Igor Iatsenko
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View article: Infection-induced elevation of gut glycosaminoglycans fosters microbiota expansion in Drosophila melanogaster
Infection-induced elevation of gut glycosaminoglycans fosters microbiota expansion in Drosophila melanogaster Open
While host genetics influence the composition of intestinal microbial communities, host genetic factors controlling the abundance of intestinal commensals remain to be determined. We perform a genome-wide association study in Drosophila me…
View article: Sex Bias in Iron Sequestration by Transferrin 1 Modulates Sexually-Dimorphic Infection Outcomes in Drosophila melanogaster
Sex Bias in Iron Sequestration by Transferrin 1 Modulates Sexually-Dimorphic Infection Outcomes in Drosophila melanogaster Open
Host sexual dimorphism in the outcome of infections is a ubiquitous phenomenon across taxa. However, the immunological differences between males and females and the mechanisms underlying them remain poorly characterized. Here, we used Dros…
View article: Infection-Induced Elevation of Gut Glycosaminoglycans Fosters Microbiota Expansion in <i>Drosophila melanogaster</i>
Infection-Induced Elevation of Gut Glycosaminoglycans Fosters Microbiota Expansion in <i>Drosophila melanogaster</i> Open
Summary While host genetics influence the composition of intestinal microbial communities, host genetic factors controlling the abundance of intestinal commensals remain to be determined. Here, we performed a genome-wide association (GWA) …
View article: Sex Differences in <i>Drosophila</i> Intestinal Metabolism Contribute to Sexually Dimorphic Infection Outcome and Alter Gut Pathogen Virulence
Sex Differences in <i>Drosophila</i> Intestinal Metabolism Contribute to Sexually Dimorphic Infection Outcome and Alter Gut Pathogen Virulence Open
SUMMARY Sexual dimorphism in infection outcomes is a pervasive phenomenon, the underlying mechanisms of which remain incompletely understood. Here, utilizing Pseudomonas entomophila intestinal infection in Drosophila, we demonstrated that …
View article: <i>Drosophila</i> symbionts in infection: when a friend becomes an enemy
<i>Drosophila</i> symbionts in infection: when a friend becomes an enemy Open
The insect microbiome is comprised of extracellular microbial communities that colonize the host surfaces and endosymbionts that reside inside host cells and tissues. Both of these communities participate in essential aspects of host biolo…
View article: MprF-mediated immune evasion is necessary for Lactiplantibacillus plantarum resilience in the Drosophila gut during inflammation
MprF-mediated immune evasion is necessary for Lactiplantibacillus plantarum resilience in the Drosophila gut during inflammation Open
Multiple peptide resistance factor (MprF) confers resistance to cationic antimicrobial peptides (AMPs) in several pathogens, thereby enabling evasion of the host immune response. The role of MprF in commensals remains, however, uncharacter…
View article: The endosymbiont <i>Spiroplasma poulsonii</i> increases <i>Drosophila melanogaster</i> resistance to pathogens by enhancing iron sequestration and melanization
The endosymbiont <i>Spiroplasma poulsonii</i> increases <i>Drosophila melanogaster</i> resistance to pathogens by enhancing iron sequestration and melanization Open
Facultative endosymbiotic bacteria, such as Wolbachia and Spiroplasma species, are commonly found in association with insects and can dramatically alter their host physiology. Many endosymbionts are defensive and protect their hosts agains…
View article: MprF-mediated immune evasion is necessary for<i>Lactiplantibacillus plantarum</i>resilience in<i>Drosophila</i>gut during inflammation
MprF-mediated immune evasion is necessary for<i>Lactiplantibacillus plantarum</i>resilience in<i>Drosophila</i>gut during inflammation Open
Background Multiple peptide resistance factor (MprF) confers resistance to cationic antimicrobial peptides (AMPs) in several pathogens, thereby enabling evasion of the host immune response. While MprF has been proven to be crucial for the …
View article: The endosymbiont<i>Spiroplasma poulsonii</i>increases<i>Drosophila melanogaster</i>resistance to pathogens by enhancing iron-sequestration and melanization
