Ibuki Harada
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View article: Figure S6 from MARCH2, a Novel Oncogene-regulated SNAIL E3 Ligase, Suppresses Triple-negative Breast Cancer Metastases
Figure S6 from MARCH2, a Novel Oncogene-regulated SNAIL E3 Ligase, Suppresses Triple-negative Breast Cancer Metastases Open
Figure S6 shows prognostic significance of MARCH2 levels in different cancer types
View article: Data from MARCH2, a Novel Oncogene-regulated SNAIL E3 Ligase, Suppresses Triple-negative Breast Cancer Metastases
Data from MARCH2, a Novel Oncogene-regulated SNAIL E3 Ligase, Suppresses Triple-negative Breast Cancer Metastases Open
Epithelial–mesenchymal transition (EMT) in cancer promotes metastasis and chemotherapy resistance. A subset of triple-negative breast cancer (TNBC) exhibits a mesenchymal gene signature that is associated with poor patient outcomes. We pre…
View article: Figure S2 from MARCH2, a Novel Oncogene-regulated SNAIL E3 Ligase, Suppresses Triple-negative Breast Cancer Metastases
Figure S2 from MARCH2, a Novel Oncogene-regulated SNAIL E3 Ligase, Suppresses Triple-negative Breast Cancer Metastases Open
Fig S2 shows the effect of PTK6 kinase inhibitor 4f on SNAIL levels in TNBC cells
View article: FIGURE 2 from MARCH2, a Novel Oncogene-regulated SNAIL E3 Ligase, Suppresses Triple-negative Breast Cancer Metastases
FIGURE 2 from MARCH2, a Novel Oncogene-regulated SNAIL E3 Ligase, Suppresses Triple-negative Breast Cancer Metastases Open
PTK6 inhibition increases ubiquitination and degradation of SNAIL in TNBC. A, PTK6 inhibitor (P21d) treatment or PTK6 shRNA downregulates SNAIL in TNBC cells. Human MDA-MB-231 or mouse MMTV-myc cells were treated with P21d for 24 hours and…
View article: FIGURE 3 from MARCH2, a Novel Oncogene-regulated SNAIL E3 Ligase, Suppresses Triple-negative Breast Cancer Metastases
FIGURE 3 from MARCH2, a Novel Oncogene-regulated SNAIL E3 Ligase, Suppresses Triple-negative Breast Cancer Metastases Open
MARCH2 is a novel PTK6-regulated SNAIL E3 ligase. A, Schema of siRNA screening strategy used to identify PTK6-regulated SNAIL E3 ligases. B, MARCH2 siRNA (SMART Pool) identified as top candidate siRNA that restores SNAIL expression in P21d…
View article: FIGURE 1 from MARCH2, a Novel Oncogene-regulated SNAIL E3 Ligase, Suppresses Triple-negative Breast Cancer Metastases
FIGURE 1 from MARCH2, a Novel Oncogene-regulated SNAIL E3 Ligase, Suppresses Triple-negative Breast Cancer Metastases Open
Expression of SNAIL and PTK6 in TNBC. A, Prognostic significance of SNAIL expression in TNBC. KM survival curves of SNAIL expression in patients with TNBC (defined as estrogen receptor, progesterone receptor, and HER2 negative) using the M…
View article: Figure S8 from MARCH2, a Novel Oncogene-regulated SNAIL E3 Ligase, Suppresses Triple-negative Breast Cancer Metastases
Figure S8 from MARCH2, a Novel Oncogene-regulated SNAIL E3 Ligase, Suppresses Triple-negative Breast Cancer Metastases Open
Figure S8 shows effect of MARCH2 shRNA expression on growth of MDA-MB231 cells
View article: Figure S4 from MARCH2, a Novel Oncogene-regulated SNAIL E3 Ligase, Suppresses Triple-negative Breast Cancer Metastases
