Igor Bednarski
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View article: Non-surgical keloid management — review of established and emerging treatment strategies
Non-surgical keloid management — review of established and emerging treatment strategies Open
View article: Effective treatment of refractory auricular keloids with combined intralesional triamcinolone/5-FU and CO2 laser surgery: A case series
Effective treatment of refractory auricular keloids with combined intralesional triamcinolone/5-FU and CO2 laser surgery: A case series Open
View article: Molecular mechanisms of keloid development
Molecular mechanisms of keloid development Open
View article: New insight into the role of the pathway NLRP1 and NLRP3 inflammasomes and IL-33 in ultraviolet-induced cutaneous carcinogenesis
New insight into the role of the pathway NLRP1 and NLRP3 inflammasomes and IL-33 in ultraviolet-induced cutaneous carcinogenesis Open
Introduction Inflammasomes NLRP1 (NLR family pyrin domain containing 1) and NLRP3 are pivotal regulators of the innate immune response, activated by a spectrum of endogenous and exogenous stressors, including ultraviolet radiation (UVR). T…
View article: No Relation Between Cognitive Impairment, Physical Disability and Serum Biomarkers in a Cohort of Progressive Multiple Sclerosis Patients
No Relation Between Cognitive Impairment, Physical Disability and Serum Biomarkers in a Cohort of Progressive Multiple Sclerosis Patients Open
Despite significant efforts, there is still an existing need to identify diagnostic tools that would enable fast and reliable detection of the progressive stage of multiple sclerosis (MS) and help in monitoring the disease course and/or tr…
View article: Port-wine stain and its influence on patients’ quality of life and psychosocial issues
Port-wine stain and its influence on patients’ quality of life and psychosocial issues Open
PWS affects psychosocial well-being of patients including their quality of life, self-perception of the body or feeling of stigmatization. Interdisciplinary approach is needed to provide patients with necessary psychological or psychiatric…
View article: LED-emitted blue light improves quality of life and reduces fatigue after COVID-19 infection
LED-emitted blue light improves quality of life and reduces fatigue after COVID-19 infection Open
Our study shows that blue light therapy could be used as adjunctive treatment of fatigue and provide an opportunity for further scientific inquiries.
View article: Pruritus prevalence and characteristics in Care and Treatment Facility and Geriatric Outpatient Clinic patients: a cross-sectional study using a standardized pruritus questionnaires
Pruritus prevalence and characteristics in Care and Treatment Facility and Geriatric Outpatient Clinic patients: a cross-sectional study using a standardized pruritus questionnaires Open
One of the most common causes of pruritus is xerosis. It is essential to provide appropriate education to patients and caregivers on the use of emollients. Therefore, the development of recommendations would be desirable. Many drugs common…
View article: Do increased serum IL-12 and IL-23 levels affect cognitive function in patients with multiple sclerosis? A preliminary study
Do increased serum IL-12 and IL-23 levels affect cognitive function in patients with multiple sclerosis? A preliminary study Open
Aim of the study: To compare the serum levels of IL-12 and IL-23 between healthy volunteers and patients with multiple sclerosis with regard to their cognitive function. Materials and methods: A total of 21 patients with multiple sclerosis…
View article: Towards Effective Telerehabilitation: Assessing Effects of Applying Augmented Reality in Remote Rehabilitation of Patients Suffering from Multiple Sclerosis
Towards Effective Telerehabilitation: Assessing Effects of Applying Augmented Reality in Remote Rehabilitation of Patients Suffering from Multiple Sclerosis Open
Multiple Sclerosis (MS) is a chronic, incurable disease of the central nervous system that is also one of the most common causes of disability among young adults. Despite available pharmacological treatments, the patients often require ong…
View article: Emotional control and illness acceptance in patients with multiple sclerosis – preliminary findings
Emotional control and illness acceptance in patients with multiple sclerosis – preliminary findings Open
