Mustafa Hussain
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View article: IDEAL Phase 2a Results
IDEAL Phase 2a Results Open
Objective: To report the developmental phase results of posterior rectus sheath hiatal flap augmentation (PoRSHA), a promising surgical innovation for large and recurrent paraesophageal hernias. Background: Durable hernia repair for large …
View article: Data from Tobacco Smoke Induces Polycomb-Mediated Repression of Dickkopf-1 in Lung Cancer Cells
Data from Tobacco Smoke Induces Polycomb-Mediated Repression of Dickkopf-1 in Lung Cancer Cells Open
Limited information is available about epigenetic mechanisms by which cigarette smoke enhances the initiation and progression of lung cancer. To examine this issue, A549 and Calu-6 lung cancer cells were cultured in normal media with or wi…
View article: Supplementary Figure 1 from Tobacco Smoke Induces Polycomb-Mediated Repression of Dickkopf-1 in Lung Cancer Cells
Supplementary Figure 1 from Tobacco Smoke Induces Polycomb-Mediated Repression of Dickkopf-1 in Lung Cancer Cells Open
Supplementary Figure 1 from Tobacco Smoke Induces Polycomb-Mediated Repression of Dickkopf-1 in Lung Cancer Cells
View article: Supplementary Figure 1 from Tobacco Smoke Induces Polycomb-Mediated Repression of Dickkopf-1 in Lung Cancer Cells
Supplementary Figure 1 from Tobacco Smoke Induces Polycomb-Mediated Repression of Dickkopf-1 in Lung Cancer Cells Open
Supplementary Figure 1 from Tobacco Smoke Induces Polycomb-Mediated Repression of Dickkopf-1 in Lung Cancer Cells
View article: Data from Tobacco Smoke Induces Polycomb-Mediated Repression of Dickkopf-1 in Lung Cancer Cells
Data from Tobacco Smoke Induces Polycomb-Mediated Repression of Dickkopf-1 in Lung Cancer Cells Open
Limited information is available about epigenetic mechanisms by which cigarette smoke enhances the initiation and progression of lung cancer. To examine this issue, A549 and Calu-6 lung cancer cells were cultured in normal media with or wi…
View article: Neuro-Symbolic World Models for Adapting to Open World Novelty
Neuro-Symbolic World Models for Adapting to Open World Novelty Open
Open-world novelty--a sudden change in the mechanics or properties of an environment--is a common occurrence in the real world. Novelty adaptation is an agent's ability to improve its policy performance post-novelty. Most reinforcement lea…
View article: NovGrid: A Flexible Grid World for Evaluating Agent Response to Novelty
NovGrid: A Flexible Grid World for Evaluating Agent Response to Novelty Open
A robust body of reinforcement learning techniques have been developed to solve complex sequential decision making problems. However, these methods assume that train and evaluation tasks come from similarly or identically distributed envir…
View article: Phenotyping as disciplinary practice: Data infrastructure and the interprofessional conflict over drug use in California
Phenotyping as disciplinary practice: Data infrastructure and the interprofessional conflict over drug use in California Open
The narrative of the digital phenotype as a transformative vector in healthcare is nearly identical to the concept of “data drivenness” in other fields such as law enforcement. We examine the role of a prescription drug monitoring program …
View article: Open science, COVID-19, and the news: Exploring controversies in the circulation of early SARS-CoV-2 genomic epidemiology research
Open science, COVID-19, and the news: Exploring controversies in the circulation of early SARS-CoV-2 genomic epidemiology research Open
Some early English language news coverage of COVID-19 epidemiology focused on studies that examined how SARS-CoV-2 (the coronavirus that causes COVID-19) was evolving at the genetic level. The use of phylogenetic methods to analyse pathoge…
View article: Creation of a COVID-19 Based Educational Curriculum: A Blueprint for Redesigning Surgical Education During Times of National Crisis
Creation of a COVID-19 Based Educational Curriculum: A Blueprint for Redesigning Surgical Education During Times of National Crisis Open
Objective: To create a COVID-19 based educational curriculum for surgical residents. Background Data: The COVID-19 pandemic has resulted in disruptions to operative volume and clinical education for surgery residents. This has placed a gre…
View article: Are thinking machines breaking new frontiers in neuro-oncology? A narrative review on the emerging role of machine learning in neuro-oncological practice
Are thinking machines breaking new frontiers in neuro-oncology? A narrative review on the emerging role of machine learning in neuro-oncological practice Open
