Igor Kovalchuk
YOU?
Author Swipe
View article: Exploring the Impact of Skin Care Routines on the Skin Microbiome and Possible Skin Disease Risk—A Pilot Study
Exploring the Impact of Skin Care Routines on the Skin Microbiome and Possible Skin Disease Risk—A Pilot Study Open
Background/Objectives: Unceasing exposure of skin and its microbiome to various external and internal factors influences its health. Any imbalance ensuing may result in dysbiosis and consequently skin diseases. Thus, it becomes critical to…
View article: Glycolytic flux controls retinal progenitor cell differentiation via regulating Wnt signaling
Glycolytic flux controls retinal progenitor cell differentiation via regulating Wnt signaling Open
Metabolic pathways are remodeled in response to energy and other homeostatic demands and are dynamically regulated during embryonic development, suggesting a role in guiding cellular differentiation. Here, we show that glycolytic flux is r…
View article: Exploring Impact of Skin Care Routine on Skin Microbiome and Related Diseases – A Pilot Study
Exploring Impact of Skin Care Routine on Skin Microbiome and Related Diseases – A Pilot Study Open
Unceasing exposure of skin and its microbiome to various external and internal factors influences its health. Any imbalance ensuing may result in dysbiosis and consequently skin diseases. Thus, it becomes critical to identify and recognize…
View article: Glycolytic flux controls retinal progenitor cell differentiation via regulating Wnt signaling
Glycolytic flux controls retinal progenitor cell differentiation via regulating Wnt signaling Open
Metabolic pathways are remodeled in response to energy and other homeostatic demands and are dynamically regulated during embryonic development, suggesting a role in guiding cellular differentiation. Here, we show that glycolytic flux is r…
View article: Effects of cannabidiol (CBD) treatment on age-related cognitive decline in C57 mice
Effects of cannabidiol (CBD) treatment on age-related cognitive decline in C57 mice Open
Aging is associated with cognitive decline, and currently, there are no approved medications that can prevent these impairments. Recently, cannabinoids derived from Cannabis sativa have emerged as promising therapeutic compounds with neuro…
View article: A Positive Feedback DNA-PK/MYT1L-CXCR1-ERK1/2 Proliferative Signaling Loop in Glioblastoma
A Positive Feedback DNA-PK/MYT1L-CXCR1-ERK1/2 Proliferative Signaling Loop in Glioblastoma Open
Glioblastoma is the most common primary brain tumor in adults. Our previous studies revealed a functional interplay of myelin transcription factor 1-like (MYT1L) with the DNA-dependent protein kinase (DNA-PK) in the regulation of p21 trans…
View article: The Impact of Major and Minor Phytocannabinoids on the Maintenance and Function of INS-1 β-Cells Under High-Glucose and High-Lipid Conditions
The Impact of Major and Minor Phytocannabinoids on the Maintenance and Function of INS-1 β-Cells Under High-Glucose and High-Lipid Conditions Open
Type 2 diabetes mellites (T2DM) is the most common form of diabetes and affects a significant portion of the population. Obesity-related increases in free fatty acids and glucose in the diet contribute to β-cell dysfunction and loss, ultim…
View article: LPS-Induced Liver Inflammation Is Inhibited by Psilocybin and Eugenol in Mice
LPS-Induced Liver Inflammation Is Inhibited by Psilocybin and Eugenol in Mice Open
Background/Objectives: Liver inflammatory diseases are a major global health burden and are often exacerbated by inflammation driven by lipopolysaccharides (LPS) through toll-like receptor 4 signaling. This study evaluates the anti-inflamm…
View article: Genetic and Epigenetic Changes in Arabidopsis thaliana Exposed to Ultraviolet-C Radiation Stress for 25 Generations
Genetic and Epigenetic Changes in Arabidopsis thaliana Exposed to Ultraviolet-C Radiation Stress for 25 Generations Open
Continuous exposure to stress contributes to species diversity and drives microevolutionary processes. It is still unclear, however, whether epigenetic changes, in the form of epimutations such as, for example, differential DNA methylation…
View article: Entomopathogenic Fungi Effectively Control Phorodon cannabis Aphid Population in Cannabis sativa Plants
Entomopathogenic Fungi Effectively Control Phorodon cannabis Aphid Population in Cannabis sativa Plants Open
The rapid expansion of the cannabis industry in Canada post-legalization has heightened the prevalence of pests, particularly the cannabis aphid Phorodon cannabis (P. cannabis), which poses significant threats to crop health. This study in…
View article: Transcriptome of Arabidopsis thaliana Plants Exposed to Human Parasites Cryptosporidium parvum and Giardia lamblia
Transcriptome of Arabidopsis thaliana Plants Exposed to Human Parasites Cryptosporidium parvum and Giardia lamblia Open
Pathogen infection in animals and plants is recognized in a relatively similar manner by the interaction of pattern recognition receptors on the host cell surface with pathogen-associated molecular patterns on the pathogen surface. Previou…
View article: Single and Combined Impact of Semaglutide, Tirzepatide, and Metformin on β-Cell Maintenance and Function Under High-Glucose–High-Lipid Conditions: A Comparative Study
Single and Combined Impact of Semaglutide, Tirzepatide, and Metformin on β-Cell Maintenance and Function Under High-Glucose–High-Lipid Conditions: A Comparative Study Open
Type 2 diabetes (T2D), the most common form, is marked by insulin resistance and β-cell failure. β-cell dysfunction under high-glucose–high-lipid (HG-HL) conditions is a key contributor to the progression of T2D. This study evaluates the c…
View article: Psilocybin alleviates high-glucose and high-lipid-induced skin aging in BJ5Ta fibroblasts
Psilocybin alleviates high-glucose and high-lipid-induced skin aging in BJ5Ta fibroblasts Open
Cellular aging, driven by oxidative stress, mitochondrial dysfunction, and inflammation, is exacerbated by a high-glucose and high-lipid (HGHL) diet, leading to collagen degradation and skin aging. Psilocybin, a naturally occurring compoun…
View article: Multi-omics data integration for topology-based pathway activation assessment and personalized drug ranking
Multi-omics data integration for topology-based pathway activation assessment and personalized drug ranking Open
The main finding – the expression of long non-coding RNAs (in red) – correlates much better with mRNA, as compared to correlation between miRNA (in blue) and mRNA.
