Igor Letovanec
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View article: Extended pre-training of histopathology foundation models uncovers co-existing breast cancer archetypes characterized by RNA splicing or TGF-β dysregulation
Extended pre-training of histopathology foundation models uncovers co-existing breast cancer archetypes characterized by RNA splicing or TGF-β dysregulation Open
In recent years, histopathology foundation models (hFM) have rapidly advanced in size and complexity, achieving excellent performance in tasks such as cancer diagnosis and biomarker discovery. Here, we reveal novel capabilities of these mo…
View article: Development of patient-derived lymphomoids with preserved tumor architecture for lymphoma therapy screening
Development of patient-derived lymphomoids with preserved tumor architecture for lymphoma therapy screening Open
The efficacy of anti-cancer therapies depends on the genomic composition of the tumor, its microenvironment, spatial organization, and intra-tumor heterogeneity. B-cell lymphomas are a heterogeneous group of tumors emerging from B-cells at…
View article: EWS-WT1 fusion isoforms establish oncogenic programs and therapeutic vulnerabilities in desmoplastic small round cell tumors
EWS-WT1 fusion isoforms establish oncogenic programs and therapeutic vulnerabilities in desmoplastic small round cell tumors Open
EWS fusion oncoproteins underlie several human malignancies including Desmoplastic Small Round Cell Tumor (DSRCT), an aggressive cancer driven by EWS-WT1 fusion proteins. Here we combine chromatin occupancy and 3D profiles to identify EWS-…
View article: Patient-derived lymphomoids preserve the tumor architecture and allow to assess response to therapies in lymphoma
Patient-derived lymphomoids preserve the tumor architecture and allow to assess response to therapies in lymphoma Open
The efficacy of anti-cancer therapies depends on the genomic composition of the tumor, its microenvironment, spatial organization, and intra-tumor heterogeneity. B cell lymphomas are a heterogeneous group of tumors emerging from B cells at…
View article: SENOSI Confocal Microscopy: A New and Innovating Way to Detect Positive Margins in Non-Palpable Breast Cancer?
SENOSI Confocal Microscopy: A New and Innovating Way to Detect Positive Margins in Non-Palpable Breast Cancer? Open
In Switzerland, breast cancer is the leading cancer among women, with breast-conserving surgery (BCS) being the preferred treatment for small tumors. The margin status post-surgery is a critical predictor of local recurrence. Achieving neg…
View article: CIC-DUX4 Chromatin Profiling Reveals New Epigenetic Dependencies and Actionable Therapeutic Targets in CIC-Rearranged Sarcomas
CIC-DUX4 Chromatin Profiling Reveals New Epigenetic Dependencies and Actionable Therapeutic Targets in CIC-Rearranged Sarcomas Open
CIC-DUX4-rearranged sarcoma (CDS) is a rare and aggressive soft tissue tumor that occurs most frequently in young adults. The key oncogenic driver of this disease is the expression of the CIC-DUX4 fusion protein as a result of chromosomal …
View article: LYMPHOMA TISSUE EXPLANTS TO ANTICIPATE RESPONSE TO TARGETED THERAPIES
LYMPHOMA TISSUE EXPLANTS TO ANTICIPATE RESPONSE TO TARGETED THERAPIES Open
The concept of precision medicine emerged to match targeted therapies with the genomic fingerprint of each cancer patient. However, the cellular composition and architecture of tumor tissues are additional parameters that influence respons…
View article: Supplementary Figure 4 from Nongenetic Evolution Drives Lung Adenocarcinoma Spatial Heterogeneity and Progression
Supplementary Figure 4 from Nongenetic Evolution Drives Lung Adenocarcinoma Spatial Heterogeneity and Progression Open
Supplementary Figure 4
View article: Supplementary Table 6 from Nongenetic Evolution Drives Lung Adenocarcinoma Spatial Heterogeneity and Progression
Supplementary Table 6 from Nongenetic Evolution Drives Lung Adenocarcinoma Spatial Heterogeneity and Progression Open
Supplementary Table 6
View article: Supplementary Table 9 from Nongenetic Evolution Drives Lung Adenocarcinoma Spatial Heterogeneity and Progression
Supplementary Table 9 from Nongenetic Evolution Drives Lung Adenocarcinoma Spatial Heterogeneity and Progression Open
Supplementary Table 9
View article: Supplementary Figure 2 from Nongenetic Evolution Drives Lung Adenocarcinoma Spatial Heterogeneity and Progression
Supplementary Figure 2 from Nongenetic Evolution Drives Lung Adenocarcinoma Spatial Heterogeneity and Progression Open
Supplementary Figure 2
View article: Supplementary Figure 2 from Nongenetic Evolution Drives Lung Adenocarcinoma Spatial Heterogeneity and Progression
Supplementary Figure 2 from Nongenetic Evolution Drives Lung Adenocarcinoma Spatial Heterogeneity and Progression Open
Supplementary Figure 2
