Igor Belyaev
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View article: Evaluation of oxidative stress and genetic instability among residents near mobile phone base stations in Germany
Evaluation of oxidative stress and genetic instability among residents near mobile phone base stations in Germany Open
Human exposure to radiofrequency electromagnetic fields (RF-EMF) is restricted to prevent thermal effects in the tissue. However, at very low intensity exposure "non-thermal" biological effects, like oxidative stress, DNA or chromosomal ab…
View article: Effects of low-dose ionizing radiation on genomic instability in interventional radiology workers
Effects of low-dose ionizing radiation on genomic instability in interventional radiology workers Open
Interventional radiologists are chronically exposed to low-dose ionizing radiation (IR), which may represent a health risk. The aim of the present study was to evaluate genomic instability by analyzing chromosomal aberrations, micronuclei,…
View article: Assessment of Individual Radiosensitivity in Breast Cancer Patients Using a Combination of Biomolecular Markers
Assessment of Individual Radiosensitivity in Breast Cancer Patients Using a Combination of Biomolecular Markers Open
About 5% of patients undergoing radiotherapy (RT) develop RT-related side effects. To assess individual radiosensitivity, we collected peripheral blood from breast cancer patients before, during and after the RT, and γH2AX/53BP1 foci, apop…
View article: Cell Phone Radiation Exposure Limits and Engineering Solutions
Cell Phone Radiation Exposure Limits and Engineering Solutions Open
In the 1990s, the Institute of Electrical and Electronics Engineers (IEEE) restricted its risk assessment for human exposure to radiofrequency radiation (RFR) in seven ways: (1) Inappropriate focus on heat, ignoring sub-thermal effects. (2…
View article: Preleukemic Fusion Genes Induced via Ionizing Radiation
Preleukemic Fusion Genes Induced via Ionizing Radiation Open
Although the prevalence of leukemia is increasing, the agents responsible for this increase are not definitely known. While ionizing radiation (IR) was classified as a group one carcinogen by the IARC, the IR-induced cancers, including leu…
View article: Extremely low frequency magnetic fields emitted by cell phones
Extremely low frequency magnetic fields emitted by cell phones Open
Cell phones expose significant parts of the human brain and head to extremely low frequency (ELF) magnetic fields (MF) classified by the IARC as a 2B carcinogen. ELF MF was measured on the front and back sides of 15 cell phones in standby,…
View article: Chemotherapy and cryopreservation affects DNA repair foci in lymphocytes of breast cancer patients
Chemotherapy and cryopreservation affects DNA repair foci in lymphocytes of breast cancer patients Open
Although breast cancer (BC) patients benefit from radiotherapy (RT), some radiosensitive (RS) patients suffer from side effects caused by ionizing radiation in healthy tissues. It is thought that RS is underlaid by a deficiency in the repa…
View article: Intermittent ELF-MF Induce an Amplitude-Window Effect on Umbilical Cord Blood Lymphocytes
Intermittent ELF-MF Induce an Amplitude-Window Effect on Umbilical Cord Blood Lymphocytes Open
In a previous study of the effects of intermittent extremely low frequency (ELF) magnetic fields (MF) on umbilical cord blood lymphocytes (UCBL), we evaluated MF amplitudes between 6 µT and 24 µT and found an effect only for those below 13…
View article: Classifier Spot Count Optimization of Automated Fluorescent Slide Scanning System
Classifier Spot Count Optimization of Automated Fluorescent Slide Scanning System Open
Purpose : Ionizing radiation induced foci (IRIF) known also as DNA repair foci represent the most sensitive endpoint for assessing DNA double strand breaks (DSB). IRIF are usually visualized and enumerated with the aid of fluorescence micr…
View article: Physical model for effects of microwaves on nucleoids in living cells: role of carrier frequency, modulation and DC and AC magnetic field
Physical model for effects of microwaves on nucleoids in living cells: role of carrier frequency, modulation and DC and AC magnetic field Open
The effect of static and alternating magnetic fields on the conformation of nucleoids in cells of different types is considered. The model of slow and nonuniform rotation of the charged DNA domain is used. An equation is obtained for the r…
View article: The Critical Importance of Molecular Biomarkers and Imaging in the Study of Electrohypersensitivity. A Scientific Consensus International Report
The Critical Importance of Molecular Biomarkers and Imaging in the Study of Electrohypersensitivity. A Scientific Consensus International Report Open
