Igor Lavrov
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View article: Assessment of Chronic Multi-Electrode Spinal Cord Electrical Stimulation and Electromyography Platform in Non-Human Primates
Assessment of Chronic Multi-Electrode Spinal Cord Electrical Stimulation and Electromyography Platform in Non-Human Primates Open
Background/Objectives: Traumatic spinal cord (SC) injury (SCI) is a debilitating neurological condition. Minimally invasive approaches to monitor in real time the functional state of the neuromotor apparatus in animal models of SCI (at res…
View article: Neurophysiological Markers for the Acute Pain Model in Rats Under Urethane-induced Anesthesia
Neurophysiological Markers for the Acute Pain Model in Rats Under Urethane-induced Anesthesia Open
Certain neurophysiological mechanisms of pain can be investigated in anesthetized animals, and such a model is potentially useful for the development of pain treatment. Yet, the interference of pain-related neural patterns and anesthesia-r…
View article: Anatomical Data Driven Modeling of Evoked Compound Action Potentials Recordings During Spinal Cord Stimulation in a Swine Model
Anatomical Data Driven Modeling of Evoked Compound Action Potentials Recordings During Spinal Cord Stimulation in a Swine Model Open
Our findings suggest that ECAP characteristics may not directly represent the level of neural recruitment to a stimulus and are highly dependent on stimulation parameters. Overall, the results of this study provide a mechanistic understand…
View article: Acute Postural Effects of Spinal Cord Injury: Dual Neural Opioid and Endocrine Non-Opioid Mechanism
Acute Postural Effects of Spinal Cord Injury: Dual Neural Opioid and Endocrine Non-Opioid Mechanism Open
Lateral spinal cord injury including lateral hemisection (LHS) leads to asymmetric postural and motor deficits. After traumatic brain injury, asymmetric postural deficits are partly developed through activation of opioid receptors. We here…
View article: Acute Postural Effects of Spinal Cord Injury: Dual Neural Opioid and Endocrine Non-Opioid Mechanism
Acute Postural Effects of Spinal Cord Injury: Dual Neural Opioid and Endocrine Non-Opioid Mechanism Open
Lateral spinal cord injury including lateral hemisection (LHS) leads to asymmetric postural and motor deficits. After traumatic brain injury, asymmetric postural deficits are partly developed through activation of opioid receptors. We here…
View article: Case report: Combined transcutaneous spinal cord stimulation and physical therapy on recovery of neurological function after spinal cord infarction
Case report: Combined transcutaneous spinal cord stimulation and physical therapy on recovery of neurological function after spinal cord infarction Open
The case of a 37-year-old woman who suffered from spinal cord infarction (SI), resulting in a complete spinal cord injury (AIS A, neurological level T10), and autonomic dysfunction is presented. This study aimed to assess the effect of tra…
View article: Quantification of porcine lower thoracic spinal cord morphology with intact dura mater using high‐resolution μCT
Quantification of porcine lower thoracic spinal cord morphology with intact dura mater using high‐resolution μCT Open
Background and Purpose Spinal cord stimulation (SCS) is approved by the Food and Drug Administration for treating chronic intractable pain in the back, trunk, or limbs through stimulation of the dorsal column. Numerous studies have used sw…
View article: Epidural spinal cord recordings (ESRs): sources of neural-appearing artifact in stimulation evoked compound action potentials
Epidural spinal cord recordings (ESRs): sources of neural-appearing artifact in stimulation evoked compound action potentials Open
Objective . Evoked compound action potentials (ECAPs) measured during epidural spinal cord stimulation (SCS) can help elucidate fundamental mechanisms for the treatment of pain and inform closed-loop control of SCS. Previous studies have u…
View article: The role of spinal cord neuroanatomy in the variances of epidural spinal recordings
The role of spinal cord neuroanatomy in the variances of epidural spinal recordings Open
Background Spinal cord stimulation (SCS) has demonstrated multiple benefits in treating chronic pain and other clinical disorders related to sensorimotor dysfunctions. However, the underlying mechanisms are still not fully understood, incl…
View article: Selective Activation of the Spinal Cord with Epidural Electrical Stimulation
Selective Activation of the Spinal Cord with Epidural Electrical Stimulation Open
Spinal cord epidural electrical stimulation (EES) has been successfully employed to treat chronic pain and to restore lost functions after spinal cord injury. Yet, the efficacy of this approach is largely challenged by the suboptimal spati…
View article: Epidural Spinal Cord Recordings (ESRs): Sources of Artifact in Stimulation Evoked Compound Action Potentials
Epidural Spinal Cord Recordings (ESRs): Sources of Artifact in Stimulation Evoked Compound Action Potentials Open
Introduction: Evoked compound action potentials (ECAPs) measured using epidural spinal recordings (ESRs) during epidural spinal cord stimulation (SCS) can help elucidate fundamental mechanisms for the treatment of pain, as well as inform c…
View article: The Left-Right Side-Specific Neuroendocrine Signaling from Injured Brain: An Organizational Principle
The Left-Right Side-Specific Neuroendocrine Signaling from Injured Brain: An Organizational Principle Open
