Ignacio R. Ipharraguerre
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View article: Selective agonism of liver and gut FXR prevents cholestasis and intestinal atrophy in parenterally fed neonatal pigs
Selective agonism of liver and gut FXR prevents cholestasis and intestinal atrophy in parenterally fed neonatal pigs Open
View article: PSXII-25 Effects of Aspergillus oryzae-derived prebiotics on ruminal fermentation and the microbiome in an artificial rumen system (Rusitec).
PSXII-25 Effects of Aspergillus oryzae-derived prebiotics on ruminal fermentation and the microbiome in an artificial rumen system (Rusitec). Open
Prebiotics that stimulate beneficial microbes have had varying success in improving animal health and enhancing production efficiency. Aspergillus oryzae prebiotics (AOP) are produced from a multi-step fermentation process of a selected st…
View article: Assessment of Salivary Biomarkers of Gastric Ulcer in Horses from a Clinical Perspective
Assessment of Salivary Biomarkers of Gastric Ulcer in Horses from a Clinical Perspective Open
This study arises from the search for non-invasive diagnostic alternatives for equine gastric ulceration (EGUS), which is prevalent, clinically variable and only confirmed by gastroscopy. The aim is to quantify five salivary biomarkers (IL…
View article: Postbiotics: a perspective on their quantification
Postbiotics: a perspective on their quantification Open
A “postbiotic” is a preparation of inanimate microorganisms and/or their components that confers a health benefit on the host . To encourage collaborative problem-solving to address the issues related to the characterization and quantifica…
View article: 221 Modulation of gut microbiome and nutrient digestibility by <i>Aspergillus oryzae</i> prebiotic in pigs fed high-fiber diets: A multi-omics approach
221 Modulation of gut microbiome and nutrient digestibility by <i>Aspergillus oryzae</i> prebiotic in pigs fed high-fiber diets: A multi-omics approach Open
Traditional evaluations of feed additives in swine diets have primarily focused on performance metrics, but improving nutrient utilization from high-fiber diets requires a deeper understanding of the interactions among diet, gut microbiome…
View article: Assessing the inflammatory response in horses undergoing gastric ulceration using salivary ADA and S100A12 as biomarkers
Assessing the inflammatory response in horses undergoing gastric ulceration using salivary ADA and S100A12 as biomarkers Open
The inflammatory status in horses with gastric ulcers was monitored by two inflammatory biomarkers, S100A12 and adenosine deaminase (ADA), using saliva samples from healthy and horses with gastric ulcers. Two trials were developed: an expe…
View article: Influence of Dietary Fiber and Weaning Age on the Gut Microbiota Activity and Bile Acid Regulation in Piglets
Influence of Dietary Fiber and Weaning Age on the Gut Microbiota Activity and Bile Acid Regulation in Piglets Open
View article: The postbiotic potential of Aspergillus oryzae – a narrative review
The postbiotic potential of Aspergillus oryzae – a narrative review Open
The filamentous fungus Aspergillus oryzae has a long tradition in East Asian food processing. It is therefore not surprising that in recent years fermentation products of A. oryzae have attracted attention in the emerging field of postbiot…
View article: Selective Agonism of Liver and Gut FXR Prevents Cholestasis and Intestinal Atrophy in Parenterally Fed Neonatal Pigs
Selective Agonism of Liver and Gut FXR Prevents Cholestasis and Intestinal Atrophy in Parenterally Fed Neonatal Pigs Open
BACKGROUND & AIMS We aimed to investigate the relative efficacy of feeding different bile acids in preventing PNALD in neonatal pigs. METHODS Newborn pigs given total parenteral nutrition (TPN) combined with minimal enteral feeding of chen…
View article: A comprehensive in-vitro/in-vivo screening toolbox for the elucidation of glucose homeostasis modulating properties of plant extracts (from roots) and its bioactives
A comprehensive in-vitro/in-vivo screening toolbox for the elucidation of glucose homeostasis modulating properties of plant extracts (from roots) and its bioactives Open
Plant extracts are increasingly recognized for their potential in modulating (postprandial) blood glucose levels. In this context, root extracts are of particular interest due to their high concentrations and often unique spectrum of plant…