Clinical research aiming at objectively identifying and characterizing diseases via clinical observations and biological and radiological findings is a critical initial research step when establishing objective diagnostic criteria and trea…
View article: Imaging flow cytometry and fluorescence microscopy in assessing radiation response in lymphocytes from umbilical cord blood and cancer patients
Imaging flow cytometry and fluorescence microscopy in assessing radiation response in lymphocytes from umbilical cord blood and cancer patients Open
DNA double strand breaks (DSB) induced by ionizing radiation (IR) are usually measured using γH2AX/53BP1 DNA repair foci, that is considered to be the most sensitive assay for DSB analysis. While fluorescence microscopy (FM) is the gold st…
View article: Evaluation of Calyculin A Effect on γH2AX/53BP1 Focus Formation and Apoptosis in Human Umbilical Cord Blood Lymphocytes
Evaluation of Calyculin A Effect on γH2AX/53BP1 Focus Formation and Apoptosis in Human Umbilical Cord Blood Lymphocytes Open
Dephosphorylation inhibitor calyculin A (cal A) has been reported to inhibit the disappearance of radiation-induced γH2AX DNA repair foci in human lymphocytes. However, other studies reported no change in the kinetics of γH2AX focus induct…
View article: Induction of AML Preleukemic Fusion Genes in HSPCs and DNA Damage Response in Preleukemic Fusion Gene Positive Samples
Induction of AML Preleukemic Fusion Genes in HSPCs and DNA Damage Response in Preleukemic Fusion Gene Positive Samples Open
Preleukemic fusion genes (PFGs) occurring after DNA damage in hematopoietic stem progenitor cells (HSPCs) in utero often represent the initial event in the development of childhood leukemia. While the incidence of PFGs characteristic for a…
View article: Biodosimetry of Low Dose Ionizing Radiation Using DNA Repair Foci in Human Lymphocytes
Biodosimetry of Low Dose Ionizing Radiation Using DNA Repair Foci in Human Lymphocytes Open
Purpose: Ionizing radiation induced foci (IRIF) known also as DNA repair foci represent most sensitive endpoint for assessing DNA double strand breaks (DSB). IRIF are usually visualized and enumerated with the aid of fluorescence microscop…
View article: BCR/ABL preleukemic fusion gene in subpopulations of hematopoietic stem and progenitor cells from human UCB
BCR/ABL preleukemic fusion gene in subpopulations of hematopoietic stem and progenitor cells from human UCB Open
The BCR/ABL preleukemic fusion gene (PFG) is one of the most frequent fusion genes in acute lymphoblastic leukemia (ALL) and was also detected in hematopoietic cells from umbilical cord blood (UCB) of healthy newborns. Since hematopoietic …
View article: Microwaves from mobile phone induce reactive oxygen species but not DNA damage, preleukemic fusion genes and apoptosis in hematopoietic stem/progenitor cells
Microwaves from mobile phone induce reactive oxygen species but not DNA damage, preleukemic fusion genes and apoptosis in hematopoietic stem/progenitor cells Open
Exposure to electromagnetic fields (EMF) has been associated with the increased risk of childhood leukemia, which arises from mutations induced within hematopoietic stem cells often through preleukemic fusion genes (PFG). In this study we …
View article: BCR/ABL preleukemic fusion gene in subpopulations of hematopoietic stem and progenitor cells from human UCB
BCR/ABL preleukemic fusion gene in subpopulations of hematopoietic stem and progenitor cells from human UCB Open
Background BCR/ABL preleukemic fusion gene (PFG) is one of the most frequent fusion genes in acute lymphoblastic leukemia (ALL) and was also detected in hematopoietic cells from umbilical cord blood (UCB) of healthy newborns. Since hematop…
View article: Additional file 1: of A high throughput screening system of coils for ELF magnetic fields experiments: proof of concept on the proliferation of cancer cell lines
Additional file 1: of A high throughput screening system of coils for ELF magnetic fields experiments: proof of concept on the proliferation of cancer cell lines Open
The file is a Microsoft Excel spreadsheet with the measurements of the magnetic fields utilized in the experiments, and the colorimetric readings from the proliferation assays. (XLSX 56 kb)
View article: Backtracked analysis of preleukemic fusion genes and DNA repair foci in umbilical cord blood of children with acute leukemia
Backtracked analysis of preleukemic fusion genes and DNA repair foci in umbilical cord blood of children with acute leukemia Open
The first event in origination of many childhood leukemias is a specific preleukemic fusion gene (PFG) that arises, often in utero, in hematopoietic stem/progenitor cells (HSPC) from misrepaired DNA double strand break (DSB). An immanently…