Idan Cohen
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View article: Pharmacological Activation of SIRT6 Suppresses Progression of Head and Neck and Esophagus Squamous Cell Carcinoma by Modulation of Cellular Metabolism and Protein Translation
Pharmacological Activation of SIRT6 Suppresses Progression of Head and Neck and Esophagus Squamous Cell Carcinoma by Modulation of Cellular Metabolism and Protein Translation Open
Sirtuin 6 (SIRT6), a NAD+ -dependent histone deacetylase, has been shown to function as a tumor suppressor gene in several cancer types, including in squamous cell carcinoma of the head and neck and esophagus (HNSCC and ESCC). However, the…
View article: CLDN1 Arg81His founder variant causes ichthyosis, leukocyte vacuoles, alopecia, and sclerosing cholangitis (ILVASC) syndrome in Moroccan Jews
CLDN1 Arg81His founder variant causes ichthyosis, leukocyte vacuoles, alopecia, and sclerosing cholangitis (ILVASC) syndrome in Moroccan Jews Open
Neonatal ichthyosis and sclerosing cholangitis syndrome (NISCH), also known as ichthyosis, leukocyte vacuoles, alopecia, and sclerosing cholangitis (ILVASC), is an extremely rare disease of autosomal recessive inheritance, resulting from l…
View article: Histone Mono-Ubiquitination in Transcriptional Regulation and Its Mark on Life: Emerging Roles in Tissue Development and Disease
Histone Mono-Ubiquitination in Transcriptional Regulation and Its Mark on Life: Emerging Roles in Tissue Development and Disease Open
Epigenetic regulation plays an essential role in driving precise transcriptional programs during development and homeostasis. Among epigenetic mechanisms, histone mono-ubiquitination has emerged as an important post-transcriptional modific…
View article: MEK1/2 inhibition transiently alters the tumor immune microenvironment to enhance immunotherapy efficacy against head and neck cancer
MEK1/2 inhibition transiently alters the tumor immune microenvironment to enhance immunotherapy efficacy against head and neck cancer Open
Background Although the mitogen-activated protein kinases (MAPK) pathway is hyperactive in head and neck cancer (HNC), inhibition of MEK1/2 in HNC patients has not shown clinically meaningful activity. Therefore, we aimed to characterize t…
View article: Polycomb Repressive Complex(es) and Their Role in Adult Stem Cells
Polycomb Repressive Complex(es) and Their Role in Adult Stem Cells Open
Populations of resident stem cells (SCs) are responsible for maintaining, repairing, and regenerating adult tissues. In addition to having the capacity to generate all the differentiated cell types of the tissue, adult SCs undergo long per…
View article: MEK1/2 inhibition transiently alters the tumor immune microenvironment to enhance immunotherapy efficacy against head and neck cancer
MEK1/2 inhibition transiently alters the tumor immune microenvironment to enhance immunotherapy efficacy against head and neck cancer Open
Although the mitogen-activated protein kinases (MAPK) pathway is hyperactive in head and neck cancer (HNC), inhibition of MEK1/2 in HNC patients has not shown clinically meaningful activity. Using pre-clinical HNC models, we demonstrated t…
View article: Polycomb complexes redundantly maintain epidermal stem cell identity during development
Polycomb complexes redundantly maintain epidermal stem cell identity during development Open
Polycomb repressive complex 1 (PRC1) and PRC2 are critical epigenetic developmental regulators. PRC1 and PRC2 largely overlap in their genomic binding and cooperate to establish repressive chromatin domains demarcated by H2AK119ub and H3K2…
View article: Activity of PRC1 and Histone H2AK119 Monoubiquitination: Revising Popular Misconceptions
Activity of PRC1 and Histone H2AK119 Monoubiquitination: Revising Popular Misconceptions Open
Polycomb group proteins are evolutionary conserved chromatin‐modifying complexes, essential for the regulation of developmental and cell‐identity genes. Polycomb‐mediated transcriptional regulation is provided by two multi‐protein complexe…
View article: Epigenetic gene regulation, chromatin structure, and force-induced chromatin remodelling in epidermal development and homeostasis
Epigenetic gene regulation, chromatin structure, and force-induced chromatin remodelling in epidermal development and homeostasis Open
The skin epidermis is a constantly renewing stratified epithelium that provides essential protective barrier functions throughout life. Epidermal stratification is governed by a step-wise differentiation program that requires precise spati…
View article: Dissection of Merkel cell formation in hairy and glabrous skin reveals a common requirement for <scp>FGFR</scp>2‐mediated signalling
Dissection of Merkel cell formation in hairy and glabrous skin reveals a common requirement for <span>FGFR</span>2‐mediated signalling Open
Merkel cells are mechanosensory cells involved in tactile discrimination. Merkel cells have been primarily studied in the murine back skin, where they are found in specialized structures called touch domes located around primary hair folli…
View article: PRC1 preserves epidermal tissue integrity independently of PRC2
PRC1 preserves epidermal tissue integrity independently of PRC2 Open
Polycomb-repressive complex 1 (PRC1) and PRC2 are critical chromatin regulators of gene expression and tissue development. Here, we show that despite extensive genomic cobinding, PRC1 is essential for epidermal integrity, whereas PRC2 is d…
View article: FGF signalling controls the specification of hair placode-derived SOX9 positive progenitors to Merkel cells
FGF signalling controls the specification of hair placode-derived SOX9 positive progenitors to Merkel cells Open
Merkel cells are innervated mechanosensory cells responsible for light-touch sensations. In murine dorsal skin, Merkel cells are located in touch domes and found in the epidermis around primary hairs. While it has been shown that Merkel ce…
View article: RSRC1 mutation affects intellect and behaviour through aberrant splicing and transcription, downregulating IGFBP3
RSRC1 mutation affects intellect and behaviour through aberrant splicing and transcription, downregulating IGFBP3 Open
RSRC1, whose polymorphism is associated with altered brain function in schizophrenia, is a member of the serine and arginine rich-related protein family. Through homozygosity mapping and whole exome sequencing we show that RSRC1 mutation c…
View article: Polycomb-Mediated Repression and Sonic Hedgehog Signaling Interact to Regulate Merkel Cell Specification during Skin Development
Polycomb-Mediated Repression and Sonic Hedgehog Signaling Interact to Regulate Merkel Cell Specification during Skin Development Open
An increasing amount of evidence indicates that developmental programs are tightly regulated by the complex interplay between signaling pathways, as well as transcriptional and epigenetic processes. Here, we have uncovered coordination bet…
View article: ALFY-Controlled DVL3 Autophagy Regulates Wnt Signaling, Determining Human Brain Size
ALFY-Controlled DVL3 Autophagy Regulates Wnt Signaling, Determining Human Brain Size Open
Primary microcephaly is a congenital neurodevelopmental disorder of reduced head circumference and brain volume, with fewer neurons in the cortex of the developing brain due to premature transition between symmetrical and asymmetrical cell…