Igor Mokrousov
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View article: Draft whole-genome sequences of ancestral and modern <i>Mycobacterium tuberculosis</i> Beijing strains with different patterns of virulence
Draft whole-genome sequences of ancestral and modern <i>Mycobacterium tuberculosis</i> Beijing strains with different patterns of virulence Open
Mycobacterium tuberculosis of the Beijing Modern Sublineage displays increased virulence when compared with strains of the Ancient Sublineage. Here, we report the full genome of strains of the two sublineages isolated from tuberculosis pat…
View article: Real-time PCR assay for robust detection and global surveillance of the Mycobacterium tuberculosis Haarlem genotype
Real-time PCR assay for robust detection and global surveillance of the Mycobacterium tuberculosis Haarlem genotype Open
The Haarlem genotype is a significant yet understudied part of the Euro-American lineage of Mycobacterium tuberculosis, characterized by unique pathogenetic features. Spoligotyping is a primary method for its detection, but it is not suita…
View article: Insight into blood proteinase-inhibitor system and pathogenesis of renal tuberculosis induced by phylogenomically different Mycobacterium tuberculosis strains in rabbit model
Insight into blood proteinase-inhibitor system and pathogenesis of renal tuberculosis induced by phylogenomically different Mycobacterium tuberculosis strains in rabbit model Open
View article: Microbiota of the Lung Tuberculoma: Paucibacillary Bacterial Community
Microbiota of the Lung Tuberculoma: Paucibacillary Bacterial Community Open
Caseum, the central necrotic material of tuberculous lesions, is a reservoir of drug-resistant persisting Mycobacterium tuberculosis (MTB). However, tubercle bacilli are not the only bacterial inhabitants of this necrosis. We discuss the a…
View article: Scientific writing for biomedical journal
Scientific writing for biomedical journal Open
View article: Evaluation of Epidemiological Manifestations of Tuberculosis and Genetic Diversity of Mycobacterium tuberculosis Strains with Multiple Drug Resistance in the Omsk Region
Evaluation of Epidemiological Manifestations of Tuberculosis and Genetic Diversity of Mycobacterium tuberculosis Strains with Multiple Drug Resistance in the Omsk Region Open
Background . The prevalence of multidrug-resistant tuberculosis poses a serious public health problem, hampering the success of tuberculosis control programs around the world. Aim : Evaluation of epidemiological manifestations of tuberculo…
View article: Impact of the COVID-19 pandemic on the epidemiology and clinical course of tuberculosis: expected and paradoxical consequences
Impact of the COVID-19 pandemic on the epidemiology and clinical course of tuberculosis: expected and paradoxical consequences Open
Our results are consistent with the reportedly higher ability of Beijing B0/W148 strains (compared to Beijing 94-32) to acquire resistance to anti-TB drugs, their increased virulence and transmissibility. Thus, the seemingly paradoxical, m…
View article: Genomic Insight into Primary Adaptation of Mycobacterium tuberculosis to Aroylhydrazones and Nitrofuroylamides In Vitro
Genomic Insight into Primary Adaptation of Mycobacterium tuberculosis to Aroylhydrazones and Nitrofuroylamides In Vitro Open
Background/Objectives: New anti-tuberculosis compounds are needed to treat patients infected with multi- or extensively drug-resistant Mycobacterium tuberculosis strains. Studies based on spontaneous in vitro mutagenesis can provide insigh…
View article: Correction: Molecular snapshot of drug-resistant Mycobacterium tuberculosis strains from the Plateau State, Nigeria
Correction: Molecular snapshot of drug-resistant Mycobacterium tuberculosis strains from the Plateau State, Nigeria Open
[This corrects the article DOI: 10.1371/journal.pone.0266837.].
