Ibrahim Serag
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View article: To Bridge or Not to Bridge? A Meta‐Analysis of Intravenous Thrombolysis Before Thrombectomy in Large Ischemic Core Strokes
To Bridge or Not to Bridge? A Meta‐Analysis of Intravenous Thrombolysis Before Thrombectomy in Large Ischemic Core Strokes Open
Background Endovascular thrombectomy (EVT) is the standard treatment for acute ischemic stroke (AIS) caused by large vessel occlusion (LVO). However, the role of preceding intravenous thrombolysis (IVT) in patients with sizable ischemic co…
View article: To Bridge or Not to Bridge? A Meta‐Analysis of Intravenous Thrombolysis Before Thrombectomy in Large Ischemic Core Strokes
To Bridge or Not to Bridge? A Meta‐Analysis of Intravenous Thrombolysis Before Thrombectomy in Large Ischemic Core Strokes Open
Background Endovascular thrombectomy (EVT) is the standard treatment for acute ischemic stroke (AIS) caused by large vessel occlusion (LVO). However, the role of preceding intravenous thrombolysis (IVT) in patients with sizable ischemic co…
View article: Ergonomic stress and surgical performance of general surgeons: a cross-sectional comparison of laparoscopic and open procedures
Ergonomic stress and surgical performance of general surgeons: a cross-sectional comparison of laparoscopic and open procedures Open
The study highlights surgical ergonomics' role in reducing pain and improving outcomes. Prioritizing appropriate ergonomic training, encouraging discomfort reporting, and raising awareness of official recommendations are critical for the l…
View article: Clopidogrel Versus Ticagrelor in Dual Anti-platelet Therapy for Intracranial Aneurysm Patients Undergoing Neuroendovascular Treatment: A Systematic Review and Meta-analysis
Clopidogrel Versus Ticagrelor in Dual Anti-platelet Therapy for Intracranial Aneurysm Patients Undergoing Neuroendovascular Treatment: A Systematic Review and Meta-analysis Open
View article: Role of vitamin D as adjuvant therapy on multiple sclerosis: an updated systematic review and meta-analysis of randomized controlled trials
Role of vitamin D as adjuvant therapy on multiple sclerosis: an updated systematic review and meta-analysis of randomized controlled trials Open
View article: The Multifaceted Role of AASDH: From Metabolic Regulation to Cancer and Cardiomyopathies
The Multifaceted Role of AASDH: From Metabolic Regulation to Cancer and Cardiomyopathies Open
The enzyme 2-aminoadipic-6-semialdehyde dehydrogenase (AASDH) plays a crucial role in metabolic pathways and has emerged as a significant player in multiple pathological conditions, including cancer and cardiomyopathies. AASDH
View article: Platelet-rich plasma in anterior cruciate ligament reconstruction: An updated systematic review and quantitative meta-analysis of randomized controlled trials
Platelet-rich plasma in anterior cruciate ligament reconstruction: An updated systematic review and quantitative meta-analysis of randomized controlled trials Open
Our findings provide moderate evidence that PRP can significantly enhance knee stability post-ACL reconstruction. However, further high-quality randomized controlled trials are needed to clarify PRP's overall effectiveness and optimal use …
View article: Exploring the Efficacy and Safety of Argatroban as an Adjunct to Antiplatelet Therapy in Ischemic Stroke Patients: A Systematic Review and Meta-analysis
Exploring the Efficacy and Safety of Argatroban as an Adjunct to Antiplatelet Therapy in Ischemic Stroke Patients: A Systematic Review and Meta-analysis Open
View article: Automated Emergent Large Vessel Occlusion Detection Using Viz.ai Software and Its Impact on Stroke Workflow Metrics and Patient Outcomes in Stroke Centers: A Systematic Review and Meta-analysis
Automated Emergent Large Vessel Occlusion Detection Using Viz.ai Software and Its Impact on Stroke Workflow Metrics and Patient Outcomes in Stroke Centers: A Systematic Review and Meta-analysis Open
View article: Efficacy and safety of lemborexant vs placebo in treating adults with insomnia disorder: a systematic review and meta-analysis of 1976 patients
Efficacy and safety of lemborexant vs placebo in treating adults with insomnia disorder: a systematic review and meta-analysis of 1976 patients Open
Insomnia is a typical sleep disorder in which an individual finds it difficult to fall asleep and stay asleep resulting in poor daytime functioning and decreased health and quality of life. The orexin system, which regulates wakefulness an…