Aim of the study: Mental disorders occur in about 75% of patients with multiple sclerosis (MS). Examination of the mental state of patients with multiple sclerosis is important for assessing the course of the disease and undertaking approp…
View article: More Than Skin Deep – the Effects of Ultraviolet Radiation on Cathepsin K and Progerin Expression in Cultured Dermal Fibroblasts
More Than Skin Deep – the Effects of Ultraviolet Radiation on Cathepsin K and Progerin Expression in Cultured Dermal Fibroblasts Open
The results suggest that there could be another progerin/cathepsin K regulatory pathway, which has not been described yet. Being contradictory with previous research, the influence of ultraviolet radiation on progerin and cathepsin K needs…
View article: AntiTNF-alpha Therapy Normalizes Levels of Lipids and Adipokines in Psoriatic Patients in the Real-life Settings
AntiTNF-alpha Therapy Normalizes Levels of Lipids and Adipokines in Psoriatic Patients in the Real-life Settings Open
Studies have shown that the levels of pro-inflammatory adipokines in patients with psoriasis are higher than in general population. The aim of the study was to investigate the influence of 36-month therapy with TNF-α inhibitors (adalimumab…
View article: Prospective 3-month study on the efficacy of UV-free bluelight in mild psoriasis vulgaris treatment
Prospective 3-month study on the efficacy of UV-free bluelight in mild psoriasis vulgaris treatment Open
Our results confirm that phototherapy using blue LED light is both a safe and highly effective way to treat psoriasis.
View article: Double-blind, randomized controlled trial comparing theuse of microneedling alone vs chemical peeling alone vsa combination of microneedling and chemical peeling inthe treatment of atrophic post-acne scars. An assessmentof clinical effectiveness and patients’ quality-of-life
Double-blind, randomized controlled trial comparing theuse of microneedling alone vs chemical peeling alone vsa combination of microneedling and chemical peeling inthe treatment of atrophic post-acne scars. An assessmentof clinical effectiveness and patients’ quality-of-life Open
A combination of microneedling and chemical peeling produces the best, objectively measured effects in the treatment of atrophic post-acne scars. All examined treatments, even if not producing a clinically significant treatment outcome, im…
View article: Serum concentration of matrix metalloproteinases and angiogenic factors in patients with venous leg ulcers
Serum concentration of matrix metalloproteinases and angiogenic factors in patients with venous leg ulcers Open
Lack of significant differences in the concentration of TIMP-1 between the control and the study group confirms that proteolysis is a hallmark of CVI, but increased concentration of VEGF and angiogenin in the study group compared to the co…
View article: Effect of aerobic training on changes in neuroplasticity marker levels in patients with multiple sclerosis – a pilot study
Effect of aerobic training on changes in neuroplasticity marker levels in patients with multiple sclerosis – a pilot study Open
Introduction: Neuroplasticity is the function of the central nervous system that allows structural and functional reorganisation in response to external and internal factors. It is a crucial aspect that allows for the restoration of motor …
View article: Assessment of fatigue, cognition and depression in correlation with the applied immunomodulating treatment based on the Lodz registry of patients with multiple sclerosis
Assessment of fatigue, cognition and depression in correlation with the applied immunomodulating treatment based on the Lodz registry of patients with multiple sclerosis Open
Introduction: Multiple sclerosis is the most common chronic inflammatory demyelinating disease of the central nervous system, mainly affecting young people. A breakthrough in the treatment of multiple sclerosis was the introduction of immu…
View article: Effectiveness and safety of secukinumab in patientswith moderate-to-severe plaque psoriasis – a real liferetrospective study
Effectiveness and safety of secukinumab in patientswith moderate-to-severe plaque psoriasis – a real liferetrospective study Open
Our results prove that secukinumab offers a good therapeutic opportunity and may be a preferred treatment option for patients with moderate-to-severe psoriasis and psoriatic arthritis.