A neurological dogma is that the contralateral effects of brain injury are set through crossed descending neural tracts. We have recently identified a novel topographic neuroendocrine system (T-NES) that operates via a humoral pathway and …
View article: Rehabilitation of spinal patients with diseases and injury of the cervical spine in the early and late postoperative period (analysis of russian and foreign recommendations)
Rehabilitation of spinal patients with diseases and injury of the cervical spine in the early and late postoperative period (analysis of russian and foreign recommendations) Open
Despite the success of modern conservative therapy of severe spinal instability, surgical methods still retain their importance in the treatment of this pathology, but even the most successful operation may be in vain without subsequent ad…
View article: Bipartite left-right sided endocrine system: processing of contralateral effects of brain injury
Bipartite left-right sided endocrine system: processing of contralateral effects of brain injury Open
The crossed descending neural tracts set a basis for contralateral effects of brain injury. In addition, the left-right side-specific effects of the unilateral brain lesions may be mediated by neurohormones through the humoral pathway as d…
View article: Evaluation of the Autologous Genetically Enriched Leucoconcentrate on the Lumbar Spinal Cord Morpho-Functional Recovery in a Mini Pig with Thoracic Spine Contusion Injury
Evaluation of the Autologous Genetically Enriched Leucoconcentrate on the Lumbar Spinal Cord Morpho-Functional Recovery in a Mini Pig with Thoracic Spine Contusion Injury Open
Background: Pathological changes associated with spinal cord injury (SCI) can be observed distant, rostral, or caudal to the epicenter of injury. These remote areas represent important therapeutic targets for post-traumatic spinal cord rep…
View article: Neurointerface with oscillator motifs for inhibitory effect over antagonist muscles
Neurointerface with oscillator motifs for inhibitory effect over antagonist muscles Open
The effect of inhibitory management is usually underestimated in artificial control systems, using biological analogy. According to our hypothesis, the muscle hypertonus could be effectively compensated via stimulation by bio-plausible pat…
View article: Characterization and applications of evoked responses during epidural electrical stimulation
Characterization and applications of evoked responses during epidural electrical stimulation Open
Background Epidural electrical stimulation (EES) of the spinal cord has been FDA approved and used therapeutically for decades. However, there is still not a clear understanding of the local neural substrates and consequently the mechanism…
View article: Memristive circuit-based model of central pattern generator to reproduce spinal neuronal activity in walking pattern
Memristive circuit-based model of central pattern generator to reproduce spinal neuronal activity in walking pattern Open
Existing methods of neurorehabilitation include invasive or non-invasive stimulators that are usually simple digital generators with manually set parameters like pulse width, period, burst duration, and frequency of stimulation series. An …
View article: Oligo (Poly (Ethylene Glycol) Fumarate)-Based Multicomponent Cryogels for Neural Tissue Replacement
Oligo (Poly (Ethylene Glycol) Fumarate)-Based Multicomponent Cryogels for Neural Tissue Replacement Open
Synthetic hydrogels provide a promising platform to produce neural tissue analogs with improved control over structural, physical, and chemical properties. In this study, oligo (poly (ethylene glycol) fumarate) (OPF)-based macroporous cryo…
View article: Characterization and Applications of Evoked Responses During Epidural Electrical Stimulation
Characterization and Applications of Evoked Responses During Epidural Electrical Stimulation Open
Epidural electrical stimulation (EES) of the spinal cord has been FDA approved and used therapeutically for decades. However, there is still not a clear understanding of the local neural substrates and consequently the mechanism of action …
View article: Neurointerface with Oscillator Motifs for inhibitory effect over antagonist muscles for compensation of spastical syndrome
Neurointerface with Oscillator Motifs for inhibitory effect over antagonist muscles for compensation of spastical syndrome Open
The inhibitory management effect is usually un- derestimated in artificial control systems, using biological anal- ogy. According to our hypothesis, the muscle hypertonus could be effectively compensated via stimulation by bio plausible pa…
View article: Consecutive Transcutaneous and Epidural Spinal Cord Neuromodulation to Restore Complete Paralysis
Consecutive Transcutaneous and Epidural Spinal Cord Neuromodulation to Restore Complete Paralysis Open
In this study the effect of transcutaneous (tSCS) and epidural electrical spinal cord stimulation (EES) to facilitate volitional movements, balance, and non-motor functions was consecutively tested in two subjects with motor complete spina…
View article: Editorial: Neuroplasticity in Rehabilitation
Editorial: Neuroplasticity in Rehabilitation Open
EDITORIAL article Front. Rehabilit. Sci., 25 May 2022Sec. Interventions for Rehabilitation https://doi.org/10.3389/fresc.2022.916174
View article: Implementing Principles of Neuroontogenesis and Neuroplasticity for Spinal Cord Injury Therapy
Implementing Principles of Neuroontogenesis and Neuroplasticity for Spinal Cord Injury Therapy Open
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