Explanipedia

Total arch frozen elephant trunk repair and TEVAR after extra-anatomic repair of coarctation Open

Aryan Meknat, Irsa Hasan, Derek Serna-Gallegos, Ibrahim Sultan · 2025

Background Coarctation of the aorta represents 5% of all congenital cardiac anomalies, with isolated coarctations occurring in 3 per 100,000 live births. Repair in adulthood include open, hybrid, and endovascular options – with prosthetic …

Transcatheter Aortic Valve Replacement for Mixed Aortic Valve Disease Versus Predominant Aortic Stenosis Open

Nav Warraich, Danial Ahmad, James A. Brown, Derek Serna-Gallegos, Dustin Kliner , et al. · 2025

We sought to evaluate survival of patients with mixed aortic valve disease (MAVD) versus predominant aortic stenosis (AS) undergoing transcatheter aortic valve replacement (TAVR). This was a study-level meta-analysis of reconstructed time-…

Cost-effectiveness of Coronary Artery Bypass Grafting Versus Percutaneous Coronary Intervention in Severe Ischemic Cardiomyopathy Open

Shumail Fatima, Gavin Hickey, Matthew E. Harinstein, John J. Pacella, Ibrahim Sultan , et al. · 2025

Impact of supra-aortic vessel false lumen communications on aortic remodeling: Analysis from the PERSEVERE trial Open

Kyle W. Eudailey, Sabin J. Bozso, Shinichi Fukuhara, Fernando Fleischman, Ibrahim Sultan , et al. · 2025

Staged Hybrid Repair of Right-Sided Aortic Arch With Kommerell Diverticulum and Aberrant Left Subclavian Open

Manuel Giraldo-Grueso, Aryan Meknat, Ibrahim Sultan, Irsa Hasan, Derek Serna-Gallegos · 2025

A staged hybrid strategy is beneficial for treating rare congenital aortic arch anomalies with aneurysmal degeneration in young adults. Successful outcomes rely on individualized surgical planning and multidisciplinary collaboration to min…

Impact of hepatic dysfunction on outcomes following adult cardiac surgery Open

B.E. Woolley, Nidhi Iyanna, Yeahwa Hong, Umar Nasim, Ander Dorken‐Gallastegi , et al. · 2025

Outcomes of Left Atrial Appendage Patency After Device Closure Detected by Cardiac CT Open

Xander Jacquemyn, Michel Pompeu Sá, Kasper Korsholm, Jens Erik Nielsen‐Kudsk, Xavier Iriart , et al. · 2025

LAA patency and PDL identified by CT may be associated with an increased risk of thromboembolism. These findings indicate that residual leaks detected by CT may be clinically significant and should not be regarded as benign.

Surgical versus transcatheter aortic valve replacement in patients age <65 years Open

Eishan Ashwat, Sarah Yousef, James A. Brown, Derek Serna‐Gallegos, Nidhi Iyanna , et al. · 2025

Robotically-assisted, totally endoscopic myocardial bridge unroofing: surgical technique Open

Andrea Amabile, Nicholas R. Hess, Bryant Fisher, Faaz Ashraf, Ariana Jackson , et al. · 2025

Cerebral malperfusion resolution after repair of acute DeBakey type I dissection with a novel hybrid prosthesis: early results of the PERSEVERE Study Open

William T. Brinkman, John J. Squiers, Arminder S. Jassar, Shinichi Fukuhara, Fernando Fleischman , et al. · 2025

OBJECTIVES Patients undergoing hemiarch repair for acute DeBakey type I dissection (ADTI) are high risk for postoperative stroke, especially if cerebral malperfusion is present preoperatively. We sought to evaluate whether the AMDS Hybrid …

Small cuts, big questions: the impact of incision length in minimally invasive robotic cardiac surgery Open

Thomas E. Rubino, Ariana Jackson, Martin Winter, Kristian Punu, Syed Faaz Ashraf , et al. · 2025

Introduction Evidence on incision lengths for ports and cardiopulmonary bypass (CPB) cannulation in robotic cardiac surgery is limited. This study aimed to assess these metrics and influencing factors. Methods 204 patients underwent roboti…

Natural History of Tricuspid Regurgitation After Transcatheter Aortic Valve Implantation Open

James A. Brown, Jack K. Donohue, Sarah Yousef, Nidhi Iyanna, Danial Ahmad , et al. · 2025

Background To determine the impact of tricuspid regurgitation (TR) on outcomes after transcatheter aortic valve implantation (TAVI), and to determine the evolution of TR severity after TAVI. Methods This was an observational study of TAVIs…

PCR-Based Analysis of HBV and HCV Viral Loads and Their Impact on Liver Disease in Chronic Patients Open

Ayesha Faheem, Shahid Hafeez, Faizan Hameed, Asim Shahid, Muhammad Imran Naseer , et al. · 2025

Background: Chronic hepatitis B (HBV) and C (HCV) infections are leading causes of global liver disease morbidity and mortality, yet the precise relationship between viral load and liver disease severity in regional populations remains ins…

72214 | Valve-in-Valve TAVR Using the Navitor Transcatheter Heart Valve Open

John Saxon, Leora T. Yarboro, Michael Ragosta, Ibrahim Sultan, D. R. F. West , et al. · 2025

Outcomes of surgical versus transcatheter aortic valve replacement in patients with low-flow, low-gradient aortic stenosis Open

James A. Brown, Eishan Ashwat, Nav Warraich, Nidhi Iyanna, Derek Serna‐Gallegos , et al. · 2025

Global Results From the Optimize PRO Study: Standardized TAVR Technique and Care Pathway Open

Kendra J. Grubb, Hemal Gada, Douglas Fraser, Josep Rodés‐Cabau, Tamim Nazif , et al. · 2025

