Ignazio Brusca
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View article: An Assessment of the Currently Available Molecular Assay for the Diagnosis of Anisakis Sensitization
An Assessment of the Currently Available Molecular Assay for the Diagnosis of Anisakis Sensitization Open
The diagnosis of allergic reactions to Anisakis remains challenging due to the lack of specific allergens available for routine clinical use. However, the latest version of the multiplex macroarray ALEX-2 now allows the detection of specif…
View article: Immune response to mosquito allergens is associated with cross-reactive bee venom components: the importance of cross-reactive carbohydrate determinants (CCDs) in the Bee-Mosquito Syndromey
Immune response to mosquito allergens is associated with cross-reactive bee venom components: the importance of cross-reactive carbohydrate determinants (CCDs) in the Bee-Mosquito Syndromey Open
Background. Mosquitoes are a family of the order Diptera. Throughout the world, there are two groups able to suck human blood and transmit diseases: the anophelines and the culicines comprise several genera such as Culex, Aedes and …
View article: Seasonal patterns of myositis-specific and myositis-associated autoantibodies in Italy
Seasonal patterns of myositis-specific and myositis-associated autoantibodies in Italy Open
View article: Screening of Anisakis-Related Allergies and Associated Factors in a Mediterranean Community Characterized by High Seafood Consumption
Screening of Anisakis-Related Allergies and Associated Factors in a Mediterranean Community Characterized by High Seafood Consumption Open
Dietary changes expose consumers to risks from Anisakis larvae in seafood, leading to parasitic diseases and allergies. Anisakis is recognized by EFSA as a significant hazard, with potential oncogenic implications. Diagnostic advancements,…
View article: A Heuristic Approach to Analysis of the Genetic Susceptibility Profile in Patients Affected by Airway Allergies
A Heuristic Approach to Analysis of the Genetic Susceptibility Profile in Patients Affected by Airway Allergies Open
Allergic respiratory diseases such as asthma might be considered multifactorial diseases, having a complex pathogenesis that involves environmental factors and the activation of a large set of immune response pathways and mechanisms. In ad…
View article: Co-sensitizations to Gibberellin Regulated Proteins (GRPs) in Italy: results of a polycentric study
Co-sensitizations to Gibberellin Regulated Proteins (GRPs) in Italy: results of a polycentric study Open
Background. Gibberellin Regulated Proteins (GRPs) are small glycoproteins that induce allergy to various types of fruit. This study aimed to evaluate co-sensitization to cypress pollen and other molecules responsible for fruit aller…
View article: Immune Response to Mosquito Allergens Is Associated with Cross-Reactive Bee Venom Components: The Importance of Cross-Reactive Carbohydrate Determinants (CCDs) in the Bee-Mosquito Syndrome.
