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View article: Supplementary Movie 1 - TEM assay MOCK transduced endothelial cells and CD8 T cells from VISTA Expression on Cancer-Associated Endothelium Selectively Prevents T-cell Extravasation
Supplementary Movie 1 - TEM assay MOCK transduced endothelial cells and CD8 T cells from VISTA Expression on Cancer-Associated Endothelium Selectively Prevents T-cell Extravasation Open
Movie of a transendothelial migration assay using MOCK transduced endothelial cells and CD8 T cells that were derived from healthy PBMCs. Total duration of the movie is 20 minutes. Each datapoint in figure 5 and supplementary figures 7 and…
View article: Supplementary Figures and Tables from VISTA Expression on Cancer-Associated Endothelium Selectively Prevents T-cell Extravasation
Supplementary Figures and Tables from VISTA Expression on Cancer-Associated Endothelium Selectively Prevents T-cell Extravasation Open
Supplementary Figures and Tables
View article: Risk-Prediction Models for Clinical Decision-Making in Sarcoma Care: An International Survey Among Soft-Tissue Sarcoma Clinicians
Risk-Prediction Models for Clinical Decision-Making in Sarcoma Care: An International Survey Among Soft-Tissue Sarcoma Clinicians Open
Introduction Risk prediction models (RPMs) are statistical tools that predict outcomes on the basis of clinical characteristics and can thereby support (shared) decision-making. With the shift toward personalized medicine, the number of RP…
View article: Immunological differences between monophasic and biphasic synovial sarcoma with implications for immunotherapy
Immunological differences between monophasic and biphasic synovial sarcoma with implications for immunotherapy Open
View article: Diagnosis of chondrosarcoma in a noninvasive way using volatile organic compounds in exhaled breath: a pilot study
Diagnosis of chondrosarcoma in a noninvasive way using volatile organic compounds in exhaled breath: a pilot study Open
Aim: Aim of this explorative pilot study was to evaluate the capability of an electronic nose (aeoNose, the eNose Company) to classify healthy individuals and patients with chondrosarcoma, based on their volatile organic compound pr…
View article: Preoperative Classification of Peripheral Nerve Sheath Tumors on MRI Using Radiomics
Preoperative Classification of Peripheral Nerve Sheath Tumors on MRI Using Radiomics Open
Malignant peripheral nerve sheath tumors (MPNSTs) are aggressive soft-tissue tumors prevalent in neurofibromatosis type 1 (NF1) patients, posing a significant risk of metastasis and recurrence. Current magnetic resonance imaging (MRI) imag…
View article: Local recurrence in malignant peripheral nerve sheath tumours: multicentre cohort study
Local recurrence in malignant peripheral nerve sheath tumours: multicentre cohort study Open
Background Malignant peripheral nerve sheath tumours (MPNSTs) have high local recurrence (LR) rates. Literature varies on LR risk factors and treatment. This study aimed to elucidate treatment options and risk factors for first and second …
View article: Survival after resection of malignant peripheral nerve sheath tumors: Introducing and validating a novel type-specific prognostic model
Survival after resection of malignant peripheral nerve sheath tumors: Introducing and validating a novel type-specific prognostic model Open
Background This study aimed to assess the performance of currently available risk calculators in a cohort of patients with malignant peripheral nerve sheath tumors (MPNST) and to create an MPNST-specific prognostic model including type-spe…
View article: Effect of radiotherapy on local recurrence, distant metastasis and overall survival in 1200 extremity soft tissue sarcoma patients. Retrospective analysis using IPTW-adjusted models
Effect of radiotherapy on local recurrence, distant metastasis and overall survival in 1200 extremity soft tissue sarcoma patients. Retrospective analysis using IPTW-adjusted models Open
NRTX and ARTX are associated with lower LR-risk, but do not seem to affect DM-risk or OS. NRTX may be favoured over ARTX as our results indicate better local control rates.