Figure S4 from MARCH2, a Novel Oncogene-regulated SNAIL E3 Ligase, Suppresses Triple-negative Breast Cancer Metastases Open
Figure S4 shows validation of screening approach and novel SNAIL E3 ligase candidates identifed by screen
View article: FIGURE 6 from MARCH2, a Novel Oncogene-regulated SNAIL E3 Ligase, Suppresses Triple-negative Breast Cancer Metastases
FIGURE 6 from MARCH2, a Novel Oncogene-regulated SNAIL E3 Ligase, Suppresses Triple-negative Breast Cancer Metastases Open
MARCH2 suppresses growth, migration, survival, and metastases of TNBC. A, MARCH2 expression is associated with favorable prognosis in patients with breast cancer using TCGA data (n = 1,052) and METABRIC data (n = 1302). Breast cancer sampl…
View article: Figure S4 from MARCH2, a Novel Oncogene-regulated SNAIL E3 Ligase, Suppresses Triple-negative Breast Cancer Metastases
Figure S4 from MARCH2, a Novel Oncogene-regulated SNAIL E3 Ligase, Suppresses Triple-negative Breast Cancer Metastases Open
Figure S4 shows validation of screening approach and novel SNAIL E3 ligase candidates identifed by screen
View article: FIGURE 3 from MARCH2, a Novel Oncogene-regulated SNAIL E3 Ligase, Suppresses Triple-negative Breast Cancer Metastases
FIGURE 3 from MARCH2, a Novel Oncogene-regulated SNAIL E3 Ligase, Suppresses Triple-negative Breast Cancer Metastases Open
MARCH2 is a novel PTK6-regulated SNAIL E3 ligase. A, Schema of siRNA screening strategy used to identify PTK6-regulated SNAIL E3 ligases. B, MARCH2 siRNA (SMART Pool) identified as top candidate siRNA that restores SNAIL expression in P21d…
View article: FIGURE 6 from MARCH2, a Novel Oncogene-regulated SNAIL E3 Ligase, Suppresses Triple-negative Breast Cancer Metastases
FIGURE 6 from MARCH2, a Novel Oncogene-regulated SNAIL E3 Ligase, Suppresses Triple-negative Breast Cancer Metastases Open
MARCH2 suppresses growth, migration, survival, and metastases of TNBC. A, MARCH2 expression is associated with favorable prognosis in patients with breast cancer using TCGA data (n = 1,052) and METABRIC data (n = 1302). Breast cancer sampl…
View article: Figure S7 from MARCH2, a Novel Oncogene-regulated SNAIL E3 Ligase, Suppresses Triple-negative Breast Cancer Metastases
Figure S7 from MARCH2, a Novel Oncogene-regulated SNAIL E3 Ligase, Suppresses Triple-negative Breast Cancer Metastases Open
Figure S7 shows effect of MARCH2 overexpression on primary tumor growth of MDA-MB231 LM2-4 primary xenografts
View article: Figure S5 from MARCH2, a Novel Oncogene-regulated SNAIL E3 Ligase, Suppresses Triple-negative Breast Cancer Metastases
Figure S5 from MARCH2, a Novel Oncogene-regulated SNAIL E3 Ligase, Suppresses Triple-negative Breast Cancer Metastases Open
Figure S5 shows effect of MARCH2 on levels of EMT driver proteins
View article: Figure S6 from MARCH2, a Novel Oncogene-regulated SNAIL E3 Ligase, Suppresses Triple-negative Breast Cancer Metastases
Figure S6 from MARCH2, a Novel Oncogene-regulated SNAIL E3 Ligase, Suppresses Triple-negative Breast Cancer Metastases Open
Figure S6 shows prognostic significance of MARCH2 levels in different cancer types
View article: Figure S1 from MARCH2, a Novel Oncogene-regulated SNAIL E3 Ligase, Suppresses Triple-negative Breast Cancer Metastases
