Explanipedia

Microglial Complement C5aR1 signalling drives inflammasome mediated neuropathology in Parkinson’s disease Open

Eduardo A. Albornoz, Richard D. Gordon, Ibrahim Javed, Gabriela O. Bodea, Vinod Kumar , et al. · 2025

Klotho overexpression protects human cortical neurons from β-amyloid induced neuronal toxicity Open

Mohammed R. Shaker, Salam Salloum‐Asfar, Rowaida Z. Taha, Ibrahim Javed, Ernst J. Wolvetang · 2025

Interactions between pathological and functional amyloid: A match made in Heaven or Hell? Open

Daniel E. Otzen, Samuel Peña‐Díaz, J J Widmann, Anders Ogechi Hostrup Daugberg, Z H Zhang , et al. · 2025

The amyloid state of proteins occurs in many different contexts in Nature and in modern society, ranging from the pathological kind (neurodegenerative diseases and amyloidosis) via man-made forms (food processing and - to a much smaller ex…

Flavonoid‐Derived Probes for the Detection of Islet Amyloid Polypeptide Aggregates Open

Zijie Luo, Yijia Xu, Jiayi Fan, I.J. Lean, Thomas P. Davis , et al. · 2024

Type‐2 diabetes (T2D) is a growing global health crisis, with over 90% of diabetes cases attributed to this condition. Misfolding and aggregation of islet amyloid polypeptide (IAPP) is a hallmark of early T2D, contributing to pancreatic β‐…

Young rat microbiota extracts strongly inhibit fibrillation of α-synuclein and protect neuroblastoma cells and zebrafish against α-synuclein toxicity Open

Mohammad Shiraz, Janni Nielsen, J J Widmann, Ka Hang Karen Chung, Thomas P. Davis , et al. · 2024

Reverse engineering the Gut-Brain Axis and microbiome-metabolomics for symbiotic/pathogenic balance in neurodegenerative diseases Open

Muhammad Usman Munir, Syed Aoun Ali, Ka Hang Karen Chung, Aleksandr Käkinen, Ibrahim Javed , et al. · 2024

Deciphering the molecular communications along the gut-brain axis can help in understanding the pathophysiology of neurodegenerative diseases and exploiting the gut microbiome for therapeutics. However, gut microbes and their metabolites h…

Lipid-Based Nanoformulations for Drug Delivery: An Ongoing Perspective Open

Mubashar Rehman, Nayab Tahir, Muhammad Sohail, Muhammad Ahmed Qadri, Sofia O. D. Duarte , et al. · 2024

Oils and lipids help make water-insoluble drugs soluble by dispersing them in an aqueous medium with the help of a surfactant and enabling their absorption across the gut barrier. The emergence of microemulsions (thermodynamically stable),…

Valproic acid-induced teratogenicity is driven by senescence and prevented by Rapamycin in human spinal cord and animal models Open

Giovanni Pietrogrande, Mohammed R. Shaker, Sarah J. Stednitz, Mohammad Soheilmoghaddam, Julio Aguado , et al. · 2024

Alzheimer’s Disease: A Culprit from the Gut Open

Ibrahim Javed · 2024

Senolytic therapy alleviates physiological human brain aging and COVID-19 neuropathology Open

Julio Aguado, Alberto A. Amarilla, Atefeh Taherian Fard, Eduardo A. Albornoz, Alexander Tyshkovskiy , et al. · 2023

Aging is a major risk factor for neurodegenerative diseases, and coronavirus disease 2019 (COVID-19) is linked to severe neurological manifestations. Senescent cells contribute to brain aging, but the impact of virus-induced senescence on …

Sulconazole-Loaded Solid Lipid Nanoparticles for Enhanced Antifungal Activity: In Vitro and In Vivo Approach Open

Ayesha Samee, Faisal Usman, Tanveer A. Wani, Mudassir Farooq, Hamid Saeed Shah , et al. · 2023

Solid lipid nanoparticles (SLNs) have the advantages of a cell-specific delivery and sustained release of hydrophobic drugs that can be exploited against infectious diseases. The topical delivery of hydrophobic drugs needs pharmaceutical s…

Small signal modulation of photonic crystal surface emitting lasers Open

Jonathan R. Orchard, Pavlo Ivanov, Adam F. McKenzie, Calum H. Hill, Ibrahim Javed , et al. · 2023

