Ignacio Garutti
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View article: Lidocaine Attenuates miRNA Dysregulation and Kinase Signaling Activation in a Porcine Model of Lung Ischemia/Reperfusion Injury
Lidocaine Attenuates miRNA Dysregulation and Kinase Signaling Activation in a Porcine Model of Lung Ischemia/Reperfusion Injury Open
Ischemia/reperfusion (I/R) injury is a major complication in lung transplantation. Recent evidence suggests that mitogen-activated protein kinases (MAPKs) such as p-38 mitogen-activated protein kinase (p-38 MAPK) and extracellular signal-r…
View article: High Cerebral Oxygen Saturation Levels During One-Lung Ventilation Predict Better Cognitive and Clinical Outcomes After Thoracic Surgery: A Retrospective Observational Study
High Cerebral Oxygen Saturation Levels During One-Lung Ventilation Predict Better Cognitive and Clinical Outcomes After Thoracic Surgery: A Retrospective Observational Study Open
Background: Cerebral desaturation during one-lung ventilation (OLV) in thoracic surgery has been associated with postoperative cognitive dysfunction (POCD). While the adverse effects of low intraoperative regional cerebral oxygen saturatio…
View article: Impact of Intraoperative Lidocaine During Oncologic Lung Resection on Long-Term Outcomes in Primary Lung Cancer: A Post Hoc Analysis of a Randomized Controlled Trial
Impact of Intraoperative Lidocaine During Oncologic Lung Resection on Long-Term Outcomes in Primary Lung Cancer: A Post Hoc Analysis of a Randomized Controlled Trial Open
Background/Objectives: Lidocaine has demonstrated immunomodulatory properties and promising antitumor effects in experimental models, but its impact on long-term outcomes following oncologic surgery remains unclear. This study aimed to com…
View article: Intravenous Lidocaine Modulates The Perioperative Hepatic Inflammatory Response: Implications For Personalized Medicine In Thoracic Surgery
Intravenous Lidocaine Modulates The Perioperative Hepatic Inflammatory Response: Implications For Personalized Medicine In Thoracic Surgery Open
Purpose: Lung resection surgery increases the expression of proinflammatory mediators and cause initially a local inflammatory response that later spreads to the bloodstream and affects peripheral organs, including the liver. The main goal…
View article: Evaluation of Perioperative Risk Factors for Infection by Multidrug-Resistant Bacteria in Patients Undergoing Liver Transplantation
Evaluation of Perioperative Risk Factors for Infection by Multidrug-Resistant Bacteria in Patients Undergoing Liver Transplantation Open
Background: Liver transplantation (LT) is a critical intervention for patients with end-stage liver disease. Infections caused by multidrug-resistant bacteria (MDRB) significantly worsen post-transplant outcomes. The main objective of this…
View article: Evaluation of Perioperative Risk Factors for Infection by Multidrug Resistant Bacteria in Patients Undergoing Liver Transplantation
Evaluation of Perioperative Risk Factors for Infection by Multidrug Resistant Bacteria in Patients Undergoing Liver Transplantation Open
Background: Liver transplantation (LT) is a crucial intervention in patients with severe liver disease. Infections by multidrug-resistant bacteria (MDRB) complicate the prognosis of the liver transplant patient. Main objective was analyze …
View article: Exploring the Relationship Between Perioperative Inflammatory Biomarkers and Oncological Recurrence in Patients Undergoing Pulmonary Cancer Surgery
Exploring the Relationship Between Perioperative Inflammatory Biomarkers and Oncological Recurrence in Patients Undergoing Pulmonary Cancer Surgery Open
Background: Inflammation plays a crucial role in lung cancer recurrence after surgery. This study aims to investigate the relationship between lung cancer recurrence and perioperative inflammatory status, assessed in both blood and broncho…
View article: Risk factors for readmission of COVID-19 ICU survivors: A three-year follow up
Risk factors for readmission of COVID-19 ICU survivors: A three-year follow up Open
Background & objectives Evidence suggests that individuals who have been hospitalised due to COVID-19 are more susceptible to future mortality and readmission, thereby imposing a substantial strain on their quality of life. The available d…
