Ieng Fong Sou
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View article: Dependency of NELF-E-SLUG-KAT2B epigenetic axis in breast cancer carcinogenesis
Dependency of NELF-E-SLUG-KAT2B epigenetic axis in breast cancer carcinogenesis Open
Cancer cells undergo transcriptional reprogramming to drive tumor progression and metastasis. Using cancer cell lines and patient-derived tumor organoids, we demonstrate that loss of the negative elongation factor (NELF) complex inhibits b…
View article: Centrosome dysfunction associated with somatic expression of the synaptonemal complex protein TEX12
Centrosome dysfunction associated with somatic expression of the synaptonemal complex protein TEX12 Open
View article: Meiosis initiation: a story of two sexes in all creatures great and small
Meiosis initiation: a story of two sexes in all creatures great and small Open
Meiosis facilitates diversity across individuals and serves as a major driver of evolution. However, understanding how meiosis begins is complicated by fundamental differences that exist between sexes and species. Fundamental meiotic resea…
View article: Fluorescent<i>in vivo</i>editing reporter (FIVER): A novel multispectral reporter of<i>in vivo</i>genome editing
Fluorescent<i>in vivo</i>editing reporter (FIVER): A novel multispectral reporter of<i>in vivo</i>genome editing Open
Advances in genome editing technologies have created opportunities to treat rare genetic diseases, which are often overlooked in terms of therapeutic development. Nonetheless, substantial challenges remain: namely, achieving therapeuticall…