Deficiency of fibroblast growth factor 2 promotes contractile phenotype of pericytes in ascending thoracic aortic aneurysm Open

Weijian Huang, Jennifer C. Hill, S. Patel, Tara D. Richards, Ibrahim Sultan , et al. · 2025

Here, we revealed that pericytes transition into a contractile phenotype in human ATAA. We demonstrated that FGF2 maintained pericytes in a less contractile and high angiogenic stage via MAPK and PI3K-AKT signaling pathway, whereas we foun…

Race and sex disparities in resource use and outcomes after acute type A aortic dissection repair Open

Carlos E. Díaz-Castrillón, Derek Serna‐Gallegos, Shwetabh Tarun, Nidhi Iyanna, Sarah Yousef , et al. · 2025

Significant race- and sex-based disparities exist in perioperative care following ATAAD repair. Further research on social determinants of health is needed to understand patient interactions with surgical care.

Cerebral Embolic Protection Devices in Transcatheter Aortic Valve Implantation: Meta‐Analysis With Trial Sequential Analysis Open

Nav Warraich, Michel Pompeu Sá, Xander Jacquemyn, Toshiki Kuno, Derek Serna‐Gallegos , et al. · 2025

Background We aimed to reevaluate randomized controlled trial data on outcomes of cerebral embolic protection device use during transcatheter aortic valve implantation. A conventional meta‐analysis followed by trial sequential analysis was…

Implications of tracheostomy after acute type A aortic dissection repair: Longitudinal outcomes and factors associated with patients requiring it Open

Carlos E. Díaz-Castrillón, Derek Serna‐Gallegos, Shwetabh Tarun, Pyongsoo Yoon, Johannes Bonatti , et al. · 2025

Tracheostomy is associated with significant longitudinal mortality and readmissions after ATAAD repair. The CART model highlights the relevance of reintubation for clinical decision making. Improved predictive models may enable early inter…

The current state of transcatheter aortic valve replacement explant: an updated systematic review Open

Michel Pompeu Sá, Eishan Ashwat, Xander Jacquemyn, Danial Ahmad, James A. Brown , et al. · 2025

TAVR explant remains a rare event, but its clinical impact is non-negligible. Lifetime management strategies should be adopted in younger lower-risk patients when choosing THVs for the index TAVR.

The healthcare burden of isolated aortic valve insufficiency Open

Ibrahim Sultan, Michael T. Ryan, Candace Gunnarsson, Natalie Heidrich, Prashanth Vallabhajosyula · 2025

To analyze and compare the differences in mortality, healthcare utilization, and costs between patients with symptomatic and asymptomatic isolated aortic insufficiency (AI). We utilized Optum United Health Care Database for US patients who…

Effects of Nighttime Procurement and Transplantation on Outcomes Following Heart Transplantation Open

Yeahwa Hong, Nicholas R. Hess, Ander Dorken‐Gallastegi, Mohamed Abdullah, Nidhi Iyanna , et al. · 2025

Background This study evaluates the effects of nighttime procurement and transplantation on outcomes following heart transplantation. Methods The UNOS registry was queried to analyze adult recipients who underwent isolated orthotopic heart…

Readmission Mortality After TAVR: The Combined Effect of Teaching Hospital Status and Cause of Readmission Open

Carlos E. Díaz-Castrillón, Dustin Kliner, Derek Serna‐Gallegos, Catalin Toma, AJ Conrad Smith , et al. · 2025

Preoperative Hematocrit Is Not Associated With Stroke After Surgery for Acute Type A Aortic Dissection Open

James A. Brown, Zihan Feng, Shwetabh Tarun, Veenah Stoll, Derek Serna‐Gallegos , et al. · 2025

Outcomes of acute type A aortic dissection repair in patients under the age of 75 versus 75 and older Open

Reyna Jones, Sarah Yousef, James A. Brown, Derek Serna‐Gallegos, Danial Ahmad , et al. · 2025

Objective Elderly patients are less likely to undergo surgery for an acute type A aortic dissection (ATAAD). This study aims to understand the risks of surgical treatment in patients 75 and older. Methods This was a retrospective study usi…

Mini-Sternotomy vs. Right Anterior Mini-Thoracotomy for Surgical Aortic Valve Replacement – A Systematic Review and Meta-Analysis Open

Dimitrios Starvridis, Arian Arjomandi Rad, Paola Keese Montanhesi, Hristo Kirov, Max Wacker , et al. · 2025

The results suggest that both techniques present similar perioperative mortality rates for aortic valve replacement. However, right anterior mini-thoracotomy is associated with higher rates of reoperation for bleeding, lower rates of strok…

External validation of the German Registry for Acute Aortic Dissection Type A score in patients undergoing surgery for acute type A aortic dissection Open

Danial Ahmad, Derek Serna‐Gallegos, Ariana Jackson, David Kaczorowski, Johannes Bonatti , et al. · 2024

Feasibility, safety and quality of complex mitral valve repair in the early phase of a robotic surgery programme Open

Kei Kobayashi, Yizhan Guo, Thomas E. Rubino, Luis Eduardo Ramı́rez, Stephen D. Waterford , et al. · 2024

OBJECTIVES To evaluate the feasibility, safety and quality of robotic-assisted mitral valve repair in complex versus non-complex cases during the early phase of a programme. METHODS Since the programme launch in September 2021 until Februa…

Intraoperative neurophysiologic monitoring during cardiac surgery: an observational cohort study Open

James A. Brown, Nidhi Iyanna, Sarah Yousef, Derek Serna‐Gallegos, Jianhui Zhu , et al. · 2024

Objective To evaluate the impact of intraoperative neuromonitoring (IONM) on stroke and operative mortality after coronary and/or valvular operations. Methods This was an observational study of coronary and/or valvular heart operations fro…

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