View article: Early Thrombocytopenia at Hospital Admission Predicts Mortality in Patients with Non-Isolated Severe Traumatic Brain Injury
Early Thrombocytopenia at Hospital Admission Predicts Mortality in Patients with Non-Isolated Severe Traumatic Brain Injury Open
Patients with severe traumatic brain injury (STBI) often experience an abnormal hemostasis that contributes to mortality and unfavorable neurological outcomes. Objectives: We aimed to analyze epidemiologic, clinical, and laboratory factors…
View article: Early thrombocytopenia at hospital admission predicts mortality in patients with non-isolated severe traumatic brain injury
Early thrombocytopenia at hospital admission predicts mortality in patients with non-isolated severe traumatic brain injury Open
Background Patients with severe traumatic brain injury (STBI) often experience an abnormal hemostasis that contributes to mortality and unfavorable neurological outcomes. We aimed to analyze epidemiologic, clinical and laboratory factors a…
View article: Lung and blood perioperative metalloproteinases in patients undergoing oncologic lung surgery: Prognostic implications
Lung and blood perioperative metalloproteinases in patients undergoing oncologic lung surgery: Prognostic implications Open
Background Metalloproteinases (MMPs) have been reported to be related to oncologic outcomes. The main goal of the study was to study the relationship between these proteins and the long‐term prognosis of patients undergoing oncologic lung …
View article: Individualised, perioperative open-lung ventilation strategy during one-lung ventilation (iPROVE-OLV): a multicentre, randomised, controlled clinical trial
Individualised, perioperative open-lung ventilation strategy during one-lung ventilation (iPROVE-OLV): a multicentre, randomised, controlled clinical trial Open
Instituto de Salud Carlos III and the European Regional Development Funds.
View article: Mortality Risk Prediction in Abdominal Septic Shock Treated with Polymyxin-B Hemoperfusion: A Retrospective Cohort Study
Mortality Risk Prediction in Abdominal Septic Shock Treated with Polymyxin-B Hemoperfusion: A Retrospective Cohort Study Open
Endotoxin, a component of the cell membrane of gram-negative bacteria, is a trigger for dysregulated inflammatory response in sepsis. Extracorporeal purification of endotoxin, through adsorption with polymyxin B, has been studied as a ther…
View article: COVID-19 associated infections in the ICU setting: A retrospective analysis in a tertiary-care hospital
COVID-19 associated infections in the ICU setting: A retrospective analysis in a tertiary-care hospital Open
View article: 5PSQ-051 Cost-effectiveness of a presurgical pharmaceutical care consultation
5PSQ-051 Cost-effectiveness of a presurgical pharmaceutical care consultation Open
Background and importance 4.7% of Spanish hospital patients suffer a preventable adverse event (AE) due to medication errors. In surgical specialties, errors may result in important negative consequences, so hospital pharmacists have imple…
View article: COVID-19 associated infections in the ICU setting: A retrospective analysis in a tertiary-care hospital
COVID-19 associated infections in the ICU setting: A retrospective analysis in a tertiary-care hospital Open
View article: Persistent Incisional Pain after Noncardiac Surgery: An International Prospective Cohort Study
Persistent Incisional Pain after Noncardiac Surgery: An International Prospective Cohort Study Open
Background The purpose of this study was to determine the incidence, characteristics, impact, and risk factors associated with persistent incisional pain. The hypothesis was that patient demographics and perioperative interventions are ass…
View article: Analysis and review of the perioperative management of COVID-19 patients in thoracic surgery
Analysis and review of the perioperative management of COVID-19 patients in thoracic surgery Open
View article: Possible unrecognised liver injury is associated with mortality in critically ill COVID-19 patients
Possible unrecognised liver injury is associated with mortality in critically ill COVID-19 patients Open
Background: Coronavirus disease (COVID-19) with acute respiratory distress syndrome is a life-threatening condition. A previous diagnosis of chronic liver disease is associated with poorer outcomes. Nevertheless, the impact of silent liver…