View article: VISTA Expression on Cancer-Associated Endothelium Selectively Prevents T-cell Extravasation
VISTA Expression on Cancer-Associated Endothelium Selectively Prevents T-cell Extravasation Open
Cancers evade T-cell immunity by several mechanisms such as secretion of anti-inflammatory cytokines, down regulation of antigen presentation machinery, upregulation of immune checkpoint molecules, and exclusion of T cells from tumor tissu…
View article: P11.45.B LOCAL RECURRENCE IN MALIGNANT PERIPHERAL NERVE SHEATH TUMORS: A MULTICENTER COHORT STUDY
P11.45.B LOCAL RECURRENCE IN MALIGNANT PERIPHERAL NERVE SHEATH TUMORS: A MULTICENTER COHORT STUDY Open
BACKGROUND Malignant Peripheral Nerve Sheath Tumors (MPNSTs) are rare and aggressive malignant soft-tissue sarcomas (STS) and compromise 5-10% of STS. About 40% of MPNST cases are associated with neurofibromatosis type 1 (NF1). High-grade …
View article: Noninvasive detection of soft tissue sarcoma using volatile organic compounds in exhaled breath: a pilot study
Noninvasive detection of soft tissue sarcoma using volatile organic compounds in exhaled breath: a pilot study Open
Aim: The aim of this pilot study was to assess whether an electronic nose can detect patients with soft tissue sarcoma (STS) based on volatile organic compound profiles in exhaled breath. Patients & methods: In this cross-sec…
View article: Intermuscular extremity myxoid liposarcoma can be managed by marginal resection following neoadjuvant radiotherapy
Intermuscular extremity myxoid liposarcoma can be managed by marginal resection following neoadjuvant radiotherapy Open
View article: Prediction tools for the personalized management of soft-tissue sarcomas of the extremity
Prediction tools for the personalized management of soft-tissue sarcomas of the extremity Open
Prediction tools are instruments which are commonly used to estimate the prognosis in oncology and facilitate clinical decision-making in a more personalized manner. Their popularity is shown by the increasing numbers of prediction tools, …
View article: The added value of chest imaging after neoadjuvant radiotherapy for soft tissue sarcoma of the extremities and trunk wall: A retrospective cohort study
The added value of chest imaging after neoadjuvant radiotherapy for soft tissue sarcoma of the extremities and trunk wall: A retrospective cohort study Open
View article: The role of perioperative chemotherapy in primary high-grade extremity soft tissue sarcoma: a risk-stratified analysis using PERSARC
The role of perioperative chemotherapy in primary high-grade extremity soft tissue sarcoma: a risk-stratified analysis using PERSARC Open
View article: Corrigendum to ‘Age-related differences of oncological outcomes in primary extremity soft tissue sarcoma: a multistate model including 6260 patients’ [Eur J Cancer 141 (2020) 128-136]
Corrigendum to ‘Age-related differences of oncological outcomes in primary extremity soft tissue sarcoma: a multistate model including 6260 patients’ [Eur J Cancer 141 (2020) 128-136] Open
View article: Multimodality treatment of undifferentiated pleomorphic soft tissue sarcoma of the extremity (eUPS) in the elderly
Multimodality treatment of undifferentiated pleomorphic soft tissue sarcoma of the extremity (eUPS) in the elderly Open
View article: The Association of Metastasis Pattern and Management of Metastatic Disease with Oncological Outcomes in Patients with Malignant Peripheral Nerve Sheath Tumors: A Multicenter Cohort Study
The Association of Metastasis Pattern and Management of Metastatic Disease with Oncological Outcomes in Patients with Malignant Peripheral Nerve Sheath Tumors: A Multicenter Cohort Study Open
Purpose: This multicenter cohort study aimed to identify clinicopathologic and treatment-related factors associated with the development of distant metastasis (DM) and with overall survival (OS) after DM diagnosis in patients with malignan…
View article: Management of Soft Tissue Sarcomas in Extremities: Variation in Treatment Recommendations and Surveillance According to Specialty and Continent
Management of Soft Tissue Sarcomas in Extremities: Variation in Treatment Recommendations and Surveillance According to Specialty and Continent Open
View article: ASO Author Reflections: Towards Patient-Tailored Management of Extremity Soft Tissue Sarcoma
ASO Author Reflections: Towards Patient-Tailored Management of Extremity Soft Tissue Sarcoma Open
View article: Survival Analysis of 3 Different Age Groups and Prognostic Factors among 402 Patients with Skeletal High-Grade Osteosarcoma. Real World Data from a Single Tertiary Sarcoma Center
Survival Analysis of 3 Different Age Groups and Prognostic Factors among 402 Patients with Skeletal High-Grade Osteosarcoma. Real World Data from a Single Tertiary Sarcoma Center Open
Age is a known prognostic factor for many sarcoma subtypes, however in the literature there are limited data on the different risk profiles of different age groups for osteosarcoma survival. This study aims to provide an overview of surviv…
View article: Prognostic Significance of Immunohistochemical Markers and Genetic Alterations in Malignant Peripheral Nerve Sheath Tumors: A Systematic Review
Prognostic Significance of Immunohistochemical Markers and Genetic Alterations in Malignant Peripheral Nerve Sheath Tumors: A Systematic Review Open
Background Malignant peripheral nerve sheath tumors (MPNSTs) are aggressive soft tissue sarcomas with dismal prognosis. Pathological and genetic markers may predict more aggressive behavior in MPNSTs but have uncommonly been investigated, …
View article: Age-related differences of oncological outcomes in primary extremity soft tissue sarcoma: a multistate model including 6260 patients
Age-related differences of oncological outcomes in primary extremity soft tissue sarcoma: a multistate model including 6260 patients Open