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View article: Evaluation of the cecal withdrawal vocal timer in screening colonoscopies for optimizing withdrawal time and adenoma detection rate
Evaluation of the cecal withdrawal vocal timer in screening colonoscopies for optimizing withdrawal time and adenoma detection rate Open
Background: Longer cecal withdrawal time has been linked to a higher adenoma detection rate (ADR), with a minimum duration of 6 min recommended. Therefore, we developed the cecal withdrawal vocal timer (CWVT), a novel software tool that is…
View article: Metachronous colorectal cancer risks after extended or segmental resection in <i>MLH1</i>, <i>MSH2</i>, and <i>MSH6</i> Lynch syndrome: multicentre study from the Prospective Lynch Syndrome Database
Metachronous colorectal cancer risks after extended or segmental resection in <i>MLH1</i>, <i>MSH2</i>, and <i>MSH6</i> Lynch syndrome: multicentre study from the Prospective Lynch Syndrome Database Open
This first prospective observational study evaluates the impact of extended versus segmental colorectal surgery on the risk of metachronous colorectal cancer (CRC) in patients with Lynch syndrome, analyzing data from the Prospective Lynch …
View article: The genetic landscape of Lynch syndrome in the Israeli population
The genetic landscape of Lynch syndrome in the Israeli population Open
Deciphering the spectrum and founder disease-causing variants (DCVs) in specific populations can shape and facilitate the diagnostic process of Lynch Syndrome (LS). The aim of this report was to comprehensively update on the genetic landsc…
View article: Serum matrix metalloproteinase‐7, Syndecan‐1, and <scp>CA</scp> 19‐9 as a biomarker panel for diagnosis of pancreatic ductal adenocarcinoma
Serum matrix metalloproteinase‐7, Syndecan‐1, and <span>CA</span> 19‐9 as a biomarker panel for diagnosis of pancreatic ductal adenocarcinoma Open
Aims and Background Matrix metalloproteinase‐7 (MMP‐7) and Syndecan‐1 (SDC1) are involved in multiple functions during tumorigenesis. We aimed to evaluate the diagnostic and prognostic performance of these serum proteins, as potential biom…
View article: Incidences of colorectal adenomas and cancers under colonoscopy surveillance suggest an accelerated “Big Bang” pathway to CRC in three of the four Lynch syndromes
Incidences of colorectal adenomas and cancers under colonoscopy surveillance suggest an accelerated “Big Bang” pathway to CRC in three of the four Lynch syndromes Open
Background: Colorectal cancers (CRCs) in the Lynch syndromes have been assumed to emerge through an accelerated adenoma-carcinoma pathway. In this model adenomas with deficient mismatch repair have an increased probability of acquiring add…
View article: Risk of colorectal advanced neoplasia in patients with acute diverticulitis with and without previous colonoscopy
Risk of colorectal advanced neoplasia in patients with acute diverticulitis with and without previous colonoscopy Open
Background and Aim Guidelines recommend a colonoscopy after an episode of complicated diverticulitis and after a first episode of uncomplicated diverticulitis. The influence of a previous colonoscopy on postdiverticulitis colonoscopic find…
View article: Characterization of blood-derived exosomal hTERT mRNA as a biomarker for colon cancer and Lynch syndrome
Characterization of blood-derived exosomal hTERT mRNA as a biomarker for colon cancer and Lynch syndrome Open
Background Human telomerase reverse transcriptase (hTERT)- mRNA was shown to be elevated in exosomes derived from the sera of a variety of hematological and solid cancer patients. We aimed to evaluate its role as a diagnostic marker in pat…
View article: Adenomatous Polyposis Phenotype in BMPR1A and SMAD4 Variant Carriers
Adenomatous Polyposis Phenotype in BMPR1A and SMAD4 Variant Carriers Open
INTRODUCTION: Variants in SMAD4 or BMPR1A cause juvenile polyposis syndrome, a rare autosomal dominant condition characterized by multiple gastrointestinal hamartomatous polyps. A phenotype of attenuated adenomatous polyposis without hamar…
View article: Serum Syndecan-1: A Novel Biomarker for Pancreatic Ductal Adenocarcinoma
Serum Syndecan-1: A Novel Biomarker for Pancreatic Ductal Adenocarcinoma Open