Immune Response to Mosquito Allergens Is Associated with Cross-Reactive Bee Venom Components: The Importance of Cross-Reactive Carbohydrate Determinants (CCDs) in the Bee-Mosquito Syndrome. Open
Mosquitoes are a family of the order Diptera, which includes more than 3500 species. Two groups able to suck human blood and transmit diseases: the anophelines and the culicines comprise several genera such as Culex, Aedes and Aedes commun…
View article: Mollusk allergy in shrimp-allergic patients: still a complex diagnosis. An Italian multicenter study
Mollusk allergy in shrimp-allergic patients: still a complex diagnosis. An Italian multicenter study Open
Introduction | Shellfish allergy is an important cause of food allergies worldwide. Both in vivo and in vitro diagnostics failure nowadays is caused by the poor quality of the extracts associated with the scarce availability of allergenic …
View article: Basophil Activation Test in the Diagnosis of Anisakis Allergy: An Observational Study from an Area of High Seafood Consumption in Italy
Basophil Activation Test in the Diagnosis of Anisakis Allergy: An Observational Study from an Area of High Seafood Consumption in Italy Open
The rising popularity of undercooked or raw seafood containing larvae of the Anisakis parasite has led to issues of public health concern due to allergic manifestations. We conducted an observational study on the use of an innovative Anisa…
View article: Mollusk allergy in shrimp-allergic patients: Still a complex diagnosis. An Italian real-life cross-sectional multicenter study
Mollusk allergy in shrimp-allergic patients: Still a complex diagnosis. An Italian real-life cross-sectional multicenter study Open
View article: 1255 A point-of-care test useful to detect underdiagnosed coelic disease in children
1255 A point-of-care test useful to detect underdiagnosed coelic disease in children Open
Aims This study, part of a project on a Decision Support System (DSS) on coeliac disease (CD), aimed at assessing the usefulness of a minimally invasive, cheap Point-of-Care Test (POCT) in a population of school children, who underwent the…
View article: Recognizing the Emergent and Submerged Iceberg of the Celiac Disease: ITAMA Project—Global Strategy Protocol
Recognizing the Emergent and Submerged Iceberg of the Celiac Disease: ITAMA Project—Global Strategy Protocol Open
Coeliac disease (CD) is frequently underdiagnosed with a consequent heavy burden in terms of morbidity and health care costs. Diagnosis of CD is based on the evaluation of symptoms and anti-transglutaminase antibodies IgA (TGA-IgA) levels,…
View article: A Fuzzy-Based Clinical Decision Support System for Coeliac Disease
A Fuzzy-Based Clinical Decision Support System for Coeliac Disease Open
Coeliac disease (CD) is a permanent inflammatory disease of the small intestine characterized by the destruction of the mucous membrane of this intestinal tract. Coeliac disease represents the most frequent food intolerance and affects abo…
View article: Allergy to Polyethilenglicole of Anti-SARS CoV2 Vaccine Recipient: A Case Report of Young Adult Recipient and the Management of Future Exposure to SARS-CoV2
Allergy to Polyethilenglicole of Anti-SARS CoV2 Vaccine Recipient: A Case Report of Young Adult Recipient and the Management of Future Exposure to SARS-CoV2 Open
The main contraindication to the anti-SARS CoV2 vaccine is an anaphylactic reaction to a vaccine component. The need to vaccinate allergic people who are at higher risk can be of public health interest and this report shows a case of an al…
View article: A new diagnostic algorithm for pattern-oriented autoantibody testing according to the ICAP nomenclature: A pilot study
A new diagnostic algorithm for pattern-oriented autoantibody testing according to the ICAP nomenclature: A pilot study Open
View article: Anti-DFS70 antibodies detected by specific methods in patients with thrombosis or recurrent pregnancy loss: no evidence of an association
Anti-DFS70 antibodies detected by specific methods in patients with thrombosis or recurrent pregnancy loss: no evidence of an association Open
View article: Emerging Allergens in Goji Berry Superfruit: The Identification of New IgE Binding Proteins towards Allergic Patients’ Sera
Emerging Allergens in Goji Berry Superfruit: The Identification of New IgE Binding Proteins towards Allergic Patients’ Sera Open
The goji berry (Lycium barbarum L.) (GB) is gaining increasing attention with high consumption worldwide due to its exceptional nutritional value and medicinal benefits displayed in humans. Beyond their beneficial properties, GBs contain r…
