Igor Shmarakov
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View article: Decreased endothelial cell retinoic acid signaling accelerates progression of single ventricle pulmonary arteriovenous malformations
Decreased endothelial cell retinoic acid signaling accelerates progression of single ventricle pulmonary arteriovenous malformations Open
Background Pulmonary arteriovenous malformations (PAVMs) are vascular complications that universally develop in patients with single ventricle congenital heart disease after Glenn surgery. However, the pathophysiological mechanisms underly…
View article: 7288 A Preclinical Mouse Model of Gender-Affirming Hormone Therapy: Metabolic and Behavioral Outcomes
7288 A Preclinical Mouse Model of Gender-Affirming Hormone Therapy: Metabolic and Behavioral Outcomes Open
Disclosure: A. Yasrebi: None. K. Otersen: None. O. Groh: None. E. Guthman: None. I. Shmarakov: None. S. Campbell: None. T.A. Roepke: None. The long-term metabolic effects of gender-affirming hormone therapy (GAHT) is largely unknown, in pa…
View article: Retinoids stored locally in the lung are required to attenuate the severity of acute lung injury in male mice
Retinoids stored locally in the lung are required to attenuate the severity of acute lung injury in male mice Open
Retinoids are potent transcriptional regulators that act in regulating cell proliferation, differentiation, and other cellular processes. We carried out studies in male mice to establish the importance of local cellular retinoid stores wit…
View article: Vitamin A and Vitamin E: Will the Real Antioxidant Please Stand Up?
Vitamin A and Vitamin E: Will the Real Antioxidant Please Stand Up? Open
Vitamin A, acting through its metabolite, all- trans-retinoic acid, is a potent transcriptional regulator affecting expression levels of hundreds of genes through retinoic acid response elements present within these genes. However, the lit…
View article: Actin fence therapy with exogenous V12Rac1 protects against acute lung injury
Actin fence therapy with exogenous V12Rac1 protects against acute lung injury Open
High mortality in acute lung injury (ALI) results from sustained proinflammatory signaling by alveolar receptors, such as TNF-α receptor type 1 (TNFR1). Factors that determine the sustained signaling are not known. Unexpectedly, optical im…
View article: Actin fence therapy with exogenous V12Rac1 protects against Acute Lung Injury
Actin fence therapy with exogenous V12Rac1 protects against Acute Lung Injury Open
High mortality in Acute Lung Injury (ALI) results from sustained proinflammatory signaling by alveolar receptors, such as TNFα receptor type 1 (TNFR1). Factors that determine the sustained signaling are not known. Unexpectedly, optical ima…
View article: Retinol-binding protein 2 (RBP2) binds monoacylglycerols and modulates gut endocrine signaling and body weight
Retinol-binding protein 2 (RBP2) binds monoacylglycerols and modulates gut endocrine signaling and body weight Open
Retinol-binding protein 2 (RBP2) binds 2-monoacylglycerols affecting their intestinal levels and enteroendocrine responses.
View article: The Potential Protective Effect of Oligoribonucleotides-d-Mannitol Complexes against Thioacetamide-Induced Hepatotoxicity in Mice
The Potential Protective Effect of Oligoribonucleotides-d-Mannitol Complexes against Thioacetamide-Induced Hepatotoxicity in Mice Open
This study investigated the potential hepatoprotective effect of oligoribonucleotides-d-mannitol complexes (ORNs-d-M) against thioacetamide (TAA)-induced hepatotoxicity in mice. The hepatoprotective activity of ORNs-d-M was evaluated in th…
View article: Effect of ω-3 polyunsaturated fatty acids on the functional activity of monooxygenase system in the liver microsomal fraction of tumor-bearing rats
Effect of ω-3 polyunsaturated fatty acids on the functional activity of monooxygenase system in the liver microsomal fraction of tumor-bearing rats Open
Досліджено вплив ω-3 поліненасичених жирних кислот (ПНЖК) на активність компонентів монооксигеназної системи (МОС) печінки щурів-пухлиноносіїв.Показано, що ріст в організмі карциноми Герена супроводжується дисфункціонуванням компонентів МО…
