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View article: Endocrine effects of long-term calcineurin inhibitor use in solid organ transplant recipients
Endocrine effects of long-term calcineurin inhibitor use in solid organ transplant recipients Open
Background The calcineurin inhibitors (CNIs) ciclosporin and tacrolimus are cornerstone immunosuppressants in solid organ transplantation, yet calcineurin blockade in endocrine tissues produces characteristic metabolic sequelae. This revie…
View article: Drug-Drug Interactions Between Glucagon-Like Peptide 1 Receptor Agonists and Oral Medications: A Systematic Review
Drug-Drug Interactions Between Glucagon-Like Peptide 1 Receptor Agonists and Oral Medications: A Systematic Review Open
View article: Post metabolic bariatric surgery weight regain: the importance of GLP-1 levels
Post metabolic bariatric surgery weight regain: the importance of GLP-1 levels Open
Weight regain and insufficient weight loss are essential problems after metabolic bariatric surgery (MBS) in people living with obesity. Changes in the level of glucagon-like peptide-1 (GLP-1) secreted from the gut after bariatric surgery …
View article: P164 Dysplasia detection rates in a surveillance program real-world data from a tertiary referral center for inflammatory bowel diseases
P164 Dysplasia detection rates in a surveillance program real-world data from a tertiary referral center for inflammatory bowel diseases Open
Background Patients with inflammatory bowel diseases (IBD) with an increased risk of developing colorectal carcinoma should undergo periodic surveillance colonoscopies. There is no quality metric for dysplasia detection rate (DDR) in IBD s…
View article: P467 5-ASA is not superior to no-maintenance in patients with newly diagnosed Crohn’s disease - a nationwide cohort from the epi-IIRN
P467 5-ASA is not superior to no-maintenance in patients with newly diagnosed Crohn’s disease - a nationwide cohort from the epi-IIRN Open
Background 5-aminosalicylates (5-ASA) are widely used in Crohn's disease (CD) despite guidelines advising otherwise. In this nationwide study, we aimed to assess the outcomes of first-line 5-ASA-maintenance therapy (5-ASA-MT) compared with…
View article: P661 Clinical response over 24 weeks for initial and delayed responders to induction therapy with risankizumab in Crohn’s disease: data from the ADVANCE and MOTIVATE studies
P661 Clinical response over 24 weeks for initial and delayed responders to induction therapy with risankizumab in Crohn’s disease: data from the ADVANCE and MOTIVATE studies Open
Background The efficacy and safety of risankizumab (RZB) in patients with Crohn’s disease (CD) has been demonstrated.1,2 We reported that an additional 12 weeks (ie, induction period 2) of RZB therapy could induce clinical response in pati…
View article: OP34 Enteral Nutrition Compared with Steroids in Children with Crohn’s Disease – In Israel: a nationwide study from the epi-IIRN
OP34 Enteral Nutrition Compared with Steroids in Children with Crohn’s Disease – In Israel: a nationwide study from the epi-IIRN Open
Background Studies have shown that exclusive enteral nutrition (EEN) treatment is as effective to corticosteroids (CS) for induction of remission in pediatric Crohn's disease (CD) with fewer side effects, but long-term outcome data are sca…
View article: P560 Curcumin-QingDai combination for patients with active ulcerative colitis: A randomized double-blinded placebo-controlled trial
P560 Curcumin-QingDai combination for patients with active ulcerative colitis: A randomized double-blinded placebo-controlled trial Open
Background The herbal extracts Curcumin and QingDai (QD, Indigo) were previously shown to be effective in mild-moderate and in moderate-severe ulcerative colitis (UC), respectively. We evaluated the efficacy and safety of a combination of …
View article: Clinical Study and Systematic Review of Pituitary Microadenomas vs. Macroadenomas in Cushing’s Disease: Does Size Matter?