View article: Microevolution of Mycobacterium tuberculosis strains during long-term observation of chronic patients
Microevolution of Mycobacterium tuberculosis strains during long-term observation of chronic patients Open
BACKGROUND: A significant proportion of TB patients undergo multiple courses of long-term treatment. AIM: To gain molecular insight into Mycobacterium tuberculosis variation during long-term observation and treatment of chronic tuberculosi…
View article: Genetics of mycobacterial adaptation to selective pressure of antituberculous compounds dissected at the in vitro and in vivo levels
Genetics of mycobacterial adaptation to selective pressure of antituberculous compounds dissected at the in vitro and in vivo levels Open
BACKGROUND: Different spontaneous mutations emerge in Mycobacterium tuberculosis and those beneficial for bacterial survival are selected leading to bacterial drug resistance, tolerance and ultimately - persistence. AIM: To study M. tuberc…
View article: Pre-extensively drug-resistant tuberculosis among newly diagnosed patients in Siberia, Russia
Pre-extensively drug-resistant tuberculosis among newly diagnosed patients in Siberia, Russia Open
AIM: Molecular characterization of M. tuberculosis isolates from newly diagnosed pre-XDR-TB patients in West Siberia, Russia. BACKGROUND: Russia is among the top high-burden countries for multidrug-resistant tuberculosis (MDR-TB). Fluoroqu…
View article: Circulation of <i>Mycobacterium tuberculosis</i> strains of the Beijing Central Asian Outbreak genotype in the Kemerovo region — Kuzbass in 2018–2022
Circulation of <i>Mycobacterium tuberculosis</i> strains of the Beijing Central Asian Outbreak genotype in the Kemerovo region — Kuzbass in 2018–2022 Open
Introduction. The Kemerovo region — Kuzbass is characterized by a high prevalence of multidrug-resistant (MDR) tuberculosis (TB), including coinfection with HIV (HIV/TB). A previously unknown in Russia relationship between MDR and the Beij…
View article: Molecular Genetic Characteristics of Mycobacterium tuberculosis Isolates from Patients with HIV-Associated Tuberculosis
Molecular Genetic Characteristics of Mycobacterium tuberculosis Isolates from Patients with HIV-Associated Tuberculosis Open
The objective: to provide molecular genetic characteristics of Mycobacterium tuberculosis isolates from patients with HIV-associated tuberculosis. Subjects and Methods . Two groups of M. tuberculosis isolates were included in the study: 10…
View article: Antimycobacterial Activity of Essential Oils from Bulgarian Rosa Species Against Phylogenomically Different Mycobacterium tuberculosis Strains
Antimycobacterial Activity of Essential Oils from Bulgarian Rosa Species Against Phylogenomically Different Mycobacterium tuberculosis Strains Open
In this study, we aimed to assess the activity of the essential oils from four Bulgarian oil-bearing roses Rosa damascena Mill., R. alba L., R. centifolia L., and R. gallica L., on the reference strain Mycobacterium tuberculosis H37Rv and …
View article: The Intriguing Pattern of Nontuberculous Mycobacteria in Bulgaria and Description of Mycobacterium bulgaricum sp. nov.
The Intriguing Pattern of Nontuberculous Mycobacteria in Bulgaria and Description of Mycobacterium bulgaricum sp. nov. Open
We investigated the rise of nontuberculous mycobacteria (NTM) infections in Bulgaria, focusing on species identification and distribution from 2018 to 2022. Utilizing advanced diagnostic tools, including the Hain Mycobacterium CM/AS method…
View article: Phylogenomic and genomic analysis reveals unique and shared genetic signatures of Mycobacterium kansasii complex species
Phylogenomic and genomic analysis reveals unique and shared genetic signatures of Mycobacterium kansasii complex species Open
Species belonging to the Mycobacterium kansasii complex (MKC) are frequently isolated from humans and the environment and can cause serious diseases. The most common MKC infections are caused by the species M. kansasii ( sensu stricto ), l…
View article: Molecular characteristics of fluoroquinolone-resistant <i>Mycobacterium tuberculosis</i> strains from newly diagnosed tuberculosis patients in the Northwest of Russia
Molecular characteristics of fluoroquinolone-resistant <i>Mycobacterium tuberculosis</i> strains from newly diagnosed tuberculosis patients in the Northwest of Russia Open
Introduction. Fluoroquinolones remain the key second-line anti-tuberculosis drugs. The aim of the study was the molecular characterization of fluoroquinolone-resistant Mycobacterium tuberculosis strains from newly diagnosed tuberculosis pa…
View article: Phylogenomic and genomic analysis reveals unique and shared genetic signatures of Mycobacterium kansasii complex species
Phylogenomic and genomic analysis reveals unique and shared genetic signatures of Mycobacterium kansasii complex species Open
Species belonging to the Mycobacterium kansasii complex (MKC) are frequently isolated from humans and the environment and can cause serious diseases. The most common MKC infections are caused by the species M. kansasii (stricto sensu), lea…
