İbrahim Meteoğlu
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Can ABO Blood Type Determine Small Cell Lung Cancer Risk? Open
Introduction: Many cases of small cell lung cancer (SCLC) are diagnosed at an advanced stage, which remains the biggest barrier to improving survival. Identifying high-risk patients for early diagnosis and treatment is crucial. ABO blood g…
Predictive Factors for Acute and Complicated Appendicitis in Children: A Prospective Study Open
Introduction: Acute appendicitis is one of the most common surgical emergencies in children, where early diagnosis is crucial to reducing morbidity and mortality. This study aimed to identify predictive factors for appendicitis and evaluat…
Clinicopathological Significance of Immunohistochemical PD-L1 and Androgen Receptor Expressions in Triple Negative Breast Cancers Open
Objective: Triple negative breast cancers(TNBC), a subset of breast cancers, despite the wide range of morphologies, are high-grade, and related to younger age, higher incidence of metastases, higher risk of recurrence and poorer prognosis…
Evaluation of the mutation profile detected in lung adenocarcinomas with different N status Open
Background Lymph node status is the most important prognostic factor in resectable non-small cell lung cancer (NSCLC). Considering the critical importance of lymph nodes, determining N status and related molecular biomarkers may contribute…
PIK3CA Mutations and Co-Mutations in Operated Non-Small Cell Lung Carcinoma Open
Background: Understanding PIK3CA mutations and co-mutations in non-small cell lung carcinoma (NSCLC) is critical to developing personalized treatment strategies. Therefore, this study aims to investigate PIK3CA mutations and the accompanyi…
The NF1 gene mutations and co-mutations in lung adenocarcinomas with brain metastasis Open
Background: The co-occurrence of lung adenocarcinoma and brain metastasis remains a significant cause of morbidity and mortality despite advancements in cancer treatment. The activity of neurofibromin, the product of Neurofibromatosis Type…
Investigation of Possible Positive Effects of Arbutin Application in Experimental Colitis Model Open
Our study's results elaborated that using arbutin alone or in combination with mesalazine produced positive effects in colitis-induced rats.
Microsatellite instability and somatic gene variant profile in solid organ tumors Open
Introduction Absence of mismatch repair (MMR) genes in tumor cells or errors in the replication repair process may lead to DNA-MMR deficiency and microsatellite instability (MSI) formation. Specific tumor environments where gene variations…
Variation Analysis in Premenopausal and Postmenopausal Breast Cancer Cases Open
Menopausal status affects the prognoses and consequences of breast cancer. Therefore, this retrospective study aimed to reveal the molecular variation profile differences in breast cancer patients according to their menopausal status, with…
Mutation Profile via Next-Generation Sequencing in Patients with Colorectal Adenocarcinoma and Its Clinicopathological Correlation Open
It is necessary to have a comprehensive database of genomic alterations of colorectal carcinomas to interpret mutations more accurately clinically. There are no studies on the frequency of mutations in colorectal carcinomas in the Turkish …
A Rare Nephrotic Syndrome Related to Chronic Lymphocytic Leukemia: Focal Segmental Glomerulosclerosis Open
Chronic lymphocytic leukemia (CLL) is a hematological disease characterized by the proliferation of monoclonal B-lymphocytes. Although autoimmune complications such as autoimmune hemolytic anemia and immune thrombocytopenia are common in C…
Evaluation of the Mutation Profile via Next-Generation Sequencing in a Turkish Population With Non-small Cell Lung Cancer Open
This study shows that Turkish patients have higher rates of PIK3CA, BRAF and NF1 mutations compared to the literature. Studies to determine the molecular profile specific to Turkish people will guide clinicians in treatment and contribute …
Efficacy of thymoquinone in the treatment of experimentallipopolysaccharide-induced acute lung injury Open
The results of this study showed that TQ may have a protective effect against LPS-induced acute lung injury. The possible mechanism could be considered to be cyclooxygenase 2 (COX-2) inhibition.
Effects of Topical Thymoquinone in an Experimental Dry Eye Model Open
TQ treatment was associated with reduced inflammation in pathological examination, but did not significant lower cytokine levels.
The correlation of prognostic biomarkers (Ki-67, Bcl-2, HIF-1α, cyclin D1) with metabolic tumor volume measured by F-FDG PET/CT inlaryngeal cancer Open
Objectives: To investigate the correlation between tumor stage, Ki-67, Bcl-2, hypoxia inducible factor-1α (HIF-1α), cyclin D1 and metabolic tumor volume (MTV), total lesion glycolysis (TLG), maximum standardized uptake value (SUV max ) mea…
Effects of Glutamine, Arginine and Beta Hydroxymethybutyrate on Anastomotic Leakage in Experimental Colon Anastomosis Open
Objective:The studies on anastomotic leakage which is one of the leading serious complications of colonic anastomoses keep going as well as other surgical researches. This study was designed to investigate effects of hydroxy-ß-methyl butyr…
View article: Screening Fabry’s disease in chronic kidney disease patients not on dialysis: a multicenter study
Screening Fabry’s disease in chronic kidney disease patients not on dialysis: a multicenter study Open
Objectives: Fabry's disease is an X-linked inherited, rare, progressive, lysosomal storage disorder, affecting multiple organs due to the deficient activity of α-galactosidase A (α-Gal A) enzyme. The prevalence has been reported to be 0.15…
Inhibitory Effect of Pycnogenol® on Airway Inflammation in Ovalbumin-Induced Allergic Rhinitis Open
PYC has multiple suppressive effects on allergic response. Thus, PYC may be used as a supplementary agent in allergic response.