Ignacio Insua
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View article: Self-assembly of cyclic peptide monolayers by hydrophobic supramolecular hinges
Self-assembly of cyclic peptide monolayers by hydrophobic supramolecular hinges Open
A novel supramolecular tryptophan hinge motif enables the self-assembly of nanotube monolayers by hierarchical non-covalent polymerisation of cyclic peptides in lateral contact.
View article: Bottom-up supramolecular assembly in two dimensions
Bottom-up supramolecular assembly in two dimensions Open
The self-assembly of molecules in two dimensions (2D) is gathering attention from all disciplines across the chemical sciences. This perspective discusses the main strategies to direct the supramolecular self-assembly of organic monomers i…
View article: Supramolecular fibrillation of peptide amphiphiles induces environmental responses in aqueous droplets
Supramolecular fibrillation of peptide amphiphiles induces environmental responses in aqueous droplets Open
One-dimensional (1D) supramolecular polymers are commonly found in natural and synthetic systems to prompt functional responses that capitalise on hierarchical molecular ordering. Despite amphiphilic self-assembly being significantly studi…
View article: Sequence Decoding of 1D to 2D Self‐Assembling Cyclic Peptides
Sequence Decoding of 1D to 2D Self‐Assembling Cyclic Peptides Open
The inherent ability of peptides to self‐assemble with directional and rationally predictable interactions has fostered a plethora of synthetic two‐dimensional (2D) supramolecular biomaterials. However, the design of peptides with hierarch…
View article: Environmental interactions with amoebae as drivers of bacterial-fungal endosymbiosis and pathogenicity
Environmental interactions with amoebae as drivers of bacterial-fungal endosymbiosis and pathogenicity Open
Opportunistic infections by environmental fungi are a growing clinical problem, driven by an increasing population of people with immunocompromising conditions. Spores of the Mucorales order are ubiquitious in the environment but can also …
View article: Structural Determinants of the Stability of Enzyme‐Responsive Polyion Complex Nanoparticles Targeting <i>Pseudomonas aeruginosa</i>’s Elastase
Structural Determinants of the Stability of Enzyme‐Responsive Polyion Complex Nanoparticles Targeting <i>Pseudomonas aeruginosa</i>’s Elastase Open
Here, we report how the stability of polyion complex (PIC) particles containing Pseudomonas aeruginosa ’s elastase (LasB) degradable peptides and antimicrobial poly(ethylene imine) is significantly improved by careful design of the peptide…
View article: Correction: Engineering microbial physiology with synthetic polymers: cationic polymers induce biofilm formation in<i>Vibrio cholerae</i>and downregulate the expression of virulence genes
Correction: Engineering microbial physiology with synthetic polymers: cationic polymers induce biofilm formation in<i>Vibrio cholerae</i>and downregulate the expression of virulence genes Open
Correction for ‘Engineering microbial physiology with synthetic polymers: cationic polymers induce biofilm formation inVibrio choleraeand downregulate the expression of virulence genes’ by Nicolas Perez-Sotoet al.,Chem. Sci., 2017,8, 5291–…
View article: Engineering microbial physiology with synthetic polymers: cationic polymers induce biofilm formation in <i>Vibrio cholerae</i> and downregulate the expression of virulence genes
Engineering microbial physiology with synthetic polymers: cationic polymers induce biofilm formation in <i>Vibrio cholerae</i> and downregulate the expression of virulence genes Open
Here we report the first application of non-bactericidal synthetic polymers to modulate the physiology of a bacterial pathogen.
View article: Engineering Microbial Physiology with Synthetic Polymers: Cationic Polymers Induce Biofilm Formation in<i>Vibrio cholerae</i>and Downregulate the Expression of Virulence Genes
Engineering Microbial Physiology with Synthetic Polymers: Cationic Polymers Induce Biofilm Formation in<i>Vibrio cholerae</i>and Downregulate the Expression of Virulence Genes Open
Here we report the first application of non-bactericidal synthetic polymers to modulate the physiology of a bacterial pathogen. Poly( N -[3-(dimethylamino)propyl]methacrylamide) ( P1 ) and poly( N -(3-aminopropyl) methacrylamide) ( P2 ), c…
View article: Enzyme-responsive polyion complex (PIC) nanoparticles for the targeted delivery of antimicrobial polymers
Enzyme-responsive polyion complex (PIC) nanoparticles for the targeted delivery of antimicrobial polymers Open
Here we present new enzyme-responsive polyion complex (PIC) nanoparticles prepared from antimicrobial poly(ethylene imine) and an anionic enzyme-responsive peptide targeting Pseudomonas aeruginosa's elastase.
View article: Fundamentals, achievements and challenges in the electrochemical sensing of pathogens
Fundamentals, achievements and challenges in the electrochemical sensing of pathogens Open
Electrochemical sensors are powerful tools widely used in industrial, environmental and medical applications.