View article: Non-invasive brain stimulation for borderline personality disorder: a systematic review and network meta-analysis
Non-invasive brain stimulation for borderline personality disorder: a systematic review and network meta-analysis Open
View article: Multimodal diagnostic tools and advanced data models for detection of prodromal Parkinson’s disease: a scoping review
Multimodal diagnostic tools and advanced data models for detection of prodromal Parkinson’s disease: a scoping review Open
Background Parkinson’s Disease (PD) is a progressive neurodegenerative disorder characterized by the loss of dopaminergic neurons in the substantia nigra pars compacta. PD is diagnosed by a combination of motor symptoms including bradykine…
View article: Efficacy of membranectomy for the treatment of chronic subdural hematoma: an updated meta-analysis
Efficacy of membranectomy for the treatment of chronic subdural hematoma: an updated meta-analysis Open
Background Chronic subdural hematoma is a prevalent neurosurgical condition that necessitates surgical intervention. However, initial management remains controversial. This meta-analysis aimed to determine the benefits of Membranectomy whe…
View article: Exploring Research Barriers: A National Multicenter Study Among Obstetrics and Gynecology Residents
Exploring Research Barriers: A National Multicenter Study Among Obstetrics and Gynecology Residents Open
View article: Deep brain stimulation (DBS) in movement disorders management: exploring therapeutic efficacy, neurobiological mechanisms, and clinical implications
Deep brain stimulation (DBS) in movement disorders management: exploring therapeutic efficacy, neurobiological mechanisms, and clinical implications Open
Introduction: Deep brain stimulation (DBS) has emerged as a promising therapeutic approach, offering targeted neuromodulation for movement disorders refractory to medical management or stereotactic surgery. However, assessing its benefits …
View article: Efficacy and safety of laser interstitial thermal therapy versus radiofrequency ablation and stereotactic radiosurgery in the treatment of intractable mesial temporal lobe epilepsy: a systematic review and meta-analysis
Efficacy and safety of laser interstitial thermal therapy versus radiofrequency ablation and stereotactic radiosurgery in the treatment of intractable mesial temporal lobe epilepsy: a systematic review and meta-analysis Open
Epilepsy is a common neurological disease that is treated with medications; however, patients with drug-resistant epilepsy, commonly intractable temporal lobe epilepsy, tend to have better control with surgical treatment. While the mainsta…
View article: Presentation and surgical management approaches of giant presacral and sacral schwannomas: a case report and systematic review and meta-analysis
Presentation and surgical management approaches of giant presacral and sacral schwannomas: a case report and systematic review and meta-analysis Open
Background Giant sacral and presacral schwannomas are very rare conditions and their prevalence is estimated to account for only 0.3 to 3.3% of overall schwannomas. Current published literature about these tumors is limited to case reports…
View article: Beyond the Therapeutic Window: Efficacy and Safety of Intravenous Thrombolysis Beyond 4.5 Hours in Acute Ischemic Stroke: A Systematic Review and Meta-Analysis of 50322 Patients
Beyond the Therapeutic Window: Efficacy and Safety of Intravenous Thrombolysis Beyond 4.5 Hours in Acute Ischemic Stroke: A Systematic Review and Meta-Analysis of 50322 Patients Open
View article: Automated Emergent Large Vessel Occlusion Detection using Viz.ai Software and its Impact on Stroke Workflow Metrics and Patients Outcomes in Stroke Centers: A Systematic Review and Meta-analysis
Automated Emergent Large Vessel Occlusion Detection using Viz.ai Software and its Impact on Stroke Workflow Metrics and Patients Outcomes in Stroke Centers: A Systematic Review and Meta-analysis Open
View article: Comprehensive Comparative Analysis of Non-Invasive Brain Stimulation and Pharmacotherapy in Migraine Management: A Network Meta-Analysis Empowering Physician-Patient Decision-Making
Comprehensive Comparative Analysis of Non-Invasive Brain Stimulation and Pharmacotherapy in Migraine Management: A Network Meta-Analysis Empowering Physician-Patient Decision-Making Open