View article: Molecular epidemiological monitoring of the tuberculosis pathogen in the Arkhangelsk region
Molecular epidemiological monitoring of the tuberculosis pathogen in the Arkhangelsk region Open
Introduction. Against the background of improvement of the main epidemiological indicators (morbidity and mortality) for tuberculosis in the Arkhangelsk region, the proportion of newly diagnosed tuberculosis patients with multidrug-resista…
View article: A multifaceted interplay between virulence, drug resistance, and the phylogeographic landscape of <i>Mycobacterium tuberculosis</i>
A multifaceted interplay between virulence, drug resistance, and the phylogeographic landscape of <i>Mycobacterium tuberculosis</i> Open
Latin-American Mediterranean (LAM) family is one of the most significant and global genotypes of Mycobacterium tuberculosis . Here, we used the murine model to study the virulence and lethality of the genetically and epidemiologically dist…
View article: Insight into pathogenomics and phylogeography of hypervirulent and highly-lethal Mycobacterium tuberculosis strain cluster
Insight into pathogenomics and phylogeography of hypervirulent and highly-lethal Mycobacterium tuberculosis strain cluster Open
View article: Insight into Population Structure and Drug Resistance of Pediatric Tuberculosis Strains from China and Russia Gained through Whole-Genome Sequencing
Insight into Population Structure and Drug Resistance of Pediatric Tuberculosis Strains from China and Russia Gained through Whole-Genome Sequencing Open
This study aimed to determine phenotypic and genotypic drug resistance patterns of Mycobacterium tuberculosis strains from children with tuberculosis (TB) in China and Russia, two high-burden countries for multi/extensively-drug resistant …
View article: Epidemiological manifestations of tuberculosis infection in the Omsk region: dynamics and trends
Epidemiological manifestations of tuberculosis infection in the Omsk region: dynamics and trends Open
Background. Tuberculosis (TB) infection remains relevant as one of the leading public health problems in Russia. The aim. To characterize the dynamics and trends of epidemiological manifestations of TB infection in the Omsk region. Materia…
View article: Phylogenetic relationships of Mycobacterium tuberculosis isolates in Poland: The emergence of Beijing genotype among multidrug-resistant cases
Phylogenetic relationships of Mycobacterium tuberculosis isolates in Poland: The emergence of Beijing genotype among multidrug-resistant cases Open
Introduction The epidemiological situation of tuberculosis (TB) in Poland urges for its continuous and scrupulous monitoring. The objective of this study was to explore the genetic diversity of multidrug-resistant (MDR) and drug-susceptibl…
View article: Molecular detection and phylogeography of the hypervirulent subtype of <i>Mycobacterium tuberculosis</i> Beijing 14717-15
Molecular detection and phylogeography of the hypervirulent subtype of <i>Mycobacterium tuberculosis</i> Beijing 14717-15 Open
Aim. To develop a method for detecting Mycobacterium tuberculosis strains belonging to highly lethal, hypervirulent, multidrug-resistant Beijing 14717-15-cluster to be applied to screen for M. tuberculosis retrospective collections obtaine…
View article: First Insight into Diversity of Minisatellite Loci in Mycobacterium bovis/M. caprae in Bulgaria
First Insight into Diversity of Minisatellite Loci in Mycobacterium bovis/M. caprae in Bulgaria Open
The aim of this study was to assess the diversity of minisatellite VNTR loci in Mycobacterium bovis/M. caprae isolates in Bulgaria and view their position within global M. bovis diversity. Forty-three M. bovis/M. caprae isolates from cattl…
View article: Epidemiology and Drug Resistance Patterns of Mycobacterium tuberculosis in High-Burden Area in Western Siberia, Russia
Epidemiology and Drug Resistance Patterns of Mycobacterium tuberculosis in High-Burden Area in Western Siberia, Russia Open
Russia is a high-burden area for multidrug-resistant tuberculosis (MDR-TB). Here, we studied the epidemiological situation and drug resistance patterns of Mycobacterium tuberculosis in the Omsk region in Western Siberia. M. tuberculosis is…
View article: Genetic Diversity and Primary Drug Resistance of Mycobacterium tuberculosis Beijing Genotype Strains in Northwestern Russia
Genetic Diversity and Primary Drug Resistance of Mycobacterium tuberculosis Beijing Genotype Strains in Northwestern Russia Open
The Beijing genotype is the main family of Mycobacterium tuberculosis in Russia. We analyzed its diversity and drug resistance in provinces across Northwestern Russia to identify the epidemiologically relevant Beijing strains. The study co…
View article: Additional file 2 of Insight into pathogenomics and phylogeography of hypervirulent and highly-lethal Mycobacterium tuberculosis strain cluster
Additional file 2 of Insight into pathogenomics and phylogeography of hypervirulent and highly-lethal Mycobacterium tuberculosis strain cluster Open
Supplementary Material 2