatinine detection. Knowing creatinine levels in the human body is related to its possible association with renal, muscul…
ACTH-secreting parotid acinic cell carcinoma unusually reported as a paraneoplastic syndrome Open
Paraneoplastic syndromes, induced by an immunological cross-reaction or hormone/peptide secretion, are an atypical presentation of tumors. Some tumors, such as small cell lung cancer and bronchial carcinoid, can be adrenocorticotropic horm…
Oncogenic KRAS-Induced Protein Signature in the Tumor Secretome Identifies Laminin-C2 and Pentraxin-3 as Useful Biomarkers for the Early Diagnosis of Pancreatic Cancer Open
KRAS mutations characterize pancreatic cell transformation from the earliest stages of carcinogenesis, and are present in >95% of pancreatic ductal adenocarcinoma (PDAC) cases. In search of novel biomarkers for the early diagnosis of PDAC,…
Debilitating Manifestation of a Disease with Multiple Names: A Severe Case of Sclerosing Mesenteritis Open
Sclerosing mesenteritis (SM) is a rare inflammatory condition with unknown etiology that affects the mesenteric adipose tissue. We present a case of a 49-year-old male with severe abdominal pain who underwent abdominal biopsy confirming th…
Hyperspectral Imaging Based on Compressive Sensing: Determining Cancer Margins in Human Pancreatic Tissue <i>ex Vivo</i>, a Pilot Study Open
Cancer is the second-leading cause of death in the United State and surgery remains the primary treatment for most solid mass tumors.However, accurately identifying tumor margins in real-time remains a challenge.In this study, the design a…
Abdominal aortic aneurysm and its association with duodenal obstruction: aortoduodenal syndrome Open
Proximal small bowel obstruction in the region of the duodenum is an uncommon clinical entity. Our case, which involves obstruction of the third portion of the duodenum due to an abdominal aortic aneurysm (AAA), is even more unusual. A rev…
MON-916 Pure Large Cell Neuroendocrine Carcinoma (LCNEC) of the Gall Bladder in a Patient with Down Syndrome - a Rare Case of an Aggressive Tumor of the Gall Bladder Open
Background: Pure large cell neuroendocrine carcinoma of the gall bladder (LCNEC-GB) is an extremely rare entity, with only 12 such cases reported in literature to date. None has been reported in a patient with genetic disorders. We describ…
PD39-04 PREDICTING CD8+ T CELL INFILTRATION AND PD-L1 EXPRESSION IN RENAL CELL CARCINOMA USING CT RADIOMIC SIGNATURES Open
You have accessJournal of UrologyKidney Cancer: Advanced (including Drug Therapy) II (PD39)1 Apr 2020PD39-04 PREDICTING CD8+ T CELL INFILTRATION AND PD-L1 EXPRESSION IN RENAL CELL CARCINOMA USING CT RADIOMIC SIGNATURES Vinay Duddalwar*, Ha…
Deciphering the transcriptomic landscape of tumor-infiltrating CD8 lymphocytes in B16 melanoma tumors with single-cell RNA-Seq Open
Recent studies have proposed that tumor-specific tumor-infiltrating CD8(+) T lymphocytes (CD8 TIL) can be classified into two main groups: “exhausted” TILs, characterized by high expression of the inhibitory receptors PD-1 and TIM-3 and la…
View article: Offset-free Nonlinear Model Predictive Control of A Drum-boiler Pilot Plant
Offset-free Nonlinear Model Predictive Control of A Drum-boiler Pilot Plant Open
ACODS 2020, 6th Conference on Advances in Control and Optimization of Dynamical Systems, Chennai, INDE, 16-/02/2020 - 19/02/2020
Outcome of Endoscopic Repair of CSF Rhinorrhea with Endonasal Endoscopic Approach in terms of Success of Repair. Open
Objective: This descriptive case series conducted to evaluate the outcome of CSF rhinorrhea repair with the Endonasal Endoscopic approach in terms of success of the repair.Materials and Methods: The study was conducted at Neurosurgery depa…
Intratumoral CD8 <sup>+</sup> T cells with stem cell–like properties: Implications for cancer immunotherapy Open
Intratumoral PD-1 + TCF1 + CD8 + T cells with stem cell–like properties mediate cellular expansion and tumor control in response to immunotherapy.
Deciphering the transcriptomic landscape of tumor-infiltrating CD8 lymphocytes in B16 melanoma tumors with single-cell RNA-Seq Open
Recent studies have proposed that tumor-specific tumor-infiltrating CD8 + T lymphocytes (CD8 TIL) can be classified into two main groups: “exhausted” TILs, characterized by high expression of the inhibitory receptors PD-1 and TIM-3 and lac…