View article: Serum and synovial fluid concentrations of interleukin-18 and interleukin-20 in patients with osteoarthritis of the knee and their correlation with other markers of inflammation and turnover of joint cartilage
Serum and synovial fluid concentrations of interleukin-18 and interleukin-20 in patients with osteoarthritis of the knee and their correlation with other markers of inflammation and turnover of joint cartilage Open
Introduction Osteoarthritis (OA) is the most common degenerative joint disease, and its aetiology is not entirely known. The aim of the study was to evaluate the involvement of interleukin-18 (IL-18) and interleukin-20 (IL-20) in the patho…
View article: NLRP1 and NLRP3 inflammasomes as a new approach to skin carcinogenesis (Review)
NLRP1 and NLRP3 inflammasomes as a new approach to skin carcinogenesis (Review) Open
Inflammasomes are key innate immune system receptors that detect pathogenic endo- and exogenous stressors like microorganisms or ultraviolet radiation (UVR) which activate the highly proinflammatory cytokines interleukin-1β and interleukin…
View article: Overexpression of cathepsin K and vascular endothelial growth factor in chronic venous ulcerations
Overexpression of cathepsin K and vascular endothelial growth factor in chronic venous ulcerations Open
Increased immunoexpression of VEGF and cathepsin K suggests that both of these proteins may play a role in VU development.
View article: Interleukin-18, interleukin-20, and matrix metalloproteinases (MMP-1, MMP-3) as markers of psoriatic arthritis disease severity and their correlations with biomarkers of inflammation and turnover of joint cartilage
Interleukin-18, interleukin-20, and matrix metalloproteinases (MMP-1, MMP-3) as markers of psoriatic arthritis disease severity and their correlations with biomarkers of inflammation and turnover of joint cartilage Open
IL-18 and IL-20 as well as MMP-3 and COMP may be sensitive markers in the diagnosis of PsA.
View article: The influence of tumour necrosis factor α inhibitors treatment – etanercept on serum concentration of biomarkers of inflammation and cartilage turnover in psoriatic arthritis patients
The influence of tumour necrosis factor α inhibitors treatment – etanercept on serum concentration of biomarkers of inflammation and cartilage turnover in psoriatic arthritis patients Open
IL-6, MMP-1 and YKL-40 may be useful for monitoring the effectiveness of anti-TNF-α treatment.
View article: Interleukin 22 and 6 serum concentrations decreaseunder long-term biologic therapy in psoriasis
Interleukin 22 and 6 serum concentrations decreaseunder long-term biologic therapy in psoriasis Open
According to obtained results, IL-6 and IL-22 serum concentration may be an accurate marker of response to antipsoriatic therapy, even though not correlated with PASI index. Biologic therapy in psoriasis allows for long-term clinical impro…
View article: Single Dose of Del Nido Cardioplegic Solution in Comparison with St Thomas Hospital Solution in Mitral Valve Surgery: A Propensity Matched Comparison
Single Dose of Del Nido Cardioplegic Solution in Comparison with St Thomas Hospital Solution in Mitral Valve Surgery: A Propensity Matched Comparison Open
View article: The effects of listening to classical music on dehydroepiandrosterone sulfate and subjective anxiety levels in female in-patients with psoriasis
The effects of listening to classical music on dehydroepiandrosterone sulfate and subjective anxiety levels in female in-patients with psoriasis Open
ENWEndNote BIBJabRef, Mendeley RISPapers, Reference Manager, RefWorks, Zotero AMA Krasiński-Heringa O, Owczarek W, Kozłowska M, et al. The effects of listening to classical music on dehydroepiandrosterone sulfate and subjective anxiety lev…
View article: Ingenol mebutate treatment in actinic keratosis – clinical effectiveness and potential side effects
Ingenol mebutate treatment in actinic keratosis – clinical effectiveness and potential side effects Open
Our study shows that ingenol mebutate is highly efficacious field treatment for actinic keratosis.
View article: Proteins involved in cutaneous basal cell carcinoma development
Proteins involved in cutaneous basal cell carcinoma development Open
Basal cell carcinoma (BCC) is the most common skin malignancy type in the Caucasian population, with a continuously increasing incidence rate. The etiology of BCC remains unknown, but it appears to have a multifactorial origin resulting fr…
View article: Omalizumab for urticaria treatment in clinical practice: a case series
Omalizumab for urticaria treatment in clinical practice: a case series Open
Omalizumab appears to be a safe drug, which in a quick and effective way inducts remission in patients who have not responded to previous treatment.