Explanipedia

Acetylation-dependent clustering of BRD2 instructs transcription dynamics Open

Niyazi Umut Erdogdu, Sukanya Guhathakurta, Maria Shvedunova, Ronald Oellers, Eric M. Patrick , et al. · 2025

BET protein inhibitors represent one of the most prominent classes of epigenetic drugs. However, the specific contributions of individual BET family members to transcription regulation remain largely unknown. Here, by acutely co-depleting …

RNA Dynamics Regulate Transcriptional Condensate Vivacity to Drive Gene Coordination Open

Koichi Ogami, Ming Zheng, Seiko Yoshino, Yohei Sugimoto, Mayu Seida , et al. · 2025

Summary Transcriptional condensates (TCs), enriched with Mediator, orchestrate super-enhancer (SE)-driven gene expression critical for cell identity. However, how their dynamic physical properties shape transcriptional activities remains u…

Direct observation of a condensate effect on super-enhancer controlled gene bursting Open

Manyu Du, Simon Hendrik Stitzinger, Jan-Hendrik Spille, Won‐Ki Cho, Choongman Lee , et al. · 2024

Light-Induced Targeting Enables Proteomics on Endogenous Condensates Open

Choongman Lee, Andrea Quintana, Ida Suppanz, Gerhard Mittler, Ibrahim I. Cissé · 2024

Direct observation of a condensate effect on super-enhancer controlled gene bursting Open

Manyu Du, Simon Hendrik Stitzinger, Jan-Hendrik Spille, Won‐Ki Cho, Choongman Lee , et al. · 2024

Regularly spaced tyrosines in EBF1 mediate BRG1 recruitment and formation of nuclear subdiffractive clusters Open

Nikolay Zolotarev, Yuanting Wang, Manyu Du, Marc Bayer, Anna Grosschedl , et al. · 2024

B lineage priming by pioneer transcription factor EBF1 requires the function of an intrinsically disordered region (IDR). Here, we examine the role of regularly spaced tyrosines in the IDR as potential determinants of IDR function and acti…

CCDC 2235598: Experimental Crystal Structure Determination Open

Sérigne Fallou Pouye, Sylvain Bernès, Lamine Yaffa, Waly Diallo, Ibrahim I. Cissé , et al. · 2023

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …

The dynamic clustering of insulin receptor underlies its signaling and is disrupted in insulin resistance Open

Alessandra Dall’Agnese, Jesse M. Platt, Ming Zheng, Max Friesen, Giuseppe Dall’Agnese , et al. · 2022

Hijacking of transcriptional condensates by endogenous retroviruses Open

Vahid Asimi, Abhishek Sampath Kumar, Henri Niskanen, Christina Riemenschneider, Sara Hetzel , et al. · 2022

Drug misuse by teenagers in schools in Benin and genetic polymorphism of cytochrome p450: interest and perspectives of cytochrome p450 genotyping Open

Arnaud Agbanlinsou, Ibrahim I. Cissé, Anatóle Laleye · 2022

The misuse of psychoactive substances by students is a reality in Beninese schools. These students are exposed to experimentation with these substances with or without prescriptions. The systematic genotyping of cytochromes in these studen…

CCDC 2118461: Experimental Crystal Structure Determination Open

Sérigne Fallou Pouye, Ibrahim I. Cissé, Libasse Diop, Sylvain Bernès · 2021

CCDC 2118462: Experimental Crystal Structure Determination Open

Sérigne Fallou Pouye, Ibrahim I. Cissé, Lamine Diop, Sylvain Bernès · 2021

CCDC 2118459: Experimental Crystal Structure Determination Open

Sérigne Fallou Pouye, Ibrahim I. Cissé, Lamine Diop, Sylvain Bernès · 2021

CCDC 2118460: Experimental Crystal Structure Determination Open

Sérigne Fallou Pouye, Ibrahim I. Cissé, Libasse Diop, Sylvain Bernès · 2021

RNA-Mediated Feedback Control of Transcriptional Condensates Open

Jonathan E. Henninger, Ozgur Oksuz, Krishna Shrinivas, Ido Sagi, Gary LeRoy , et al. · 2020

A dual role for H2A.Z.1 in modulating the dynamics of RNA Polymerase II initiation and elongation Open

Constantine Mylonas, Alexander L. Auld, Choongman Lee, Ibrahim I. Cissé, Laurie A. Boyer · 2020

RNAPII pausing immediately downstream of the transcription start site (TSS) is a critical rate limiting step at most metazoan genes that allows fine-tuning of gene expression in response to diverse signals 1–5 . During pause-release, RNA P…

