Ibrahim Malami
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View article: Enhancing colorectal cancer treatment with a triple therapy approach involving 5-fluorouracil, thymoquinone, Polygonum minus
Enhancing colorectal cancer treatment with a triple therapy approach involving 5-fluorouracil, thymoquinone, Polygonum minus Open
Colorectal cancer (CRC) remains a leading cause of cancer-related mortality globally, with chemoresistance to 5-fluorouracil (5-FU) and dose-limiting toxicities posing major therapeutic challenges. This study investigates the synergistic p…
View article: Assessment of Cooperative Society Involvement in Extension Services Delivery in Lapai Local Government Area of Niger State, Nigeria
Assessment of Cooperative Society Involvement in Extension Services Delivery in Lapai Local Government Area of Niger State, Nigeria Open
The study assessed the cooperative society involvement in extension services delivery in Lapai Local Government Area of Niger State, Nigeria. Multistage sampling procedure was used to select a total of ninety (90) respondents for the study…
View article: Comparative Label-Based Proteomics of Venoms from Echis ocellatus, Naja nigricollis, and Bitis arietans
Comparative Label-Based Proteomics of Venoms from Echis ocellatus, Naja nigricollis, and Bitis arietans Open
Background: Snake envenomation is a major public health issue in Nigeria, primarily due to bites from Echis ocellatus, Naja nigricollis, and Bitis arietans. Understanding their venom composition is essential for effective antivenom develop…
View article: <b>Chloroform Fraction of <i>Mitracarpus hirtus</i> Induces p53-Mediated Cell Cycle Arrest and Apoptosis in MCF-7 Breast Cancer Cells</b>
<b>Chloroform Fraction of <i>Mitracarpus hirtus</i> Induces p53-Mediated Cell Cycle Arrest and Apoptosis in MCF-7 Breast Cancer Cells</b> Open
Background: Breast cancer remains a serious life-threatening disease to women worldwide, contributing to a high rate of mortality among women. A critical molecular event implicated in breast cancer progression is the dysregulation of the t…
View article: Genotoxic Effects of Aristolochia albida Extract Using Drosophila melanogaster
Genotoxic Effects of Aristolochia albida Extract Using Drosophila melanogaster Open
This study investigated the toxicological effects of Aristolochia albida extracts using antioxidant defence assays and the Drosophila Somatic Mutation and Recombination Test (SMART) assay. For acute toxicity, adult Drosophila melanogaster …
View article: Ameliorative Effect of Faidherbia albida Against 2.4-Dinitrophenylhydrazine Induced Hyperbilirubinemia in Wistar Albino Rats
Ameliorative Effect of Faidherbia albida Against 2.4-Dinitrophenylhydrazine Induced Hyperbilirubinemia in Wistar Albino Rats Open
F. albida ameliorated the hyperbilirubinemia induced by 2.4-dinitrophenylhydrazine in Wistar albino rats, thus providing some support for its use in traditional medicine to treat jaundice.
View article: 5-Methylcoumarin-4β-glucoside mitigated colon tumor progression in mice with AOM/DSS-induced colon carcinogenesis
5-Methylcoumarin-4β-glucoside mitigated colon tumor progression in mice with AOM/DSS-induced colon carcinogenesis Open
Context: The in vitro cytotoxicity profile of 5-Methylcoumarin-4β-glucoside (5-MC4βG) has been demonstrated to inhibit the proliferation of HT-29 adenocarcinoma cells. Aim: The need for newer and affordable chemotherapeutic agents is criti…
View article: A review of the medicinal uses and biological activity of <i>Piliostigma thonningii</i> (Schum). Milne-Redh.
A review of the medicinal uses and biological activity of <i>Piliostigma thonningii</i> (Schum). Milne-Redh. Open
Objective Piliostigma thonningii is a medicinal plant commonly found in Eastern and Western Africa with a potential traditional usage to treat various diseases. Several studies have revealed interesting pharmacological activity of the plan…
View article: Consumption of some Nigerian local rice varieties and effect on development of insulin resistance and obesity in Drosophila melanogaster
Consumption of some Nigerian local rice varieties and effect on development of insulin resistance and obesity in Drosophila melanogaster Open
There is evidence to suggest that the increased incidence of insulin resistance and obesity is associated with the consumption of energy-dense and highly processed foods like polished rice. This study, therefore, investigated the effects o…
View article: Analysis of sildenafil citrate in herbal aphrodisiac preparations marketed in Sokoto metropolis and its public health implications
Analysis of sildenafil citrate in herbal aphrodisiac preparations marketed in Sokoto metropolis and its public health implications Open
Aphrodisiacs are among the most widely marketed and consumed herbal products in North-Western Nigeria. There are speculations that these products are being adulterated with orthodox medicines in order to boost their effects and sales. The …
View article: Nutrigenomic Effects of White Rice and Brown Rice on the Pathogenesis of Metabolic Disorders in a Fruit Fly Model
Nutrigenomic Effects of White Rice and Brown Rice on the Pathogenesis of Metabolic Disorders in a Fruit Fly Model Open
Consumption of white rice (WR) has been shown to predispose individuals to metabolic disorders. However, brown rice (BR), which is relatively richer in bioactive compounds, possesses anti-glycaemic and antioxidant effects. In this study, f…
View article: Bioactive evaluation for wound healing of stem back extracts of Acacia nilotica Linn. (Fabaceae)
Bioactive evaluation for wound healing of stem back extracts of Acacia nilotica Linn. (Fabaceae) Open
Acacia nilotica (Linn) is an important medicinal plant, found in Africa, the Middle East, and the Indian subcontinent as well as in Sokoto State, Nigeria. It has been utilized to treat wounds and intestinal disorders among other uses. It h…
View article: Ethnomedicinal study and in vitro validation of medicinal plants used for treating Jaundice in Zuru emirate of Kebbi State, Nigeria
Ethnomedicinal study and in vitro validation of medicinal plants used for treating Jaundice in Zuru emirate of Kebbi State, Nigeria Open
Background: For decades, the resident of Zuru emirate have used herbal medicine to treat liver-related diseases including jaundice. Therefore, the present study was designed to investigate and document the herbal medicine used for treating…
View article: BJN volume 128 issue 5 Cover and Back matter
BJN volume 128 issue 5 Cover and Back matter Open
An abstract is not available for this content so a preview has been provided. As you have access to this content, a full PDF is available via the ‘Save PDF’ action button.