View article: 281 Effects of dietary <i>Aspergillus oryzae</i> postbiotic during gestation and lactation on sow and progeny performance
281 Effects of dietary <i>Aspergillus oryzae</i> postbiotic during gestation and lactation on sow and progeny performance Open
This study aimed to evaluate effects of Aspergillus oryzae postbiotic (AOP) supplementation in gestation and lactation diets on sow performance, litter performance, and offspring performance through the nursery period. Sows [n = 118; Landr…
View article: Stearidonic acid improves eicosapentaenoic acid status: studies in humans and cultured hepatocytes
Stearidonic acid improves eicosapentaenoic acid status: studies in humans and cultured hepatocytes Open
Background Ahiflower oil from the seeds of Buglossoides arvensis is rich in α-linolenic acid (ALA) and stearidonic acid (SDA). ALA and SDA are potential precursor fatty acids for the endogenous synthesis of eicosapentaenoic acid (EPA) and …
View article: Canine Mucosal Artificial Colon: development of a new colonic in vitro model adapted to dog sizes
Canine Mucosal Artificial Colon: development of a new colonic in vitro model adapted to dog sizes Open
View article: Impact of Supplementing a Backgrounding Diet with Nonprotein Nitrogen on In Vitro Methane Production, Nutrient Digestibility, and Steer Performance
Impact of Supplementing a Backgrounding Diet with Nonprotein Nitrogen on In Vitro Methane Production, Nutrient Digestibility, and Steer Performance Open
Two experiments were conducted to evaluate the effect of nonprotein nitrogen (NPN) supplementation on in vitro fermentation and animal performance using a backgrounding diet. In experiment 1, incubations were conducted on three separate da…
View article: Non-protein nitrogen supplementation on in vitro fermentation profile, methane production, and microbial nitrogen synthesis in a corn silage-based substrate
Non-protein nitrogen supplementation on in vitro fermentation profile, methane production, and microbial nitrogen synthesis in a corn silage-based substrate Open
Non-protein nitrogen (NPN) supplements improve animal performance in backgrounding diets. However, there is scarce information regarding the effect of different NPN sources and combinations on ruminal fermentation profile. The current stud…
View article: Lithium Affects Sodium Balance But Not Intestinal Microbiota - Studies in Drosophila Melanogaster
Lithium Affects Sodium Balance But Not Intestinal Microbiota - Studies in Drosophila Melanogaster Open
View article: Graduate Student Literature Review: Developmental adaptations of immune function in calves and the influence of the intestinal microbiota in health and disease
Graduate Student Literature Review: Developmental adaptations of immune function in calves and the influence of the intestinal microbiota in health and disease Open
This graduate student literature review provides an examination of the ontological adaptations of the calf's immune system and how the intestinal microbiota influences calf immune function in health and disease. Within dairy rearing system…
View article: Heat stress–associated changes in the intestinal barrier, inflammatory signals, and microbiome communities in dairy calves
Heat stress–associated changes in the intestinal barrier, inflammatory signals, and microbiome communities in dairy calves Open
Recent studies indicate that heat stress pathophysiology is associated with intestinal barrier dysfunction, local and systemic inflammation, and gut dysbiosis. However, inconclusive results and a poor description of tissue-specific changes…
View article: Prophylactic feeding of neomycin to Holstein calves alters gut microbiota, bile acid metabolism, and expression of genes involved in immunometabolic regulation
Prophylactic feeding of neomycin to Holstein calves alters gut microbiota, bile acid metabolism, and expression of genes involved in immunometabolic regulation Open
The objective of this study was to evaluate the effects of prophylactic neomycin administration on Holstein bull calves’ intestinal microbiota, bile acid (BA) metabolism, and transcript abundance of genes related to BA metabolism. A total …
View article: Effects of Gut Microbiota Modifying Feed Additives on Growth Performance of Nursery Pigs
Effects of Gut Microbiota Modifying Feed Additives on Growth Performance of Nursery Pigs Open