Figure S1 from MARCH2, a Novel Oncogene-regulated SNAIL E3 Ligase, Suppresses Triple-negative Breast Cancer Metastases Open
Figure S1 shows Kaplan-Meier curves associated with EMT driver genes
View article: Figure S7 from MARCH2, a Novel Oncogene-regulated SNAIL E3 Ligase, Suppresses Triple-negative Breast Cancer Metastases
Figure S7 from MARCH2, a Novel Oncogene-regulated SNAIL E3 Ligase, Suppresses Triple-negative Breast Cancer Metastases Open
Figure S7 shows effect of MARCH2 overexpression on primary tumor growth of MDA-MB231 LM2-4 primary xenografts
View article: FIGURE 5 from MARCH2, a Novel Oncogene-regulated SNAIL E3 Ligase, Suppresses Triple-negative Breast Cancer Metastases
FIGURE 5 from MARCH2, a Novel Oncogene-regulated SNAIL E3 Ligase, Suppresses Triple-negative Breast Cancer Metastases Open
PTK6 inhibition enhances MARCH2:SNAIL association. A, MDA-MB-231 cells expressing FLAG-Snail and HA-MARCH2 (WT) were treated with vehicle control or P21d for 4 or 18 hours in the presence of MG132. MARCH2–SNAIL interaction was assessed by …
View article: Data from MARCH2, a Novel Oncogene-regulated SNAIL E3 Ligase, Suppresses Triple-negative Breast Cancer Metastases
Data from MARCH2, a Novel Oncogene-regulated SNAIL E3 Ligase, Suppresses Triple-negative Breast Cancer Metastases Open
Epithelial–mesenchymal transition (EMT) in cancer promotes metastasis and chemotherapy resistance. A subset of triple-negative breast cancer (TNBC) exhibits a mesenchymal gene signature that is associated with poor patient outcomes. We pre…
View article: Figure S8 from MARCH2, a Novel Oncogene-regulated SNAIL E3 Ligase, Suppresses Triple-negative Breast Cancer Metastases
Figure S8 from MARCH2, a Novel Oncogene-regulated SNAIL E3 Ligase, Suppresses Triple-negative Breast Cancer Metastases Open
Figure S8 shows effect of MARCH2 shRNA expression on growth of MDA-MB231 cells
View article: FIGURE 7 from MARCH2, a Novel Oncogene-regulated SNAIL E3 Ligase, Suppresses Triple-negative Breast Cancer Metastases
FIGURE 7 from MARCH2, a Novel Oncogene-regulated SNAIL E3 Ligase, Suppresses Triple-negative Breast Cancer Metastases Open
MARCH2 suppresses metastases of TNBC cells. A, Metastatic lung colonization by MDA-MB-231/Luciferase cells expressing vector control, WT MARCH2, or RING domain–mutant (W97A) MARCH2 following tail vein injection was serially assessed by IVI…
View article: FIGURE 2 from MARCH2, a Novel Oncogene-regulated SNAIL E3 Ligase, Suppresses Triple-negative Breast Cancer Metastases
FIGURE 2 from MARCH2, a Novel Oncogene-regulated SNAIL E3 Ligase, Suppresses Triple-negative Breast Cancer Metastases Open
PTK6 inhibition increases ubiquitination and degradation of SNAIL in TNBC. A, PTK6 inhibitor (P21d) treatment or PTK6 shRNA downregulates SNAIL in TNBC cells. Human MDA-MB-231 or mouse MMTV-myc cells were treated with P21d for 24 hours and…
View article: FIGURE 4 from MARCH2, a Novel Oncogene-regulated SNAIL E3 Ligase, Suppresses Triple-negative Breast Cancer Metastases
FIGURE 4 from MARCH2, a Novel Oncogene-regulated SNAIL E3 Ligase, Suppresses Triple-negative Breast Cancer Metastases Open