View article: Cytotoxic flavokawain B inhibits the growth and metastasis of hepatocellular carcinoma through the suppression of UCK2-mediated downregulation of the STAT3/Hif-1α/VEGF signalling pathway
Cytotoxic flavokawain B inhibits the growth and metastasis of hepatocellular carcinoma through the suppression of UCK2-mediated downregulation of the STAT3/Hif-1α/VEGF signalling pathway Open
Hepatocellular carcinoma (HCC) is currently the third most common cancer-related death worldwide. HCC is associated with a high mortality rate due to early recurrence and its distant metastasis to the nearby organs. Current treatment optio…
View article: Flavokawain B inhibits the growth and metastasis of hepatocellular carcinoma through the suppression of UCK2 mediated downregulation of STAT3/Hif-1α/VEGF signalling pathway
Flavokawain B inhibits the growth and metastasis of hepatocellular carcinoma through the suppression of UCK2 mediated downregulation of STAT3/Hif-1α/VEGF signalling pathway Open
This study investigates the effects of Flavokawain B (FKB) on the growth and development of metastatic hepatocellular carcinoma. HepG2 cells were used in this study and a neutral red assay was performed to determine the anti-proliferation …
View article: 5,6-dehydrokawain improves glycaemic control by modulating AMPK target genes in Drosophila with a high-sucrose diet-induced hyperglycaemia
5,6-dehydrokawain improves glycaemic control by modulating AMPK target genes in Drosophila with a high-sucrose diet-induced hyperglycaemia Open
Background: Type 2 diabetes (T2D) is among the leading causes of mortality and morbidity globally. Patients living with T2D are best managed with anti-diabetic agents concurrently with a lifestyle adjustment. AMP-activated protein kinase (…
View article: Prophylactic Use of Natural Products against Developmentally Programmed Metabolic Syndrome
Prophylactic Use of Natural Products against Developmentally Programmed Metabolic Syndrome Open
Parental dietary choices and/or nutritional interventions in the offspring are critical to early life development, especially during the periods of active developmental plasticity in the offspring. Exposure to a high-fructose, high-fat die…
View article: Natural Products Modulating Angiotensin Converting Enzyme 2 (ACE2) as Potential COVID-19 Therapies
Natural Products Modulating Angiotensin Converting Enzyme 2 (ACE2) as Potential COVID-19 Therapies Open
The 2019 coronavirus disease (COVID-19) is a potentially fatal multisystemic infection caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Currently, viable therapeutic options that are cost effective, safe and read…
View article: In Silico Screening of Sesquiterpene Lactones as Aldose Reductase Inhibitors
In Silico Screening of Sesquiterpene Lactones as Aldose Reductase Inhibitors Open
Aldose reductase, a key enzyme of the polyol pathway catalyses NADPH-dependent reduction of glucose to sorbitol. Increased activity of this enzyme is considered a major factor contributing to the development of diabetic complications hence…
View article: Zinc Metalloproteins in Epigenetics and Their Crosstalk
Zinc Metalloproteins in Epigenetics and Their Crosstalk Open
More than half a century ago, zinc was established as an essential micronutrient for normal human physiology. In silico data suggest that about 10% of the human proteome potentially binds zinc. Many proteins with zinc-binding domains (ZBDs…
View article: <i>Pseudocedrela kotschyi</i>: a review of ethnomedicinal uses, pharmacology and phytochemistry
<i>Pseudocedrela kotschyi</i>: a review of ethnomedicinal uses, pharmacology and phytochemistry Open
P. kotschyi is reported to be effective in treating a variety of diseases. Current phytochemical and pharmacological studies mainly focus on antimalaria, anti-leishmaniasis, anti-trypanosomiasis and anticancer potential of the root and ste…
View article: THE CHEMOPREVENTIVE PROPERTIES OF ISOTHIOCYANATE ISOLATED FROM THE SEEDS OF MORINGA OLEIFERA LAM
THE CHEMOPREVENTIVE PROPERTIES OF ISOTHIOCYANATE ISOLATED FROM THE SEEDS OF MORINGA OLEIFERA LAM Open
Isothiocyanates (ITCs) are a group of plant phytochemicals believed to have numerous therapeutic properties. In the current study, Glucomoringin Isothiocyanate (GMG-ITC) was isolated and purified from the seeds of Moringa oleifera Lam. and…