Igor Allaman
YOU?
Author Swipe
View article: Lack of PTG involvement in glycogen regulation during sleep deprivation in mice
Lack of PTG involvement in glycogen regulation during sleep deprivation in mice Open
The role of astrocytic glycogen metabolism in the regulation of the sleep/wake cycle was suggested decades ago but is still not elucidated. For a long time, glycogen was considered as an energy storage mobilized during high energy states o…
View article: Synergistic interaction of L-Lactate and Glycine to potentiate NMDA receptor activity: a new form of meta-potentiation?
Synergistic interaction of L-Lactate and Glycine to potentiate NMDA receptor activity: a new form of meta-potentiation? Open
N-methyl-d-aspartate (NMDA) receptors are a family of glutamate receptors requiring two distinct molecules to be active: glutamate as the main agonist and glycine (or D-Serine) as a potentiator. In addition, recent studies have demonstrate…
View article: Learning-Induced Gene Expression in the Hippocampus Reveals a Role of Neuron -Astrocyte Metabolic Coupling in Long Term Memory
Learning-Induced Gene Expression in the Hippocampus Reveals a Role of Neuron -Astrocyte Metabolic Coupling in Long Term Memory Open
We examined the expression of genes related to brain energy metabolism and particularly those encoding glia (astrocyte)-specific functions in the dorsal hippocampus subsequent to learning. Context-dependent avoidance behavior was tested in…
View article: A Cellular Perspective on Brain Energy Metabolism and Functional Imaging
A Cellular Perspective on Brain Energy Metabolism and Functional Imaging Open
The energy demands of the brain are high: they account for at least 20% of the body's energy consumption. Evolutionary studies indicate that the emergence of higher cognitive functions in humans is associated with an increased glucose util…
View article: Multi-timescale Modeling of Activity-Dependent Metabolic Coupling in the Neuron-Glia-Vasculature Ensemble
Multi-timescale Modeling of Activity-Dependent Metabolic Coupling in the Neuron-Glia-Vasculature Ensemble Open
Glucose is the main energy substrate in the adult brain under normal conditions. Accumulating evidence, however, indicates that lactate produced in astrocytes (a type of glial cell) can also fuel neuronal activity. The quantitative aspects…
View article: Methylglyoxal, the dark side of glycolysis
Methylglyoxal, the dark side of glycolysis Open
Glucose is the main energy substrate for the brain. There is now extensive evidence indicating that the metabolic profile of neural cells with regard to glucose utilization and glycolysis rate is not homogenous, with a marked propensity fo…
View article: Role of glycogen-derived lactate in synaptic plasticity and memory
Role of glycogen-derived lactate in synaptic plasticity and memory Open
Until recently, lactate has been viewed as a by-product of glycolysis with no relevant role in brain functions. Our laboratory has provided evidence that lactate plays a significant role in neuroenergetics. In particular, we have proposed …
View article: Modulation of astrocytic glucose metabolism by the antidiabetic drug metformin
Modulation of astrocytic glucose metabolism by the antidiabetic drug metformin Open
Reference EPFL-CONF-212084View record in Web of Science Record created on 2015-09-28, modified on 2017-05-25