Mediator Condensates Localize Signaling Factors to Key Cell Identity Genes Open

Alicia V. Zamudio, Alessandra Dall’Agnese, Jonathan E. Henninger, John C. Manteiga, Lena K. Afeyan , et al. · 2019

Pol II phosphorylation regulates a switch between transcriptional and splicing condensates Open

Yang Guo, John C. Manteiga, Jonathan E. Henninger, Benjamin R. Sabari, Alessandra Dall’Agnese , et al. · 2019

Pol II phosphorylation regulates a switch between transcriptional and splicing condensates Open

John C. Manteiga, Jan Hendrik Spille, Lena K. Afeyan, Alicia Zamudio Montes de, Krishna Shrinivas , et al. · 2019

A first order phase transition mechanism underlies protein aggregation in mammalian cells Open

Arjun Narayanan, Anatoli B. Meriin, J Owen Andrews, Jan-Hendrik Spille, Michael Y. Sherman , et al. · 2019

The formation of misfolded protein aggregates is a hallmark of neurodegenerative diseases. The aggregate formation process exhibits an initial lag phase when precursor clusters spontaneously assemble. However, most experimental assays are …

Author response: A first order phase transition mechanism underlies protein aggregation in mammalian cells Open

Arjun Narayanan, Anatoli B. Meriin, J Owen Andrews, Jan-Hendrik Spille, Michael Y. Sherman , et al. · 2018

A CRISPR/Cas9 platform for MS2-labelling of single mRNA in live stem cells Open

Jan-Hendrik Spille, Micca Hecht, Valentin Grube, Won‐Ki Cho, Choongman Lee , et al. · 2018

Hsp70–Bag3 complex is a hub for proteotoxicity-induced signaling that controls protein aggregation Open

Anatoli B. Meriin, Arjun Narayanan, Le Meng, Ilya Alexandrov, Xaralabos Varelas , et al. · 2018

Significance This work dissects how cells monitor failure of proteasomes and trigger signaling responses defining whether cells survive proteotoxic stress or undergo apoptosis. The monitoring mechanism involves detection of a buildup of ab…

Coactivator condensation at super-enhancers links phase separation and gene control Open

Benjamin R. Sabari, Alessandra Dall’Agnese, Ann Boija, Isaac A. Klein, Brian J. Abraham , et al. · 2018

Super-enhancers (SEs) are clusters of enhancers that cooperatively assemble a high density of the transcriptional apparatus to drive robust expression of genes with prominent roles in cell identity. Here we demonstrate that the SE-enriched…

Mediator and RNA polymerase II clusters associate in transcription-dependent condensates Open

Won‐Ki Cho, Jan-Hendrik Spille, Micca Hecht, Choongman Lee, Charles H. Li , et al. · 2018

Phase separation and gene control Many components of eukaryotic transcription machinery—such as transcription factors and cofactors including BRD4, subunits of the Mediator complex, and RNA polymerase II—contain intrinsically disordered lo…

Coactivator condensation at super-enhancers links phase separation and gene control Open

Benjamin R. Sabari, Alessandra Dall’Agnese, Ann Boija, Isaac A. Klein, Eliot L. Coffey , et al. · 2018

Phase separation and gene control Many components of eukaryotic transcription machinery—such as transcription factors and cofactors including BRD4, subunits of the Mediator complex, and RNA polymerase II—contain intrinsically disordered lo…

qSR: a quantitative super-resolution analysis tool reveals the cell-cycle dependent organization of RNA Polymerase I in live human cells Open

J Owen Andrews, William F. Conway, Won‐Ki Cho, Arjun Narayanan, Jan-Hendrik Spille , et al. · 2018

qSR: a quantitative super-resolution analysis tool reveals the cell-cycle dependent organization of RNA Polymerase I in live human cells Open

James Owen Andrews, William F. Conway, Won‐Ki Cho, Arjun Narayanan, Jan Hendrik Spille , et al. · 2018

We present qSR, an analytical tool for the quantitative analysis of single molecule based super-resolution data. The software is created as an open-source platform integrating multiple algorithms for rigorous spatial and temporal character…

Mediator Forms Clusters with RNA Polymerase II in Live Stem Cells Open

Won‐Ki Cho, Jan-Hendrik Spille, Micca Hecht, Choongman Lee, Ibrahim I. Cissé · 2018

CCDC 1815199: Experimental Crystal Structure Determination Open

Sérigne Fallou Pouye, Ibrahim I. Cissé, Libasse Diop, F.J. Ríos-Merino, Sylvain Bernès · 2018

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …

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