View article: Supplementary Table 9 from Nongenetic Evolution Drives Lung Adenocarcinoma Spatial Heterogeneity and Progression
Supplementary Table 9 from Nongenetic Evolution Drives Lung Adenocarcinoma Spatial Heterogeneity and Progression Open
Supplementary Table 9
View article: Supplementary Figure 5 from Nongenetic Evolution Drives Lung Adenocarcinoma Spatial Heterogeneity and Progression
Supplementary Figure 5 from Nongenetic Evolution Drives Lung Adenocarcinoma Spatial Heterogeneity and Progression Open
Supplementary Figure 5
View article: Data from Nongenetic Evolution Drives Lung Adenocarcinoma Spatial Heterogeneity and Progression
Data from Nongenetic Evolution Drives Lung Adenocarcinoma Spatial Heterogeneity and Progression Open
Cancer evolution determines molecular and morphologic intratumor heterogeneity and challenges the design of effective treatments. In lung adenocarcinoma, disease progression and prognosis are associated with the appearance of morphological…
View article: Supplementary Table 2 from Nongenetic Evolution Drives Lung Adenocarcinoma Spatial Heterogeneity and Progression
Supplementary Table 2 from Nongenetic Evolution Drives Lung Adenocarcinoma Spatial Heterogeneity and Progression Open
Supplementary Table 2
View article: Supplementary Figure 3 from Nongenetic Evolution Drives Lung Adenocarcinoma Spatial Heterogeneity and Progression
Supplementary Figure 3 from Nongenetic Evolution Drives Lung Adenocarcinoma Spatial Heterogeneity and Progression Open
Supplementary Figure 3
View article: Supplementary Figure 1 from Nongenetic Evolution Drives Lung Adenocarcinoma Spatial Heterogeneity and Progression
Supplementary Figure 1 from Nongenetic Evolution Drives Lung Adenocarcinoma Spatial Heterogeneity and Progression Open
Supplementary Figure 1
View article: Data from Nongenetic Evolution Drives Lung Adenocarcinoma Spatial Heterogeneity and Progression
Data from Nongenetic Evolution Drives Lung Adenocarcinoma Spatial Heterogeneity and Progression Open
Cancer evolution determines molecular and morphologic intratumor heterogeneity and challenges the design of effective treatments. In lung adenocarcinoma, disease progression and prognosis are associated with the appearance of morphological…
View article: Supplementary Figure 5 from Nongenetic Evolution Drives Lung Adenocarcinoma Spatial Heterogeneity and Progression
Supplementary Figure 5 from Nongenetic Evolution Drives Lung Adenocarcinoma Spatial Heterogeneity and Progression Open
Supplementary Figure 5
View article: Supplementary Table 4 from Nongenetic Evolution Drives Lung Adenocarcinoma Spatial Heterogeneity and Progression
Supplementary Table 4 from Nongenetic Evolution Drives Lung Adenocarcinoma Spatial Heterogeneity and Progression Open
Supplementary Table 4
View article: Supplementary Table 1 from Nongenetic Evolution Drives Lung Adenocarcinoma Spatial Heterogeneity and Progression
Supplementary Table 1 from Nongenetic Evolution Drives Lung Adenocarcinoma Spatial Heterogeneity and Progression Open
Supplementary Table 1
View article: Supplementary Table 1 from Nongenetic Evolution Drives Lung Adenocarcinoma Spatial Heterogeneity and Progression
Supplementary Table 1 from Nongenetic Evolution Drives Lung Adenocarcinoma Spatial Heterogeneity and Progression Open
Supplementary Table 1
View article: Supplementary Table 6 from Nongenetic Evolution Drives Lung Adenocarcinoma Spatial Heterogeneity and Progression
Supplementary Table 6 from Nongenetic Evolution Drives Lung Adenocarcinoma Spatial Heterogeneity and Progression Open
Supplementary Table 6
View article: Supplementary Figure 4 from Nongenetic Evolution Drives Lung Adenocarcinoma Spatial Heterogeneity and Progression
Supplementary Figure 4 from Nongenetic Evolution Drives Lung Adenocarcinoma Spatial Heterogeneity and Progression Open
Supplementary Figure 4
View article: Supplementary Figure 1 from Nongenetic Evolution Drives Lung Adenocarcinoma Spatial Heterogeneity and Progression
Supplementary Figure 1 from Nongenetic Evolution Drives Lung Adenocarcinoma Spatial Heterogeneity and Progression Open
Supplementary Figure 1
View article: Supplementary Table 5 from Nongenetic Evolution Drives Lung Adenocarcinoma Spatial Heterogeneity and Progression
Supplementary Table 5 from Nongenetic Evolution Drives Lung Adenocarcinoma Spatial Heterogeneity and Progression Open
Supplementary Table 5
View article: Supplementary Table 7 from Nongenetic Evolution Drives Lung Adenocarcinoma Spatial Heterogeneity and Progression
Supplementary Table 7 from Nongenetic Evolution Drives Lung Adenocarcinoma Spatial Heterogeneity and Progression Open
Supplementary Table 7
View article: Supplementary Table 3 from Nongenetic Evolution Drives Lung Adenocarcinoma Spatial Heterogeneity and Progression
Supplementary Table 3 from Nongenetic Evolution Drives Lung Adenocarcinoma Spatial Heterogeneity and Progression Open
Supplementary Table 3