Medical science in general and oncology in particular are dynamic, rapidly evolving subjects. Brain and spine tumors, whether primary or secondary, constitute a significant number of cases in any oncological practice. With the rapid influx…
View article: Alert fatigue as a consequence of external accountability approaches to patient safety
Alert fatigue as a consequence of external accountability approaches to patient safety Open
Medical error is the third leading cause of death in the United States, causing nearly a quarter million deaths each year. Clinicians such as physicians, nurses, and pharmacists are shown clinical decision support (CDS) alerts, which are i…
View article: Alternatives to sharing COVID-19 data with law enforcement: Recommendations for stakeholders
Alternatives to sharing COVID-19 data with law enforcement: Recommendations for stakeholders Open
During the COVID-19 pandemic, in some jurisdictions, police have become involved in enforcing coronavirus-related measures. Relatedly, several North American jurisdictions have established COVID-19 data sharing protocols with law enforceme…
View article: A scoping review of qualitative research in<i>JAMIA:</i>past contributions and opportunities for future work
A scoping review of qualitative research in<i>JAMIA:</i>past contributions and opportunities for future work Open
Objective Qualitative methods are particularly well-suited to studying the complexities and contingencies that emerge in the development, preparation, and implementation of technological interventions in real-world clinical practice, and m…
View article: What Is the Appropriate Use of Laparoscopy over Open Procedures in the Current COVID-19 Climate?
What Is the Appropriate Use of Laparoscopy over Open Procedures in the Current COVID-19 Climate? Open
View article: How the presentation of patient information and decision-support advisories influences opioid prescribing behavior: A simulation study
How the presentation of patient information and decision-support advisories influences opioid prescribing behavior: A simulation study Open
Objective The United States faces an opioid crisis. Integrating prescription drug monitoring programs into electronic health records offers promise to improve opioid prescribing practices. This study aimed to evaluate 2 different user inte…
View article: Medication safety alert fatigue may be reduced via interaction design and clinical role tailoring: a systematic review
Medication safety alert fatigue may be reduced via interaction design and clinical role tailoring: a systematic review Open
Objective Alert fatigue limits the effectiveness of medication safety alerts, a type of computerized clinical decision support (CDS). Researchers have suggested alternative interactive designs, as well as tailoring alerts to clinical roles…
View article: Improving the design of California’s prescription drug monitoring program
Improving the design of California’s prescription drug monitoring program Open
Objective The US CDC identified prescription drug monitoring programs (PDMPs) as a tool to address the contemporary opioid crisis, but few studies have investigated PDMP usability and effectiveness from the users’ perspective. Even fewer h…
View article: Reducing alarm fatigue: exploring decision structures, risks, and design
Reducing alarm fatigue: exploring decision structures, risks, and design Open
View article: Reducing alarm fatigue: exploring decision structures, risks, and design
Reducing alarm fatigue: exploring decision structures, risks, and design Open
Automated patient monitoring systems suer from several design problems. Among them, alarm fatigue is one of the most critical issues, as evidenced by the Sentinel Event Alert that The Joint Commission – the U.S. hospital-accrediting body –…
View article: Parents’ Knowledge and Practice of Iron Therapy for Anemic Infants in Primary Health Care in Bahrain
Parents’ Knowledge and Practice of Iron Therapy for Anemic Infants in Primary Health Care in Bahrain Open
BACKGROUND: Anemia in children aged less than five years is a common medical problem worldwide. Iron deficiency anemia is the most prevalent anemia in infants and has been shown to be a public health problem. Many studies have been conduct…
View article: Thinking Together: Modeling Clinical Decision-Support as a Sociotechnical System.
Thinking Together: Modeling Clinical Decision-Support as a Sociotechnical System. Open
Computerized clinical decision-support systems are members of larger sociotechnical systems, composed of human and automated actors, who send, receive, and manipulate artifacts. Sociotechnical consideration is rare in the literature. This …