The endosymbiont<i>Spiroplasma poulsonii</i>increases<i>Drosophila melanogaster</i>resistance to pathogens by enhancing iron-sequestration and melanization Open
Facultative endosymbiotic bacteria, such as Wolbachia and Spiroplasma species, are commonly found in association with insects and can dramatically alter their host physiology. Many endosymbionts are defensive and protect their hosts agains…
View article: Resistance to host antimicrobial peptides mediates resilience of gut commensals during infection and aging in <i>Drosophila</i>
Resistance to host antimicrobial peptides mediates resilience of gut commensals during infection and aging in <i>Drosophila</i> Open
Resilience to short-term perturbations, like inflammation, is a fundamental feature of microbiota, yet the underlying mechanisms of microbiota resilience are incompletely understood. Here, we show that Lactiplantibacillus plantarum , a maj…
View article: Resistance to host antimicrobial peptides mediates resilience of gut commensals during infection and aging in<i>Drosophila</i>
Resistance to host antimicrobial peptides mediates resilience of gut commensals during infection and aging in<i>Drosophila</i> Open
Resilience to short-term perturbations, like inflammation, is a fundamental feature of microbiota, yet the underlying mechanisms of microbiota resilience are incompletely understood. Here we show that Lactiplantibacillus plantarum , a majo…
View article: Lipopolysaccharide -mediated resistance to host antimicrobial peptides and hemocyte-derived reactive-oxygen species are the major Providencia alcalifaciens virulence factors in Drosophila melanogaster
Lipopolysaccharide -mediated resistance to host antimicrobial peptides and hemocyte-derived reactive-oxygen species are the major Providencia alcalifaciens virulence factors in Drosophila melanogaster Open
Bacteria from the genus Providencia are ubiquitous Gram-negative opportunistic pathogens, causing “travelers’ diarrhea”, urinary tract, and other nosocomial infections in humans. Some Providencia strains have also been isolated as natural …
View article: The Role of Microbiota in Drosophila melanogaster Aging
The Role of Microbiota in Drosophila melanogaster Aging Open
Intestinal microbial communities participate in essential aspects of host biology, including nutrient acquisition, development, immunity, and metabolism. During host aging, dramatic shifts occur in the composition, abundance, and function …
View article: Lipopolysaccharide-mediated resistance to host antimicrobial peptides and hemocyte-derived reactive-oxygen species are the major <i>Providencia alcalifaciens</i> virulence factors in <i>Drosophila melanogaster</i>
Lipopolysaccharide-mediated resistance to host antimicrobial peptides and hemocyte-derived reactive-oxygen species are the major <i>Providencia alcalifaciens</i> virulence factors in <i>Drosophila melanogaster</i> Open
Bacteria from the genus Providencia are ubiquitous Gram-negative opportunistic pathogens, causing “travelers’ diarrhea”, urinary tract, and other nosocomial infections in humans. Some Providencia strains have also been isolated as natural …
View article: The Drosophila Baramicin polypeptide gene protects against fungal infection
The Drosophila Baramicin polypeptide gene protects against fungal infection Open
The fruit fly Drosophila melanogaster combats microbial infection by producing a battery of effector peptides that are secreted into the haemolymph. Technical difficulties prevented the investigation of these short effector genes until the…
View article: The Drosophila Baramicin polypeptide gene protects against fungal infection
The Drosophila Baramicin polypeptide gene protects against fungal infection Open
The fruit fly Drososphila melanogaster combats microbial infection by producing a battery of effector peptides that are secreted into the haemolymph. Technical difficulties prevented the investigation of these short effector genes until th…
View article: Iron sequestration by transferrin 1 mediates nutritional immunity in <i>Drosophila melanogaster</i>
Iron sequestration by transferrin 1 mediates nutritional immunity in <i>Drosophila melanogaster</i> Open
Significance Hosts sequester iron as a strategy to limit pathogen acquisition of this essential nutrient in a process termed nutritional immunity. Due to their in vitro antimicrobial activity, iron-binding proteins transferrins are suspect…