We report the small-signal characterization of a PCSEL device, extracting damping factors and modulation efficiencies, and demonstrating -3 dB modulation bandwidths of up to 4.26 GHz. Based on modelling we show that, by reducing the device…

Itraconazole Loaded Biosurfactin Micelles with Enhanced Antifungal Activity: Fabrication, Evaluation and Molecular Simulation Open

Faisal Usman, Mudassir Farooq, Tanveer A. Wani, Hassan Ahmad, Ibrahim Javed , et al. · 2023

Itraconazole (ITZ) is a broad-spectrum antifungal for superficial subcutaneous and systemic fungal infections. This study aimed to enhance the antifungal activity of ITZ using surfactin A (SA), a cyclic lipopeptide produced by the SA-produ…

Alzheimer's Progenitor Amyloid‐β Targets and Dissolves Microbial Amyloids and Impairs Biofilm Function (Adv. Sci. 29/2023) Open

Syed Aoun Ali, Ka Hang Karen Chung, Helen Forgham, William P. Olsen, Aleksandr Käkinen , et al. · 2023

Amyloid‐β Amyloid‐β (Aβ) is a neuropeptide whose aggregation leads to dementia. In article number 2301423, Daniel E. Otzen, Thomas Paul Davis, Ibrahim Javed, and co‐workers have discovered an anti‐biofilm role of Aβ where Aβ monomers targe…

Rapamycin mitigates Valproic Acid-induced teratogenicity in human and animal models by suppressing AP-1-mediated senescence Open

Giovanni Pietrogrande, Mohammed R. Shaker, Sarah J. Stednitz, Mohammad Soheilmoghaddam, Julio Aguado , et al. · 2023

Valproic acid (VPA) is an effective and widely used anti-seizure medication but is teratogenic when used during pregnancy, affecting brain and spinal cord development for reasons that remain largely unclear. Here we designed a genetic reco…

Alzheimer's Progenitor Amyloid‐β Targets and Dissolves Microbial Amyloids and Impairs Biofilm Function Open

Syed Aoun Ali, Ka Hang Karen Chung, Helen Forgham, William P. Olsen, Aleksandr Käkinen , et al. · 2023

Alzheimer's disease (AD) is a leading form of dementia where the presence of extra‐neuronal plaques of Amyloid‐β (Aβ) is a pathological hallmark. However, Aβ peptide is also observed in the intestinal tissues of AD patients and animal mode…

A Sustainable Green Synthesize of Nanocomposite of Silver Nanoparticles Functionalized with Pectin using <em>Carpesium nepalense</em> for Different Therapeutic Application: A Mechanistic Approach Open

Samiullah Burki, Muhammad Arif Asghar, Imdad Ali, Muhammad Asif Asghar, Zeba Gul Burki , et al. · 2023

Present study reports the green synthesis of pectin fabricated silver-based nanocomposite (Pectin-AgNPs) with Carpesiumnepalense leaves extract and evaluated their bactericidal kinetics, in-vivo hepatoprotective and cytotoxic potentials wi…

Advancement in oral pharmacokinetics of an antibiotic Cefixime using amphiphilic 4-armed macrocyclic surfactant based niosomes Open

Imdad Ali, Sana Rahim, Ahmad Awais, Muhammad Kawish, Remees Shuhsadh , et al. · 2023

The four -armed long carbon chains supramolecular amphiphilic macrocycles are able to self-assemble into nanosized architectures called niosomes that have a membrane bilayer structure. In this study, amphiphilic macrocycle (MCC10) was synt…

Magnetic iron oxide nanoparticles for brain imaging and drug delivery Open

Ruirui Qiao, Changkui Fu, Helen Forgham, Ibrahim Javed, Xumin Huang , et al. · 2023

Central nervous system (CNS) disorders affect as many as 1.5 billion people globally. The limited delivery of most imaging and therapeutic agents into the brain is a major challenge for treatment of CNS disorders. With the advent of nanote…

Vector enabled CRISPR gene editing – A revolutionary strategy for targeting the diversity of brain pathologies Open