Clinical Study and Systematic Review of Pituitary Microadenomas vs. Macroadenomas in Cushing’s Disease: Does Size Matter? Open
Background: Reports on clinical and biochemical differences between adrenocorticotropic hormone (ACTH)-secreting pituitary microadenomas and macroadenomas are limited and inconsistent. Objective: Compare clinical and biochemical characteri…
View article: A236 ASSOCIATION OF STOOL METABOLOMIC PROFILE AND MICROBIOME COMPOSITION RISK SCORE WITH FUTURE ONSET OF CROHN’S DISEASE
A236 ASSOCIATION OF STOOL METABOLOMIC PROFILE AND MICROBIOME COMPOSITION RISK SCORE WITH FUTURE ONSET OF CROHN’S DISEASE Open
Background Microbial composition-based risk score (MRS) was recently developed and validated to predict future risk of developing Crohn’s disease (CD) among healthy first-degree relatives (FDR) of CD patients. We hypothesized that stool me…
View article: Macrophage Jak2 deficiency accelerates atherosclerosis through defects in cholesterol efflux
Macrophage Jak2 deficiency accelerates atherosclerosis through defects in cholesterol efflux Open
Atherosclerosis is a chronic inflammatory condition in which macrophages play a major role. Janus kinase 2 (JAK2) is a pivotal molecule in inflammatory and metabolic signaling, and Jak2 V617F activating mutation has recently been implicate…
View article: P622 Comparison of midterm outcomes in Pediatric Crohn’s Disease patients treated with either Exclusive Enteral Nutrition or Corticosteroids around disease diagnosis– a population based study
P622 Comparison of midterm outcomes in Pediatric Crohn’s Disease patients treated with either Exclusive Enteral Nutrition or Corticosteroids around disease diagnosis– a population based study Open
Background Corticosteroids (CS) and exclusive enteral nutrition (EEN) are commonly used as induction therapy in pediatric Crohn’s disease (PCD). Pediatric studies showed that CS treatment is equivalent to EEN for induction of remission, an…
View article: The Biochemical Diagnosis of Acromegaly
The Biochemical Diagnosis of Acromegaly Open
Background: The diagnosis of acromegaly still poses a clinical challenge, and prolonged diagnostic delay is common. The most important assays for the biochemical diagnosis and management of acromegaly are growth hormone (GH) and insulin-li…
View article: Dj1 deficiency protects against atherosclerosis with anti-inflammatory response in macrophages
Dj1 deficiency protects against atherosclerosis with anti-inflammatory response in macrophages Open
Inflammation is a key contributor to atherosclerosis with macrophages playing a pivotal role through the induction of oxidative stress and cytokine/chemokine secretion. DJ1, an anti-oxidant protein, has shown to paradoxically protect again…
View article: P626 Patients with IBD seek extra supportive care: insights from Israeli social media networks
P626 Patients with IBD seek extra supportive care: insights from Israeli social media networks Open
Background Social Media (SM) networks are a major communication tool for patients with inflammatory bowel diseases (IBD) and healthcare professionals (HCPs). In Israel there are several SM platforms, some guided by HCPs while others are pa…
View article: P124 Clock gene expression levels can differentially distinguish between ulcerative colitis and Crohn’s disease
P124 Clock gene expression levels can differentially distinguish between ulcerative colitis and Crohn’s disease Open
Background Pathophysiological mechanisms active in inflammatory bowel disease (IBD), such as mucosal barrier repair, innate and adaptive immune responses, intestinal motility and gut microbiome, all exhibit diurnal variations. Chronic disr…
View article: DOP31 Development and validation of the IBD-REFER criteria: when should a general practitioner or paediatrician refer a patient for suspected IBD?
DOP31 Development and validation of the IBD-REFER criteria: when should a general practitioner or paediatrician refer a patient for suspected IBD? Open
Early treatment of IBD is associated with more favourite outcomes, but this requires prompt diagnosis. Unfortunately, the delay from onset of symptoms to the diagnosis of IBD may range from 6–24 months. We thus aimed to develop and validat…
View article: P644 Mindfulness-based stress reduction in adult patients with active Crohn's disease: preliminary findings based on the subjective units of distress scale: an IIRN study
P644 Mindfulness-based stress reduction in adult patients with active Crohn's disease: preliminary findings based on the subjective units of distress scale: an IIRN study Open
Crohn’s disease patients suffer from a host of mental symptoms, particularly when the disease is active (Schwartz D et al. United European Gastroenterol J 2018; 6: Supplement 1). We postulated that psychological distress can be diminished …
View article: Improved HDL cholesterol efflux capacity in morbidly obese individuals after bariatric surgery
Improved HDL cholesterol efflux capacity in morbidly obese individuals after bariatric surgery Open
Improved HDL cholesterol efflux capacity in morbidly obese individuals after bariatric surgeryBackground. Obesity has become a global epidemic and carries excess cardiovascular (CV) morbidity and mortality. Bariatric surgery was shown to i…
View article: Correction: Engineering Multi-Walled Carbon Nanotube Therapeutic Bionanofluids to Selectively Target Papillary Thyroid Cancer Cells
Correction: Engineering Multi-Walled Carbon Nanotube Therapeutic Bionanofluids to Selectively Target Papillary Thyroid Cancer Cells Open
[This corrects the article DOI: 10.1371/journal.pone.0149723.].
View article: Engineering Multi-Walled Carbon Nanotube Therapeutic Bionanofluids to Selectively Target Papillary Thyroid Cancer Cells
Engineering Multi-Walled Carbon Nanotube Therapeutic Bionanofluids to Selectively Target Papillary Thyroid Cancer Cells Open
A BioNanofluid platform offering a potential therapeutic path for papillary thyroid cancer has been investigated, with our in vitro results suggesting the development of a potent and rapid method of selective cancer cell killing. Therefore…