MARCH2 promotes ubiquitination and downregulation of SNAIL. A, HA-tagged WT, but not RING domain–mutant (W97A), MARCH2 downregulates SNAIL levels in MDA-MB-231 cells. B, MARCH2 coprecipitates with SNAIL in MDA-MB-231 cells coexpressing FLA…
View article: FIGURE 7 from MARCH2, a Novel Oncogene-regulated SNAIL E3 Ligase, Suppresses Triple-negative Breast Cancer Metastases
FIGURE 7 from MARCH2, a Novel Oncogene-regulated SNAIL E3 Ligase, Suppresses Triple-negative Breast Cancer Metastases Open
MARCH2 suppresses metastases of TNBC cells. A, Metastatic lung colonization by MDA-MB-231/Luciferase cells expressing vector control, WT MARCH2, or RING domain–mutant (W97A) MARCH2 following tail vein injection was serially assessed by IVI…
View article: FIGURE 5 from MARCH2, a Novel Oncogene-regulated SNAIL E3 Ligase, Suppresses Triple-negative Breast Cancer Metastases
FIGURE 5 from MARCH2, a Novel Oncogene-regulated SNAIL E3 Ligase, Suppresses Triple-negative Breast Cancer Metastases Open
PTK6 inhibition enhances MARCH2:SNAIL association. A, MDA-MB-231 cells expressing FLAG-Snail and HA-MARCH2 (WT) were treated with vehicle control or P21d for 4 or 18 hours in the presence of MG132. MARCH2–SNAIL interaction was assessed by …
View article: Figure S1 from MARCH2, a Novel Oncogene-regulated SNAIL E3 Ligase, Suppresses Triple-negative Breast Cancer Metastases
Figure S1 from MARCH2, a Novel Oncogene-regulated SNAIL E3 Ligase, Suppresses Triple-negative Breast Cancer Metastases Open
Figure S1 shows Kaplan-Meier curves associated with EMT driver genes
View article: FIGURE 1 from MARCH2, a Novel Oncogene-regulated SNAIL E3 Ligase, Suppresses Triple-negative Breast Cancer Metastases
FIGURE 1 from MARCH2, a Novel Oncogene-regulated SNAIL E3 Ligase, Suppresses Triple-negative Breast Cancer Metastases Open
Expression of SNAIL and PTK6 in TNBC. A, Prognostic significance of SNAIL expression in TNBC. KM survival curves of SNAIL expression in patients with TNBC (defined as estrogen receptor, progesterone receptor, and HER2 negative) using the M…
View article: Figure S2 from MARCH2, a Novel Oncogene-regulated SNAIL E3 Ligase, Suppresses Triple-negative Breast Cancer Metastases
Figure S2 from MARCH2, a Novel Oncogene-regulated SNAIL E3 Ligase, Suppresses Triple-negative Breast Cancer Metastases Open
Fig S2 shows the effect of PTK6 kinase inhibitor 4f on SNAIL levels in TNBC cells
View article: FIGURE 4 from MARCH2, a Novel Oncogene-regulated SNAIL E3 Ligase, Suppresses Triple-negative Breast Cancer Metastases
FIGURE 4 from MARCH2, a Novel Oncogene-regulated SNAIL E3 Ligase, Suppresses Triple-negative Breast Cancer Metastases Open
MARCH2 promotes ubiquitination and downregulation of SNAIL. A, HA-tagged WT, but not RING domain–mutant (W97A), MARCH2 downregulates SNAIL levels in MDA-MB-231 cells. B, MARCH2 coprecipitates with SNAIL in MDA-MB-231 cells coexpressing FLA…
View article: Figure S5 from MARCH2, a Novel Oncogene-regulated SNAIL E3 Ligase, Suppresses Triple-negative Breast Cancer Metastases
Figure S5 from MARCH2, a Novel Oncogene-regulated SNAIL E3 Ligase, Suppresses Triple-negative Breast Cancer Metastases Open
Figure S5 shows effect of MARCH2 on levels of EMT driver proteins