View article: Evaluation of two commercial peach extracts for skin prick testing in the diagnosis of hypersensitivity to lipid transfer protein. A multicenter study
Evaluation of two commercial peach extracts for skin prick testing in the diagnosis of hypersensitivity to lipid transfer protein. A multicenter study Open
The clinical usefulness of two commercial peach extracts for SPT (by Lofarma SpA and ALK-Abellò, respectively) was compared in a multicenter study carried out in Italy. Peach allergic patients were tested with the two extracts in parallel …
View article: Comparison of the Performance of Skin Prick and ISAC Tests in the Diagnosis of Allergy
Comparison of the Performance of Skin Prick and ISAC Tests in the Diagnosis of Allergy Open
The recent European Union and Italian regulations in the matter of in vivo test could strongly impact on current diagnostic approach, increasing the usage of in vitro tests in daily clinical practice. We evaluated 506 patients with both sk…
View article: Use of a comprehensive diagnostic algorithm for Anisakis allergy in a high seroprevalence Mediterranean setting
Use of a comprehensive diagnostic algorithm for Anisakis allergy in a high seroprevalence Mediterranean setting Open
Background.Diagnosis of anisakis allergy (AA) is based on the skin prick test (SPT) and specific IgE (sIgE) determination. Anyway, false positivity cases are due to cross reactivity with numerous allergens. The aim of the study was …
View article: House dust mite allergy and shrimp allergy: a complex interaction
House dust mite allergy and shrimp allergy: a complex interaction Open
Background and Objective. Sensitization and allergy to shrimp among Italian house dust mite allergic patients are not well defined and were investigated in a large multicenter study. Methods. Shrimp sensitization and allergy …
View article: House dust mite allergy in Italy—Diagnostic and clinical relevance of Der p 23 (and of minor allergens): A real‐life, multicenter study
House dust mite allergy in Italy—Diagnostic and clinical relevance of Der p 23 (and of minor allergens): A real‐life, multicenter study Open
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View article: Safety of Oats in Children with Celiac Disease: A Double-Blind, Randomized, Placebo-Controlled Trial
Safety of Oats in Children with Celiac Disease: A Double-Blind, Randomized, Placebo-Controlled Trial Open
View article: Recommendations for the use of molecular diagnostics in the diagnosis of allergic dis-eases
Recommendations for the use of molecular diagnostics in the diagnosis of allergic dis-eases Open
FIGURE 9. Photophore pattern of Pseudoscopelus bothrorrhinos, based on LACM 31494-1, paratype.
View article: An unusual case of positive sIgE to Galactose-alpha-1,3-galactose from South Italy
An unusual case of positive sIgE to Galactose-alpha-1,3-galactose from South Italy Open
We report the case of a 38-year-old man who was bitten several times during his life by a tick. He didn't report any previous history of anaphylaxis after the ingestion of red meat. The serum specific IgE showed positivity to α-Gal. The pr…
View article: Erratum a: Raccomandazioni per l’utilizzo della diagnostica molecolare in Allergologia
Erratum a: Raccomandazioni per l’utilizzo della diagnostica molecolare in Allergologia Open
View article: The ANA-reflex test as a model for improving clinical appropriateness in autoimmune diagnostics
The ANA-reflex test as a model for improving clinical appropriateness in autoimmune diagnostics Open
View article: Computer-Assisted Classification Patterns in Autoimmune Diagnostics: The AIDA Project
Computer-Assisted Classification Patterns in Autoimmune Diagnostics: The AIDA Project Open
Antinuclear antibodies (ANAs) are significant biomarkers in the diagnosis of autoimmune diseases in humans, done by mean of Indirect ImmunoFluorescence (IIF) method, and performed by analyzing patterns and fluorescence intensity. This pape…
View article: Different co-sensitizations could determine different risk assessment in peach allergy? Evaluation of an anaphylactic biomarker in Pru p 3 positive patients
Different co-sensitizations could determine different risk assessment in peach allergy? Evaluation of an anaphylactic biomarker in Pru p 3 positive patients Open
View article: Comparative Study of Human and Automated Screening for Antinuclear Antibodies by Immunofluorescence on HEp-2 Cells
Comparative Study of Human and Automated Screening for Antinuclear Antibodies by Immunofluorescence on HEp-2 Cells Open
Background: Several automated systems had been developed in order to reduce inter-observer variability in indirect immunofluorescence (IIF) interpretation. We aimed to evaluate the performance of a processing system in antinuclear antibodi…