View article: Exploring the Efficacy and Safety of Argatroban as an Adjunct to Antiplatelet Therapy in Ischemic Stroke Patients: A Systematic Review and Meta-analysis
Exploring the Efficacy and Safety of Argatroban as an Adjunct to Antiplatelet Therapy in Ischemic Stroke Patients: A Systematic Review and Meta-analysis Open
View article: Prevalence of endometriosis in women undergoing laparoscopic surgery for various gynecological indications: a Jordanian multi-center retrospective study
Prevalence of endometriosis in women undergoing laparoscopic surgery for various gynecological indications: a Jordanian multi-center retrospective study Open
This is the most extensive Jordanian study assessing the prevalence of endometriosis in women undergoing gynecological laparoscopy. Our results suggest that the prevalence of endometriosis among Jordanian women remains high, albeit lower t…
View article: Abstract 091: Efficacy and Safety of Andexanet Alpha Versus Four Factor Prothrombin Complex Concentrate for Emergent Reversal of Factor Xa Inhibitor Associated Intracranial Hemorrhage: A Systematic Review and Meta‐Analysis
Abstract 091: Efficacy and Safety of Andexanet Alpha Versus Four Factor Prothrombin Complex Concentrate for Emergent Reversal of Factor Xa Inhibitor Associated Intracranial Hemorrhage: A Systematic Review and Meta‐Analysis Open
Introduction Factor Xa inhibitors (FXaI) are increasingly used for anticoagulation therapy, yet their association with intracranial hemorrhage poses a significant challenge. While Andexanet alpha (AA) and four factor prothrombin complex co…
View article: Abstract 093: Efficacy of Rescue Stenting After Mechanical Thrombectomy Failure compared to non‐stenting in Acute Ischemic Stroke: A Systematic Review and Meta‐Analysis
Abstract 093: Efficacy of Rescue Stenting After Mechanical Thrombectomy Failure compared to non‐stenting in Acute Ischemic Stroke: A Systematic Review and Meta‐Analysis Open
View article: Barbed sutures versus conventional sutures for wound closure in spine surgeries: a systematic review and meta-analysis
Barbed sutures versus conventional sutures for wound closure in spine surgeries: a systematic review and meta-analysis Open
View article: Efficacy and Safety of Andexanet Alfa Versus Four Factor Prothrombin Complex Concentrate for Emergent Reversal of Factor Xa Inhibitor Associated Intracranial Hemorrhage: A Systematic Review and Meta-Analysis
Efficacy and Safety of Andexanet Alfa Versus Four Factor Prothrombin Complex Concentrate for Emergent Reversal of Factor Xa Inhibitor Associated Intracranial Hemorrhage: A Systematic Review and Meta-Analysis Open
View article: Analysis of moderate and severe traumatic brain injury associated with skull base fracture: a local tertiary center experience
Analysis of moderate and severe traumatic brain injury associated with skull base fracture: a local tertiary center experience Open
Background Traumatic brain injury (TBI) is a major medical and social concern in developing countries. TBI-related morbidity and mortality statistics in Egypt are lacking and do not reflect the actual magnitude of the problem. Objectives T…
View article: Exploring the Mechanisms and Therapeutic Approaches of Mitochondrial Dysfunction in Alzheimer’s Disease: An Educational Literature Review
Exploring the Mechanisms and Therapeutic Approaches of Mitochondrial Dysfunction in Alzheimer’s Disease: An Educational Literature Review Open
View article: Multicolumn Spinal Cord Stimulation for Chronic Back and Leg Pain in Patients with Failed Back Surgery Syndrome: A Systematic Review and Meta-Analysis
Multicolumn Spinal Cord Stimulation for Chronic Back and Leg Pain in Patients with Failed Back Surgery Syndrome: A Systematic Review and Meta-Analysis Open
Introduction Failed Back Surgery Syndrome (FBSS) presents a formidable challenge, marked by the persistence of chronic lower back pain and leg pain despite undergoing surgical interventions. Multicolumn spinal cord stimulation (m-SCS) has …
View article: Anxiety and Depression Among Adults and Children With Celiac Disease: A Meta‐Analysis of Different Psychiatry Scales
Anxiety and Depression Among Adults and Children With Celiac Disease: A Meta‐Analysis of Different Psychiatry Scales Open
Background Celiac disease (CD) is an autoimmune disorder in which genetically susceptible individuals cannot digest gluten (wheat) and its homologs such as Scalin (rye) and Hordein (barley). Aim This systematic review and meta‐analysis aim…