Igor Gavrish
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View article: Dysplastic lung repair fosters a tuberculosis-promoting microenvironment through maladaptive macrophage polarization
Dysplastic lung repair fosters a tuberculosis-promoting microenvironment through maladaptive macrophage polarization Open
Pulmonary TB that develops in immunocompetent adult humans is responsible for approximately 85% of the disease burden and is central for Mtb transmission. Most humans contain Mtb infection within primary granulomatous lesions, but in certa…
View article: Protocol for Developing a Mouse Model of Post Primary Pulmonary Tuberculosis after Hematogenous Spread in Native Lungs and Lung Implants
Protocol for Developing a Mouse Model of Post Primary Pulmonary Tuberculosis after Hematogenous Spread in Native Lungs and Lung Implants Open
Summary This protocol describes a mouse model of post-primary pulmonary tuberculosis (PTB) that develops after hematogenous spread from the primary lesion in native lungs and subcutaneous lung implants. It demonstrates that virulent Mycoba…
View article: Aberrant macrophage activation and maladaptive lung repair promote tuberculosis progression uniquely in the lung
Aberrant macrophage activation and maladaptive lung repair promote tuberculosis progression uniquely in the lung Open
Pulmonary tuberculosis (PTB) represents 85% of the disease burden caused by Mycobacterium tuberculosis (Mtb) and promotes aerosol transmission infecting about a quarter of people globally. Most Mtb infections are effectively limited within…
View article: Progression and Dissemination of Pulmonary Mycobacterium Avium Infection in a Susceptible Immunocompetent Mouse Model
Progression and Dissemination of Pulmonary Mycobacterium Avium Infection in a Susceptible Immunocompetent Mouse Model Open
Pulmonary infections caused by the group of nontuberculosis mycobacteria (NTM), Mycobacterium avium complex (MAC), are a growing public health concern with incidence and mortality steadily increasing globally. Granulomatous inflammation is…
View article: Dissemination and progression of pulmonary<i>Mycobacterium avium</i>infection in mouse model is associated with type 2 macrophage activation
Dissemination and progression of pulmonary<i>Mycobacterium avium</i>infection in mouse model is associated with type 2 macrophage activation Open
Pulmonary infections caused by the group of nontuberculosis mycobacteria (NTM), Mycobacterium avium complex (MAC), are increasing worldwide and a growing public health concern. Pulmonary granulomas are the hallmark of MAC lung infection, y…