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View article: Visium sample preparation from human Middle Temporal Gyrus v1
Visium sample preparation from human Middle Temporal Gyrus v1 Open
This protocol describes a workflow to prepare and Run Visium Spatial Transcriptomics samples from human Middle Temporal Gyrus.
View article: Experimental and Computational Methods for Allelic Imbalance Analysis from Single-Nucleus RNA-seq Data
Experimental and Computational Methods for Allelic Imbalance Analysis from Single-Nucleus RNA-seq Data Open
Single-cell RNA-seq (scRNA-seq) is emerging as a powerful tool for understanding gene function across diverse cells. Recently, this has included the use of allele-specific expression (ASE) analysis to better understand how variation in the…
View article: Health phenome of Parkinson’s patients reveals prominent mood-sleep cluster
Health phenome of Parkinson’s patients reveals prominent mood-sleep cluster Open
Background: Associations between phenotypic traits, environmental exposures, and Parkinson’s disease have largely been evaluated one-by-one, piecemeal, and pre-selections. A comprehensive picture of comorbidities, phenotypes, exposures, an…
View article: Utilizing low‐volume PBMC samples from Alzheimer’s disease clinical research cohorts for immune cell RNA‐sequencing
Utilizing low‐volume PBMC samples from Alzheimer’s disease clinical research cohorts for immune cell RNA‐sequencing Open
Background Studies using peripheral blood mononuclear cells (PBMCs) from individuals with Alzheimer’s disease (AD) biomarker information has the potential to clarify the role of peripheral immune systems in AD. However, PBMC collection oft…
View article: Repeated mild traumatic brain injury triggers pathology in asymptomatic C9ORF72 transgenic mice
Repeated mild traumatic brain injury triggers pathology in asymptomatic C9ORF72 transgenic mice Open
Frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) are fatal neurodegenerative diseases that represent ends of the spectrum of a single disease. The most common genetic cause of FTD and ALS is a hexanucleotide repeat exp…
View article: Positive maternal affect during mother–litter interaction is reduced in new mother rats exhibiting a depression-like phenotype
Positive maternal affect during mother–litter interaction is reduced in new mother rats exhibiting a depression-like phenotype Open
The experience of positive affect during new motherhood is considered essential for a healthy mother–infant relationship, with life-long consequences for both mother and child. Affective availability and contingent responsiveness are often…
View article: Plasma biomarkers for diagnosis of Alzheimer's disease and prediction of cognitive decline in individuals with mild cognitive impairment
Plasma biomarkers for diagnosis of Alzheimer's disease and prediction of cognitive decline in individuals with mild cognitive impairment Open
Background The last few years have seen major advances in blood biomarkers for Alzheimer's Disease (AD) with the development of ultrasensitive immunoassays, promising to transform how we diagnose, prognose, and track progression of neurode…
View article: Clinical Trial-Ready Patient Cohorts for Multiple System Atrophy: Coupling Biospecimen and iPSC Banking to Longitudinal Deep-Phenotyping
Clinical Trial-Ready Patient Cohorts for Multiple System Atrophy: Coupling Biospecimen and iPSC Banking to Longitudinal Deep-Phenotyping Open
Multiple system atrophy (MSA) is a fatal neurodegenerative disease of unknown etiology characterized by widespread aggregation of the protein alpha-synuclein in neurons and glia. Its orphan status, biological relationship to Parkinson’s di…
View article: Proteome profiling of cerebrospinal fluid reveals biomarker candidates for Parkinson’s disease
Proteome profiling of cerebrospinal fluid reveals biomarker candidates for Parkinson’s disease Open
Parkinson's disease (PD) is a growing burden worldwide, and there is no reliable biomarker used in clinical routines to date. Cerebrospinal fluid (CSF) is routinely collected in patients with neurological symptoms and should closely reflec…
View article: Plasma biomarkers for diagnosis of Alzheimer’s disease and prediction of cognitive decline in individuals with mild cognitive impairment
Plasma biomarkers for diagnosis of Alzheimer’s disease and prediction of cognitive decline in individuals with mild cognitive impairment Open
Background The last few years have seen major advances in blood biomarkers for Alzheimer’s Disease (AD) with the development of ultrasensitive immunoassays, promising to transform how we diagnose, prognose, and track progression of neurode…
View article: Towards a phenome-wide view of Parkinson’s disease
Towards a phenome-wide view of Parkinson’s disease Open
Background and Objectives Many studies have examined the relation between PD and environmental variables serially --- one candidate association at a time. In the real world however, both environmental exposures and patients are much more c…
View article: Glucosylceramide in cerebrospinal fluid of patients with GBA-associated and idiopathic Parkinson’s disease enrolled in PPMI
Glucosylceramide in cerebrospinal fluid of patients with GBA-associated and idiopathic Parkinson’s disease enrolled in PPMI Open
Protein-coding variants in the GBA gene modulate susceptibility and progression in ~10% of patients with Parkinson’s disease (PD). GBA encodes the β-glucocerebrosidase enzyme that hydrolyzes glucosylceramide. We hypothesized that GBA mutat…
View article: Proteome Profiling of Cerebrospinal Fluid Reveals Novel Biomarker Candidates for Parkinson’s Disease
Proteome Profiling of Cerebrospinal Fluid Reveals Novel Biomarker Candidates for Parkinson’s Disease Open
SUMMARY Parkinson’s disease (PD) is a growing burden worldwide, and despite ongoing efforts to find reliable biomarkers for early and differential diagnosis, prognosis and disease monitoring, there is no biofluid biomarker used in clinical…
View article: Vocal Communication During Early Mother-Infant Interaction: Studies Using the Wistar-Kyoto Rat Model of Depression
Vocal Communication During Early Mother-Infant Interaction: Studies Using the Wistar-Kyoto Rat Model of Depression Open
Postpartum depression is a serious psychiatric condition that has deleterious effects on the mother and poses a risk for the mother-infant relationship and ultimately the infant’s development. Maternal anhedonia and social communication de…
View article: β-Glucocerebrosidase activity in <i>GBA</i> -linked Parkinson disease
β-Glucocerebrosidase activity in <i>GBA</i> -linked Parkinson disease Open
Residual activity of the β-glucocerebrosidase enzyme measured in blood inversely correlates with clinical severity types of GBA mutations in PD. β-Glucocerebrosidase activity is a quantitative endophenotype that can be monitored noninvasiv…