View article: ROLE OF MITOCHONDRIAL NO-SYNTHASE IN THE IMPLEMENTATION OF ANTITUMOR EFFECTS OF POLYUNSATURATED FATTY ACIDS IN THE MODEL OF GUERIN’S CARCINOMA UNDER IN VIVO CONDITIONS
ROLE OF MITOCHONDRIAL NO-SYNTHASE IN THE IMPLEMENTATION OF ANTITUMOR EFFECTS OF POLYUNSATURATED FATTY ACIDS IN THE MODEL OF GUERIN’S CARCINOMA UNDER IN VIVO CONDITIONS Open
NO-synthase activity and NO level in the mitochondrial fraction of rats Guerin’s carcinoma under conditions of different ю-3 and ю-6 polyunsaturated fatty acids (PUFAs) supplementation has been investigated. Guerin’s carcinoma was used as …
View article: <strong>Hepatoprotective Effect of Oligoribonucleotides-D-mannitol Complexes under Thioacetamide-induced Hepatotoxicity</strong>
<strong>Hepatoprotective Effect of Oligoribonucleotides-D-mannitol Complexes under Thioacetamide-induced Hepatotoxicity</strong> Open
Therapeutic application of oligonucleotides is a leading trend in correction of metabolic disorders and related pathologies and is perceived as a unique foundation of innovative biomedicine. Oligoribonucleotides-D-mannitol complexes (ORNs-…
View article: Antitumor Activity of Alloy and Core-Shell-Type Bimetallic AgAu Nanoparticles
Antitumor Activity of Alloy and Core-Shell-Type Bimetallic AgAu Nanoparticles Open
Nanoparticles (NPs) of noble metals, namely gold and silver, remain promising anticancer agents capable of enhancing current surgery- and chemotherapeutic-based approaches in cancer treatment. Bimetallic AgAu composition can be used as a m…
View article: Hepatic Detoxification of Bisphenol A Is Retinoid-Dependent
Hepatic Detoxification of Bisphenol A Is Retinoid-Dependent Open
Bisphenol A (BPA, 2,2-bis(4-hydroxyphenyl) propane) is a widely used industrial chemical. The extensive distribution of BPA in the environment poses risks to humans. However, the molecular mechanisms underlying BPA toxicity as well as its …
View article: Monooxygenase system in Guerin’s carcinoma of rats under conditions of ω-3 polyunsaturated fatty acids administration
Monooxygenase system in Guerin’s carcinoma of rats under conditions of ω-3 polyunsaturated fatty acids administration Open
The aim of the study was to determine the variations of function in components of monooxygenase system (MOS) of rat Guerin’s carcinoma under ω-3 polyunsaturated fatty acids (PUFAs) administration. The activity of Guerin’s carcinoma microso…
View article: Hepatotoxicity of bisphenol A under conditions of differential supplementation with retinoids
Hepatotoxicity of bisphenol A under conditions of differential supplementation with retinoids Open
Classical xenoestrogenic in vivo effects of bisphenol A (2,2-bis(4-hydroxyphenyl)propane, BPA) are well-described in the literature, however the molecular mechanisms of BPA-induced hepatotoxicity are not fully characterized. The work is ai…
View article: Lipid peroxidation in cardiac mitochondrial fraction of rats exposed to different supplementation with polyunsaturated fatty acids
Lipid peroxidation in cardiac mitochondrial fraction of rats exposed to different supplementation with polyunsaturated fatty acids Open
The effect of diet supplementation with polyunsaturated fatty acids (PUFAs) used at different ratios of w-6/w-3 was studied on the content of primary (diene conjugates, DC; triene conjugates, TC), secondary (ketodienes, CD; coupled trienes…
View article: Retinoid-xenobiotic interactions: the Ying and the Yang.
Retinoid-xenobiotic interactions: the Ying and the Yang. Open
The literature provides compelling evidence pointing to tight metabolic interactions between retinoids and xenobiotics. These are extensive and important for understanding xenobiotic actions in the body. Within the body, retinoids affect x…
View article: Hepatoprotective activity of exogenous RNA
Hepatoprotective activity of exogenous RNA Open
Hepatoprotective activity of Nuclex, a pharmaceutical composed of low-molecular yeast RNA, was investigated during acute and chronic thioacetamide-induced hepatotoxicity. It is demonstrated, that Nuclex administration at a dose of 200 mg/k…