View article: Targeting carbohydrate metabolism in colorectal cancer - synergy between DNA-damaging agents, cannabinoids, and intermittent serum starvation
Targeting carbohydrate metabolism in colorectal cancer - synergy between DNA-damaging agents, cannabinoids, and intermittent serum starvation Open
Chemotherapy is a therapy of choice for many cancers. However, it is often inefficient for long-term patient survival and is usually accompanied by multiple adverse effects. The adverse effects are mainly associated with toxicity to normal…
View article: Development of efficient and scalable regeneration tissue culture method for Cannabis sativa
Development of efficient and scalable regeneration tissue culture method for Cannabis sativa Open
Large scale production of uniform disease-free plants is crucial for Cannabis sativa biotechnology. Existing micropropagation protocols rely heavily on shoot multiplication from existing meristems via direct organogenesis. Such protocols d…
View article: Glycolytic flux controls retinal progenitor cell differentiation via regulating Wnt signaling
Glycolytic flux controls retinal progenitor cell differentiation via regulating Wnt signaling Open
Metabolic pathways are remodeled in response to energy and other homeostatic demands and are dynamically regulated during embryonic development, suggestive of a role in guiding cellular differentiation. Here, we show that glycolytic flux i…
View article: Glycolytic flux controls retinal progenitor cell differentiation via regulating Wnt signaling
Glycolytic flux controls retinal progenitor cell differentiation via regulating Wnt signaling Open
Metabolic pathways are remodeled in response to energy and other homeostatic demands and are dynamically regulated during embryonic development, suggesting a role in guiding cellular differentiation. Here, we show that glycolytic flux is r…
View article: Evaluating the Impact of Repeated Global Ransomware Attacks on Governance, Risk, and Compliance Frameworks: A Computational Perspective
Evaluating the Impact of Repeated Global Ransomware Attacks on Governance, Risk, and Compliance Frameworks: A Computational Perspective Open
Nowadays, ransomware is one of the most significant threats to organizational security, causing widespread disruption across various sectors and challenging existing cybersecurity defenses. A novel concept examined in this study is the ass…
View article: Targeting β-Cell Plasticity: A Promising Approach for Diabetes Treatment
Targeting β-Cell Plasticity: A Promising Approach for Diabetes Treatment Open
The β-cells within the pancreas play a pivotal role in insulin production and secretion, responding to fluctuations in blood glucose levels. However, factors like obesity, dietary habits, and prolonged insulin resistance can compromise β-c…
View article: Glycolytic flux controls retinal progenitor cell differentiation via regulating Wnt signaling
Glycolytic flux controls retinal progenitor cell differentiation via regulating Wnt signaling Open
Metabolic pathways are remodeled in response to energy and other homeostatic demands and are dynamically regulated during embryonic development, suggesting a role in guiding cellular differentiation. Here, we show that glycolytic flux is r…
View article: Using advanced biotechnological techniques to improve cannabis cultivars
Using advanced biotechnological techniques to improve cannabis cultivars Open
This comprehensive review paper explores methods of improvement of Cannabis sativa L. propagation and applications. Inherent breeding limitations, genetic instability, and psychoactive compounds have impeded utilization, however, applicati…
View article: Ontogenesis of honey bees (Apis mellifera) under the influence of temperature stress
Ontogenesis of honey bees (Apis mellifera) under the influence of temperature stress Open
The productivity of bee colonies mostly depends on the influence of exogenous factors. The most significant ones include: the presence of a honey base, climatic conditions, environmental temperature, etc. The stability of microclimate indi…
View article: Targeting Colorectal Cancer: Unravelling the Transcriptomic Impact of Cisplatin and High-THC Cannabis Extract
Targeting Colorectal Cancer: Unravelling the Transcriptomic Impact of Cisplatin and High-THC Cannabis Extract Open
Cisplatin and other platinum-derived chemotherapy drugs have been used for the treatment of cancer for a long time and are often combined with other medications. Unfortunately, tumours often develop resistance to cisplatin, forcing scienti…