View article: Effect of Intravenous Lidocaine on Inflammatory and Apoptotic Response of Ischemia‐Reperfusion Injury in Pigs Undergoing Lung Resection Surgery
Effect of Intravenous Lidocaine on Inflammatory and Apoptotic Response of Ischemia‐Reperfusion Injury in Pigs Undergoing Lung Resection Surgery Open
Background . Ischemia‐reperfusion injury is one of the most critical phenomena in lung transplantation and causes primary graft failure. Its pathophysiology remains incompletely understood, although the inflammatory response and apoptosis …
View article: Unrecognized liver injury assessed by fibrosis indexes is associated with mortality in critically ill COVID-19 patients
Unrecognized liver injury assessed by fibrosis indexes is associated with mortality in critically ill COVID-19 patients Open
Background Coronavirus disease (COVID-19) with acute respiratory distress syndrome is a life-threatening condition. A previous diagnosis of chronic liver disease is associated with poorer outcomes. Nevertheless, the impact of silent liver …
View article: Análisis y revisión del manejo perioperatorio del paciente COVID-19 en la cirugía torácica
Análisis y revisión del manejo perioperatorio del paciente COVID-19 en la cirugía torácica Open
View article: Effects of oxygen on post-surgical infections during an individualised perioperative open-lung ventilatory strategy: a randomised controlled trial
Effects of oxygen on post-surgical infections during an individualised perioperative open-lung ventilatory strategy: a randomised controlled trial Open
View article: Effect of intraoperative paravertebral or intravenous lidocaine versus control during lung resection surgery on postoperative complications: A randomized controlled trial
Effect of intraoperative paravertebral or intravenous lidocaine versus control during lung resection surgery on postoperative complications: A randomized controlled trial Open
Background Use of minimally invasive surgical techniques for lung resection surgery (LRS), such as video-assisted thoracoscopy (VATS), has increased in recent years. However, there is little information about the best anesthetic technique …
View article: Association between complications and death within 30 days after noncardiac surgery
Association between complications and death within 30 days after noncardiac surgery Open
Among adults undergoing noncardiac surgery, 99.3% of deaths occurred after the procedure and 44.9% of deaths were associated with 3 complications: major bleeding, MINS and sepsis. Given these findings, focusing on the prevention, early ide…
View article: Articles to Appear in Future Issues
Articles to Appear in Future Issues Open
View article: Valor preditivo das citocinas plasmáticas para lesão renal aguda após cirurgia de ressecção pulmonar: estudo observacional prospectivo
Valor preditivo das citocinas plasmáticas para lesão renal aguda após cirurgia de ressecção pulmonar: estudo observacional prospectivo Open
Os pacientes submetidos à cirurgia de ressecção pulmonar apresentam risco de desenvolver lesão renal aguda pós-operatória. A determinação dos níveis de citocinas permite detectar uma resposta inflamatória precoce. Investigamos a relação te…
View article: Predictive value of plasma cytokines for acute kidney injury following lung resection surgery: prospective observational study
Predictive value of plasma cytokines for acute kidney injury following lung resection surgery: prospective observational study Open
View article: Rationale and Study Design for an Individualized Perioperative Open Lung Ventilatory Strategy in Patients on One-Lung Ventilation (iPROVE-OLV)
Rationale and Study Design for an Individualized Perioperative Open Lung Ventilatory Strategy in Patients on One-Lung Ventilation (iPROVE-OLV) Open
View article: O efeito do pré‐condicionamento anestésico com sevoflurano sobre as vias de transdução de sinal intracelular e a apoptose, em modelo experimental de autotransplante pulmonar
O efeito do pré‐condicionamento anestésico com sevoflurano sobre as vias de transdução de sinal intracelular e a apoptose, em modelo experimental de autotransplante pulmonar Open
Anesthetic pre-conditioning attenuates inflammatory response during ischemia-reperfusion lung injury. The molecular mechanisms to explain it are not fully understood. The aim of our investigation was to analyze the molecular mechanism that…