Helen Forgham, Liwei Liu, Jiayuan Zhu, Ibrahim Javed, Weibo Cai , et al. · 2023

Senolytic therapy alleviates physiological human brain aging and COVID-19 neuropathology Open

Julio Aguado, Alberto A. Amarilla, Atefeh Taherian Fard, Eduardo A. Albornoz, Alexander Tyshkovskiy , et al. · 2023

Aging is the primary risk factor for most neurodegenerative diseases, and recently coronavirus disease 2019 (COVID-19) has been associated with severe neurological manifestations that can eventually impact neurodegenerative conditions in t…

Senolytic therapy alleviates physiological human brain aging and COVID-19 neuropathology Open

Julio Aguado, Alberto A. Amarilla, Atefeh Taherian Fard, Eduardo A. Albornoz, Alexander Tyshkovskiy , et al. · 2023

Aging is the primary risk factor for most neurodegenerative diseases, and recently coronavirus disease 2019 (COVID-19) has been associated with severe neurological manifestations that can eventually impact neurodegenerative conditions in t…

Inhibition of Amyloid Aggregation and Toxicity with Janus Iron Oxide Nanoparticles Open

Nikolaos K. Andrikopoulos, Zhiyuan Song, Xulin Wan, Alon M. Douek, Ibrahim Javed , et al. · 2021

Amyloid aggregation is a ubiquitous form of protein misfolding underlying the pathologies of Alzheimer's disease (AD), Parkinson's disease (PD) and type 2 diabetes (T2D), three primary forms of human amyloid diseases. While much has been l…

Nanotoxicology and nanomedicine: The Yin and Yang of nano-bio interactions for the new decade Open

Olesja Bondarenko, Monika Mortimer, Anne Kahru, Neus Feliu, Ibrahim Javed , et al. · 2021

Nano-hydroxyapatite as a delivery system: overview and advancements Open

Muhammad Usman Munir, Sajal Salman, Ibrahim Javed, Syed Nasir Abbas Bukhari, Naveed Ahmad , et al. · 2021

Nano-hydroxyapatite is being investigated as vital components of implants and dental and tissue engineering devices. It is found as a bone replacement due to its non-toxicity and cytocompatibility with dental tissues and bone. The reality …

The Membrane Axis of Alzheimer's Nanomedicine Open

Yuhuan Li, Huayuan Tang, Nikolaos K. Andrikopoulos, Ibrahim Javed, Luca Cecchetto , et al. · 2020

Alzheimer's disease (AD) is a major neurological disorder impairing its carrier's cognitive function, memory, and lifespan. While the development of AD nanomedicine is still nascent, the field is evolving into a new scientific frontier dri…

Amyloid Beta Pathogenesis: Accelerated Amyloid Beta Pathogenesis by Bacterial Amyloid FapC (Adv. Sci. 18/2020) Open

Ibrahim Javed, Zhenzhen Zhang, Jozef Adamčík, Nikolaos K. Andrikopoulos, Yuhuan Li , et al. · 2020

In article number 2001299, Thomas P. Davis, Feng Ding, Pu Chun Ke, and co‐workers examine the aggregation of amyloid beta, the pathogenic peptide associated with Alzheimer's disease, seeded by the amyloid fragments of FapC, a protein const…

Amyloidosis inhibition, a new frontier of the protein corona Open

Pengyu Chen, Feng Ding, Rong Cai, Ibrahim Javed, Wen Yang , et al. · 2020

Accelerated Amyloid Beta Pathogenesis by Bacterial Amyloid FapC Open

Ibrahim Javed, Zhenzhen Zhang, Jozef Adamčík, Nikolaos K. Andrikopoulos, Yuhuan Li , et al. · 2020

The gut–brain axis has attracted increasing attention in recent years, fueled by accumulating symptomatic, physiological, and pathological findings. In this study, the aggregation and toxicity of amyloid beta (A β ), the pathogenic peptide…

Nanosilver Mitigates Biofilm Formation via FapC Amyloidosis Inhibition Open

Zile Huma, Ibrahim Javed, Zhenzhen Zhang, Hajira Bilal, Yunxiang Sun , et al. · 2020

Multidrug resistance of bacteria is a major challenge due to the wide‐spread use of antibiotics. While a range of strategies have been developed in recent years, suppression of bacterial activity and virulence via their network of extracel…

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