INTRODUCTION: Syndecan-1 (SDC1) has multiple functions in tumorigenesis in general and specifically in pancreatic cancer. We aimed to evaluate SDC1 as a diagnostic and prognostic biomarker in patients with pancreatic ductal adenocarcinoma …
View article: Risk factors and prediction algorithm for advanced neoplasia on screening colonoscopy for average-risk individuals
Risk factors and prediction algorithm for advanced neoplasia on screening colonoscopy for average-risk individuals Open
Background: Screening with colonoscopy for all average-risk population is probably not cost-effective due to the limited sources and over-generalization of the risk, and risk stratification can be used to optimize colorectal cancer screeni…
View article: P119 Hereditary Colorectal Cancer Syndromes and Inflammatory Bowel Diseases: an ECCO CONFER Multicenter Case Series
P119 Hereditary Colorectal Cancer Syndromes and Inflammatory Bowel Diseases: an ECCO CONFER Multicenter Case Series Open
Background Hereditary colorectal cancer syndromes (HCCS) are rare polyposis or nonpolyposis syndromes with a higher risk of developing colorectal cancer (CRC). Coexisting inflammatory bowel disease (IBD), including ulcerative colitis (UC) …
View article: Post‐polypectomy surveillance colonoscopy: Comparison of the updated guidelines
Post‐polypectomy surveillance colonoscopy: Comparison of the updated guidelines Open
Background Recently, three updated guidelines for post‐polypectomy colonoscopy surveillance (PPCS) have been published. These guidelines are based on a comprehensive summary of the literature, while some recommendations are similar, differ…
View article: Distinct Prognostic Factors in Sporadic and Multiple Endocrine Neoplasia Type 1-Related Pancreatic Neuroendocrine Tumors
Distinct Prognostic Factors in Sporadic and Multiple Endocrine Neoplasia Type 1-Related Pancreatic Neuroendocrine Tumors Open
Pancreatic neuroendocrine tumors (PNET) may develop sporadically or in the context of hereditary syndromes. In patients with multiple endocrine neoplasia type 1 (MEN1), PNET is the leading cause of death. Our aim was to compare the mortali…
View article: Sense of Coherence in People with and without Inflammatory Bowel Diseases – Is there a Difference?
Sense of Coherence in People with and without Inflammatory Bowel Diseases – Is there a Difference? Open
Background & Aims: Sense of coherence (SOC) is a theoretical concept reflecting a person‘s resources and orientation, which enable individuals to cope with stressors in a health-promoting manner. In several multifactorial chronic diseases,…
View article: Serum MMP-9: a novel biomarker for prediction of clinical relapse in patients with quiescent Crohn’s disease, a <i>post hoc</i> analysis
Serum MMP-9: a novel biomarker for prediction of clinical relapse in patients with quiescent Crohn’s disease, a <i>post hoc</i> analysis Open
Background: Matrix metalloproteinase-9 (MMP-9) is a novel marker of intestinal inflammation. The aim of this study was to assess if serum MMP-9 levels predict clinical flare in patients with quiescent Crohn’s disease (CD). Methods: This st…
View article: Identification of Synergistic Interaction Between Cannabis-Derived Compounds for Cytotoxic Activity in Colorectal Cancer Cell Lines and Colon Polyps That Induces Apoptosis-Related Cell Death and Distinct Gene Expression
Identification of Synergistic Interaction Between Cannabis-Derived Compounds for Cytotoxic Activity in Colorectal Cancer Cell Lines and Colon Polyps That Induces Apoptosis-Related Cell Death and Distinct Gene Expression Open
Introduction: Colorectal cancer remains the third most common cancer diagnosis and fourth leading cause of cancer-related mortality worldwide. Purified cannabinoids have been reported to prevent proliferation, metastasis, and induce apopto…
View article: Genomic Alterations Are Enhanced in Placentas from Pregnancies with Fetal Growth Restriction and Preeclampsia: Preliminary Results
Genomic Alterations Are Enhanced in Placentas from Pregnancies with Fetal Growth Restriction and Preeclampsia: Preliminary Results Open
Fetal growth restriction (FGR) secondary to placental insufficiency and preeclampsia (PE) are associated with substantially increased childhood and adult morbidity and mortality. The long-term outcomes are related to placental aberrations …