View article: Effects of <i>Aspergillus oryzae</i> prebiotic on dietary energy and nutrient digestibility of growing pigs
Effects of <i>Aspergillus oryzae</i> prebiotic on dietary energy and nutrient digestibility of growing pigs Open
The objective of this study was to determine the effects of Aspergillus oryzae prebiotic (AOP) on nutrient digestibility in growing pigs fed high-fiber diets. Eighteen growing barrows (initial body weight = 50.6 ± 4.9 kg) were surgically e…
View article: Induction of leaky gut by repeated intramuscular injections of indomethacin to preweaning Holstein calves
Induction of leaky gut by repeated intramuscular injections of indomethacin to preweaning Holstein calves Open
This study was designed to develop a protocol for repeated intramuscular indomethacin injections to replicate leaky-gut-like symptoms in male Holstein calves to model and study the detrimental effects of leaky gut on gut tissue function an…
View article: Triterpenes from <i>Olea europaea</i> modulate in vitro ruminal fermentation
Triterpenes from <i>Olea europaea</i> modulate in vitro ruminal fermentation Open
Bioactive compounds present in Olea europaea have shown promising antimicrobial potential as an alternative to conventional coccidiostats. These effects are exerted by triterpenic acids (TT) present in the olive plant, namely, oleanolic ac…
View article: Physiological responses of Holstein calves to heat stress and dietary supplementation with a postbiotic from Aspergillus oryzae
Physiological responses of Holstein calves to heat stress and dietary supplementation with a postbiotic from Aspergillus oryzae Open
View article: Avens Root (Geum Urbanum L.) Extract Discovered by Target-Based Screening Exhibits Antidiabetic Activity in the Hen’s Egg Test Model and Drosophila melanogaster
Avens Root (Geum Urbanum L.) Extract Discovered by Target-Based Screening Exhibits Antidiabetic Activity in the Hen’s Egg Test Model and Drosophila melanogaster Open
Medicinal plant extracts are becoming increasingly important as an alternative for traditional drugs against diabetes mellitus (DM). For this reason, we initialized a target-based screening of 111 root extracts from an open access plant ex…
View article: Informal nutrition symposium: leveraging the microbiome (and the metabolome) for poultry production
Informal nutrition symposium: leveraging the microbiome (and the metabolome) for poultry production Open
View article: Physiological responses of Holstein calves to prolonged heat stress and dietary supplementation with a postbiotic from Aspergillus oryzae
Physiological responses of Holstein calves to prolonged heat stress and dietary supplementation with a postbiotic from Aspergillus oryzae Open
Increased ambient temperature causes heat stress in mammals, which affects physiological and molecular functions. We have recently reported that the dietary administration of a postbiotic from Aspergillus oryzae (AO) improves tolerance to …
View article: A postbiotic from Aspergillus oryzae attenuates the impact of heat stress in ectothermic and endothermic organisms
A postbiotic from Aspergillus oryzae attenuates the impact of heat stress in ectothermic and endothermic organisms Open
Heat stress is detrimental to food-producing animals and animal productivity remains suboptimal despite the use of heat abatement strategies during summer. Global warming and the increase of frequency and intensity of heatwaves are likely …
View article: The effect of plant bioactive compounds on lamb performance, intake, gastrointestinal parasite burdens, and lipid peroxidation in muscle
The effect of plant bioactive compounds on lamb performance, intake, gastrointestinal parasite burdens, and lipid peroxidation in muscle Open
Plant extracts have been widely used in animal production systems due to the benefits promoted by their bioactive components, mainly through their antioxidant effects and positive effects on animal growth, health, and meat quality. We dete…
View article: 134 Effects of Aspergillus oryzae prebiotic on in vitro digestibility and fermentability of fibrous ingredients and diets
134 Effects of Aspergillus oryzae prebiotic on in vitro digestibility and fermentability of fibrous ingredients and diets Open
It has been an increasing interest to develop strategies to improve utilization of fibrous ingredients in swine. The objective of this study was to determine the effects of an Aspergillus oryzae prebiotic (AOP, Amaferm®) on in vitro digest…